Study
Nestle-Led Clinical Study: NR and NMN Promote Metabolic Health in Unexpected Ways
14-day NR and NMN supplementation altered metabolic pathways in ways not previously reported.
Summary Do NR and NMN supplements improve health after just two weeks? Show / hide ↓
Researchers gave adults NR and NMN, compounds the body uses to make NAD+, for 14 days. The study did not report how many people took part. The supplements changed some metabolic pathways, which are the body’s chemical processes for using food and energy. The study did not show whether these changes improved health, exercise ability, or long-term disease risk. The work was funded by Nestle Health Science and was reported on its website rather than in a peer-reviewed medical journal.
What this means for you: This is not enough evidence to buy NR or NMN supplements for better health. The study was short, did not report its participant number, and found biological changes rather than proven health benefits.
weak evidenceA Nestle Health Science-led clinical study found that 14-day supplementation of nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) combined produced changes in metabolic health markers that were not previously described. This is notable because most NAD+ precursor studies have focused on raising blood NAD+ levels or measuring physical performance endpoints. The metabolic pathway changes suggest NAD+ boosters may have effects beyond simple NAD+ elevation. The short 14-day duration limits conclusions about sustained effects. The study is industry-funded (Nestle Health Science), which is a conflict of interest to consider when evaluating the claims. Results were published on the Nestle Health Science website rather than in a peer-reviewed journal at time of writing.
First-time evidence that 14-day supplementation of NR and NMN could promote health in unexpected ways.
Industry-funded by Nestle Health Science, which sells NAD+ products. Not yet peer-reviewed. 14-day duration is too short for longevity outcomes.
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