Study

HbA1c variability increases mortality risk in diabetes

Healio editorial summary of ADA data

PRIMARY 2021
Summary Do big swings in blood sugar predict earlier death? Show / hide ↓

Researchers studied adults with diabetes who had repeated HbA1c tests. HbA1c is a blood test showing average blood sugar over the past two to three months. They compared people whose results stayed fairly steady with those whose results changed a lot between tests. People with more change in their HbA1c readings had a higher risk of dying during follow-up. This was an observational study, so it cannot prove that the swings themselves caused the higher risk.

What this means for you: This does not show that buying a product or forcing HbA1c to stay perfectly flat will extend life. It supports discussing repeated large changes in blood sugar with a clinician, while remembering that other health problems may explain part of the link.

moderate evidence
DesignPRIMARY
TierTier 3, Ingredient RCT (matching dose)
Year2021
JournalHealio Endocrinology
Added to NO1GEVITYMay 24, 2026

Read the source

Cited by

1 encyclopedia entries reference this study.