Effects of Dasatinib and Quercetin senolytic treatment on epigenetic age, DNA methylation, and immune cell subsets

Researchers gave a small group of adults a short course of dasatinib and quercetin, two medicines being studied as senolytics, or treatments intended to remove worn-out cells. They checked blood samples before and after treatment. They measured epigenetic age, an estimate of aging based on chemical tags on DNA, along with DNA methylation, chemical tags that help control genes, and different types of immune cells. The treatment did not clearly make participants’ epigenetic age younger, although some DNA and immune-cell changes were reported.

What this means for you: This small, preliminary human study does not show that these drugs slow or reverse aging. Do not buy or use dasatinib and quercetin for anti-aging purposes outside a properly supervised clinical study, since both can have important side effects.