Study

Blueprint protocol snapshot exposes a prescription-stack discrepancy

Bryan Johnson

N=1 SELF-EXPERIMENT / CURRENT PROTOCOL-PAGE REVISION WITH AN INTERNAL PRESCRIPTION DISCREPANCY 2026

NEW PROTOCOL CHANGE / CONTROVERSY: the current page exposes metformin 500 mg on 6-week on/off cycles and acarbose 200 mg in the daily Rx stack, while its separate Rx section still lists acarbose 400 mg and no metformin.

DesignN=1 SELF-EXPERIMENT / CURRENT PROTOCOL-PAGE REVISION WITH AN INTERNAL PRESCRIPTION DISCREPANCY
TierTier 4, Ingredient RCT (different dose)
Year2026
JournalSelf-published — protocol.bryanjohnson.com
N1
PublishedSep 23, 2026
Added to NO1GEVITYSep 23, 2026

The 23 September 2026 capture of Bryan Johnson’s canonical protocol page contains a newly visible “My Rx stack” block in the daily routine. It lists Armour Thyroid 60 mg, levothyroxine 100 mcg, minoxidil 3.75 mg, metformin 500 mg with a note that he is experimenting with six-week on/off cycles, tadalafil 5 mg, Jardiance 10 mg, acarbose 200 mg and Repatha 140 mg once every other week. The preceding 16 September snapshot contained the “My Rx stack” heading but no entries beneath it. The same current page still has a separate “Rx / Prescriptions” section that lists acarbose at 400 mg daily, tadalafil 5 mg daily, candesartan 8 mg daily, Jardiance 10 mg daily and Repatha 140 mg/mL every two weeks; that section does not list metformin. The page metadata remains dated January 2026, so the onset of the discrepancy cannot be dated. This record treats the difference as a current-text protocol change or disclosure discrepancy, not proof of a new treatment effect. It also does not assume that the daily-routine dose supersedes the formal prescription section. Medical dosing requires confirmation from a clinician and an updated primary protocol.

The page does not provide a dated scientific conclusion. It presents conflicting current prescription lists; the discrepancy remains unresolved.
Critic notes

A Wellness Radar review says the full stack is an uncontrolled n=1 combination and that biological-age clocks cannot establish decades of age reversal: https://wellnessradar.ca/articles/bryan-johnson-blueprint-protocol-evidence. PubMed review 41655607 found 28 randomized human NAD-related intervention studies but concluded anti-aging and wellness effectiveness remains inconclusive; it does not justify an ingredient-grade upgrade: https://pubmed.ncbi.nlm.nih.gov/41655607/.

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