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Pure Spermidine - 1 mg, 180 capsules

Autophagy · Capsule · 180 servings

Label snapshot

What the label says

What the product contains and what one serving costs, according to our catalog. Label amounts are not personal dose recommendations.

Active per serving
Spermidine 1 mg
Form
Capsule
List price (catalog, USD)
$29.95
Price per serving
$0.17List price divided by servings per container. A per-day cost only if the label serving is once daily.
Full label record: servings, testing, ingredients
Servings per container
180
Catalog monthly estimate
$4.99
Testing disclosure
Brand lists third-party testing and a public certificate of analysis (CoA)Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Ingredients as listed

IngredientAmount per serving
Spermidine1 mg

What to check on the label

  • Read the spermidine line, not the extract line. '800 mg wheat-germ extract' may contain only a few milligrams of spermidine.
  • Check the serving size. Capsule counts per serving vary from one to three.
  • If wheat-germ based, the label states gluten content. The catalog does not store allergen data.

Amounts are per label serving as recorded in the catalog and are not a recommendation. Testing status reflects what the brand lists. Nothing here is medical advice.

Editorial score and research-dose calculations

These calculations describe our scoring method. They are not a recommended dose or proof of benefit from this product.

7.1/10
Overall score
#1 / 25 in Autophagy

Public lab certificate, tested by independent lab, top 23% value.

Read the evidence (2 studies)
Watch outEU restricted1 ingredient restricted in the EU
  • Spermidine — Novel Food status for concentrates >7 mg; wheat-germ traditional food
You can legally buy these outside the EU. Sale as a food supplement inside the EU requires a Novel Food authorisation these ingredients do not have.
Tier 4
Ingredient RCT (different dose)
The ingredient was tested in an RCT but at a different dose, or only in animals.
See the 2 supporting studies
  • Jiang et al. 2026 (npj Aging) (Spermidine)Comprehensive review identifying eIF5A-TFEB axis as central autophagy mechanism. SmartAge Phase IIb showed no memory improvement at 12 months. 3.3 mg/day rice germ extract improved cardiometabolic biomarkers. 40 mg/day high-purity spermidine safe for 28 days in older men. Studied at 40 mg. This product: 1 mg.
  • SmartAge (Schwarz et al. 2022, JAMA Network Open) (Spermidine)12-month RCT in 100 adults with subjective cognitive decline: 0.9 mg/day spermidine did not improve memory or biomarkers versus placebo.
How we scored this product Show the full breakdown
Composite How this 7.1 is built. 0.50 × 6.0 + 0.20 × 9.0 + 0.10 × 9.9 + 0.10 × 5.0 + 0.05 × 8.5 + 0.05 × 7.5 = 7.1 out of 10. Safety caps applied after. 7.1
7.1 composite
Dose vs. studies50%6.0
Transparency20%9.0
Value10%9.9
Formulation10%5.0
Safety5%8.5
Community5%7.5

Evidence gates dose: the evidence grade sets the ceiling, and the dose decides how much of that ceiling the product reaches. Value = inverse of price-per-trial-dose-day. Community = mean sentiment of external reviews. Safety caps applied after weighting.

This score is our editorial judgment, not a scientific standard. We combine published evidence, dose, price, transparency, and consumer signals into one composite: this is our method, not a peer-reviewed clinical rating. A higher score means a product does better on the factors we weight, not that it is medically proven to work.

Read the full method →

Editorial verdict

Quick verdict

7.1 / 10
Best for
Full trial dose, Public lab certificate, Budget-friendly
Avoid if
No major red flags
Full-dose status
Meets trial dose
Price/month
$5
COA status
Public
Biggest caveat
No significant weaknesses identified in the current scoring framework.
Nearest alternatives
Catalog snapshot. Check linked sources for current price, label and batch-specific testing.
Price verification
Current price: $29.95
Last price check: Sep 01, 2026
Layer 2 · Context
In plain language

Why this scored this way

This ProHealth Longevity Pure Spermidine - 1 mg, 180 capsules scores 7.1, making it a mid-tier product with both strengths and weaknesses. It delivers 1mg of Spermidine, inside the studied range of 0–6mg with grade C evidence (mostly preclinical, limited human data). Transparency is a clear strength (score: 9.0), with third-party testing and a public lab certificate. At $0.20/day it's priced well for what you get.

What drives the score up

  • Dose-evidence score of 6.0 shows decent alignment with trial doses.
  • Quality transparency of 9.0: tested by independent lab with a public lab certificate.
  • Value score of 9.9 at $0.20/day.

What drags it down

  • No significant weaknesses identified in the current scoring framework.

Why you'd choose it

  • You want good value at $0.20/day.
  • You prioritise tested by independent lab products with public lab certificates.

Why you might skip it

  • You want a product in a different category.
  • You want a cheaper autophagy option.
  • You prefer products with more consumer feedback.
Question 1

Does the molecule work?

The science behind each active ingredient, independent of which brand sells it.

Spermidine

The autophagy-inducing polyamine; the largest human trial found no cognitive benefit.

2 landmark RCTs · US: Dietary supplement · EU: Novel Food status for concentrates >7 mg; wheat-germ traditional food
Question 2

Is this bottle good?

The specific product: dose, price, transparency, and what buyers report.

Dose vs research
100% of trial dose
Meets or exceeds the published effective dose
Cost at trial dose
$0.20/day at trial dose
What one effective daily dose actually costs
Transparency
9.0/10 · Public lab certificate (quality: not assessed)
Independent batch testing confirmed
Consumer signals
No consumer signals collected yet
Operational signal only, never used as clinical evidence
Question 3

What's the catch?

Safety flags, transparency gaps, dosing concerns, and recurring buyer complaints.

Buyer complaints
Amazon: One reviewer reported not noticing any changes
Recurring themes from consumer review platforms.
Plain English

What’s inside

The main ingredients of this product, in plain language.

Spermidine1 mgEvidence C

The autophagy-inducing polyamine; the largest human trial found no cognitive benefit.

Read about Spermidine →
Layer 3 · Evidence vault

Product data & verification

Hard numbers and independently checked status. Expand each block for its source.

The numbers

Price
$30
per bottle · 180 servings
Dose vs. research
of trial dose 100%
of published effective dose
$ / day at studied dose
$0.20
what one effective daily dose costs
$ / g active
$166.39
per gram of active substance
Independently checked

Data verification

COA status
Public
Evidence grade
C
Per-ingredient breakdown
CSpermidine

All product data is checked against original sources. Prices, doses, and testing status are updated when product pages change. Evidence grades are reviewed when new human RCTs are published. Read how we verify.

What's inside

Ingredient
Dose in this product
Trial dose
Evidence
Spermidine
The autophagy-inducing polyamine; the largest human trial found no cognitive benefit.
1 mg 83% of trial dose
1.2 mg
3.8 /5
High confidence
91 reviews across 3 platforms (3 sources)
Source diversity: 69%
AmazonTrustpilotiHerb
PraiseImproved energy reported after regular useStrong endorsement for longevity support
ComplaintsOne reviewer reported not noticing any changes
Last checked: 2026-08-20

Consumer signals

Consumer signals gathered from 3 platforms.

Medium confidence

6 reviews · positive sentiment

PraiseImproved energy reported after regular useStrong endorsement for longevity supportPure formulation with no 'junk additives'
ComplaintsOne reviewer reported not noticing any changes
Themes

ProHealth's own product page shows mostly positive (5 of 6) reviews for Pure Spermidine, citing energy and longevity support, with one reviewer noting no perceptible effect.

Compiled from a ProHealth product page listing located during research; verified at build time.

5 reviews · positive sentiment

PraiseDeeper sleep and faster recoverySharper daytime focus and reduced burnout

Purity, third-party testing, and good value for 180-capsule bottle

Themes

iHerb reviewers of ProHealth Pure Spermidine highlight improved sleep quality, recovery, and mental clarity, along with appreciation for third-party-tested purity.

Compiled from a iHerb listing located during research; verified at build time.

80 reviews · 3.8/5

These are consumer sentiment signals. They do not measure whether the product actually works. See our evidence section for that.

What others say (unverified)

No external reviews aggregated yet for this product.

Layer 3 · Evidence vault

Evidence, claims & regulation

Published evidence, claim checks, regulatory status and what could not be verified.

Evidence

Research behind this product

The studies that established the trial dose and evidence grade for each active ingredient in this product. Click through to read the original paper.

What we could not verify

We list this openly. If a claim isn't backed by a source we can trace, we'd rather flag it than repeat it.

  • Reddit community discussion community forum
    mixed sentiment

    Community discussion exists, with positive themes around longevity, skin, and vitality alongside concern about the high price of 1 mg servings. No single Reddit thread is treated as a representative product review.

    no direct URLchecked 2026-08-07
  • ProHealth on-site reviews own platform

    The product page includes first-party reviews without a public aggregate rating or count.

    verified 2026-08-07Open source →
Important to know
SpermidineProduct labels often say 'wheat germ extract 800 mg', that could be 0.8 mg or 8 mg of actual spermidine. Insist on labeled spermidine content.

Editorial notes

A modestly dosed (1mg/capsule, up to 3mg/day) wheat-germ-derived spermidine product; per-mg dose is on the lower end compared to some competitor spermidine products offering 5-15mg per serving.

Brand owners

Spot an error?

If you are the manufacturer or brand owner of Pure Spermidine - 1 mg, 180 capsules and believe any data on this page is incorrect (wrong dose, wrong ingredient, wrong price, missing certification, outdated status), you can request a correction.

We review every request, verify it against primary sources, and publish any accepted change with a dated note. Corrections from brand owners are treated the same as corrections from anyone else: verified before they move.

Request a correction →
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