Study

Retraction and Republication: Primary Prevention of Cardiovascular Disease with a Mediterranean Diet (PREDIMED)

Estruch R, et al.

PRIMARY 2018
Summary Does a Mediterranean-style diet lower the risk of heart attacks and strokes? Show / hide ↓

Researchers studied 7,447 adults aged 55 to 80 who had a high risk of heart disease. They assigned people by chance to follow a Mediterranean diet with extra-virgin olive oil, a Mediterranean diet with nuts, or a low-fat diet. After about five years, the Mediterranean diet groups had roughly 30% fewer heart attacks, strokes, or related deaths. A later check of the data found broadly similar results, despite problems with how some people were originally assigned.

What this means for you: This supports eating more vegetables, fruit, beans, whole grains, nuts, fish, and olive oil, while limiting highly processed foods. The participants already had a high risk of heart disease, so the benefit for healthier people may be smaller.

moderate evidence
DesignPRIMARY
TierTier 3, Ingredient RCT (matching dose)
Year2018
JournalNew England Journal of Medicine
Added to NO1GEVITYJul 24, 2026

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