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Category · 25 products

Autophagy

Molecules that push cellular clean-up: spermidine is the anchor, with fasting mimetics alongside.

Category statistics and scoring
25
5.5
A
T1
22
$0.04
Compare the top 3 → Filter the full index →
Ranked

Every Autophagy product we score

Same formula as the rest of the site. Position here has never been bought.

Reading guide

How to read this shelf

Spermidine dominates, with fisetin and some combinations. Spermidine amounts are small (1 to 10 mg per serving) and often come from wheat-germ or rice-germ extract, where extract weight and spermidine content differ by a large factor.

Check on every label

  • Read the spermidine line, not the extract line. '800 mg wheat-germ extract' may contain only a few milligrams of spermidine.
  • Check the serving size. Capsule counts per serving vary from one to three.
  • If wheat-germ based, the label states gluten content. The catalog does not store allergen data.
Catalog figures for this shelf (25)
Products
25
Most common lead ingredients
Spermidine (16), Fisetin (5), Resveratrol (1)
Forms
Capsule (19), Powder (3), Tablet (2)
Range of Spermidine per serving
1 mg to 25 mg across 16 products
Price per serving
$0.17 to $3.00
Testing listed
21 of 25 list third-party testing · 6 publish a CoA
Multi-ingredient products
4 of 25 list three or more ingredients

Counts and ranges are catalog facts about the labels, not a ranking. The score, evidence and safety sections below are separate.

Top 3 for this shelf

The three best-evidenced options here, with the plain verdict and the catch first. The full ranking continues below.

01
ProHealth Longevity
Pure Spermidine - 1 mg, 180 capsules
Autophagy
Active per serving
Spermidine 1 mgCapsule · 180 servings
Price per serving
$0.17$29.95 · 180 servings
Testing
3rd-party listed · public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 7.1/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$0.20
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with www.prohealth.com

Verdict: This ProHealth Longevity Pure Spermidine - 1 mg, 180 capsules scores 7.1, making it a mid-tier product with both strengths and weaknesses. It delivers 1mg of Spermidine, inside the studied range of 0–6mg with grade C evidence (mostly preclinical, limited human data). Transparency is a clear strength (score: 9.0), with third-party testing and a public lab certificate. At $0.20/day it's priced well for what you get.

02
Oxford Healthspan
Primeadine Original
Autophagy
Active per serving
Spermidine 1 mgCapsule · 30 servings
Price per serving
$3.00$90.00 · 30 servings
Testing
3rd-party listed · no public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 6.2/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$3.60
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with oxfordhealthspan.com

Verdict: This Oxford Healthspan Primeadine Original scores 6.2, making it below the site average. It delivers 1mg of Spermidine, inside the studied range of 0–6mg with grade C evidence (mostly preclinical, limited human data). At $3.60/day it's among the more expensive options in Autophagy.

The catch: No public lab certificate available for independent verification.

03
Solaray
Unlimit Spermidine
Autophagy
Active per serving
Spermidine 3.3 mgVegCap · 60 servings
Price per serving
$0.64$38.19 · 60 servings
Testing
3rd-party listed · no public lab certificate

Daily use may exceed one serving

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 6.2/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$0.23
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with solaray.com

Verdict: This Solaray Unlimit Spermidine scores 6.2, making it below the site average. It delivers 3mg of Spermidine, inside the studied range of 0–6mg with grade C evidence (mostly preclinical, limited human data). At $0.23/day it's priced well for what you get.

The catch: Spermidine (3.3mg is 275% of the 1.2mg trial dose) is well above the trial dose. More is not always better.

Quick compare

Top 5 in Autophagy

Sorted by overall score. Same numbers you'll see on each product page.

#ProductScorePrimary activeDose vs RCTPrice/moValue rankDose+Evidence
#1Pure Spermidine - 1 mg, 180 capsules
ProHealth Longevity
7.10/10Spermidine 1mg✅ 100%$5/moTop 23%6.0/10
#2Primeadine Original
Oxford Healthspan
6.20/10Spermidine 1mg✅ 100%$90/moBottom 15%6.0/10
#3Unlimit Spermidine
Solaray
6.20/10Spermidine 3mg✅ 100%$38/moMid-range6.0/10
#4spermidineLIFE Ultra+
Longevity Labs
6.20/10Spermidine 3mg✅ 100%$80/moMid-range5.5/10
#5spermidineLIFE Original 365+
Longevity Labs
6.20/10Spermidine 2mg✅ 100%$69/moMid-range5.5/10

Tied scores are shown to two decimals. Ties break in this order: dose vs study dose, then transparency, then value, then price per day at studied dose.

Show all 25 Autophagy products →
04
Longevity Labs
spermidineLIFE Ultra+
Autophagy
Active per serving
Spermidine 3 mg+ Zinc 1.65 mg
Price per serving
$2.67$80.10 · 30 servings
Testing
3rd-party listed · no public lab certificate

Elemental vs compound: check label

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 6.2/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$1.07
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with spermidinelife.us
05
Longevity Labs
spermidineLIFE Original 365+
Autophagy
Active per serving
Spermidine 2 mg+ Zinc 1 mg
Price per serving
$2.32$69.49 · 30 servings
Testing
3rd-party listed · no public lab certificate

Elemental vs compound: check label

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 6.2/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$1.39
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with www.fromaustria.com
06
Supersmart
Spermidine 3mg
Autophagy
Active per serving
Spermidine 3 mgCapsule · 30 servings
Price per serving
$0.69$20.80 · 30 servings
Testing
None listed

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 6.1/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$0.28
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with us.supersmart.com
07
Oxford Healthspan
Primeadine Original Powder
Autophagy
Active per serving
Spermidine 1 mgPowder · 90 servings
Price per serving
$2.67$240.00 · 90 servings
Testing
3rd-party listed · no public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 6.0/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$3.20
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with oxfordhealthspan.com
08
Double Wood Supplements
Spermidine 8 mg
Autophagy
Active per serving
Spermidine 8 mgCapsule · 60 servings
Price per serving
$0.58$35.00 · 60 servings
Testing
3rd-party listed · public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 5.9/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

889%
of trial dose
$0.09
per research-dose day, not label serving
889% · over 2× trial dose0Trial dose2×
Catalog price · Confirm current price with doublewoodsupplements.com
09
DoNotAge
Pure Spermidine
Autophagy
Active per serving
Spermidine 10 mgCapsule · 30 servings
Price per serving
$2.00$60.00 · 30 servings
Testing
3rd-party listed · public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 5.9/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

1111%
of trial dose
$0.24
per research-dose day, not label serving
1111% · over 2× trial dose0Trial dose2×
Catalog price · Confirm current price with donotage.org
10
Oxford Healthspan
Primeadine GF (Gluten-Free)
Autophagy
Active per serving
Spermidine 1 mgTablet · 30 servings
Price per serving
$3.00$90.00 · 30 servings
Testing
None listed

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 5.9/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$3.60
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with oxfordhealthspan.com
11
ProHealth Longevity
Pure Fisetin - 250 mg, 60 capsules
Autophagy
Active per serving
Fisetin 250 mgCapsule · 60 servings
Price per serving
$0.65$39.17 · 60 servings
Testing
3rd-party listed · public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 5.8/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$1.31
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with www.prohealth.com
12
GenuinePurity
Liposomal Spermidine
Autophagy
Active per serving
Spermidine 8 mgCapsule · 30 servings
Price per serving
$1.67$49.95 · 30 servings
Testing
3rd-party listed · public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 5.6/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

889%
of trial dose
$0.25
per research-dose day, not label serving
889% · over 2× trial dose0Trial dose2×
Catalog price · Confirm current price with www.genuinepurity.com
13
Renue By Science
Spermidine (Liposomal)
Autophagy
Active per serving
Spermidine 8 mgCapsule · 45 servings
Price per serving
$1.11$49.95 · 45 servings
Testing
3rd-party listed · no public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 5.5/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

889%
of trial dose
$0.17
per research-dose day, not label serving
889% · over 2× trial dose0Trial dose2×
Catalog price · Confirm current price with renuebyscience.com
14
DoNotAge
Pure Fisetin
Autophagy
Active per serving
Fisetin 400 mgCapsule · 366 servings
Price per serving
$0.26$95.00 · 366 servings
Testing
3rd-party listed · no public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 5.5/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$0.32
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with donotage.org
15
Life Extension
GEROPROTECT Stem Cell
Autophagy
Active per serving
Resveratrol 378 mgCapsule · 30 servings
Price per serving
$1.20$36.00 · 30 servings
Testing
3rd-party listed · no public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 5.3/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$1.59
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with www.lifeextension.com
16
Neurogan Health
Spermidine Tablets
Autophagy
Active per serving
Spermidine 10 mgTablet · 60 servings
Price per serving
$0.58$34.99 · 60 servings
Testing
3rd-party listed · no public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 5.2/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

1111%
of trial dose
$0.07
per research-dose day, not label serving
1111% · over 2× trial dose0Trial dose2×
Catalog price · Confirm current price with neuroganhealth.com
17
Green as Nature
Spermidine Capsules 12mg
Autophagy
Active per serving
Spermidine 12 mgCapsule · 60 servings
Price per serving
$0.66$39.60 · 60 servings
Testing
3rd-party listed · public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 5.2/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

1333%
of trial dose
$0.07
per research-dose day, not label serving
1333% · over 2× trial dose0Trial dose2×
Catalog price · Confirm current price with www.greenasnature.com.au
18
Renue By Science
Fisetin (Liposomal)
Autophagy
Active per serving
Fisetin 150 mgCapsule · 90 servings
Price per serving
$0.72$64.95 · 90 servings
Testing
3rd-party listed · no public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 5.2/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$2.41
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with renuebyscience.com
19
BulkSupplements
Fisetin Powder
Autophagy
Active per serving
Fisetin 100 mgPowder · 100 servings
Price per serving
$0.22$21.97 · 100 servings
Testing
None listed

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 5.1/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$1.10
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with www.bulksupplements.com
20
Life Extension
Senolytic Activator
Autophagy
Ingredients listed
3 ingredients listedlargest listed: Fisetin 312 mg
Price per serving
$1.66$19.89 · 12 servings
Testing
3rd-party listed · no public lab certificate

Multi-ingredient bundle

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 4.9/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$2.66
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with www.lifeextension.com
Autophagy
Active per serving
Spermidine 25 mgCapsule · 120 servings
Price per serving
$0.83$100.00 · 120 servings
Testing
3rd-party listed · no public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 4.5/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

2778%
of trial dose
$0.04
per research-dose day, not label serving
2778% · over 2× trial dose0Trial dose2×
Catalog price · Confirm current price with www.revgenetics.com
22
Toniiq
Spermidine +
Autophagy
Active per serving
Spermidine 21 mgCapsule · 30 servings
Price per serving
$0.83$24.97 · 30 servings
Testing
3rd-party listed · no public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 4.5/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

2333%
of trial dose
$0.05
per research-dose day, not label serving
2333% · over 2× trial dose0Trial dose2×
Catalog price · Confirm current price with www.toniiq.com
Autophagy
Ingredients listed
6 ingredients listedlargest listed: Probiotics 200 mg
Price per serving
$1.17$34.99 · 30 servings
Testing
3rd-party listed · no public lab certificate

CFU not stored

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 4.5/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

1%
of trial dose
$358.87
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with seed.com
Autophagy
Ingredients listed
3 ingredients listedlargest listed: Quercetin 77 mg
Price per serving
$0.87$51.95 · 60 servings
Testing
3rd-party listed · no public lab certificate

Multi-ingredient bundle

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 4.5/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

31%
of trial dose
$5.62
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with renuebyscience.com
25
Supersmart
Natural Rapalogs
Autophagy
Ingredients listed
5 ingredients listedlargest listed: Curcumin 200 mg
Price per serving
$1.63$49.00 · 30 servings
Testing
None listed

Multi-ingredient bundle

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 3.9/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

40%
of trial dose
$8.17
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with us.supersmart.com
Connected

What defines this shelf

Actives used here
Spermidine (17)Fisetin (7)Zinc (2)Resveratrol (2)Quercetin (2)Quercetin Phytosome (1)Apigenin (1)Riboflavin (B2) (1)Melatonin (1)PQQ (1)Pterostilbene (1)Probiotics (1)Curcumin (1)EGCG (1)
Brands competing
Oxford Healthspan (3)Renue By Science (3)ProHealth Longevity (2)Longevity Labs (2)Supersmart (2)DoNotAge (2)Life Extension (2)Solaray (1)Double Wood Supplements (1)GenuinePurity (1)Neurogan Health (1)Green as Nature (1)BulkSupplements (1)Revgenetics (1)Toniiq (1)Seed Health (1)
Consumer signals
24 products with consumer ratings 8 high-confidence signals 25,862 total consumer reviews
Other categories
NAD+ booster (52)Omega (37)Mitochondrial (30)Antioxidant (25)Metabolic (20)Connective tissue (19)Sirtuin activator (17)Longevity stack (16)Cognition (15)Amino acid (13)Senolytic (10)Adaptogen (9)Multi/greens (9)Vitamin (7)Methyl donor (5)Mineral (5)Microbiome (1)Peptide (1)