Reduced insulin/IGF-1 signalling and human longevity

Researchers compared genes from people who lived to 100 or longer with genes from younger adults. They focused on IGF-1, a hormone involved in growth and aging, and its receptor, the cell part that receives its message. Some centenarians had rare changes in the receptor gene. Laboratory tests suggested these changes made cells respond less strongly to IGF-1. The study found a link, but it could not prove that weaker IGF-1 signals caused longer life.

What this means for you: This does not show that taking drugs or supplements to lower IGF-1 will help you live longer. It is an interesting genetic clue, not a treatment recommendation.