Longevity Map
In-depth toolWhy is this ingredient linked to that goal?
Pick a measurable outcome — ApoB, hs-CRP, NAD+, DunedinPACE. See the biology that drives it, the molecule that targets it, the products that dose it, and the studies behind the ingredient claim. Every link is clickable.
How to read this page
One complete example
Why is omega-3 linked to inflammation? Follow the chain from the biomarker to the study behind the claim.
1 · Pick a measurable outcome
Start with a biomarker you can test in blood: ApoB, hs-CRP, NAD+, or an epigenetic clock.
2 · See the biology
The mechanism that drives the biomarker, and the molecules shown to target it.
3 · Check the evidence
Which supplements dose it, and the published studies behind the ingredient claim.
Goalhs-CRPA sensitive blood marker of low-grade systemic inflammation…→MechanismInflammagingChronic, low-grade inflammation rises with age even without…→IngredientOmega-3essential fatty acid→ProductUltimate OmegaNordic Naturals · Score 8.8 · $45→StudyPublished studypmc.ncbi.nlm.nih.gov
Click any step to open that page. Use the explorer below to follow your own chain.
Pick a level to start
1 · Goal
A biomarker you can test
8-OHdG (8-hydroxy-2'-deoxyguanosine)An oxidised DNA base excreted in urine; the most widely used quantitative…2 mech · 2 molOpen →
CD4/CD8 T-Cell RatioThe ratio of helper to cytotoxic T cells in peripheral blood; inversion below…1 mech · 2 molOpen →
Carotid Intima-Media Thickness (IMT)An ultrasound measurement of carotid artery wall thickness used as a marker…1 mech · 1 molOpen →
DunedinPACE (Pace of Aging Clock)A DNA methylation measure of the current rate of biological aging, built from…1 mech · 1 molOpen →
FGF21 (Fibroblast Growth Factor 21)A liver-derived mitokine released during fasting and mitochondrial stress…2 mech · 4 molOpen →
Fasting InsulinSerum insulin after an 8-12 hour fast; it rises years before fasting glucose…1 mech · 1 molOpen →
GDF-15 (Growth Differentiation Factor 15)A mitochondrial and cellular stress cytokine that is among the strongest…3 mech · 6 molOpen →
GlycanAge (IgG Glycosylation Age)A commercial biological-age test based on antibody sugar-chain patterns…1 mech · 2 molOpen →
GrimAge (DNAm GrimAge Epigenetic Clock)A second-generation epigenetic clock trained directly on mortality data that…1 mech · 1 molOpen →
HomocysteineAn amino acid byproduct linked to cardiovascular and cognitive risk in…1 mech · 1 molOpen →
Horvath Clock (DNA Methylation Age)The first widely used epigenetic clock estimates biological age from DNA…1 mech · 1 molOpen →
Interleukin-6 (IL-6)A key inflammaging cytokine whose chronic elevation independently and…1 mech · 2 molOpen →
Lipoprotein(a) [Lp(a)]A largely genetically fixed atherogenic particle; levels above the 95th…2 mech · 3 molOpen →
NAD+ (Blood/Tissue Levels)A cellular energy coenzyme that declines with age in multiple tissues; NR and…2 mech · 1 molOpen →
PhenoAge (DNAm PhenoAge Epigenetic Clock)A second-generation epigenetic clock built from nine clinical mortality…1 mech · 1 molOpen →
Tumor Necrosis Factor-alpha (TNF-alpha)A pro-inflammatory cytokine with mortality associations that shift…1 mech · 2 molOpen →
VO2max (Maximal Oxygen Uptake)The gold-standard measure of cardiorespiratory fitness; higher VO2max…1 mech · 2 molOpen →
hs-CRP (High-Sensitivity C-Reactive Protein)A sensitive blood marker of low-grade systemic inflammation that…1 mech · 2 molOpen →
2 · Mechanism
The biology that drives it
AGE Formation (Advanced Glycation End-products)Glucose reacts non-enzymatically with long-lived proteins such as collagen…1 molOpen →
AMPK ActivationAMP-activated protein kinase senses low cellular energy and switches on…Hallmark1 molOpen →
AutophagyAutophagy is the cell's recycling system for damaged proteins and organelles…Hallmark1 molOpen →
Cellular Bioenergetics (ATP Production Capacity)How much ATP each mitochondrion actually makes, measured by 31P-MRS and…3 molOpen →
Dysbiosis (Gut Microbiome Imbalance)Age-related shifts in gut bacterial composition that leak inflammatory…Hallmark1 molOpen →
Epigenetic DriftDNA methylation patterns become progressively noisier and less predictable…Hallmark1 molOpen →
InflammagingChronic, low-grade inflammation rises with age even without infection, and it…Hallmark2 molOpen →
Lipid PeroxidationReactive oxygen species attack polyunsaturated fatty acids in membranes and…1 molOpen →
Mitochondrial BiogenesisPGC-1alpha-driven mitochondrial biogenesis declines with age, and exercise…Hallmark2 molOpen →
NAD+ DeclineNicotinamide adenine dinucleotide (NAD+) levels fall with age in animal…Hallmark1 molOpen →
Oxidative Stress and the Free Radical TheoryReactive oxygen species damage cellular components with age, but the…1 molOpen →
Proteostasis CollapseThe cellular quality-control systems that fold, refold, and clear proteins…Hallmark1 molOpen →
Senescence ClearanceSenescent cells stop dividing but refuse to die, secrete inflammatory…Hallmark3 molOpen →
Sirtuin ActivationSirtuins are NAD-dependent deacetylases that link nutrient status to DNA…Hallmark1 molOpen →
3 · Ingredient
The molecule that targets it
4 · Product
Supplements that dose it
Select an ingredient
5 · Study
Studies behind the claim
Select an ingredient