Highly-hyped senolytic; the strong evidence is in mice, not people.
The most-hyped 'senolytic' with the weakest human evidence. If used, biohackers typically pulse it (2 days on / month off) rather than daily.
Fisetin (Fisetin) is a polyphenol / senolytic with evidence grade C, meaning it is backed by mixed or small human trials. We track 18 products containing Fisetin. Typical doses range from 0.4 to 500 mg per serving. The top-ranked product scores 6.7 out of 10 on our composite scale (dose, evidence, price, testing, transparency). Prices range up to $95.00 per month.
| Product | Brand | Dose | Price/mo | 3rd-party tested | Score |
|---|---|---|---|---|---|
| Fisetin 500 mg | Double Wood Supplements | 500 mg | $30.00 | Yes | 6.7 |
| Pure Fisetin - 250 mg, 60 capsules | ProHealth Longevity | 250 mg | $39.17 | Yes | 6.6 |
| SenoAid Extra Strength Senolytic Complex | Jinfiniti | 100 mg | $49.99 | Yes | 6.6 |
| Pure Fisetin | DoNotAge | 400 mg | $95.00 | Yes | 6.3 |
| NOVOS Core | NOVOS Labs | 150 mg | $89.00 | Yes | 6.3 |
Scores are editorial judgments, not a scientific standard. See how we score.
A flavonoid found in strawberries. In mice, high intermittent doses clear senescent (zombie) cells better than quercetin and extend lifespan modestly.
Mouse data is compelling. Human data is very limited, one small trial in COVID-19 patients, one in frailty. Longevity outcomes untested.
The most-hyped 'senolytic' with the weakest human evidence. If used, biohackers typically pulse it (2 days on / month off) rather than daily.
3,3',4',7-tetrahydroxyflavone. Structural analog of quercetin, more lipophilic.
Yousefzadeh et al. 2018 (EBioMedicine) showed lifespan extension in mice at 100 mg/kg intermittent. Human RCTs (NCT03430037, NCT03675724) enrolling but few reported outcomes. Bioavailability improved by liposomal/piperine delivery.
~3 hours; short exposure window.
Standard capsules have <5% absorption. Look for liposomal or with piperine.
When a product exceeds the UL or contains an ingredient with clinically significant interactions, a "Review advised" flag appears on its product page and links here.
The trial dose above is our editorial pick from the published human trials for this ingredient. We choose the dose that the best-available studies used on the endpoint most relevant to longevity. The range shows the lowest and highest doses tested in published trials. The landmark studies below are the papers we read to set it. You can click through and check our work.
When new trials publish, our automated sweeps flag them. If a new study materially changes the dose, we update it through editorial review and record the old dose, new dose, and the triggering study in every affected product's recommendation history. The dose is never changed automatically.
Regulatory events, evidence grade changes, and key research milestones for Fisetin, most recent first. Studies link to the paper; regulatory entries name and link the responsible authority.
Verified 2026-08-06. We update this section as new peer-reviewed trials land.
Fisetin's strongest human data is safety, not efficacy. Scott Tashman, Marc Philippon, Grant Dornan, and Johnny Huard's 2025 phase I/II randomized, double-blind, placebo-controlled trial in 74 people with knee osteoarthritis found intermittent high-dose fisetin caused no significant increase in adverse events versus placebo across 12 months (https://www.ors.org/wp-content/uploads/AM25/429.pdf). That established the dosing strategy is tolerable. Beyond safety, fisetin's senolytic mechanism, clearing senescent cells, has been demonstrated in human tissue only for the related combination dasatinib plus quercetin, not fisetin alone, in LaTonya Hickson's 2019 diabetic kidney disease biopsy study (https://pmc.ncbi.nlm.nih.gov/articles/PMC6796530/).
Marketers position fisetin as a proven senolytic that clears zombie cells and extends healthspan in humans, based on mouse lifespan data. No published human RCT has shown fisetin extends lifespan or clears senescent cells in human tissue on its own. The best-designed human efficacy trial to date, the 2025 knee osteoarthritis RCT, found no significant benefit on pain, cartilage MRI T2 relaxation, physical function, or gait after a year of treatment (https://www.ors.org/wp-content/uploads/AM25/429.pdf). A 2024 study by Eric Lee and colleagues found adding fisetin to dasatinib and quercetin did not clearly improve epigenetic aging markers over dasatinib and quercetin alone, and DQ alone actually increased epigenetic age acceleration on some clocks at 3 and 6 months (https://pubmed.ncbi.nlm.nih.gov/38393697/). Human efficacy trials in cancer survivor frailty (TROFFi) are still ongoing and unpublished as of 2026.
20 mg/kg body weight for 2 consecutive days per cycle (intermittent high-dose senolytic protocol), not a daily maintenance dose
Fisetin was well tolerated in the 2025 knee osteoarthritis trial: 185 adverse events were reported across 74 subjects, mostly minor (joint pain, nausea, headache, dry mouth), with no significant difference between fisetin and placebo groups (all p>0.5). Four serious adverse events occurred, evenly split between groups, all from unrelated surgeries. Fisetin uses an intermittent hit-and-run dosing strategy rather than daily supplementation, following the senolytic model established in mouse studies. Long-term safety of chronic daily dosing has not been established.
In a 10-person pilot study, intermittent fisetin dosing (500 mg/day, one week per month for six months) produced mixed effects on biological age with no significant change in telomere length.
Read study →This randomized, placebo-controlled pilot trial tests whether two consecutive days of fisetin (20 mg/kg/day) reduces blood inflammation markers in older adults, as a senolytic intervention for frailty.
Read study →This preclinical study (mouse models plus human ex vivo adipose tissue) showed fisetin selectively clears senescent cells and extends median and maximum lifespan in mice, providing the basis for human senolytic trials of fisetin.
Read study →All products in our catalog that contain Fisetin, ranked by our overall score. Ranking is editorial, never paid.
Double Wood SupplementsStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
ProHealth LongevityStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
JinfinitiStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
DoNotAgeStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
NOVOS LabsMulti-ingredient bundle
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Multi-ingredient bundle
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Life ExtensionMulti-ingredient bundle
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Renue By ScienceStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
RevgeneticsStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
BulkSupplementsStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Life ExtensionMulti-ingredient bundle
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Perpetua LifeMulti-ingredient bundle
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
ToniiqStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Renue By ScienceMulti-ingredient bundle
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
SolarayStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
CodeageUndisclosed amounts noted
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Life ExtensionMulti-ingredient bundle
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
SupersmartMulti-ingredient bundle
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Molecules in the same class, plus the actives most often formulated alongside Fisetin in our catalogue.
See Fisetin in context: the mechanism it acts through, the biomarker it moves, the products that dose it, and the trials that tested it.
View Fisetin on the Longevity Map →A flavonoid found in strawberries. In mice, high intermittent doses clear senescent (zombie) cells better than quercetin and extend lifespan modestly.
The trial dose in published human studies is 500 mg per day, with a range of 100 to 1400 mg per day. Always consult a qualified clinician before starting any supplement.
No formal UL and no human toxicity studies exist; animal LD50 exceeds 5,000 mg/kg. Senolytic protocols use pulsed high-dose regimens (e.g., ~20 mg/kg/day for 2 consecutive days), and oral bioavailability is very low (<5%).
We track 18 products containing Fisetin. The top-ranked product scores 6.7 out of 10 on our composite scale, which evaluates dose, evidence, price, third-party testing, and transparency. See the comparison table above. Scores are editorial judgments, not a scientific standard.
Fisetin has evidence grade C, meaning it is backed by mixed or small human trials. Grade A means replicated human RCTs with hard endpoints. Grade B means human RCTs with biomarker outcomes. Grade C means mixed or small human trials. See our evidence grading methodology.
Evidence grades are reviewed when new human RCTs are published. Product counts update automatically as new products are added. Dose ranges reflect published trial data, not brand recommendations. Read how we verify.
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