Studies , Encyclopedia

Study T3

12‑weeks fisetin supplementation and interval resistance with aerobic training: changes in Maresin‑1 and inflammatory markers in men with obesity: a randomized controlled trial.

four-arm parallel-group randomised controlled trial · 2026

Study T3

6 Eye Health Protocols

n=1 biomarker mapping / protocol guide · 2026

Study T3

A bacterial enzyme enhances both energy metabolism and health across the life span of C. elegans and mice

preclinical animal study · 2026

Study T2

A cross-species drug-discovery platform to accelerate the identification of lifespan-extending interventions.

High-throughput cross-species preclinical drug-discovery platform · 2026

Study T3

A geroprotective probiotic and its functional metabolite counteract inflammaging to extend healthspan

Human multi-cohort microbiome analysis plus oral intervention in naturally aged mice · 2026

Study T3

A phase-II randomized controlled pilot study of nicotinamide riboside supplementation in older adults with amnestic mild cognitive impairment.

phase II, double-blind, randomised, placebo-controlled pilot trial · 2026

Study T2

A randomized controlled trial of L-taurine for fatigue in decompensated cirrhosis

Open-label randomized controlled trial, 12 weeks, 1000 mg/day L-taurine plus standard care vs standard care alone · 2026

Study T2

A randomized trial of omega-3 fatty acids plus inositol versus N-acetylcysteine for the treatment of depression and mania in emotionally dysregulated youth age 5-17 with and without autism traits.

randomized controlled trial · 2026

Study T2

A randomized, open-label, pilot clinical study to evaluate the effect of omega-3-enriched egg supplementation in healthy participants.

randomized controlled trial · 2026

Study T1

A self-selected vegan diet reduces skeletal muscle mass in healthy older adults: a randomized controlled trial.

Three-arm 12-week randomized controlled trial · 2026

Study T2

A Vegan Diet Epigenetically Modulates Inflammatory Pathways and Biological Aging: Genome-Wide DNA Methylation Analysis of a One-Month Isocaloric Vegan Versus Meat-Rich Dietary Intervention.

One-month randomized isocaloric dietary intervention comparing vegan and meat-rich diets · 2026

Study T4

About Derek Lowe

primary · 2026

Study T4

About Dr. Rhonda Patrick

primary · 2026

Study T2

Accelerated biological age linked to high normal serum sodium in general healthcare electronic medical records and NHANES

Observational analysis of healthcare electronic medical records and NHANES · 2026

Study T3

Acid hydrolysis of jaboticaba (Myrciaria jaboticaba) peel and seed powder increases urolithin excretion in a cross-over clinical trial with normoweight subjects.

randomised crossover clinical trial with acute urinary metabolite endpoints · 2026

Study T4

ADD-IT1: A Randomized Study of Adjuncts to Immunotherapy in Patients With Advanced Cancers (Phase 2)

Phase 2 randomised trial of multiple adjuncts (propranolol, desloratadine, magnesium and vitamin D) added to standard immunotherapy in advanced cancers, not yet recruiting · 2026

Study T3

Aerobic exercise training modalities: a scoping review of study designs

primary · 2026

Study T2

Alpha-lipoic acid as a preventive measure in radiation-induced oral mucositis in head and neck cancer patients: A randomized controlled study.

randomised, placebo-controlled trial during radiotherapy · 2026

Study T4

Altos Labs corporate site

primary · 2026

Study T4

American Federation for Aging Research leadership

primary · 2026

Study T2

An open benchmark and language models for AI in aging biology

Benchmark study of AI systems across five aging-biology biodata domains with domain-specific model fine-tuning · 2026

Study T4

Andrew D. Huberman

primary · 2026

Study T4

Andrew Huberman x AG1

primary · 2026

Study T4

Anti-inflammatory effects of nicotinamide mononucleotide (NMN) in human skeletal muscle after BFR-exercise.

randomised, placebo-controlled, counterbalanced crossover mechanistic study · 2026

Study T2

Aspirin and healthy longevity within racial and ethnic minoritized older adults in the United States

Post-hoc subgroup analysis of the randomized, double-blind, placebo-controlled ASPREE trial · 2026

Study T3

Assessment of the Efficacy of Quercetin in Adult Patients With Autism Spectrum Disorder: A Randomized, Triple-Blind, Placebo-Controlled Trial.

randomised, triple-blind, placebo-controlled clinical trial · 2026

Study T3

Association between blood nicotinamide adenine dinucleotide levels and blood laboratory parameters at baseline and after nicotinamide mononucleotide supplementation in middle-aged healthy individuals: post hoc analysis of a randomized, double-blinded, placebo-controlled clinical trial.

post hoc analysis of a randomised, double-blind, placebo-controlled trial · 2026

Study T1

Berberine and Adiposity in Diabetes-Free Individuals With Obesity and MASLD: A Randomized Clinical Trial (BRAVO)

Multicenter, double-blind, randomized clinical trial (11 hospitals in China) · 2026

Study T4

Bill Gifford author page

primary · 2026

Study T4

Bill Gifford speaker profile

primary · 2026

Study T2

Biological age measured by DNA methylation clocks and reproductive history: Systematic review and meta-analysis

Systematic review and cross-sectional meta-analysis of 29 studies using DNA-methylation age clocks · 2026

Study T2

Blocking PD-L2 prevents senescent cell accumulation and age-related dysfunction

Mechanistic cellular study and mouse intervention study · 2026

Study T3

Blueprint adds CONNEQT Pulse to its Protocol Marketplace

commercial partnership and product listing; no clinical outcome study · 2026

Study T4

Blueprint protocol page no longer displays its daily prescription stack

n=1 public protocol-page revision; text comparison only, no outcome data · 2026

Study T4

Blueprint protocol snapshot exposes a prescription-stack discrepancy

n=1 self-experiment / current protocol-page revision with an internal prescription discrepancy · 2026

Study T2

Brain-gut crosstalk associated with brain ageing in young and mid-life adults: a multicohort cross-sectional study

Multicohort cross-sectional neuroimaging, cognitive, microbiome, and metabolomic study · 2026

Study T2

Bryan Johnson and Kate Tolo publicise a female-health measurement protocol

two-person n=2 planned biomarker and sauna-telemetry experiment; no results reported · 2026

Study T3

Bryan Johnson announces a new Blueprint creatine batch

n=1 public product and supply update; no clinical study · 2026

Study T3

Bryan Johnson announces an Eight Sleep machine-learning model

public sponsored short; no study design reported · 2026

Study T2

Bryan Johnson highlights LDL reduction and vascular-event evidence

public evidence summary citing a meta-analysis of randomized trials · 2026

Study T4

Bryan Johnson posts a measured morning routine

n=1 daily protocol / biomarker tracking · 2026

Study T3

Bryan Johnson recaps a Baseten longevity event

public reaction / event recap; not a controlled study · 2026

Study T4

Bryan Johnson reports 51-day dunk-training changes

n=1 self-experiment / instrumented jump-training update · 2026

Study T4

Bryan Johnson reports a 265-pound front-box-squat PR

n=1 self-experiment / strength-training update · 2026

Study T4

Bryan Johnson reports a 385-pound training PR

n=1 self-experiment / training update · 2026

Study T4

Bryan Johnson reports a high mold-spore count in his gym

single-site indoor-air sampling with a self-reported outdoor comparison; no health outcome study · 2026

Study T4

Bryan Johnson reports an eHbA1c of 4.4%

n=1 biomarker update with personal tracking · 2026

Study T4

Bryan Johnson reports short-term metric changes during a five-day high-altitude trip

n=1 naturalistic self-experiment; five days at about 7,000 ft with self-reported sleep, nervous-system, and resting-heart-rate metrics · 2026

Study T4

Bryan Johnson reports touching the rim at a 31-inch vertical

n=1 self-experiment / self-reported jump-training performance update · 2026

Study T4

Bryan Johnson took a transplant drug to live longer, then the side effects changed his mind

primary · 2026

Study T3

Bryan Johnson uploads “Can I dunk at 49?”

public video about an n=1 performance experiment; no controlled study design reported · 2026

Study T4

Bryan Johnson's Best Result Is the One He Doesn't Lead With

primary · 2026

Study T2

Bryan Johnson’s Biomarkers: The Science and Limits of Biological Age

critical evidence review / commentary · 2026

Study T2

Caloric restriction modulates genome-wide somatic mutation in mice

Preclinical caloric-restriction study using high-fidelity duplex DNA sequencing · 2026

Study T3

Can systemic resveratrol improve periodontal treatment outcomes in smokers?

double-blind placebo-controlled RCT (commentary), 12 months, systemic resveratrol 500 mg/day · 2026

Study T2

Causal association between lipoproteins and risk of coronary artery disease: a systematic review and meta-analysis of Mendelian randomization studies

meta-analysis · 2026

Study T2

Cells of the same age follow dramatically different biological aging paths

Original research: single-cell DNA methylation analysis across mouse and human tissues · 2026

Study T2

Characterization of DNA methylation in PBMCs and donor-matched iPSCs shows age-related methylation is reset during stem cell reprogramming

Human donor-matched PBMC and induced-pluripotent-stem-cell methylation study · 2026

Study T4

Charles Perkins Centre Royal Prince Alfred Clinic

primary · 2026

Study T4

Clinical Translation of Senolytic Therapy With Fisetin to Improve Vascular Function in Older Adults (Phase 1/2)

Phase 1/2 pilot randomised controlled trial of intermittent fisetin in adults aged 65 and older, active, not recruiting · 2026

Study T2

CNS target engagement of high-dose DHA supplementation in older adults at risk for dementia: a randomised, double-blind, placebo-controlled trial.

phase IIa randomised, double-blind, placebo-controlled trial · 2026

Study T2

Cognitive and affective effects of L-Theanine: a systematic review and meta-analysis of 31 randomized trials

RCT · 2026

Study T3

Combined Aerobic-Resistance Training and Taurine Supplementation Reduce Asprosin and Elevate Spexin in Men with Obesity: A 12-Week Supplement-Blinded, Randomized Controlled Trial.

randomised, placebo-controlled, supplement-blinded four-group trial · 2026

Study T3

Comparison of mediterranean and healthy eating guideline interventions on the dietary inflammatory index in rheumatoid arthritis: results from a dietary randomised controlled intervention trial.

two-arm randomised dietary intervention trial · 2026

Study T2

Could creatine supplementation combined with physical rehabilitation accelerate return to play in athletes with patellar tendinopathy?

randomized controlled trial · 2026

Study T2

Creatine supplementation modifies fat deposition in arm and leg tissues in individuals with Down syndrome.

prospective, randomised, double-blind, placebo-controlled trial · 2026

Study T2

Curcumin supplementation during high-altitude exposure modulates body composition and its relationship with gut microbiota: a randomized controlled trial.

randomized controlled trial · 2026

Study T3

Curcumin-mediated Modulation of T-bet and CD8+ T Cells: A Potential Anti-inflammatory Mechanism in Knee Osteoarthritis.

mechanistic sub-study of a double-blind placebo-controlled trial, secondary molecular analysis of RNA biospecimens · 2026

Study T4

Curriculum Vitae

primary · 2026

Study T2

Daily Multivitamins May Slow Biological Aging, Two-Year Trial Suggests

Two-year randomized controlled trial with biological age (DNAmAge) endpoints · 2026

Study T4

David A. Sinclair

primary · 2026

Study T4

David A. Sinclair's Affiliations

primary · 2026

Study T4

Dog Aging Project

primary · 2026

Study T3

Donor Age Impairs Vasculogenic Potential of hiPSC-Derived Endothelial Progenitors via Elevated Mitochondrial Reactive Oxygen Species

in-vitro comparative preprint using donor-derived hiPSC endothelial progenitors · 2026

Study T2

Dulaglutide vs insulin in adolescents with thalassaemia-induced diabetes: effect on metabolism and atherogenesis (DIADEMA).

randomized controlled trial · 2026

Study T2

Early-life sugar restriction causally reduces adult cancer incidence and slows biological aging

Natural experiment using UK sugar rationing and UK Biobank follow-up · 2026

Study T2

Eating less protein could slow aging: major review of 350+ studies

Comprehensive narrative review of 350+ studies · 2026

Study T2

Effect of a pro-fertility diet combined with omega-3 supplementation on embryo quality in infertile women undergoing IVF: a randomized controlled trial.

randomized controlled trial · 2026

Study T2

Effect of alpha-lipoic acid supplementation on polycystic ovary syndrome clinical outcome in infertile females treated with letrozole: a randomized controlled trial

randomized, open-label controlled trial · 2026

Study T2

Effect of an oral complementary medicine combination for symptomatic knee osteoarthritis: A double-blind, randomized, placebo-controlled trial.

randomized controlled trial · 2026

Study T4

Effect of Branched-Chain Amino Acid Supplementation Alone or Combined With Tryptophan or Methionine on Appetite Control and Related Health Outcomes in Older Adults: Protocol for a Randomized Controlled Trial.

four-arm randomised controlled trial protocol · 2026

Study T3

Effect of different sources of saturated and polyunsaturated fatty acids on postprandial inflammation: A double-blind randomized crossover trial.

double-blind, randomised, four-way crossover acute meal trial · 2026

Study T4

Effect of mTOR Inhibition and Other Metabolism Modulating Interventions on the Elderly: Immune, Cognitive, and Functional Consequences (Phase 2)

Phase 2 substudy of mTOR inhibition in older adults with cardiac MRI endpoints (RAPA cMRI with LGE), active, not recruiting · 2026

Study T3

Effect of Omega-3 Fatty Acid Intake on Circulating Biomarkers of Atrial Fibrillation-Related Pathways in the PREDIMED-Plus Study.

observational longitudinal analysis within PREDIMED-Plus · 2026

Study T4

Effects of a Multi-Component Nutraceutical (NUT2) on the Lipid Profile in Adults with Low-to-Moderate Cardiovascular Risk: A Randomized Placebo-Controlled Trial

12-week randomized double-blind placebo-controlled parallel-group trial · 2026

Study T2

Effects of Berberine, White Mulberry Leaf Extract and Chromium Picolinate on Body Composition and Insulin Resistance in Adults with Obesity: A Randomized Controlled Trial.

randomized controlled trial · 2026

Study T2

Effects of creatine supplementation with and without exercise and diet intervention on body composition, cognitive function, and markers of health in middle-aged and older adults.

randomized controlled trial · 2026

Study T2

Effects of daily multivitamin-multimineral supplementation on metabolomic profiles: 2-year findings from the COSMOS randomized clinical trial.

randomized controlled trial · 2026

Study T2

Effects of high-load, velocity-intentional variable resistance training combined with creatine supplementation on neuroplasticity, oxidative stress, inflammation, physical function, cognitive performance and quality of life in older adults: A randomized, double-blind, placebo-controlled trial.

six-arm randomised controlled trial of training plus creatine or placebo · 2026

Study T3

Effects of magnesium supplementation on serum brain-derived neurotrophic factor levels and cognitive function in patients undergoing fluoxetine therapy for depression.

randomised adjunctive trial of magnesium plus fluoxetine versus fluoxetine · 2026

Study T4

Effects of Omega-3 and Omega-9 Fatty Acid Supplementation on HOMA-IR and Inflammatory Markers in Children with Obesity and Insulin Resistance: A Triple-Blind RCT with Post-Intervention Follow-Up

3-month triple-blind three-arm randomized controlled trial with 2-month follow-up · 2026

Study T3

Effects of Omega-3 Supplementation in Sarcopenia After Bariatric Surgery: A Triple-Blind Randomized Controlled Clinical Trial.

triple-blind randomised placebo-controlled perioperative trial · 2026

Study T1

Effects of resistance training on strength, function, and muscle mass in older women with sarcopenia

primary · 2026

Study T2

Effects of Urolithin A supplementation on muscle health outcomes in humans from randomized controlled trials

Systematic review and meta-analysis of 5 randomized controlled trials · 2026

Study T4

Efficacy and Safety of Berberine in Non-alcoholic Steatohepatitis: a Multicentre, Randomised, Placebo-controlled Trial (Phase 2)

Phase 2 multicentre randomised placebo-controlled trial of berberine in non-alcoholic steatohepatitis, terminated · 2026

Study T2

Efficacy and Safety of Pregabalin and Alpha-Lipoic Acid Combination in Patients With Painful Diabetic Peripheral Neuropathy: A Randomized, Open-Label, Non-Inferiority, Phase IV Clinical Trial and Subgroup Analysis (OPTIMUM Study).

phase IV randomised, active-controlled, open-label, multicentre trial · 2026

Study T1

Efficacy and Safety of Time-Restricted Eating in Adults With Type 1 Diabetes: A Randomized Controlled Trial

randomized controlled trial · 2026

Study T3

Efficacy of multi-layered human iPS cell-derived cardiovascular cell sheets in a pacing-induced canine dilated cardiomyopathy model

controlled preclinical large-animal study · 2026

Study T5

Elixir Pharmaceuticals overview

primary · 2026

Study T2

Enhanced bioavailability of a novel double-layered nano-liposomal curcumin (BNT-C060): a randomized, double-blind, clinical trial.

randomized controlled trial · 2026

Study T1

ENLIGHTENme: Translating the Benefits of Self-Administered Daytime Light Supplementation to Older Adults in the Real World

Prospective randomized interventional study in older adults across three European cities · 2026

Study T2

Ensemble DNA methylation clock demonstrates Immune-metabolic Aging signatures associated with Mortality

survival-model cohort analysis · 2026

Study T2

Epigenetic aging during adjuvant chemotherapy for colon cancer and modification by a resistance training intervention.

Secondary longitudinal analysis of the randomized FORCE resistance-training trial · 2026

Study T2

Epigenetic Clocks of Biological Aging and Cognitively Healthy Longevity: The Women's Health Initiative Memory Study.

Prospective cohort analysis of 15 epigenetic clocks · 2026

Study T2

Everolimus-based immunosuppression induces alloreactive regulatory T cell expansion combined with loss of alloreactive effector T cells.

randomized controlled trial · 2026

Study T3

Examining the feasibility and preliminary effects of resistance exercise training and creatine supplementation in individuals treated for colorectal cancer.

randomised, placebo-controlled pilot trial of hybrid resistance training · 2026

Study T3

Exploring a tolerable and effective dosage of omega-3 fatty acids as a supplement in enterally fed patients with severe pneumonia: A pilot study.

randomised, controlled, three-group pilot study in enterally fed severe-pneumonia patients · 2026

Study T4

Fatty Acid Research Institute

primary · 2026

Study T3

Feasibility, safety and tolerability of intradialytic creatine supplementation in hemodialysis: A double-blind, randomized, placebo-controlled pilot study.

double-blind, randomised, placebo-controlled pilot trial · 2026

Study T2

Fine-mapping HLA-II haplotypes in Alzheimer’s disease and healthy longevity reveals distinct associations with microglial HLA-II load and neuropathology

Genetic fine-mapping and neuropathology analysis across centenarians, population controls, and Alzheimer disease patients · 2026

Study T2

First Large-Scale NMN RCT Shows Significant Improvement in Cognitive Function

Randomized, double-blind, placebo-controlled trial · 2026

Study T2

Fish oil-derived fatty acids during pregnancy and risk of neurodevelopmental disorders in children at age 10 - A randomized controlled trial.

randomized controlled trial · 2026

Study T2

From Broad-Spectrum Senolysis to Precision Reprogramming: Senolytics Enter Next Generation

Review/Perspective article · 2026

Study T4

George Church (geneticist)

primary · 2026

Study T4

George Church — Select Achievements

primary · 2026

Study T2

Geroprotective insights into the natural metabolite spermidine in aging and age-related diseases

Narrative review of mechanistic, preclinical, and clinical evidence · 2026

Study T2

GlyNAC Reversed 9 Hallmarks of Aging in Humans

Controlled supplementation trial · 2026

Study T3

HSP-1/HSPA8 directs selective translation towards longevity or immunity

mechanistic preprint using C. elegans and human cells · 2026

Study T2

Identification of the tendon/ligament stem cell in mice and humans

Comparative stem-cell identification, lineage tracing, and disease-mechanism study · 2026

Study T1

Immune-Enhancing Nutrition and Outcomes After Radical Cystectomy: A Randomized Clinical Trial.

multicentre randomised, double-blind phase 3 clinical trial · 2026

Study T4

In the Pipeline

primary · 2026

Study T1

Integration of proteomic aging clocks in a phase 2a clinical trial supports simultaneous geroprotective assessment

Secondary biomarker analysis of a 12-week phase 2a randomized clinical trial in idiopathic pulmonary fibrosis · 2026

Study T2

Intraocular Pressure During Short-Term Topical or Systemic Corticosteroid Treatment: Analysis of 3 Randomized Clinical Trials.

randomized controlled trial · 2026

Study T3

is cialis a longevity medicine?

public short video; no study design reported · 2026

Study T4

Jan Vijg, PhD

primary · 2026

Study T2

Krill oil increases plasma omega-3 fatty acids more than fish oil in healthy adults: a double-blind randomized controlled trial.

double-blind, randomised clinical trial · 2026

Study T4

L-Nutra corporate site and founder page

primary · 2026

Study T4

Life Biosciences corporate site

primary · 2026

Study T4

Lithium Orotate & NDGA: The Two Compounds Bryan Johnson Added After Dropping Rapamycin

primary · 2026

Study T3

Long-term impact of caloric restriction on liver health and cell survival in a mouse model

preprint; longitudinal mouse comparison of ad-libitum, chronic and intermittent caloric restriction · 2026

Study T3

Long-term NMN treatment increases lifespan and healthspan in mice in a sex dependent manner

preprint; long-term dietary NMN intervention in male and female mice · 2026

Kane A, Chellappa K, Schultz M, Carr A, Arnold M, Li J, Amorim J, Zheng M, Gao Y, Rich K, Lichter J, Dixon-McDougall T, O'Donnell C, Ibrahim N, Joshi N, Zambrano R, Thompson E, Ouyang S, Tyshkovskiy A, Diener C, Zhu D, Mitchell S, Griffin P, Tian X, Petty C, Conway R, Walsh K, Shelerud L, Duesing C, Mueller A, Li K, McNamara M, Shima R, Tobias-Wallingford H, Ross J, Coppotellii G, de Cabo R, Gladyshev V, Wu L, Yuji I, Gibbons S, Baur J, Rajman L, Sinclair D · Research Square preprint Published Sep 21, 2026 · Added Sep 27, 2026 Read →

Study T4

Longevity expert Dr. Peter Attia steps down from David Protein after Epstein links

primary · 2026

Study T4

Longevity Mix Actives

primary · 2026

Study T2

Longevity pharmacology: are we finally seeing clinical progression?

Critical perspective and narrative review (January 2000 to April 2026) · 2026

Study T3

Longitudinal association of dietary spermidine with hepatic function indexes and cardiometabolic traits in older adults with metabolic syndrome.

one-year longitudinal observational analysis of dietary intake · 2026

Study T4

Low-Dose Fisetin Supplementation and Chronic Inflammation in Middle-Aged and Older Adults: Study Protocol for a Triple-Blind, Randomised, Placebo-Controlled Trial

Randomised controlled trial protocol, triple-blind, placebo-controlled · 2026

Study T1

Low-dose omega-3 supplementation does not raise atrial fibrillation risk: largest meta-analysis to date

Meta-analysis of 35 randomized controlled trials · 2026

Study T4

Luteolin and glycitein from Codonopsis pilosula ameliorate age-related locomotor decline in C. elegans via DAF-16-dependent but autophagy-divergent pathways

Mechanistic intervention study in aged Caenorhabditis elegans · 2026

Study T3

Macadamia Nut Slaw Recipe

consumer-facing recipe and product content · 2026

Study T1

Magnesium Sulfate to Prevent Perioperative Atrial Fibrillation in Cardiac Surgery: A Randomized Clinical Trial.

double-blind, randomised, placebo-controlled single-centre clinical trial · 2026

Study T4

Max Planck Institute for Biology of Ageing

primary · 2026

Study T1

Maximizing weight loss with cagrisema: a systematic review and GRADE-assessed meta-analysis of randomized controlled trials.

systematic review and meta-analysis · 2026

Study T3

Mesenchymal stem cell therapy for diabetes: clinical evidence, emerging strategies, and future perspectives

review of registered interventional trials · 2026

Study T2

Mesenchymal stromal cell-based therapy in the COVID-19 pandemic: results from an academic phase I/II double-blind, randomized, placebo-controlled clinical trial and reflections for the field.

Multicenter, double-blind, randomized, placebo-controlled Phase I/II pilot trial · 2026

Study T4

Metformin Enhances Antioxidant Defenses and Limits Lipid Peroxidation Through the Modulation of Nrf2/KEAP1 Pathway in Hippocampal Neurons Exposed to Amyloid-β Oligomers

Experimental study in primary fetal rat hippocampal neuron cultures · 2026

Study T1

Metformin Therapy Increases Leukocyte Telomere Length, Telomerase Activity, and Longevity Gene Expression in Asian Indians with Prediabetes: A 24-Week Participant-Blind, Outcome-Assessor-Blinded Randomized Controlled Trial.

Participant-blind, outcome-assessor-blinded, placebo-controlled randomized trial · 2026

Study T4

Mind-Body Reprocessing Therapy and Nicotinamide Riboside in Long COVID: a 2x2 Factorial Randomised Controlled Trial (Phase 2)

Phase 2, 2x2 factorial randomised controlled trial, quadruple-blind for the supplement comparison, completed · 2026

Study T3

Mitochondrial-derived peptides (MDPs) activated by physical exercise as therapeutic targets for metabolic disorders: a systematic review.

systematic review · 2026

Study T4

Molecular mechanisms of brain rejuvenation

primary · 2026

Study T4

NAD+ augmentation by nicotinamide riboside engages SLIT2/ROBO1 signaling to attenuate Th17 inflammation in psoriasis.

randomised, placebo-controlled mechanistic supplementation study · 2026

Study T3

Nestle-Led Clinical Study: NR and NMN Promote Metabolic Health in Unexpected Ways

Controlled supplementation trial, 14-day intervention · 2026

Study T2

Neuroinflammation and Graft Survival in Pluripotent Stem Cell-Derived Therapies for the Central Nervous System.

Peer-reviewed review of pluripotent stem-cell CNS transplantation · 2026

Study T4

Niagen Bioscience corporate site

primary · 2026

Study T4

NICE-PAD II: Nicotinamide Riboside to Improve Functioning in Peripheral Artery Disease (Phase 3)

Phase 3 randomised controlled trial, quadruple-blind, not yet recruiting · 2026

Study T4

Nir Barzilai, M.D.

primary · 2026

Study T3

Omega-3 fatty acids and oral and systemic inflammation: A secondary analysis of a randomized trial in patients with coronary artery disease.

secondary analysis of a randomised supplementation trial · 2026

Study T2

Omega-3 fatty acids and tear cytokines modulation in dry eye patients with low omega-3 index. Have the beneficiaries been pinpointed?

randomised controlled trial with olive-oil placebo · 2026

Study T4

Omega-3 Supplementation Modulates Whole-Blood EPA and DHA Without Improving Patient-Reported Outcomes in Youth with Migraine: A Quasi-Randomized Pilot Trial.

quasi-randomized, double-blind, placebo-controlled pilot, 12 weeks, 340 mg EPA + 510 mg DHA/day · 2026

Study T4

Optispan Geroscience corporate site

primary · 2026

Study T2

Oral Semaglutide in Routine Clinical Practice: 24-Month Real-World Effectiveness, Persistence and Safety in Adults With Type 2 Diabetes

24-month retrospective real-world cohort of adults with type 2 diabetes · 2026

Study T2

Organism-wide cellular dynamics and epigenomic remodeling in mammalian aging

Single-cell atlas study across 21 organs · 2026

Study T4

Peak Performance Stack — Blueprint by Bryan Johnson

primary · 2026

Study T3

Peptide supplements and their therapeutic applications in sports medicine and orthopaedics.

scoping review · 2026

Study T2

Periodontitis, Edentulism, and Accelerated Biological Aging: A Population-Based Study of Epigenetic Clocks

population-based cross-sectional NHANES analysis of adults aged 50 years and older · 2026

Study T4

Peter Attia

primary · 2026

Study T4

Peter Attia Cost: Is His $150,000 Longevity Program and Podcast Membership Worth It?

primary · 2026

Study T4

Peter Attia resigns from CBS News following Epstein backlash

primary · 2026

Study T3

Pilot Randomized Controlled Trial of Krill Oil Supplementation for Chronic Musculoskeletal Pain in Older Adults.

double-blind, randomised, placebo-controlled pilot trial · 2026

Study T2

Plasma glycine decelerates biological aging via the redox-inflammatory axis: A large-scale study modulated by sex and dietary patterns

UK Biobank observational analysis · 2026

Study T3

Plasma levels of antimicrobial peptide LL-37 as a biomarker of sleep quality in patients with obstructive sleep apnea.

observational cohort · 2026

Study T2

Polyphenols increase circulating lipids but improve LDL particle quality and reduce LDL oxidation in postmenopausal women: metabotype- and age-dependent effects in a randomised, placebo-controlled crossover trial.

randomised, placebo-controlled crossover trial (8 weeks active, 4-week washout, 8 weeks placebo) · 2026

Study T2

Polyphenols increase circulating lipids but improve LDL particle quality and reduce LDL oxidation in postmenopausal women: metabotype- and age-dependent effects in a randomised, placebo-controlled crossover trial.

randomized controlled trial · 2026

Study T3

Post-activation performance enhancement (PAPE) and taurine combination improves anaerobic performance in highly trained wrestlers: a double-blind, randomized, crossover study.

double-blind, randomised crossover study with acute performance endpoints · 2026

Study T3

Practical Nutritional Strategies to Attenuate Physiological Stress in Adolescent Soccer Players: A Comparative Trial of CoQ10 and Taurine.

three-arm randomised, double-blind, placebo-controlled trial · 2026

Study T2

Protocol for a randomized, controlled trial of a bioactive dietary polyphenol preparation to promote resilience in healthy individuals.

randomized controlled trial · 2026

Study T2

Psychological adversities are associated with accelerated epigenetic aging: systematic review and meta-analysis

Systematic review and random-effects meta-analysis of observational studies · 2026

Study T2

Quercetin prophylaxis in prevention of acute mountain sickness (AMS): a randomized, double blind, placebo controlled phase-II clinical trials.

double-blind, randomised, placebo-controlled altitude-acclimatisation trial · 2026

Study T4

Randomized clinical trial evaluating triazolopyridazine SLU-2633 as a treatment for gastric cryptosporidiosis in eastern indigo snakes (Drymarchon couperi).

randomised controlled animal treatment study in eastern indigo snakes · 2026

Study T3

Randomized, Double-Blind, Placebo-Controlled Trial of Meriva (Curcuminoids) as a Candidate Chemoprevention Agent for Gastric Carcinogenesis.

double-blind, phase IIa randomised placebo-controlled trial · 2026

Study T3

Randomized, open-label study of the short-term pharmacokinetics of oral magnesium oxide in healthy volunteers.

randomised, open-label, single-dose pharmacokinetic study · 2026

Study T3

Rapamycin Exerts Its Geroprotective Effects in the Ageing Human Immune System by Enhancing Resilience Against DNA Damage

Placebo-controlled experimental medicine study in older adults with ex vivo human T cell experiments · 2026

Study T4

Regenerative Neural Stem Cell Therapy Improves Multidomain Neurological Deficits after Traumatic Brain Injury in Nonhuman Primates

Randomized dose-ranging preclinical study in common marmosets with controlled cortical impact · 2026

Study T2

Responsiveness of epigenetic aging biomarkers to longevity interventions in humans

harmonized longitudinal interventional-study database analysis · 2026

Study T3

Resveratrol and immunomodulation: tabular summary of human trial endpoints

Tabular review of resveratrol effects on immune and inflammatory endpoints across human studies · 2026

Study T3

Roles of autophagy in brain homeostasis and disease

Narrative mechanistic review · 2026

Study T4

S. Jay Olshansky

primary · 2026

Study T4

Safety and Efficacy of Oral AV078 in Participants With Tuberous Sclerosis Complex Refractory Epilepsy (Phase 2)

Phase 2 randomised double-blind placebo-controlled trial of oral AV078 (selective mTORC1 inhibitor) in refractory epilepsy due to tuberous sclerosis complex, not yet recruiting · 2026

Study T4

Saul Villeda, PhD

primary · 2026

Study T4

Sauna use topic hub

primary · 2026

Study T4

Should You Take Olive Oil Shots?

primary · 2026

Study T4

SingulOmics Corp. corporate site

primary · 2026

Study T4

Sir Henry Dale Fellow: Linda Partridge

primary · 2026

Study T3

Spermidine Mitigates Immune Cell Senescence and Boosts Vaccine Responses in Healthy Older Adults-A Pilot Study.

double-blind randomised placebo-controlled pilot study · 2026

Study T2

Sublingual NMN administration increases early circulating terminal catabolites 2PY and 4PY compared with oral administration in healthy adult men.

randomized controlled trial · 2026

Study T2

Supplements and Drugs Are Associated With Biological Age in a Cohort of Exceptionally Healthy Individuals.

Cross-sectional cohort study with longitudinal subset · 2026

Study T1

Survodutide Once Weekly for the Treatment of Adults with Obesity (SYNCHRONIZE-1)

Phase 3, randomized, double-blind, placebo-controlled trial; three arms (survodutide 3.6 mg, 6.0 mg, placebo) 1:1:1; 76 weeks · 2026

Carel W le Roux, Sean Wharton, Elena Startseva, Isabel M Kloer, Samina Ajaz Hussain, Anna Unseld, Biykem Bozkurt, Jamy D Ard, Harold E Bays, Pawel Bogdanski, Elif I Ekinci, Ania M Jastreboff, Linong Ji, Wataru Ogawa, Sue D Pedersen, Kirsi H Pietilainen, Naveed Sattar, Jochen Seufert, Kaj Stenlof, Andre P van Beek, Roman Vangoitsenhoven, Martina Brueckmann, Ramy Younes, Lee M Kaplan, SYNCHRONIZE-1 Investigators · New England Journal of Medicine Published Aug 20, 2026 · Added Sep 1, 2026 Read →

Study T4

Targeting Aging with Metformin (TAME)

primary · 2026

Study T3

Targeting RANKL Prevents Bone Loss, Improves Muscle Function and Extends Lifespan in Progeroid Mice

Preclinical genetic and translational mouse study · 2026

Study T2

Tau-induced mitochondrial reverse electron transport drives neurodegeneration

Mechanistic study in flies, mice, human brain tissue, and human iPSC-derived neurons · 2026

Study T2

Taurine supplementation shows promise for metabolic health and aging: comprehensive review

Comprehensive narrative review · 2026

Study T2

The effect of hydrogen-rich water interventions on lipid profiles in adults with overweight or obesity and associated metabolic disorders: a systematic review and meta-analysis of randomized controlled trials

Systematic review and meta-analysis of 13 RCTs (12 articles), PRISMA guidelines · 2026

Study T2

The effect of oral magnesium supplementation on glycemic control and metabolic parameters in type 2 diabetes mellitus: a double-blind randomized controlled trial.

prospective randomised, double-blind, placebo-controlled parallel-group trial · 2026

Study T2

The effects of 8-week creatine supplementation with and without ubiquinol on sperm quality biomarkers in normospermic and oligospermic men: A randomized controlled pilot trial.

randomized controlled trial · 2026

Study T5

The Interventions Testing Program Shows that Another Eleven Compounds Do Not Slow Aging in Mice

preclinical · 2026

Study T2

The longevity gene APOE2 enhances pericyte function and reduces lipid droplets

Mechanistic study using APOE knock-in mice, isogenic human iPSC-derived pericytes, a human blood–brain barrier model, proteomics, lipidomics, and recombinant APOE2 treatment · 2026

Study T3

The proBNPage reduction (PBAR) trial-results of a randomized, double blind, placebo-controlled, pilot study to fine tune an NT-proBNP-based method to assess the effect of anti-aging treatments.

randomised, double-blind, placebo-controlled pilot trial · 2026

Study T2

The regenerative potential of glycyl-L-histidyl-L-lysine-copper in aesthetic medicine: a systematic review.

systematic review · 2026

Study T3

The Relative Bioavailability of Lutein and Zeaxanthin in the Presence of Omega-3 Supplements and Their Effect on Oxidative Stress Levels in Humans: A Pilot Study.

randomised, non-blinded, controlled pilot study · 2026

Study T1

Three-week Alternate-day Fasting Improves Myocardial Flow Reserve and Reduces Oxygen Use in Overweight Individuals.

primary · 2026

Study T2

Time-restricted eating, immunomodulation and ketone metabolism in humans

narrative mini-review · 2026

Study T2

Timing-Dependent Clearance of p16-Positive Cells Mitigates Radiation-Induced Accelerated Aging.

Preclinical irradiation model with timed genetic clearance of p16-positive cells · 2026

Study T4

Valter Longo

primary · 2026

Study T4

Vittorio Sebastiano, PhD

primary · 2026

Study T3

Weight Loss and Omega-3 Supplementation Modulate the Microbiome in Women with Increased Breast Cancer Risk.

randomised placebo-controlled pilot during a weight-loss intervention · 2026

Study T4

What to Look for in a Sauna

n=1 self-experiment / protocol report with biomarker tracking · 2026

Study T2

you’re not going to believe this

public short video; no study design reported · 2026

Study T3

A pharmacokinetic study and critical reappraisal of curcumin formulations enhancing bioavailability

primary · 2025

Study T5

A Review of Telomere Attrition in Cancer and Aging

primary · 2025

Study T4

Anti-aging guru Bryan Johnson ditches controversial drug after infections

primary · 2025

Study T3

Are GLP-1s the first longevity drugs?

primary · 2025

Study T2

Association of an inflammaging score based on IL-6, IL-10 and CXCL9, and frailty with long-term mortality in hospitalized older adults

primary · 2025

Study T2

Association of Sarcopenia and Visceral Obesity with Clinical Outcomes in Older Adults with Cardiovascular Disease

primary · 2025

Study T1

Body composition changes during weight reduction with tirzepatide

primary · 2025

Study T5

Circulate Health commercial platform and patent portfolio

primary · 2025

Study T2

Clinical Trial and Multi-omics Analysis Demonstrates the Impact of Therapeutic Plasma Exchange on Biological Age

primary · 2025

Study T4

Could humans live to 150? Why some researchers think so

primary · 2025

Study T2

Effect of collagen supplementation on knee osteoarthritis: an updated systematic review and meta-analysis of randomised controlled trials

RCT · 2025

Study T1

Effect of creatine supplementation on kidney function: a systematic review and meta-analysis

systematic review and meta-analysis · 2025

Study T1

Effect of resveratrol supplementation on SIRT1 expression and serum levels: a GRADE-assessed systematic review and dose-response meta-analysis

GRADE-assessed systematic review and dose-response meta-analysis of 11 RCTs · 2025

Study T1

Effects of blood donation on cardiometabolic markers: a randomized sham-controlled trial

RCT · 2025

Study T2

Effects of Collagen Supplements on Skin Aging: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

RCT · 2025

Study T4

Effects of nicotinamide riboside on NAD+ levels, cognition, and symptom recovery in long-COVID: a randomized controlled trial

Double-blind, placebo-controlled randomised trial with a placebo lead-in, 24 weeks, single centre, 2:1 allocation · 2025

Study T3

Emerging strategies, applications and challenges of targeting NAD+ in the clinic

Narrative review of NAD+ clinical trials · 2025

Study T1

Epigenetic clock evidence for rejuvenation following therapeutic plasma exchange

primary · 2025

Study T3

Examine.com research feed: aging biomarkers overview

primary · 2025

Study T3

Examine.com telomere length research summary

primary · 2025

Study T3

Experimental Evidence Against Taurine Deficiency as a Driver of Aging in Humans

primary · 2025

Study T3

GLP-1 receptor agonists, body composition, skeletal muscle and risk of sarcopaenia: from promising findings in animal models to debated concern in human studies

primary · 2025

Study T4

GlycanAge: The Science

primary · 2025

Study T3

HDL cholesterol, cardiovascular disease, and mortality

primary · 2025

Study T2

Heart Rate Variability as a Predictor of Mortality in Heart Failure

primary · 2025

Study T2

Human whole-blood NAD+ levels do not vary with age or lifestyle in a general population sample

primary · 2025

Study T2

Improving quercetin bioavailability: A systematic review and meta-analysis of human intervention studies

meta-analysis · 2025

Study T2

Is taurine an aging biomarker?

primary · 2025

Study T4

Longevity or Marketing? Dissecting the Claims of the Blueprint Protocol

primary · 2025

Study T5

NIH researchers conclude that taurine is unlikely to be a good aging biomarker

primary · 2025

Study T2

Oral Hyaluronic Acid Supplement: Efficacy in Skin Hydration, Elasticity, and Wrinkle Depth Reduction

primary · 2025

Study T3

Periodic fasting-mimicking diets and lifespan: mouse and human evidence

preclinical · 2025

Study T4

Perspectives as Charles Brenner challenges David Sinclair on longevity claims

primary · 2025

Study T5

PGC-1α: key regulator of mitochondrial biogenesis and function

primary · 2025

Study T3

Senolytic therapy combining Dasatinib and Quercetin restores the chondrogenic phenotype of human osteoarthritic chondrocytes by the release of pro-anabolic mediators

primary · 2025

Study T5

Senolytics as Modulators of Critical Signaling Pathways

primary · 2025

Study T1

Senolytics for cognition and mobility in older adults at risk for Alzheimer's disease

primary · 2025

Study T2

SIRT6 activator fucoidan extends healthspan and lifespan in aged wild-type mice

Preclinical (aged wild-type mouse study) · 2025

Study T2

Sleep duration and mortality hazard ratios in the Semmelweis Study

cohort · 2025

Study T5

Spermidine for the Prevention of Radiation-Induced Xerostomia in Head and Neck Cancer (NCT07035626) — registration only, no results

Registered randomized trial, currently RECRUITING (started 2025-06-25), no results section · 2025

Study T2

Taurine may not be a useful biomarker for aging after all

primary · 2025

Study T3

The effect of Urolithin A (Mitopure®) supplementation on muscle strength in healthy middle-aged adults

Clinical trial registration (randomised, double-blind, placebo-controlled, parallel) · 2025

Study T3

The Effect of Urolithin A (Mitopure®) Supplementation on Muscle Strength in Healthy Middle-Aged Adults (ATLAS 2)

Clinical trial registration (randomised, double-blind, placebo-controlled, parallel) · 2025

Study T5

The relationship between telomere length and aging-related diseases

primary · 2025

Study T1

Therapeutic plasma exchange with IVIG reduces epigenetic biological age: a placebo-controlled trial

RCT · 2025

Study T1

Umbilical cord-derived mesenchymal stem cells for frailty: a phase 2 randomized trial

RCT · 2025

Study T2

Utility of coronary artery calcium scoring in low-risk patients: The Multi-Ethnic Study of Atherosclerosis (MESA)

primary · 2025

Study T2

Validity of Blue Zones demographic claims: a 2025 reassessment

primary · 2025

Study T4

'Wellness bro' Andrew Huberman is accused of lying to women he dates. Does it matter to his millions of listeners?

primary · 2024

Study T5

A Blood NAD+ Test Can't Tell One's Biological Age

primary · 2024

Study T4

A pilot study evaluating dosing tolerability of 17α-estradiol in the common marmoset

primary · 2024

Study T5

Acarbose (oral route) - Side effects and dosage

primary · 2024

Study T4

AGZ Is More Shaky Science from the Makers of AG1

primary · 2024

Study T2

Alpha-lipoic acid for diabetic peripheral neuropathy

primary · 2024

Study T4

Andrew Huberman's Mechanisms of Control

primary · 2024

Study T4

Anti-aging zealot replaces 'liquid gold' plasma in his body in quest for immortality

primary · 2024

Study T5

Apigenin: a natural molecule at the intersection of sleep and aging

primary · 2024

Study T3

Apolipoprotein B: Bridging the Gap Between Evidence and Clinical Practice

primary · 2024

Study T2

Association between change in heart rate over years and life span (PMC version)

primary · 2024

Study T2

Association between change in heart rate over years and life span in the Paris Prospective 1, the Whitehall 1, and Framingham studies

primary · 2024

Study T4

Blue Zones 'fake' data claims: analysis of UN mortality data across 236 jurisdictions

primary · 2024

Study T3

Blue Zones and longevity: a balanced review of the Power 9 lifestyle factors

primary · 2024

Study T4

Bryan Johnson's biological age claims, explained by the scientist behind DunedinPACE and PhenoAge

primary · 2024

Study T2

Can molecular hydrogen supplementation enhance physical performance in healthy adults? A systematic review and meta-analysis

Systematic review and meta-analysis, 27 publications, PRISMA guidelines, 6 databases searched · 2024

Study T3

Cold-water immersion for health outcomes: a systematic review

meta-analysis · 2024

Study T2

Comprehensive investigation of resveratrol as an anti-aging supplement in randomised clinical trials

Systematic review of 137 published RCTs (104 individual RCTs, >4,800 subjects) · 2024

Study T4

Demographers' Statement on Blue Zones validity

primary · 2024

Study T2

Dietary polyphenol intake and all-cause mortality: a meta-analysis of cohort studies

meta-analysis · 2024

Study T4

Does NAD+ decline with age? Blood and tissue data tell different stories

primary · 2024

Study T1

Effect of multivitamin-mineral supplementation versus placebo on cognitive function: results from the clinic subcohort of the COSMOS trial and meta-analysis of 3 cognitive studies

Randomized controlled clinic subcohort (N=573, 2 years) plus pooled meta-analysis of 5,203 non-overlapping participants across COSMOS-Clinic, COSMOS-Mind and COSMOS-Web · 2024

Study T2

Effects of chamomile (Matricaria chamomilla L.) on sleep: A systematic review and meta-analysis of clinical trials

meta-analysis · 2024

Study T4

Effects of Dasatinib and Quercetin senolytic treatment on epigenetic age, DNA methylation, and immune cell subsets

preprint · 2024

Study T4

Effects of Nicotinamide Mononucleotide on Glucose and Lipid Metabolism in Adults: A Systematic Review and Meta-analysis of Randomised Controlled Trials

Systematic review with meta-analysis of randomised controlled trials · 2024

Study T4

Efficacy of oral nicotinamide mononucleotide supplementation on glucose and lipid metabolism for adults: a systematic review with meta-analysis on randomized controlled trials

Systematic review with meta-analysis of randomised controlled trials · 2024

Study T3

Epigenetic drift underlies epigenetic clock signals, but displays distinct dynamics from epigenetic age

primary · 2024

Study T2

EU heads of food safety agencies identify 117 supplement substances as potential health risks, prioritize 12 for restriction

Multi-country regulatory risk assessment report · 2024

Study T2

Excess Apolipoprotein B and Cardiovascular Risk in Women and Men

primary · 2024

Study T3

Exercise intensity, VO2max, and additional aerobic training study evidence

primary · 2024

Study T4

Fasting-mimicking diet lowers biological age

primary · 2024

Study T2

Fasting-mimicking diet reduces biological age measured by epigenetic clock

primary · 2024

Study T5

Follistatin gene therapy effects on epigenetic clocks: preprint

preprint · 2024

Study T5

Hallmarks of aging: A user's guide for comparative biologists

primary · 2024

Study T3

Health impacts of blood donation: a systematic review

meta-analysis · 2024

Study T2

HIIT versus MICT in older adults: a comprehensive meta-analysis

meta-analysis · 2024

Study T4

How I Reversed My Hair Loss

primary · 2024

Study T5

IL-6 signaling pathway in inflammaging: mechanistic review

primary · 2024

Study T4

Improved Physical Performance Parameters in Patients Taking Nicotinamide Mononucleotide (NMN): A Systematic Review of Randomized Control Trials

Systematic review of randomised controlled trials · 2024

Study T3

Intermittent fasting and metabolic health: mechanistic review

primary · 2024

Study T5

Links between autophagy and healthy aging

primary · 2024

Study T4

Longevity Expert Explains How Bryan Johnson Has Not Reduced His Pace of Aging by 31 Years

primary · 2024

Study T2

Magnesium and Cognitive Health in Adults: A Systematic Review and Meta-Analysis

meta-analysis · 2024

Study T5

Minicircle's Honduras gene therapy operation and funders

primary · 2024

Study T4

Morgan Levine, PhD

primary · 2024

Study T3

MTHFR gene variants and homocysteine metabolism

primary · 2024

Study T3

NIH National Heart, Lung, and Blood Institute — blood cholesterol overview

primary · 2024

Study T3

NIH Office of Dietary Supplements — chromium and glycemic control fact sheet

primary · 2024

Study T3

NIH Office of Dietary Supplements — Vitamin B12 fact sheet for health professionals

primary · 2024

Study T3

NIH Office of Dietary Supplements — Vitamin D fact sheet for health professionals

primary · 2024

Study T3

NY-TREAT: Time-Restricted Eating in Adults with Overweight/Obesity

primary · 2024

Study T2

p53/MDM2 signaling pathway in aging, senescence and tumorigenesis

primary · 2024

Study T5

Progress aggregation on unregulated longevity gene therapy offerings

primary · 2024

Study T2

Sarcopenic obesity and health outcomes: An umbrella review of systematic reviews with meta-analysis

meta-analysis · 2024

Study T3

SGLT2 Inhibitors and Aging: A Promising Approach to Healthy Longevity

primary · 2024

Study T3

Single-cell genomics reveals mosaic genomic diversity...

primary · 2024

Study T2

Social network integration, telomere length, and mortality in a Costa Rican cohort (CRELES)

cohort · 2024

Study T3

Supercentenarian and remarkable age records exhibit patterns indicative of clerical errors and pension fraud

preprint · 2024

Study T5

Targeting Cellular Senescence for Healthy Aging

primary · 2024

Study T2

The effects of creatine supplementation on cognitive function in adults: a systematic review and meta-analysis

Systematic review and meta-analysis of 16 RCTs (492 participants); creatine monohydrate; memory, attention, processing speed, executive function, overall cognition · 2024

Study T1

The effects of creatine supplementation on cognitive function in adults: a systematic review and meta-analysis

systematic review and meta-analysis · 2024

Study T5

The hallmarks of aging as a conceptual framework for translational research

primary · 2024

Study T3

The role of high sensitivity C-reactive protein in cardiovascular disease risk assessment

primary · 2024

Study T3

The TAME Trial for Metformin Remains Only Partially Funded

primary · 2024

Study T4

Things that make you age faster, and slower

primary · 2024

Study T1

Time-Restricted Eating in Adults With Metabolic Syndrome

primary · 2024

Study T3

Transient Epigenetic Reprogramming: The Future of Skin Rejuvenation

primary · 2024

Study T3

Turning back the clock: Can exercise and a healthy diet reduce your biological age?

primary · 2024

Study T5

Acarbose - StatPearls

primary · 2023

Study T1

Alpha-ketoglutarate supplementation and BiologicaL agE in middle-aged adults (ABLE) — intervention study protocol

primary · 2023

Study T3

Alternate-day fasting and cardiometabolic risk factors: systematic review

meta-analysis · 2023

Study T4

Anti-Aging Scientist Insists NR Is the Superior NAD+ Precursor, Is There Any Truth to His Claims?

primary · 2023

Study T3

Apolipoprotein B in cardiovascular risk assessment

primary · 2023

Study T3

Assessing tolerability and physiological responses to 17α-estradiol in a human pilot dosing study

primary · 2023

Study T4

Bryan Johnson eats a strict diet of 1977 calories a day and 70 pounds of veggies

primary · 2023

Study T4

Bryan Johnson is being used as a human guinea pig in unproven tests to reprogram his genes

primary · 2023

Study T4

Bryan Johnson's Prescription Drugs - What He Uses & Why

primary · 2023

Study T3

C-reactive protein and cardiovascular disease risk stratification

primary · 2023

Study T1

Cardiovascular Safety of Testosterone-Replacement Therapy.

primary · 2023

Study T3

Carotid atherosclerosis imaging in cardiovascular risk stratification

primary · 2023

Study T5

Cellular senescence: a key therapeutic target in aging and disease

primary · 2023

Study T5

Chronic inflammation and the hallmarks of aging

primary · 2023

Study T1

Comparison of moderate-intensity continuous and interval training on VO2max in women

primary · 2023

Study T2

Declaring 'Victory' in the Pursuit of Human Longevity

primary · 2023

Study T5

DNA damage response and repair in aging

primary · 2023

Study T3

Dose-response relationship between resistance training and health outcomes: a review

primary · 2023

Study T2

DunedinPACE technical/methods summary

primary · 2023

Study T1

Effects of cocoa extract and a multivitamin on cognitive function: A randomized clinical trial

Randomized, double-blind, placebo-controlled 2x2 factorial trial; cocoa extract and daily multivitamin vs placebo for 3 years; phone-based cognitive battery · 2023

Study T1

Effects of creatine supplementation on memory in healthy individuals: a systematic review and meta-analysis of randomized controlled trials

systematic review and meta-analysis · 2023

Study T2

Effects of Tai Chi and Qigong on cognitive and physical functions in older adults: systematic review, meta-analysis, and meta-regression of randomized clinical trials.

primary · 2023

Study T5

Ergothioneine: an underrecognised dietary micronutrient required for healthy ageing?

primary · 2023

Study T3

Evaluation of off-label rapamycin use to promote healthspan in 333 adults

primary · 2023

Study T4

Extracellular vesicles in aging: an emerging hallmark?

primary · 2023

Study T3

Fasting-mimicking diet and stem-cell-based regeneration mechanisms

primary · 2023

Study T3

Fingerstick blood assay maps real-world NAD+ disparity

primary · 2023

Study T3

Functional Role of Taurine in Aging and Cardiovascular Health (review, section 4: Taurine and Aging)

primary · 2023

Study T5

GDF11 and aging biology: controversies resolved and pending

primary · 2023

Study T3

Glucagon-like peptide 1 receptor agonists in chronic disease management beyond diabetes

primary · 2023

Study T5

Hallmarks of aging: An expanding universe

primary · 2023

Study T3

Homocysteine and cardiovascular disease: a systematic review of prospective studies

meta-analysis · 2023

Study T5

Inside the offshore clinic offering unproven gene therapy for aging

primary · 2023

Study T3

Intermittent fasting protocols and human trial evidence

primary · 2023

Study T4

MetroBiotech, Co-Founded by Harvard's David Sinclair, Launches Human Trial of New NAD+ Booster MIB-725

primary · 2023

Study T4

Millionaire infuses himself with son's blood to stay young

primary · 2023

Study T3

NAD+ metabolism, aging, and disease

primary · 2023

Study T4

Nir Barzilai, M.D. Named Chief Medical Advisor of Life Biosciences

primary · 2023

Study T4

Outlive: The Science and Art of Longevity

primary · 2023

Study T4

Pilot trial of D+Q in mild cognitive impairment

primary · 2023

Study T2

Polyphenol subclasses and mortality in a Spanish nationwide cohort

cohort · 2023

Study T3

Quantity of Melatonin and CBD in Melatonin Gummies Sold in the US

primary · 2023

Study T1

Randomized Controlled Clinical Trial of the Effect of Treatment with Vitamin K2 on Vascular Calcification in Hemodialysis Patients (Trevasc-HDK)

RCT · 2023

Study T5

Relating aging and autophagy: a new perspective towards the treatment of age-related diseases

primary · 2023

Study T1

Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes

primary · 2023

Study T2

Sleep duration, cardiovascular risk, and all-cause mortality in a Chilean cohort (SantOSA)

cohort · 2023

Study T2

Social isolation, loneliness, living alone, and mortality risk: updated meta-analysis

meta-analysis · 2023

Study T4

Stanford's Dr. Andrew Huberman Takes Two NAD+ Precursors Daily: NMN and NR

primary · 2023

Study T2

Taurine deficiency as a driver of aging

primary · 2023

Study T1

Taurine deficiency as a driver of aging (open-access version)

primary · 2023

Study T3

Telomere length in long-term meditators: a cross-sectional comparison

cross-sectional · 2023

Study T2

The healthy donor effect and survey participation, becoming a donor and donor career

primary · 2023

Study T4

The NIA Interventions Testing Program shows that fisetin does not extend life in mice

preclinical · 2023

Study T4

The Outlive Podcast

primary · 2023

Study T1

The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials

primary · 2023

Study T3

Time-restricted eating and cardiometabolic health: review

primary · 2023

Study T4

Turn Biotechnologies raises Series B funding

primary · 2023

Study T2

Universal DNA methylation age across mammalian tissues.

primary · 2023

Study T1

Vitamin D supplementation and major cardiovascular events: D-Health randomised controlled trial.

primary · 2023

Study T2

A critical evaluation of NAD+ precursor claims and the sirtuin narrative advanced in David Sinclair's Lifespan

primary · 2022

Study T2

Acute cold exposure and energy expenditure: a meta-analysis

meta-analysis · 2022

Study T4

Aged muscle stem cell niche contributes to regenerative decline

primary · 2022

Study T2

ApoB is the only independent driver of lipid-associated MI risk

primary · 2022

Study T3

Biological Age Predictors: The Status Quo and Future Trends

primary · 2022

Study T2

Caloric restriction and its mimetics in aging

primary · 2022

Study T2

Cardiorespiratory Fitness and Mortality Risk Across the Spectra of Age, Race, and Sex

primary · 2022

Study T5

Cellular senescence and senolytics: the path to the clinic

primary · 2022

Study T4

Charles Brenner Critiques David Sinclair's Best-Selling Book on Aging

primary · 2022

Study T1

Creatine supplementation for older adults: Focus on sarcopenia, osteoporosis, frailty and Cachexia

narrative review · 2022

Study T2

Dietary total and food-specific spermidine intake and all-cause, cardiovascular mortality: cohort study

cohort · 2022

Study T2

DNA methylation GrimAge version 2

primary · 2022

Study T2

DunedinPACE, a DNA methylation biomarker of the pace of aging

primary · 2022

Study T1

Effect of Dietary Pyrroloquinoline Quinone Disodium Salt on Cognitive Function in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study

RCT · 2022

Study T2

Effect of Vitamin K on Bone Mineral Density and Fracture Risk in Adults: Systematic Review and Meta-Analysis

meta-analysis · 2022

Study T1

Effects of Spermidine Supplementation on Cognition and Biomarkers in Older Adults With Subjective Cognitive Decline (SmartAge): A Randomized Clinical Trial

Randomized double-blind placebo-controlled trial, 12 months · 2022

Study T1

Effects of Spermidine Supplementation on Cognition and Biomarkers in Older Adults With Subjective Cognitive Decline: A Randomized Clinical Trial

RCT · 2022

Study T3

Health effects of cold-water immersion: a review of over 100 studies

primary · 2022

Study T2

Heart rate variability in the prediction of mortality (ScienceDirect version)

primary · 2022

Study T2

Heart rate variability in the prediction of mortality: A systematic review and meta-analysis of healthy and patient populations

meta-analysis · 2022

Study T3

Hyperbaric oxygen therapy and cellular senescence: mechanisms and evidence review

primary · 2022

Study T5

Independent replication attempt of HBOT telomere effects: thesis

primary · 2022

Study T1

Influence of age, sex, and type of exercise on the efficacy of creatine supplementation on lean body mass: A systematic review and meta-analysis of randomized clinical trials

systematic review and meta-analysis · 2022

Study T3

Low Plasma Ergothioneine Predicts Cognitive and Functional Decline in an Elderly Cohort Attending Memory Clinics

cohort · 2022

Study T5

Metformin's Mechanisms in Attenuating Hallmarks of Aging

primary · 2022

Study T5

Metformin: Activation of 5' AMP-activated protein kinase

primary · 2022

Study T2

Muscle-strengthening activities are associated with lower risk and mortality in major non-communicable diseases: a systematic review and meta-analysis of cohort studies

meta-analysis · 2022

Study T3

Nicotinamide mononucleotide supplementation and NAD+ levels in humans

primary · 2022

Study T3

Poster 125: Determining Biological Age and Prolonging the Healthspan by Targeting Senescence

primary · 2022

Study T4

Pterostilbene Promotes Mean Lifespan in Both Male and Female Drosophila Melanogaster Modulating Different Proteins in the Two Sexes

preclinical · 2022

Study T3

Redefining human aging: Is it a curable disease or destiny?

primary · 2022

Study T2

Reply: The Relationship Between Cardiorespiratory Fitness and Mortality

primary · 2022

Study T5

Role of autophagy in aging: The good, the bad, and the ugly

primary · 2022

Study T2

Sauna bathing and socioeconomic status-related mortality risk

primary · 2022

Study T3

Study challenges 'good cholesterol's' role in universally predicting heart disease risk

primary · 2022

Study T3

Supplementing GlyNAC in aging improves glutathione, mitochondria, and aging hallmarks: a randomized clinical trial

RCT · 2022

Study T2

Tai Chi and health outcomes: an umbrella review of systematic reviews and meta-analyses

meta-analysis · 2022

Study T2

Tai Chi and Qigong for health: a review of systematic reviews

meta-analysis · 2022

Study T3

The Relationship Between Cardiorespiratory Fitness and Mortality (correspondence)

primary · 2022

Study T3

Time-efficient training: comparative reviews of interval and continuous training

primary · 2022

Study T2

Total, Dietary, and Supplemental Magnesium Intakes and Risk of All-Cause, Cardiovascular, and Cancer Mortality: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies

meta-analysis · 2022

Study T3

Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults

Randomised, placebo-controlled trial · 2022

Study T2

A ketogenic drink improves cognition in mild cognitive impairment: Results of a 6-month RCT

Randomized, double-blind, placebo-controlled trial; ketogenic MCT drink 15 g twice daily (30 g/day) for 6 months in mild cognitive impairment · 2021

Study T5

Autophagy in healthy aging and disease

primary · 2021

Study T4

Can the blood of young people slow aging? Silicon Valley has bet billions it will

primary · 2021

Study T3

Coronary artery calcium scoring: current status and future directions

primary · 2021

Study T4

Ergothioneine supplementation in people with metabolic syndrome (ErgMS): protocol for a randomised, double-blind, placebo-controlled pilot study

RCT · 2021

Study T3

Glycine and N-acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, and cognition: Results of a pilot clinical trial

primary · 2021

Study T3

HbA1c variability increases mortality risk in diabetes

primary · 2021

Study T1

Heavy resistance training in older adults at retirement age (LISA study)

primary · 2021

Study T1

Hyperbaric oxygen therapy effects on skin aging markers in men

primary · 2021

Study T1

Impact of Semaglutide on Body Composition in Adults With Overweight or Obesity: Exploratory Analysis of the STEP 1 Study

primary · 2021

Study T5

Important Patient and Consumer Information About Regenerative Medicine Therapies

primary · 2021

Study T2

Interval training vs continuous training in middle-aged and older adults

primary · 2021

Study T4

Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice

preclinical · 2021

Study T2

Mediterranean Diet and Cardiovascular Disease: A Meta-Analysis

meta-analysis · 2021

Study T3

Mesenchymal stem cell therapy for aging: promise and caution

primary · 2021

Study T3

Muscle mass, sarcopenia, and mortality in aging populations: cohort review

cohort · 2021

Study T4

New company's wild mission: Bring back the woolly mammoth

primary · 2021

Study T1

Once-Weekly Semaglutide in Adults with Overweight or Obesity (STEP 1)

primary · 2021

Study T2

Oral magnesium supplementation for insomnia in older adults: a Systematic Review & Meta-Analysis

meta-analysis · 2021

Study T2

Polyphenol antioxidant capacity and biological age acceleration (Moli-sani study)

cohort · 2021

Study T4

Rejuvant, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging, after an average of 7 months of use, in the TruAge DNA methylation test

primary · 2021

Study T5

The aging proteostasis decline: From nematode to human

primary · 2021

Study T3

The effects of 6-month hydrogen-rich water intake on molecular and phenotypic biomarkers of aging in older adults aged 70 years and over: A randomized controlled pilot trial

Randomized controlled pilot trial, parallel-group design, 6 months · 2021

Study T5

The mechanism of action of N-acetylcysteine (NAC): The emerging role of H2S and sulfane sulfur species

primary · 2021

Study T3

Time Course for Fasting-induced Autophagy in Humans

primary · 2021

Study T3

Time-restricted feeding and circadian metabolic regulation

primary · 2021

Study T5

Unproven Stem Cell Interventions Put Patients at Risk

primary · 2021

Study T4

A metabolite produced by the body increases lifespan and dramatically compresses late-life morbidity in mice

preclinical · 2020

Study T5

Age-related NAD+ decline

primary · 2020

Study T3

Aging and inflammatory cytokines: clinical measurement considerations

primary · 2020

Study T4

Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice

preclinical · 2020

Study T2

Alpha-lipoic acid supplementation significantly reduces the risk of obesity in an updated systematic review and dose-response meta-analysis of randomised placebo-controlled clinical trials

RCT · 2020

Study T5

Ashwagandha

primary · 2020

Study T5

Benefits of Metformin in Attenuating the Hallmarks of Aging

primary · 2020

Study T2

Caloric restriction in humans: impact on physiological, psychological, and behavioral outcomes

primary · 2020

Study T3

Carotid intima-media thickness and cardiovascular risk assessment

primary · 2020

Study T4

ChromaDex Chief Scientific Advisor Dr. Charles Brenner Receives 2020 National Scientific Achievement Award from the American Society for Nutrition

primary · 2020

Study T3

Clinical translation of senolytic therapies: mouse to human

preclinical · 2020

Study T3

CRISPR and gene therapy approaches for age-related neurodegenerative disease

primary · 2020

Study T5

Does proteostasis get lost in translation? Implications for protein aggregation across the lifespan

primary · 2020

Study T1

Effect of High-Dose Omega-3 Fatty Acids vs Corn Oil on Major Adverse Cardiovascular Events in Patients at High Cardiovascular Risk: The STRENGTH Randomized Clinical Trial.

Randomized, double-blind, placebo-controlled trial · 2020

Study T1

Effects of Time-Restricted Eating on Weight Loss and Other Metabolic Parameters (TREAT trial)

primary · 2020

Study T5

Forget antioxidants: McGill researchers cast doubt on role of free radicals in aging

primary · 2020

Study T2

FOXO3 and Exceptional Longevity: Insights From Hydra to Humans

primary · 2020

Study T3

Genetic and environmental influences on VO2max heritability: twin studies review

primary · 2020

Study T2

Handgrip strength is inversely associated with fatal cardiovascular and all-cause mortality events

primary · 2020

Study T4

Health benefits attributed to 17α-estradiol, a lifespan-extending compound, are mediated through estrogen receptor alpha

primary · 2020

Study T2

Heart Rate Variability and Risk of All-Cause Death and Cardiovascular Events in Patients With Cardiovascular Disease: A Meta-Analysis of Cohort Studies

meta-analysis · 2020

Study T1

Hyperbaric oxygen therapy increases telomere length and decreases immunosenescence in isolated blood cells

primary · 2020

Study T2

In Vivo Amelioration of Age-Associated Hallmarks in Aged Mice by Whole-Body Expression of the Yamanaka Factors

preclinical · 2020

Study T3

N-glycosylation as a marker of biological age: a review

primary · 2020

Study T3

PGC-1α-mediated regulation of mitochondrial function and physical activity

primary · 2020

Study T2

Principal Results of the VITamin D and OmegA-3 TriaL (VITAL) and Updated Meta-analyses

primary · 2020

Study T4

Rejuvenate Bio banks $10M to advance gene therapy for aging in humans and dogs

primary · 2020

Study T5

Sirtuins and their Biological Relevance in Aging and Age-Related Diseases

primary · 2020

Study T4

Six Intriguing Ideas from David Sinclair's Book, Lifespan

primary · 2020

Study T3

Targeting Cellular Senescence with Dasatinib and Quercetin (D+Q) in Diabetic Kidney Disease

primary · 2020

Study T1

The effect of vitamin MK-7 on bone mineral density and microarchitecture in postmenopausal women with osteopenia, a 3-year randomized, placebo-controlled clinical trial

RCT · 2020

Study T4

The Experiment That Started It All

primary · 2020

Study T5

The Target of Rapamycin Signalling Pathway in Ageing and Lifespan Regulation

primary · 2020

Study T5

TNF-alpha signaling and cellular senescence: mechanistic review

primary · 2020

Study T3

Transitions between frailty states in the very old: the influence of deprivation

primary · 2020

Study T1

2 years of calorie restriction and cardiometabolic risk (CALERIE): exploratory outcomes of a multicentre, phase 2, randomised controlled trial.

primary · 2019

Study T2

2019 ESC/EAS Guidelines for the management of dyslipidaemias

primary · 2019

Study T1

A Randomized, Double-Blind, Placebo-Controlled, Crossover Study Examining the Hormonal and Vitality Effects of Ashwagandha (Withania somnifera) in Aging, Overweight Males

RCT · 2019

Study T4

Acarbose improves health and lifespan in aging HET3 mice

preclinical · 2019

Study T4

Alpha-ketoglutarate, an endogenous metabolite, extends lifespan and compresses morbidity in aging mice (preprint)

preprint · 2019

Study T1

Alternate day fasting improves physiological and molecular markers of aging in healthy, non-obese humans

primary · 2019

Study T1

An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study

RCT · 2019

Study T4

Berberine Directly Affects the Gut Microbiota to Promote Weight Loss via Bile Acid Metabolism and FXR Activation

primary · 2019

Study T5

Broccoli or Sulforaphane: Is It the Source or Dose That Matters?

primary · 2019

Study T1

Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia (REDUCE-IT)

Multicenter, randomized, double-blind, placebo-controlled trial · 2019

Study T5

DNA methylation aging clocks: challenges and recommendations

primary · 2019

Study T2

DNA methylation GrimAge strongly predicts lifespan and healthspan

primary · 2019

Study T2

Effects of intermittent fasting on health, aging, and disease

primary · 2019

Study T1

Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial

RCT · 2019

Study T1

Empagliflozin Reduced Mortality and Hospitalization for Heart Failure Across the Spectrum of Cardiovascular Risk in the EMPA-REG OUTCOME Trial

primary · 2019

Study T2

Frailty, hospital use and mortality in the older population

primary · 2019

Study T4

Gene therapy to fend off aging? Buzzy Harvard startup Rejuvenate Bio says it works in mice

preclinical · 2019

Study T2

Genome-wide detection of somatic mutation and copy number alteration by single-molecule analysis

primary · 2019

Study T3

Grip strength across the life course: normative values and clinical use

primary · 2019

Study T2

Inconvenient Truths About Human Longevity

primary · 2019

Study T4

International Symposium to Honor a Pioneer in Neuroscience and Fasting

primary · 2019

Study T1

L-theanine in the adjunctive treatment of generalized anxiety disorder: A double-blind, randomised, placebo-controlled trial

RCT · 2019

Study T5

Mitochondrial Dysfunction and Alpha-Lipoic Acid: Beneficial or Harmful in Alzheimer's Disease?

primary · 2019

Study T5

mTOR as a central regulator of lifespan and aging

primary · 2019

Study T2

Oral turmeric/curcumin effects on inflammatory markers in chronic inflammatory diseases: A systematic review and meta-analysis of randomized controlled trials

RCT · 2019

Study T4

Proteostasis collapse is a driver of cell aging and death

primary · 2019

Study T4

Rejuvenate Bio launches to help dogs live longer, healthier lives

primary · 2019

Study T4

Reversal of epigenetic aging and immunosenescent trends in humans (TRIIM trial)

primary · 2019

Study T4

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease

primary · 2019

Study T1

Senolytics in idiopathic pulmonary fibrosis: results from a first-in-human, open-label, pilot study

primary · 2019

Study T2

Statins and coronary artery calcium progression: a meta-analysis

meta-analysis · 2019

Study T2

The association of resistance training with mortality: A systematic review and meta-analysis.

primary · 2019

Study T5

The role of IGF-1 signaling in longevity and aging

primary · 2019

Study T1

Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease (VITAL trial)

primary · 2019

Study T2

An epigenetic biomarker of aging for lifespan and healthspan

primary · 2018

Study T2

Association Between Gait Speed With Mortality, Cardiovascular Disease and Cancer: A Systematic Review and Meta-analysis

meta-analysis · 2018

Study T2

CALERIE biobank epigenetic aging analysis

primary · 2018

Study T5

Chronic inflammation in the etiology of disease across the life span

primary · 2018

Study T2

Clinical intervention studies with resveratrol: a review

Narrative review of major resveratrol clinical trials (Alzheimer's phase II n=119, PREDIMED substudy n=1000, obesity crossover n=45) · 2018

Study T2

Coronary Artery Calcium Score and Cardiovascular Risk: 2018 ACC/AHA Guideline Context

primary · 2018

Study T5

DNA methylation-based biomarkers and the epigenetic clock theory of ageing

primary · 2018

Study T2

Effects of Coenzyme Q10 on Statin-Induced Myopathy: An Updated Meta-Analysis of Randomized Controlled Trials

RCT · 2018

Study T2

Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies

primary · 2018

Study T2

Erythrocyte Long-Chain Omega-3 Fatty Acid Levels are Inversely Associated with Mortality and with Incident Cardiovascular Disease: The Framingham Heart Study

Prospective cohort study (Framingham Offspring cohort) · 2018

Study T4

Fisetin is a senotherapeutic that extends health and lifespan

primary · 2018

Study T1

High-intensity interval training versus moderate-intensity continuous training in cardiac rehabilitation

primary · 2018

Study T2

Higher spermidine intake is linked to lower mortality: a prospective population-based study

primary · 2018

Study T3

How Does Empagliflozin Reduce Cardiovascular Mortality? Insights From a Mediation Analysis

primary · 2018

Study T5

Inflammaging: a new immune-metabolic viewpoint for age-related diseases

primary · 2018

Study T2

Initial level and rate of change in grip strength predict all-cause mortality in very old adults

primary · 2018

Study T2

Intermittent metabolic switching, neuroplasticity and brain health

primary · 2018

Study T1

Male lifespan extension with 17-α estradiol is linked to a sex-specific metabolomic response modulated by gonadal hormones in mice

preclinical · 2018

Study T2

Mean HbA1c, HbA1c variability, and mortality in people with diabetes aged 70 years and older

primary · 2018

Study T1

Nicotinamide riboside supplementation raises human blood NAD+ metabolome

primary · 2018

Study T1

Primary Prevention of Cardiovascular Disease with a Mediterranean Diet Supplemented with Extra-Virgin Olive Oil or Nuts

primary · 2018

Study T3

Retraction and Republication: Primary Prevention of Cardiovascular Disease with a Mediterranean Diet (PREDIMED)

primary · 2018

Study T2

Sauna bathing and cardiorespiratory fitness: 26.1-year follow-up

primary · 2018

Study T2

Sauna bathing and risk of psychotic, mood, and cardiovascular outcomes: dose-response tables by sex

primary · 2018

Study T3

Sauna bathing, blood pressure, and cardiovascular function

primary · 2018

Study T1

Senolytics improve physical function and increase lifespan in old age

primary · 2018

Study T3

Survival of the fittest: VO2max, a key predictor of longevity

primary · 2018

Study T2

Telomere Length and All-Cause Mortality: A Meta-analysis

meta-analysis · 2018

Study T2

Telomere Length and All-Cause Mortality: A Meta-analysis (registered report)

meta-analysis · 2018

Study T3

The effect of spermidine on memory performance in older adults at risk for dementia: A randomized controlled trial

RCT · 2018

Study T5

The Paradox of Coenzyme Q10 in Aging

primary · 2018

Study T2

Alpha-Lipoic Acid (ALA) as a supplementation for weight loss: Results from a Meta-Analysis of Randomized Controlled Trials

RCT · 2017

Study T1

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

primary · 2017

Study T5

DNA methylation-based biomarkers and the epigenetic clock of ageing

primary · 2017

Study T3

DXA-derived body composition and mortality risk in older adults

primary · 2017

Study T1

Effect of creatine supplementation during resistance training on lean tissue mass and muscular strength in older adults: a meta-analysis

systematic review and meta-analysis · 2017

Study T1

Effect of Intravenous Allogeneic Mesenchymal Stem Cells on Aging Frailty (CRATUS-related dose-escalation trial)

primary · 2017

Study T3

Effect of sarcopenia, subcutaneous adipose tissue and abdominal visceral fat on mortality risk of community-dwelling older adults: a Brazilian cohort study

cohort · 2017

Study T5

Exercise-induced PGC-1α transcriptional factors in skeletal muscle

primary · 2017

Study T1

Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease

primary · 2017

Study T2

Hs-CRP and all-cause, cardiovascular, and cancer mortality risk: A meta-analysis

meta-analysis · 2017

Study T2

Impact of intermittent fasting on health and disease processes

primary · 2017

Study T1

International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine

position stand · 2017

Study T4

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

primary · 2017

Study T4

Oral Ingestion of Collagen Hydrolysate Leads to the Transportation of Highly Concentrated Gly-Pro-Hyp and Its Hydrolyzed Form of Pro-Hyp into the Bloodstream and Skin

primary · 2017

Study T2

Resistance training effects on muscular strength in previously untrained adults: a meta-analysis

meta-analysis · 2017

Study T2

Safety of pyrroloquinoline quinone disodium salt as a novel food pursuant to Regulation (EC) No 258/97

primary · 2017

Study T5

Stem cell aging: mechanisms, regulators and therapeutic opportunities

primary · 2017

Study T1

The Identification of a SIRT6 Activator from Brown Algae Fucus distichus

Preclinical (in-vitro screening of brown algae extracts) · 2017

Study T5

Werner syndrome: a model for the study of human aging

primary · 2017

Study T5

Absorption of Orally Administered Hyaluronan

primary · 2016

Study T2

Ageing, neurodegeneration and brain rejuvenation.

primary · 2016

Study T3

Brown adipose tissue activation and thermogenesis: mechanistic review

primary · 2016

Study T2

Calorie restriction in humans: An update

primary · 2016

Study T1

Cold acclimation recruits human brown fat and increases metabolic rate

primary · 2016

Study T1

Curcumin and cognition: a randomised, placebo-controlled, double-blind study of community-dwelling older adults

RCT · 2016

Study T2

DNA methylation-based measures of biological age: meta-analysis predicting time to death

meta-analysis · 2016

Study T1

Effect of Two-Year Caloric Restriction on Bone Metabolism and Bone Mineral Density

primary · 2016

Study T2

Extension of Drosophila lifespan by rapamycin depends on dietary composition and calorie intake

preclinical · 2016

Study T2

HbA1c and all-cause mortality risk among patients with type 2 diabetes

primary · 2016

Study T5

Long live FOXO: unraveling the role of FOXO proteins in aging and longevity

primary · 2016

Study T4

Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer

preclinical · 2016

Study T3

Metformin as a Tool to Target Aging

primary · 2016

Study T2

Predicting Survival from Telomere Length versus Conventional Predictors

primary · 2016

Study T3

Rationale and design of the allogeneiC human mesenchymal stem cells (hMSC) in patients with aging fRAilTy via intravenoUS delivery (CRATUS) study: A phase I/II, randomized, blinded and placebo controlled trial to evaluate the safety and potential efficacy of allogeneic human mesenchymal stem cell infusion in patients with aging frailty.

primary · 2016

Study T3

Regulatory gaps in unproven stem cell interventions: case reports and call for FDA enforcement

primary · 2016

Study T4

Scientists up stakes in bet on whether humans will live to 150

primary · 2016

Study T3

SGLT2 Inhibitors and Cardiovascular Risk: Lessons Learned from the EMPA-REG OUTCOME Study

primary · 2016

Study T3

The Dog Aging Project: Translational Geroscience in Companion Animals

primary · 2016

Study T5

The Immateriality of Circulating GDF11

primary · 2016

Study T5

The mechanistic Target of Rapamycin: The grand conducTOR of metabolism and aging

primary · 2016

Study T4

This chemist-blogger has become an influential voice in the drug industry

primary · 2016

Study T4

'Young blood' anti-ageing mechanism called into question

primary · 2015

Study T1

A 2-Year Randomized Controlled Trial of Human Caloric Restriction: Feasibility and Effects on Predictors of Health Span and Longevity

RCT · 2015

Study T2

Age-related frailty and its association with biological markers of ageing

primary · 2015

Study T2

Association Between Sauna Bathing and Fatal Cardiovascular and All-Cause Mortality Events

primary · 2015

Study T3

Bioavailability of Fatty Acids from Krill Oil, Krill Meal and Fish Oil in Healthy Subjects

Randomized, single-dose, single-blind, crossover trial · 2015

Study T2

Effects of statins on carotid intima-media thickness progression: a meta-analysis of randomized controlled trials

RCT · 2015

Study T1

Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes

primary · 2015

Study T1

Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes (PubMed record)

primary · 2015

Study T3

Fishing for Answers: Is Oxidation of Fish Oil Supplements a Problem?

Systematic review of 171 fish oil supplements from 49 brands · 2015

Study T2

Leukocyte Telomere Length and Mortality in the National Health and Nutrition Examination Survey

primary · 2015

Study T2

Loneliness and Social Isolation as Risk Factors for Mortality: A Meta-Analytic Review

primary · 2015

Study T2

Prognostic value of grip strength: findings from the Prospective Urban Rural Epidemiology (PURE) study.

primary · 2015

Study T5

Sirtuin regulation in aging and injury

primary · 2015

Study T4

Spring Chicken: Stay Young Forever (or Die Trying)

primary · 2015

Study T5

The Biology of Proteostasis in Aging and Disease

primary · 2015

Study T5

Cellular senescence: a translational perspective

primary · 2014

Study T2

Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence

primary · 2014

Study T4

Diabetes drug increases lifespan of male mice, shows smaller effect in females

preclinical · 2014

Study T5

Existing and potential therapeutic uses for N-acetylcysteine: the need for conversion to intracellular glutathione for antioxidant benefits

primary · 2014

Study T3

Insulin autoimmune syndrome (Hirata Disease) in European Caucasians taking alpha-lipoic acid

primary · 2014

Study T2

Meal frequency and timing in health and disease

primary · 2014

Study T2

Meal frequency and timing in health and disease (author list confirmation)

primary · 2014

Study T2

Mediterranean diet and health status: an updated meta-analysis and a proposal for a literature-based adherence score.

meta-analysis · 2014

Study T1

mTOR inhibition improves immune function in the elderly

primary · 2014

Study T1

Pterostilbene on Metabolic Parameters: A Randomized, Double-Blind, and Placebo-Controlled Trial

RCT · 2014

Study T2

Safety and efficacy of acarbose in the treatment of diabetes in Chinese patients

primary · 2014

Study T2

Sleep Duration and Cardiovascular Disease Mortality Among the NIH-AARP Diet and Health Study Cohort

cohort · 2014

Study T3

Somatic mutations, genome mosaicism, cancer and aging.

primary · 2014

Study T1

Sulforaphane treatment of autism spectrum disorder (ASD)

primary · 2014

Study T1

The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: results from Q-SYMBIO: a randomized double-blind trial

RCT · 2014

Study T2

The HbA1c and all-cause mortality relationship in patients with type 2 diabetes is J-shaped: a meta-analysis of observational studies

meta-analysis · 2014

Study T2

Total polyphenol intake and mortality in the PREDIMED trial

primary · 2014

Study T2

Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of observational studies and randomised trials.

meta-analysis · 2014

Study T5

Yeast sirtuins and the regulation of aging

preclinical · 2014

Study T1

Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice

preclinical · 2014

Study T1

Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice (journal record)

preclinical · 2014

Study T3

Brown adipose tissue and human obesity/metabolic disease

primary · 2013

Study T5

Differences in the Glucuronidation of Resveratrol and Pterostilbene: Altered Enzyme Specificity and Potential Gender Differences

primary · 2013

Study T1

DNA methylation age of human tissues and cell types

primary · 2013

Study T2

Genome instability and aging

primary · 2013

Study T4

Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy

primary · 2013

Study T2

Inflammatory markers in population studies of aging

primary · 2013

Study T2

Iron deficiency among frequent blood donors (RISE study)

primary · 2013

Study T3

Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers

primary · 2013

Study T2

Meta-Analysis: Melatonin for the Treatment of Primary Sleep Disorders

meta-analysis · 2013

Study T1

Primary Prevention of Cardiovascular Disease with a Mediterranean Diet (PREDIMED)

primary · 2013

Study T2

Protective Role of Resting Heart Rate on All-Cause and Cardiovascular Disease Mortality

primary · 2013

Study T5

Redox-regulating sirtuins in aging, caloric restriction, and exercise

primary · 2013

Study T1

The effect of modified alternate-day fasting diet on weight loss and CAD risk factors in obese women

primary · 2013

Study T5

The free radical theory of aging revisited: the cell signaling disruption theory of aging.

primary · 2013

Study T5

The Hallmarks of Aging

primary · 2013

Study T5

The sirtuin family's role in aging and age-associated pathologies

primary · 2013

Study T2

Trajectories of Gait Speed Predict Mortality in Well-Functioning Older Adults: The Health, Aging and Body Composition Study

primary · 2013

Study T5

Aging and the aggregating proteome

primary · 2012

Study T1

Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases

meta-analysis · 2012

Study T2

Berberine in the Treatment of Type 2 Diabetes Mellitus: A Systemic Review and Meta-Analysis

meta-analysis · 2012

Study T2

Cardiovascular benefits and safety profile of acarbose therapy in prediabetes and established type 2 diabetes

primary · 2012

Study T2

Carotid intima-media thickness for cardiovascular risk assessment: systematic review and meta-analysis

meta-analysis · 2012

Study T3

Cross-sectional findings from the Newcastle 85+ Study

cross-sectional · 2012

Study T2

Homocysteine-lowering trials and cardiovascular disease outcomes: a meta-analysis

meta-analysis · 2012

Study T3

Lipid-lowering effect of berberine in human subjects and rats

primary · 2012

Study T3

New therapeutic strategy for amino acid medicine: glycine improves the quality of sleep

primary · 2012

Study T1

Oral Administration of Polymer Hyaluronic Acid Alleviates Symptoms of Knee Osteoarthritis: A Double-Blind, Placebo-Controlled Study over a 12-Month Period

RCT · 2012

Study T2

Diabetes mellitus, fasting glucose, and risk of cause-specific death

primary · 2011

Study T2

Gait Speed and Survival in Older Adults

primary · 2011

Study T2

Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans

primary · 2011

Study T4

Kenyon's Ageless Quest

primary · 2011

Study T1

Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy (AIM-HIGH trial)

primary · 2011

Study T3

Seniors' Walking Speed May Predict Life Expectancy (clinical commentary)

primary · 2011

Study T5

Sirtuins, aging, and metabolism

primary · 2011

Study T3

Stress, telomeres, and psychological wellbeing: theoretical review

primary · 2011

Study T5

Telomeres, lifestyle, cancer, and aging

primary · 2011

Study T3

Age-stratified associations between sleep duration and mortality

primary · 2010

Study T1

Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials

RCT · 2010

Study T4

GSK and Sirtris: A Bit More

primary · 2010

Study T1

Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial

Randomized, double-blind, placebo-controlled trial; folic acid 0.8 mg + B12 0.5 mg + B6 20 mg daily for 24 months; MRI-measured brain atrophy · 2010

Study T5

Insulin/IGF-1 signaling and longevity

primary · 2010

Study T2

Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster

preclinical · 2010

Study T5

Pharmacokinetics, oral bioavailability, and metabolic profile of resveratrol and its dimethylether analog, pterostilbene, in rats

primary · 2010

Study T5

Progeria syndromes and ageing: what is the connection?

review · 2010

Study T5

Pyrroloquinoline quinone stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increased PGC-1alpha expression

primary · 2010

Study T3

Rapamycin in the context of Pascal's Wager: generalized hormesis and safe treatments

primary · 2010

Study T3

Resveratrol for Improved Performance in the Elderly (RIPE) — clinical trial listing

Two-year randomised trial comparing 300 mg/day vs 1,000 mg/day vs placebo on cognitive and physical outcomes in older adults · 2010

Study T2

Sleep duration and all-cause mortality: a systematic review and meta-analysis

meta-analysis · 2010

Study T5

SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1

primary · 2010

Study T5

The genetics of ageing

primary · 2010

Study T1

Antioxidants prevent health-promoting effects of physical exercise in humans

primary · 2009

Study T2

Association of FOXO3A variation with human longevity confirmed in German centenarian studies

primary · 2009

Study T3

Comparative biology of aging

primary · 2009

Study T5

PGC-1α in aging and anti-aging interventions

primary · 2009

Study T2

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

preclinical · 2009

Study T5

Using Mice to Examine p53 Functions in Cancer, Aging, and Longevity

preclinical · 2009

Study T2

Using nontraditional risk factors in coronary heart disease risk assessment: U.S. Preventive Services Task Force recommendation statement.

primary · 2009

Study T2

Adherence to Mediterranean diet and health status: meta-analysis

meta-analysis · 2008

Study T4

AMPK and PPARdelta agonists are exercise mimetics

primary · 2008

Study T5

Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action

primary · 2008

Study T3

Effect of Calorie Restriction on Bone Mineral Density (6-month trial)

primary · 2008

Study T2

FOXO3A genotype is strongly associated with human longevity

primary · 2008

Study T1

Ginkgo biloba for prevention of dementia: a randomized controlled trial

Randomized, double-blind, placebo-controlled trial; EGb 761 120 mg twice daily (240 mg/day), median 6.1 years; elderly with normal cognition or MCI · 2008

Study T2

Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans

primary · 2008

Study T2

Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition

primary · 2008

Study T1

Effects of torcetrapib in patients at high risk for coronary events

primary · 2007

Study T2

Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and meta-analysis.

RCT · 2007

Study T3

Resistance exercise reverses aging in human skeletal muscle

primary · 2007

Study T3

Does melatonin help people sleep? It's a misapplied but probably safe miracle drug

primary · 2006

Study T1

Homocysteine lowering with folic acid and B vitamins in vascular disease

primary · 2006

Study T2

Homocysteine, B vitamins, and cardiovascular disease (correspondence)

primary · 2006

Study T2

One Year of Caloric Restriction in Humans: Feasibility and Effects on Body Composition and Abdominal Adiposity

primary · 2006

Study T5

DNA repair, genome stability, and aging

primary · 2005

Study T1

Effects of N-acetylcysteine on outcomes in chronic obstructive pulmonary disease (BRONCUS trial)

primary · 2005

Study T2

Reduced insulin/IGF-1 signalling and human longevity

primary · 2005

Study T2

The plasticity of aging: insights from long-lived mutants.

primary · 2005

Study T3

Elevated levels of tumor necrosis factor alpha and mortality risk in centenarians

primary · 2003

Study T2

Oral creatine monohydrate supplementation improves brain performance: a double-blind, placebo-controlled, cross-over trial

randomized controlled trial (double-blind, placebo-controlled, cross-over) · 2003

Study T3

Predicting death from tumour necrosis factor-alpha and interleukin-6 in 80-year-old people

primary · 2003

Study T3

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

primary · 2003

Study T4

"Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally

preclinical · 2002

Study T4

'Super p53' mice age normally

preclinical · 2002

Study T5

Cancer and Aging: Yin, Yang, and p53

primary · 2002

Study T2

Melatonin for the prevention and treatment of jet lag

meta-analysis · 2002

Study T4

p53 mutant mice that display early ageing-associated phenotypes

preclinical · 2002

Study T1

Frequency of blood donations and coronary heart disease risk in the Health Professionals Follow-up Study

primary · 2001

Study T4

The Long-Lived Bet

primary · 2001

Study T4

The Quest for Immortality: Science at the Frontiers of Aging

primary · 2001

Study T1

Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers

primary · 1998

Study T1

Effect of vitamin E and beta carotene on the incidence of lung cancer (ATBC trial)

primary · 1994

Study T1

A C. elegans mutant that lives twice as long as wild type

preclinical · 1993

Study T2

Social network characteristics and mortality after adjustment for baseline health: a 14-year Danish cohort

cohort · 1990

Study T2

Heart rate and cardiovascular mortality: the Framingham Study

primary · 1987

Studies

Recently added

Studies on BPC-157, MOTS-c, Epitalon and 16 more