Study

Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster

Bjedov I, Toivonen JM, Kerr F, et al., Partridge L

PRECLINICAL 2010
Summary Can rapamycin help fruit flies live longer, and how might it work? Show / hide ↓

Researchers fed adult fruit flies different amounts of rapamycin and tracked how long they lived. Rapamycin extended their lives by about 14%. It reduced TOR, a cell-growth control system, and increased autophagy, the cells’ cleanup and recycling process. The treated flies handled starvation and oxidative stress, a type of cell damage, better, but handled heat stress worse. They also had fewer offspring, although this did not fully explain the longer lives.

What this means for you: This is an interesting result in fruit flies, not proof that rapamycin extends human life. You can ignore this as a reason to buy or take rapamycin, which can have important side effects and should only be used under medical supervision.

early evidence
DesignPRECLINICAL
TierTier 2, Product RCT (not peer-reviewed)
Year2010
JournalCell Metabolism (PubMed)
Added to NO1GEVITYJun 2, 2026

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