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Polyphenol / Senolytic

Quercetin · Quercetin

Best-studied 'senolytic' ingredient, though evidence is early.

B
Evidence grade
Human RCTs, biomarker outcomes
Strongest study
Tier 2 · 4 linked studies

Short answer

Safe, cheap, mild anti-inflammatory. Don't expect miracle rejuvenation from daily 500 mg capsules, the interesting senolytic protocols are periodic and use quercetin as part of a combo.

Product and dose overview

Quercetin (Quercetin) is a polyphenol / senolytic with evidence grade B, meaning it is supported by human RCTs. We track 26 products containing Quercetin. Typical doses range from 14 to 1000 mg per serving. The top-ranked product scores 7.8 out of 10 on our composite scale (dose, evidence, price, testing, transparency). Prices range up to $35.00 per month.

Evidence grade: B Products in database: 26 Category: Polyphenol / Senolytic

Top Quercetin products

ProductBrandDosePrice/mo3rd-party testedScore
Quercetin Tablets | 95% AnhydrousNootropics Depot500 mg$17.99Yes7.8
Two-Per-Day Multivitamin (capsules/tablets)Life Extension14 mg$24.50Yes7.7
Quercetin Supplement (with Bromelain)Double Wood Supplements1000 mg$24.95Yes7.6
MetaQuercetin SuperZRevgenetics250 mg$20.37Yes7.6
Pure QuercetinDoNotAge400 mg$35.00Yes7.3

Scores are editorial judgments, not a scientific standard. See how we score.

What it is

A yellow-orange plant compound found in onions, apples, and capers. Being studied as a 'senolytic', a molecule that clears out old, malfunctioning cells that accumulate as we age and drive inflammation.

Why people take it

The theory is exciting: kill off 'zombie cells' and inflammation drops, tissues heal better. Mouse studies show benefits. In humans, most trials use quercetin + dasatinib (a cancer drug) intermittently, not daily supplements.

Our verdict

Safe, cheap, mild anti-inflammatory. Don't expect miracle rejuvenation from daily 500 mg capsules, the interesting senolytic protocols are periodic and use quercetin as part of a combo.

Structure & class

2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one. Flavonoid. Bioavailability enhanced by phytosome or lecithin delivery.

Mechanism & clinical data

Hickson et al. 2019 pilot showed dasatinib+quercetin cleared senescent cells in diabetic kidney disease. Standalone senolytic effect at typical supplement doses (500 to 1000 mg/day) is unproven. Anti-inflammatory and antihistamine effects better established.

Pharmacokinetics

~11 hours.

Dose & forms

Trial dose
500 mg
/ day
Range in trials
250 to 1000 mg
/ day
Common forms
Powder, Phytosome (Quercefit®), Combined with bromelain

What to watch out for

Plain quercetin dihydrate has poor absorption. Phytosome forms deliver 10 to 20× more into blood.

Safety limits and interactions

When a product exceeds the UL or contains an ingredient with clinically significant interactions, a "Review advised" flag appears on its product page and links here.

Safety note
No formal UL. Considered safe up to 500-1,000 mg/day in most 12-week trials; nephrotoxicity risk emerges primarily above 2,000 mg/day orally, especially in individuals with pre-existing kidney disease. Long-term safety data beyond 12 weeks at doses ≥1,000 mg are lacking.

Source: https://pubmed.ncbi.nlm.nih.gov/29127724/

Where this dose comes from

The trial dose above is our editorial pick from the published human trials for this ingredient. We choose the dose that the best-available studies used on the endpoint most relevant to longevity. The range shows the lowest and highest doses tested in published trials. The landmark studies below are the papers we read to set it. You can click through and check our work.

When new trials publish, our automated sweeps flag them. If a new study materially changes the dose, we update it through editorial review and record the old dose, new dose, and the triggering study in every affected product's recommendation history. The dose is never changed automatically.

Regulatory status

EUFood supplement (extract-dependent)
USDietary supplement
UKFood supplement
CANHP

Timeline

Regulatory events, evidence grade changes, and key research milestones for Quercetin, most recent first. Studies link to the paper; regulatory entries name and link the responsible authority.

  • 2026-08-07 Evidence grade
    Evidence grade changed: C → B
    Multiple human RCTs and two meta-analyses of RCTs confirm efficacy for blood pressure reduction, a longevity-relevant cardiovascular endpoint. The 2016 meta-analysis pooled 7 RCTs (587 patients) and the 2022 update pooled 10 RCTs (841 participants). A registered 30-person pilot trial (NCT05838560) is ongoing for biological aging endpoints.
    Source → Source → Source → +1 more
  • 2025-04 Regulatory single source
    EU Court sharpens the bar for botanical health claims
    A Court of Justice of the European Union ruling in April 2025 further tightened the requirements for how botanical ingredients (herbs, plant extracts) can be marketed with health claims in the EU, effectively removing much of the flexibility of the on-hold list.
  • 2025 Research milestone
    D+Q pilot trial 2025 (F1000Research)
    This registered 30-person pilot trial (NCT05838560) is testing intermittent dasatinib plus quercetin dosing for feasibility and effects on accelerated biological aging and cognitive decline in older adults.
    Source →
  • 2024-06 Regulatory confirmed
    EU report identifies 117 supplement substances as potential health risks
    The HoA Working Group on Food Supplements (26 European countries) published its first report evaluating 117 substances used in food supplements. Of these, 65 were assessed as likely novel foods, 6 were already regulated, 34 had insufficient data, and 12 were prioritized for Article 8 restriction under Regulation (EC) No 1925/2006. The 12 priority substances include ashwagandha, curcumin, melatonin, piperine, St. John's wort, coumarin, p-synephrine, maca, holy basil, Melaleuca, black cohosh, and L-tryptophan. The report drew on 1,500 RASFF alerts reviewed between 2017 and mid-2022.
    Source →
  • 2022 Research milestone
    Quercetin + blood pressure 2022 meta-analysis
    An updated meta-analysis of 10 RCTs (841 participants) confirmed quercetin significantly lowers systolic blood pressure in both normotensive and hypertensive adults.
    Source →
  • 2021-11 Regulatory confirmed
    EU classifies encapsulated quercetin-zein as novel food
    The EU Commission classified encapsulated quercetin-zein as a novel food because the encapsulation process significantly increases oral absorption and bioavailability, allowing quercetin to cross the blood-brain barrier. Standard quercetin from chemical synthesis or extraction from onions (Allium cepa) remains permitted as a food supplement without novel food authorisation. Quercetin (95%) derived from Dimorphandra mollis was also classified as novel.
    Source →
  • 2019 Research milestone
    Hickson et al. 2019 (senolytics in humans)
    In 9 patients with diabetic kidney disease, a 3-day course of dasatinib plus quercetin significantly reduced senescent cell markers and circulating inflammatory (SASP) factors within 11 days.
    Source →
  • 2016 Research milestone
    Quercetin + blood pressure 2016 meta-analysis
    Across 7 RCTs (587 patients), quercetin supplementation significantly reduced systolic and diastolic blood pressure, with greater effect at doses ≥500 mg/day.
    Source →
  • 2006-12 Regulatory confirmed
    EU Health Claims Regulation adopted
    Regulation (EC) No 1924/2006 laid down harmonised rules for nutrition and health claims made on foods, including supplements. Only claims listed in the EU Register of authorised claims can be used. Rejected botanical claims are held in a separate on-hold list.
    Source →
  • 1997 Regulatory confirmed
    EU introduces the Novel Food Regulation
    Regulation (EC) No 258/97 required any food or food ingredient without a history of consumption in the EU before 15 May 1997 to be authorised before being placed on the market. This is the framework that captures NMN, spermidine as a supplement ingredient, urolithin A, and many other longevity actives.
    Source →
2026 evidence refresh

Quercetin is a plant flavonoid that modestly lowers systolic blood pressure and, combined with dasatinib, clears senescent cells in humans.

Verified 2026-07-24. We update this section as new peer-reviewed trials land.

Human RCT base
40+
peer-reviewed randomised trials
Largest single trial
n = 743
Quercetin significantly reduced systolic blood pressure by about 3.2 mmHg in hypertensive and normotensive adults; diastolic blood pressure did not change significantly. source

Best-supported claim

The most reliable human evidence for quercetin is a small, consistent reduction in systolic blood pressure. An umbrella review of 5 meta-analyses covering 18 RCTs, plus 5 additional trials, found quercetin significantly lowers systolic blood pressure by about 1.9 mmHg and lowers fasting insulin, but has no effect on diastolic blood pressure, lipids, inflammation markers, body measurements, or insulin resistance (https://pubmed.ncbi.nlm.nih.gov/37654199/). Separately, LaTonya Hickson and colleagues at Mayo Clinic showed that quercetin paired with the cancer drug dasatinib reduces senescent cell markers in human adipose tissue and skin within 11 days of a short 3-day course, the first direct evidence senolytics work in humans (https://pubmed.ncbi.nlm.nih.gov/31542391/). Quercetin alone has not been shown to have this senolytic effect in humans; the evidence is for the drug combination.

Not supported by the evidence base

Quercetin is marketed as a broad anti-aging senolytic and immune booster based on mouse lifespan studies and its role in dasatinib-plus-quercetin protocols. Taken alone, at typical supplement doses, quercetin's human evidence is much narrower. The umbrella review found no significant effect on lipids, inflammation, or insulin resistance despite its reputation as an anti-inflammatory (https://pubmed.ncbi.nlm.nih.gov/37654199/). For exercise performance, a systematic review of 13 studies concluded quercetin supplementation does not improve exercise performance itself, even though marketing often cites its antioxidant profile as an athletic performance driver (https://aber.apacsci.com/index.php/JBRHA/article/view/8162). A 2011 meta-analysis of 254 subjects found a real but tiny effect on endurance capacity, about a 2% improvement over placebo, far smaller than typically implied (https://pubmed.ncbi.nlm.nih.gov/21606866/). Oral bioavailability is also a genuine limitation: absorption of quercetin glucoside ranges from only 3% to 17% in healthy people at 100 mg doses.

Typical dose

500 mg to 1000 mg daily for blood pressure and metabolic effects; senolytic protocols use quercetin 1000 mg total daily (500 mg twice) paired with dasatinib 100 mg for 2-3 days per cycle, under medical supervision

Safety

Oral quercetin has been safe and well tolerated across dozens of RCTs at doses up to 1000 mg/day for 12 weeks, with no serious adverse events reported in blood pressure trials. The dasatinib-plus-quercetin senolytic combination used in Mayo Clinic pilot trials caused no serious adverse events (hospitalization, kidney injury, death) over a 3-day hit-and-run dosing course, but this combination involves a prescription chemotherapy drug and should not be self-administered. Bioavailability is low and highly variable between individuals, which limits predictable dosing from supplements alone.

Interactions worth flagging

  • blood thinners
  • blood pressure medications
  • dasatinib and other chemotherapy agents (senolytic protocols specifically combine these under medical supervision)
  • cyclosporine

Three recent studies to know

  • The effects of Quercetin supplementation on cardiometabolic outcomes: An umbrella review of meta-analyses of randomized controlled trials
    Phytotherapy Research 2023

    Read study →
  • The effect of quercetin supplementation on the components of metabolic syndrome in adults: A systematic review and dose-response meta-analysis of randomized controlled trials
    Open-access peer-reviewed journal (DOAJ-indexed) 2024

    Read study →
  • Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease
    EBioMedicine 2019

    Read study →

Landmark studies

Found in these products (26)

All products in our catalog that contain Quercetin, ranked by our overall score. Ranking is editorial, never paid.

Sirtuin activator
Active per serving
Quercetin 500 mgTablet · 120 servings
Price per serving
$0.15$17.99 · 120 servings
Testing
3rd-party listed · public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 7.8/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$0.15
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with nootropicsdepot.com
Multi/greens
Ingredients listed
5 ingredients listedlargest listed: Vitamin C 470 mg
Price per serving
$0.41$24.50 · 60 servings
Testing
3rd-party listed · no public lab certificate

Multi-ingredient bundle

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 7.7/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$0.43
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with www.lifeextension.com
Double Wood Supplements
Quercetin Supplement (with Bromelain)
Antioxidant
Active per serving
Quercetin 1,000 mgCapsule · 30 servings
Price per serving
$0.83$24.95 · 30 servings
Testing
3rd-party listed · public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 7.6/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$0.42
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with doublewoodsupplements.com
Revgenetics
MetaQuercetin SuperZ
Senolytic
Active per serving
Quercetin 250 mg+ Zinc 25 mg
Price per serving
$0.68$20.37 · 30 servings
Testing
3rd-party listed · no public lab certificate

Elemental vs compound: check label

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 7.6/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$1.36
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with www.revgenetics.com
DoNotAge
Pure Quercetin
Sirtuin activator
Active per serving
Quercetin 400 mgCapsule · 366 servings
Price per serving
$0.10$35.00 · 366 servings
Testing
3rd-party listed · no public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 7.3/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$0.12
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with donotage.org
Thorne HealthTech
ResveraCel
Longevity stack
Ingredients listed
4 ingredients listedlargest listed: NR 300 mg
Price per serving
$1.75$105.00 · 60 servings
Testing
3rd-party listed · public lab certificate

Multi-ingredient bundle

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 7.0/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$1.75
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with www.thorne.com
BulkSupplements
Quercetin Dihydrate Powder
Sirtuin activator
Active per serving
Quercetin 1,000 mgPowder · 100 servings
Price per serving
$0.27$26.97 · 100 servings
Testing
None listed

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 6.9/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$0.13
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with www.bulksupplements.com
Sirtuin activator
Active per serving
Resveratrol 1,000 mg+ Quercetin 420 mg
Price per serving
$1.04$31.08 · 30 servings
Testing
3rd-party listed · public lab certificate

Undisclosed amounts noted

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 6.9/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$0.52
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with www.prohealth.com
Longevity stack
Ingredients listed
8 ingredients listedlargest listed: Creatine 3,000 mg
Price per serving
$4.30$129.00 · 30 servings
Testing
3rd-party listed · no public lab certificate

Multi-ingredient bundle

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 6.9/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

50%
of trial dose
$17.20
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with im8health.com
Thorne HealthTech
Advanced Nutrients
Multi/greens
Ingredients listed
10 ingredients listedlargest listed: Vitamin C 425 mg
Price per serving
$2.40$72.00 · 30 servings
Testing
3rd-party listed · no public lab certificate

Multi-ingredient bundle

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 6.8/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$2.82
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with www.thorne.com
Multi/greens
Ingredients listed
6 ingredients listedlargest listed: Vitamin C 90 mg
Price per serving
$1.33$39.99 · 30 servings
Testing
3rd-party listed · no public lab certificate

Multi-ingredient bundle

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 6.7/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$1.33
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with seed.com
Senolytic
Active per serving
Quercetin 500 mg+ Fisetin 100 mg
Price per serving
$1.67$49.99 · 30 servings
Testing
3rd-party listed · no public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 6.6/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$1.67
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with www.jinfiniti.com
Renue By Science
Quercetin (Liposomal)
Senolytic
Active per serving
Quercetin 150 mgCapsule · 90 servings
Price per serving
$0.53$47.95 · 90 servings
Testing
3rd-party listed · public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 6.6/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

60%
of trial dose
$1.78
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with renuebyscience.com
Longevity stack
Ingredients listed
9 ingredients listedlargest listed: Glycine 3,000 mg
Price per serving
$4.97$149.00 · 30 servings
Testing
3rd-party listed · no public lab certificate

Multi-ingredient bundle

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 6.3/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$4.97
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with im8health.com
NAD+ booster
Ingredients listed
4 ingredients listedlargest listed: NMN 500 mg
Price per serving
$2.67$79.99 · 30 servings
Testing
3rd-party listed · no public lab certificate

Multi-ingredient bundle

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 6.3/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$2.67
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with www.codeage.com
NAD+ booster
Ingredients listed
4 ingredients listedlargest listed: NR 300 mg
Price per serving
$1.50$45.00 · 30 servings
Testing
3rd-party listed · no public lab certificate

Multi-ingredient bundle

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 6.2/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$1.50
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with www.lifeextension.com
ID Formulas
Advanced ID
Longevity stack
Ingredients listed
10 ingredients listedlargest listed: Collagen Peptides 5 g
Price per serving
$9.00$270.00 · 30 servings
Testing
None listed

EPA/DHA split not stored

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 6.1/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$18.00
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with www.idformulas.com
Longevity stack
Ingredients listed
7 ingredients listedlargest listed: NMN 250 mg
Price per serving
$1.97$59.00 · 30 servings
Testing
3rd-party listed · no public lab certificate

Multi-ingredient bundle

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 5.7/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$3.93
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with perpetualife.bio
Gundry MD
Elevate NAD+
NAD+ booster
Precursor per serving
NMN 300 mg+ Quercetin 150 mg
Price per serving
$5.00$149.95 · 30 servings
Testing
3rd-party listed · no public lab certificate

Undisclosed amounts noted

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 5.6/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$8.33
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with gundrymd.com
Sirtuin activator
Ingredients listed
4 ingredients listedlargest listed: Resveratrol 200 mg
Price per serving
$0.47$28.21 · 60 servings
Testing
None listed

Multi-ingredient bundle

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 5.6/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$1.18
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with acuatlanta.net
Sirtuin activator
Ingredients listed
3 ingredients listedlargest listed: Resveratrol 250 mg
Price per serving
$1.33$40.00 · 30 servings
Testing
3rd-party listed · public lab certificate

Multi-ingredient bundle

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 5.6/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$2.67
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with www.lifeextension.com
Cognition
Ingredients listed
6 ingredients listedlargest listed: Probiotics 100 mg
Price per serving
$1.17$34.99 · 30 servings
Testing
3rd-party listed · no public lab certificate

CFU not stored

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 5.5/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

1%
of trial dose
$358.87
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with seed.com
Autophagy
Ingredients listed
3 ingredients listedlargest listed: Quercetin 77 mg
Price per serving
$0.87$51.95 · 60 servings
Testing
3rd-party listed · no public lab certificate

Multi-ingredient bundle

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 5.3/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

31%
of trial dose
$5.62
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with renuebyscience.com
Autophagy
Ingredients listed
6 ingredients listedlargest listed: Probiotics 200 mg
Price per serving
$1.17$34.99 · 30 servings
Testing
3rd-party listed · no public lab certificate

CFU not stored

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 5.3/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

1%
of trial dose
$358.87
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with seed.com
Nuchido
TIME+
NAD+ booster
Precursor per serving
Alpha-Lipoic Acid 100 mg+ Quercetin 50 mg
Price per serving
$2.17$65.00 · 30 servings
Testing
3rd-party listed · no public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 5.1/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

33%
of trial dose
$13.00
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with nuchido.com
Life Extension
GEROPROTECT Ageless Cell
Senolytic
Ingredients listed
4 ingredients listedlargest listed: Quercetin 60 mg
Price per serving
$1.40$42.00 · 30 servings
Testing
3rd-party listed · public lab certificate

Multi-ingredient bundle

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 5.0/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

45%
of trial dose
$15.56
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with www.lifeextension.com
Editorial guides

Buying guides and comparisons

Neighbouring molecules

Related ingredients

See all in Polyphenol / Senolytic →

Molecules in the same class, plus the actives most often formulated alongside Quercetin in our catalogue.

FisetinCsame categoryResveratrolCstacked together in 10 productsNMNBstacked together in 5 productsVitamin CAstacked together in 4 productsMagnesiumAstacked together in 4 productsSpermidineCstacked together in 4 productsVitamin D3Astacked together in 4 productsZincAstacked together in 3 products
Product shelves
See all in Sirtuin activator (6)See all in Longevity stack (5)See all in Senolytic (4)See all in NAD+ booster (4)See all in Multi/greens (3)See all in Autophagy (2)See all in Antioxidant (1)See all in Cognition (1)

See Quercetin in context: the mechanism it acts through, the biomarker it moves, the products that dose it, and the trials that tested it.

View Quercetin on the Longevity Map →

Frequently asked questions

What is Quercetin?

A yellow-orange plant compound found in onions, apples, and capers. Being studied as a 'senolytic', a molecule that clears out old, malfunctioning cells that accumulate as we age and drive inflammation.

What dose of Quercetin should I take?

The trial dose in published human studies is 500 mg per day, with a range of 250 to 1000 mg per day. Always consult a qualified clinician before starting any supplement.

Is Quercetin safe?

No formal UL. Considered safe up to 500-1,000 mg/day in most 12-week trials; nephrotoxicity risk emerges primarily above 2,000 mg/day orally, especially in individuals with pre-existing kidney disease. Long-term safety data beyond 12 weeks at doses ≥1,000 mg are lacking.

What is the best Quercetin supplement?

We track 26 products containing Quercetin. The top-ranked product scores 7.8 out of 10 on our composite scale, which evaluates dose, evidence, price, third-party testing, and transparency. See the comparison table above. Scores are editorial judgments, not a scientific standard.

What is the evidence grade for Quercetin?

Quercetin has evidence grade B, meaning it is supported by human RCTs. Grade A means replicated human RCTs with hard endpoints. Grade B means human RCTs with biomarker outcomes. Grade C means mixed or small human trials. See our evidence grading methodology.

Independently checked

Data verification

Evidence grade
B
Human RCTs, biomarker outcomes
Research dose
500 mg
Products tracked
26
Updated continuously
Safety signal
No formal UL. Considered safe up to 500-1,000 mg/day in m...

Evidence grades are reviewed when new human RCTs are published. Product counts update automatically as new products are added. Dose ranges reflect published trial data, not brand recommendations. Read how we verify.