A naturally occurring copper peptide with tissue repair and anti-aging effects in skin; systemic longevity claims are mostly preclinical.
Strong topical evidence for skin benefits. Systemic longevity claims are early-stage and mostly mechanistic. If taken orally, absorption and bioavailability are uncertain.
GHK-Cu (Glycyl-L-Histidyl-L-Lysine Copper Complex) is a peptide bioregulator with evidence grade D, meaning it is primarily supported by animal studies. We track 1 products containing GHK-Cu. Typical doses range from 5 to 5 mg per serving. The top-ranked product scores 4.0 out of 10 on our composite scale (dose, evidence, price, testing, transparency). Prices range up to $134.99 per month.
| Product | Brand | Dose | Price/mo | 3rd-party tested | Score |
|---|---|---|---|---|---|
| GHK-Cu | LVLUP Health | 5 mg | $134.99 | No | 4.0 |
Scores are editorial judgments, not a scientific standard. See how we score.
GHK-Cu is a small copper-binding peptide found naturally in human blood. Levels drop with age. It has been shown to promote wound healing, collagen synthesis, and tissue repair. Most human data comes from topical skin applications.
In cell and animal studies, GHK-Cu modulates over 4,000 genes related to tissue repair, anti-inflammation, and collagen production. Topical GHK-Cu has solid evidence for skin rejuvenation. Oral or injectable systemic anti-aging claims are mostly preclinical.
Strong topical evidence for skin benefits. Systemic longevity claims are early-stage and mostly mechanistic. If taken orally, absorption and bioavailability are uncertain.
Glycyl-L-Histidyl-L-Lysine-Copper(II), a tripeptide-copper complex. Endogenous levels decline from ~200 ng/mL at age 20 to ~80 ng/mL at age 60. Modulates gene expression via unidentified receptor mechanisms.
Pickart 2012 compiled in vitro data showing GHK-Cu modulates expression of over 4,000 genes. Multiple small studies show accelerated wound healing and tissue regeneration. Human trials are mostly small or topical.
Short; tissue-specific. Rapidly incorporated into tissue repair sites.
Oral bioavailability is uncertain. Injectable forms are not approved as dietary supplements in most jurisdictions. Copper toxicity risk if taken long-term at high doses.
The trial dose above is our editorial pick from the published human trials for this ingredient. We choose the dose that the best-available studies used on the endpoint most relevant to longevity. The range shows the lowest and highest doses tested in published trials. The landmark studies below are the papers we read to set it. You can click through and check our work.
When new trials publish, our automated sweeps flag them. If a new study materially changes the dose, we update it through editorial review and record the old dose, new dose, and the triggering study in every affected product's recommendation history. The dose is never changed automatically.
Regulatory events, evidence grade changes, and key research milestones for GHK-Cu, most recent first. Studies link to the paper; regulatory entries name and link the responsible authority.
Review: GHK-Cu modulates over 4,000 human genes, promoting tissue repair, anti-inflammatory responses, and collagen synthesis. Blood levels decline with age.
Read study →All products in our catalog that contain GHK-Cu, ranked by our overall score. Ranking is editorial, never paid.
LVLUP HealthStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Molecules in the same class, plus the actives most often formulated alongside GHK-Cu in our catalogue.
Nothing else in the database sits close enough to this molecule to list.
See GHK-Cu in context: the mechanism it acts through, the biomarker it moves, the products that dose it, and the trials that tested it.
View GHK-Cu on the Longevity Map →GHK-Cu is a small copper-binding peptide found naturally in human blood. Levels drop with age. It has been shown to promote wound healing, collagen synthesis, and tissue repair. Most human data comes from topical skin applications.
The trial dose in published human studies is 5 mg per day, with a range of 1 to 10 mg per day. Always consult a qualified clinician before starting any supplement.
Oral bioavailability is uncertain. Injectable forms are not approved as dietary supplements in most jurisdictions. Copper toxicity risk if taken long-term at high doses.
We track 1 products containing GHK-Cu. The top-ranked product scores 4.0 out of 10 on our composite scale, which evaluates dose, evidence, price, third-party testing, and transparency. See the comparison table above. Scores are editorial judgments, not a scientific standard.
GHK-Cu has evidence grade D, meaning it is primarily supported by animal studies. Grade A means replicated human RCTs with hard endpoints. Grade B means human RCTs with biomarker outcomes. Grade C means mixed or small human trials. See our evidence grading methodology.
Evidence grades are reviewed when new human RCTs are published. Product counts update automatically as new products are added. Dose ranges reflect published trial data, not brand recommendations. Read how we verify.