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Senolytique (Liposomal Quercetin, Fisetin, Spermidine)

Autophagy · Capsule · 60 servings

Label snapshot

What the label says

What the product contains and what one serving costs, according to our catalog. Label amounts are not personal dose recommendations.

Ingredients listed
3 ingredients listed largest listed: Quercetin 77 mg
Form
Capsule
List price (catalog, USD)
$51.95
Price per serving
$0.87List price divided by servings per container. A per-day cost only if the label serving is once daily.

Reading notes

  • Multi-ingredient product. Amounts are per ingredient per serving; the product is assessed as one bundle, not as a recommendation for each ingredient.
Full label record: servings, testing, ingredients
Servings per container
60
Catalog monthly estimate
$25.98
Testing disclosure
Brand lists third-party testing; no public lab certificate listedStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Ingredients as listed

IngredientAmount per serving
Quercetin77 mg
Fisetin35 mg
Spermidine3 mg

What to check on the label

  • Read the spermidine line, not the extract line. '800 mg wheat-germ extract' may contain only a few milligrams of spermidine.
  • Check the serving size. Capsule counts per serving vary from one to three.
  • If wheat-germ based, the label states gluten content. The catalog does not store allergen data.

Amounts are per label serving as recorded in the catalog and are not a recommendation. Testing status reflects what the brand lists. Nothing here is medical advice.

Editorial score and research-dose calculations

These calculations describe our scoring method. They are not a recommended dose or proof of benefit from this product.

4.5/10
Overall score
#24 / 25 in Autophagy

Tested by independent lab.

Read the evidence (2 studies)
Watch outEU restricted1 ingredient restricted in the EU
  • Spermidine — Novel Food status for concentrates >7 mg; wheat-germ traditional food
You can legally buy these outside the EU. Sale as a food supplement inside the EU requires a Novel Food authorisation these ingredients do not have.
Tier 4
Ingredient RCT (different dose)
The ingredient was tested in an RCT but at a different dose, or only in animals.
See the 2 supporting studies
  • Jiang et al. 2026 (npj Aging) (Spermidine)Comprehensive review identifying eIF5A-TFEB axis as central autophagy mechanism. SmartAge Phase IIb showed no memory improvement at 12 months. 3.3 mg/day rice germ extract improved cardiometabolic biomarkers. 40 mg/day high-purity spermidine safe for 28 days in older men. Studied at 40 mg. This product: 3 mg.
  • SmartAge (Schwarz et al. 2022, JAMA Network Open) (Spermidine)12-month RCT in 100 adults with subjective cognitive decline: 0.9 mg/day spermidine did not improve memory or biomarkers versus placebo.
How we scored this product Show the full breakdown
Composite How this 4.5 is built. 0.50 × 4.7 + 0.20 × 7.0 + 0.10 × 3.0 + 0.10 × 5.0 + 0.05 × 7.0 + 0.05 × 8.6 = 4.5 out of 10. Safety caps applied after. 4.5
4.5 composite
Dose vs. studies50%4.7
Transparency20%7.0
Value10%3.0
Formulation10%5.0
Safety5%7.0
Community5%8.6

Evidence gates dose: the evidence grade sets the ceiling, and the dose decides how much of that ceiling the product reaches. Value = inverse of price-per-trial-dose-day. Community = mean sentiment of external reviews. Safety caps applied after weighting.

This score is our editorial judgment, not a scientific standard. We combine published evidence, dose, price, transparency, and consumer signals into one composite: this is our method, not a peer-reviewed clinical rating. A higher score means a product does better on the factors we weight, not that it is medically proven to work.

Read the full method →

Editorial verdict

Quick verdict

4.5 / 10
Best for
Budget-friendly
Avoid if
Only 31% of trial dose, No public lab certificate
Full-dose status
31% of trial dose
Price/month
$26
COA status
Not public
Biggest caveat
Dose-evidence score of 4.7 is below average for the site.
Nearest alternatives
Catalog snapshot. Check linked sources for current price, label and batch-specific testing.
Price verification
Current price: $51.95
Last price check: Sep 01, 2026
Layer 2 · Context
In plain language

Why this scored this way

This Renue By Science Senolytique (Liposomal Quercetin, Fisetin, Spermidine) scores 5.3, making it among the lowest-scoring products we track. It delivers 77mg of Quercetin, 30% of the studied range low edge (250mg) with grade B evidence (promising human data, not yet comprehensive). At $5.62/day it's among the more expensive options in Autophagy.

What drives the score up

  • Tested by independent lab (transparency 7.0).
  • Community score of 8.6 with positive consumer feedback.

What drags it down

  • Dose-evidence score of 4.7 is below average for the site.
  • Overall dose is only 31% of the trial dose across ingredients.
  • Quercetin (77.0mg is 15% of the 500mg trial dose) is significantly under-dosed.
  • Fisetin (35.0mg is 7% of the 500mg trial dose) is significantly under-dosed.
  • Spermidine (3.0mg is 250% of the 1.2mg trial dose) is well above the trial dose. More is not always better.

Why you'd choose it

  • You want Quercetin from a Renue By Science product.
  • You want a tested by independent lab product.

Why you might skip it

  • You want a product with a publicly available CoA.
  • You need a full trial dose of quercetin (this product under-doses it).
  • You want a standard dose of spermidine (this product is well above it).
Question 1

Does the molecule work?

The science behind each active ingredient, independent of which brand sells it.

Quercetin

Best-studied 'senolytic' ingredient, though evidence is early.

4 landmark RCTs · US: Dietary supplement · EU: Food supplement (extract-dependent)
Fisetin

Highly-hyped senolytic; the strong evidence is in mice, not people.

3 landmark RCTs · US: Dietary supplement · EU: Food supplement
Spermidine

The autophagy-inducing polyamine; the largest human trial found no cognitive benefit.

2 landmark RCTs · US: Dietary supplement · EU: Novel Food status for concentrates >7 mg; wheat-germ traditional food

Full ingredient breakdown

Every active in this formula, its declared dose per serving, the dose used in the primary human trial, how much of that trial dose this product delivers, and the evidence grade for the ingredient itself.

IngredientDose / servingResearch dose% of researchEvidence grade
Quercetin77 mg500 mg15%B
Fisetin35 mg500 mg7%C
Spermidine3 mg1.2 mg250%C

Percentages are dose per serving ÷ primary trial dose. Below 50% means the formula is unlikely to reproduce the trial outcome for that active. Grade A = multiple large human RCTs. Grade F = no human evidence. How grades work. Full glossary →

Question 2

Is this bottle good?

The specific product: dose, price, transparency, and what buyers report.

Dose vs research
31% of trial dose
Well below the trial dose
Cost at trial dose
$5.62/day at trial dose
What one effective daily dose actually costs
Transparency
7.0/10 · No public lab certificate
Independent batch testing confirmed
Consumer signals
No consumer signals collected yet
Operational signal only, never used as clinical evidence
Question 3

What's the catch?

Safety flags, transparency gaps, dosing concerns, and recurring buyer complaints.

Safety flag
fisetin: warfarin/anticoagulant interaction
Dose or interaction risk detected. See ingredient page for details.
No public lab certificate
Certificate of Analysis not published
Without a public lab certificate, batch purity and potency cannot be independently verified.
Underdosed
Dose at 31% of trial dose
Below 50% of the dose used in published clinical trials.
Buyer complaints
Trustpilot: Australia Post delivery issues
Recurring themes from consumer review platforms.
Plain English

What’s inside

The main ingredients of this product, in plain language.

Quercetin77 mgEvidence B

Best-studied 'senolytic' ingredient, though evidence is early.

Read about Quercetin →
Fisetin35 mgEvidence C

Highly-hyped senolytic; the strong evidence is in mice, not people.

Read about Fisetin →
Spermidine3 mgEvidence C

The autophagy-inducing polyamine; the largest human trial found no cognitive benefit.

Read about Spermidine →
Layer 3 · Evidence vault

Product data & verification

Hard numbers and independently checked status. Expand each block for its source.

The numbers

Price
$52
per bottle · 60 servings
Dose vs. research
Below trial dose 31%
of published effective dose
$ / day at studied dose
$5.62
what one effective daily dose costs
$ / g active
$7.53
per gram of active substance
Independently checked

Data verification

COA status
Not public
Evidence grade
BCC
Per-ingredient breakdown
BQuercetin
CFisetin
CSpermidine

All product data is checked against original sources. Prices, doses, and testing status are updated when product pages change. Evidence grades are reviewed when new human RCTs are published. Read how we verify.

What's inside

Ingredient
Dose in this product
Trial dose
Evidence
77 mg 15% of trial dose
500 mg
35 mg 7% of trial dose
500 mg
Spermidine
The autophagy-inducing polyamine; the largest human trial found no cognitive benefit.
3 mg 250% of trial dose
1.2 mg
4.4 /5
Medium confidence Strong value signal
172 reviews across 2 platforms (2 sources)
Source diversity: 46%
RedditTrustpilot
Praisepersonal positive experience reported over timeexcellent product quality
ComplaintsAustralia Post delivery issues
Last checked: 2026-08-07

Consumer signals

Consumer signals gathered from 2 platforms.

Medium confidence

1 thread discussed · positive sentiment

Praisepersonal positive experience reported over time
Themes

A Reddit user's ongoing account of taking Renue by Science Senolytique reports a positive experience with the combination senolytic formula.

Compiled from a Reddit discussion thread listing located during research; verified at build time.

172 reviews · 4.4/5 · mixed sentiment

Praiseexcellent product qualitytesting results available on website
ComplaintsAustralia Post delivery issues
Themes

The Australian Trustpilot listing for Renue by Science praises product quality and available third-party test results, though delivery via Australia Post drew complaints.

Compiled from a Trustpilot listing located during research; verified at build time.

These are consumer sentiment signals. They do not measure whether the product actually works. See our evidence section for that.

What others say (unverified)

No external reviews aggregated yet for this product.

Layer 3 · Evidence vault

Evidence, claims & regulation

Published evidence, claim checks, regulatory status and what could not be verified.

Important to know
QuercetinPlain quercetin dihydrate has poor absorption. Phytosome forms deliver 10 to 20× more into blood.
FisetinStandard capsules have <5% absorption. Look for liposomal or with piperine.
SpermidineProduct labels often say 'wheat germ extract 800 mg', that could be 0.8 mg or 8 mg of actual spermidine. Insist on labeled spermidine content.

Editorial notes

A genuinely liposomal 3-in-1 combo, but each ingredient is present at a fraction of its individual standalone Renue product's dose and well below senolytic trial doses (e.g. Mayo Clinic fisetin trials use ~20mg/kg intermittently), best understood as a maintenance-dose antioxidant blend rather than a senolytic protocol.

Brand owners

Spot an error?

If you are the manufacturer or brand owner of Senolytique (Liposomal Quercetin, Fisetin, Spermidine) and believe any data on this page is incorrect (wrong dose, wrong ingredient, wrong price, missing certification, outdated status), you can request a correction.

We review every request, verify it against primary sources, and publish any accepted change with a dated note. Corrections from brand owners are treated the same as corrections from anyone else: verified before they move.

Request a correction →
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