Study

Higher spermidine intake is linked to lower mortality: a prospective population-based study

Kiechl S, Pechlaner R, Willeit P, Notdurfter M, Paulweber B, Willeit K, Werner P, Ruckenstuhl C, Iglseder B, Weger S, Mairhofer B, Gartner M, Kedenko L, Chmelikova M, Stekovic S, Stuppner H, Oberacher H, Weiss EK, Grabherr S, Schmidt CM, Kirchmair R, Sourij H, Motamedi A, Uribarri J, Madeo F, Eller K, Willeit J.

PRIMARY 2018

Summary Could eating more spermidine-rich foods help people live longer? Show / hide ↓

Researchers followed 829 adults in Italy for about 20 years. They estimated how much spermidine, a natural substance found in foods such as beans, mushrooms, and whole grains, each person ate. During the study, 341 people died. People with the highest estimated intake had about a 40% lower risk of death than those with the lowest intake, after adjustments for other health and lifestyle factors.

What this means for you: This study suggests that diets containing more spermidine-rich foods may be linked with longer life. It does not prove spermidine caused the benefit, so it is not a strong reason to buy spermidine supplements.

early evidence

DesignPRIMARY

TierTier 2, Product RCT (not peer-reviewed)

Year2018

JournalAm J Clin Nutr

Added to NO1GEVITYJul 3, 2026

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IngredientSpermidine From Food Sourcespolyamine (dietary source)←MechanismAutophagyAutophagy is the cell's recycling system for damaged proteins an←StudyHigher spermidine intake is linked to lower mortality: a pro…Am J Clin Nutr 2018

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1 encyclopedia entries reference this study.

MoleculeSpermidine From Food Sources