The sirtuin family's role in aging and age-associated pathologies

The researchers reviewed studies on sirtuins, a family of cell proteins that help control energy use, stress responses, and gene activity. Most evidence came from cells and laboratory animals, with some research in humans, rather than from a human treatment trial. Some studies linked sirtuins with longer life or better protection from diseases related to aging. Other studies found weaker, mixed, or tissue-specific effects, so the overall picture was uncertain.

What this means for you: This review does not show that sirtuin supplements or activators extend human life. You can ignore products making strong anti-aging claims based only on this research.