Cellular senescence: a key therapeutic target in aging and disease

This 2023 article reviewed research on cellular senescence, a state where damaged cells stop dividing but remain in the body. It did not enroll participants. Instead, it summarized studies in cells, mice, and small early human trials of senolytics, drugs designed to remove these cells. The evidence suggests senescent cells can contribute to inflammation and age-related disease, while removing them helped with some problems in mice. These findings do not yet show that the treatment extends human life or broadly improves health.

What this means for you: This is not evidence that a supplement or senolytic drug will slow aging in people. These treatments remain experimental and may have risks, because senescent cells can sometimes help with healing.