Study

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Harrison DE, Strong R, Sharp ZD, et al.

PRECLINICAL 2009
Summary Can a drug started late in life help mice live longer? Show / hide ↓

Researchers gave rapamycin, a drug that blocks a cell growth pathway, to genetically mixed mice. The mice started receiving it at about 20 months old, roughly late middle age for a mouse. About 1,900 mice took part, and treated mice lived longer than untreated mice. Average lifespan rose by about 9% in males and 14% in females. The study was in mice, not people, so it does not directly show that rapamycin helps humans live longer.

What this means for you: This is not a reason to buy or take rapamycin for longevity. It is an important animal finding, but human benefits and long-term risks remain uncertain.

early evidence
DesignPRECLINICAL
TierTier 2, Product RCT (not peer-reviewed)
Year2009
JournalNature 460:392-395
Added to NO1GEVITYMay 25, 2026

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