Study

The mechanistic Target of Rapamycin: The grand conducTOR of metabolism and aging

Kennedy BK, Lamming DW

PRIMARY 2016
Summary How does mTOR affect metabolism, aging, and possibly lifespan? Show / hide ↓

This paper reviewed research on mTOR, a cell-control system that helps decide when cells grow, make proteins, or recycle damaged parts. The evidence came from laboratory cells, animals, and some human studies rather than one new group of participants. Drugs such as rapamycin, which blocks mTOR, can extend lifespan in some animals and change metabolism. The effects depend on which part of mTOR is blocked, the dose, and the person’s health.

What this means for you: This is background science, not proof that rapamycin or other mTOR-blocking products will help healthy people live longer. Do not buy or use these drugs for longevity without medical guidance, because they can affect immunity and metabolism.

moderate evidence
DesignPRIMARY
TierTier 5, Mechanistic / animal / marketing
Year2016
JournalCell Metabolism
Added to NO1GEVITYMay 18, 2026

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