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Thorne HealthTech

ResveraCel

Longevity stack · Capsule · 60 servings

Label snapshot

What the label says

What the product contains and what one serving costs, according to our catalog. Label amounts are not personal dose recommendations.

Ingredients listed
4 ingredients listed largest listed: NR 300 mg
Form
Capsule
List price (catalog, USD)
$105.00
Price per serving
$1.75List price divided by servings per container. A per-day cost only if the label serving is once daily.

Reading notes

  • Multi-ingredient product. Amounts are per ingredient per serving; the product is assessed as one bundle, not as a recommendation for each ingredient.
Full label record: servings, testing, ingredients
Servings per container
60
Serving size (label)
1 g
Catalog monthly estimate
$52.50
Testing disclosure
Brand lists third-party testing and a public certificate of analysis (CoA)Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Ingredients as listed

IngredientAmount per serving
NR300 mg
Resveratrol150 mg
Quercetin200 mg
Betaine (TMG)150 mg

What to check on the label

  • Whether every ingredient has its own milligram line, or several are grouped in a 'blend' with one total.
  • How many capsules or scoops make a serving, and how many servings the container holds.
  • Whether the ingredients you care about appear at amounts you would accept on their own. The list below shows each figure.

Amounts are per label serving as recorded in the catalog and are not a recommendation. Testing status reflects what the brand lists. Nothing here is medical advice.

Editorial score and research-dose calculations

These calculations describe our scoring method. They are not a recommended dose or proof of benefit from this product.

6.2/10
Overall score
#6 / 16 in Longevity stack

Public lab certificate, tested by independent lab.

Read the evidence (3 studies)
Add to compareVisit brand site →
Tier 3
Ingredient RCT (matching dose)
The ingredient was tested in an RCT at the same dose this product sells.
See the 3 supporting studies
How we scored this product Show the full breakdown
Dose vs. studies (50%) Why 6.3 of 10. Primary ingredient is NR (evidence grade B). It delivers 300 mg, inside the studied range of 100–1000 mg. Read the rule → 6.3
Transparency (20%) Why 9.0 of 10. Earned points for public certificate of analysis and independent third-party testing and all doses disclosed. Read the rule → 9.0
Value (10%) Why 7.6 of 10. One day at the trial dose costs about $1.75. That is more expensive than average (179 of 313 by cost per effective day). Read the rule → 7.6
Formulation (10%) Why 5.0 of 10. No published absorption advantage or disadvantage on file. The default of 5 is not a criticism. Read the rule → 5.0 Default. No absorption data on file.
Safety (5%) Why 8.5 of 10. Baseline 5.0. Third-party testing adds 2.0. Public lab certificate adds 1.5. NSF, USP or Informed Choice certification adds 1.5. Active safety signal subtracts 3.0. Read the rule → 8.5
Community sentiment (5%) Why 6.8 of 10. Sentiment across 7 external review source(s) is mixed to positive. Community is a signal about daily use, not proof of effect. Read the rule → 6.8
Composite How this 6.2 is built. 0.50 × 6.3 + 0.20 × 9.0 + 0.10 × 7.6 + 0.10 × 5.0 + 0.05 × 8.5 + 0.05 × 6.8 = 6.2 out of 10. Safety caps applied after. 6.2
6.2 composite
Dose vs. studies50%6.3
Transparency20%9.0
Value10%7.6
Formulation10%5.0
Safety5%8.5
Community5%6.8

Evidence gates dose: the evidence grade sets the ceiling, and the dose decides how much of that ceiling the product reaches. Value = inverse of price-per-trial-dose-day. Community = mean sentiment of external reviews. Safety caps applied after weighting.

This score is our editorial judgment, not a scientific standard. We combine published evidence, dose, price, transparency, and consumer signals into one composite: this is our method, not a peer-reviewed clinical rating. A higher score means a product does better on the factors we weight, not that it is medically proven to work.

Read the full method →

Editorial verdict

Quick verdict

6.2 / 10
Best for
Full trial dose, Public lab certificate
Avoid if
No major red flags
Full-dose status
Meets trial dose
Price/month
$52
COA status
Public
Biggest caveat
Resveratrol (150mg is 30% of the 500mg trial dose) is significantly under-dosed.
Nearest alternatives
Catalog snapshot. Check linked sources for current price, label and batch-specific testing.
Price verification
Current price: $105.00
Last price check: Sep 01, 2026
Add to compareVisit brand site →
Layer 2 · Context

Our summary

ResveraCel bundles four separately-studied longevity ingredients — nicotinamide riboside, trans-resveratrol, a quercetin phytosome, and betaine — into one capsule. Each ingredient has some human evidence behind it in isolation: NR reliably raises NAD+ markers, resveratrol has shown benefits in specific populations (people with diabetes, older adults with functional limitations) but not consistently in healthy adults, and quercetin's main relevant registered trial from Thorne itself was terminated after enrolling just 5 people, with no results ever published. No study has tested this four-ingredient combination as a finished product, so the 'better together' logic in Thorne's marketing rests on one animal study of resveratrol plus quercetin, not human data on this capsule. The product is manufactured by a company with genuine quality infrastructure, but that does not substitute for combination-specific proof of effect.
In plain language

Why this scored this way

This Thorne HealthTech ResveraCel scores 7.0, making it a mid-tier product with both strengths and weaknesses. It delivers 300mg of NR, inside the studied range of 100–1000mg with grade B evidence (promising human data, not yet comprehensive). Transparency is a clear strength (score: 9.0), with third-party testing and a public lab certificate. At $1.75/day it's among the more expensive options in Longevity stack.

What drives the score up

  • Dose-evidence score of 6.3 shows decent alignment with trial doses.
  • Quality transparency of 9.0: tested by independent lab with a public lab certificate.
  • NR is dosed at the full research level with grade B evidence (promising human data, not yet comprehensive).

What drags it down

  • Resveratrol (150mg is 30% of the 500mg trial dose) is significantly under-dosed.
  • Quercetin (200mg is 40% of the 500mg trial dose) is significantly under-dosed.
  • Betaine (TMG) (150mg is 5% of the 3000mg trial dose) is significantly under-dosed.
  • At $1.75/day it's on the expensive side.

Why you'd choose it

  • You want NR from a Thorne HealthTech product.
  • You prioritise tested by independent lab products with public lab certificates.

Why you might skip it

  • You need a full trial dose of resveratrol (this product under-doses it).
  • You want a cheaper option (this is $1.75/day).
Question 1

Does the molecule work?

The science behind each active ingredient, independent of which brand sells it.

NR

The NAD+ precursor with the strongest safety file and EU approval.

2 landmark RCTs · US: GRAS, NDI accepted · EU: Authorised Novel Food (Commission Reg 2020/16)
Resveratrol

The famous red-wine molecule; longevity claims have outrun the human evidence.

3 landmark RCTs · US: Dietary supplement · EU: Authorised Novel Food (2016/1866)
Quercetin

Best-studied 'senolytic' ingredient, though evidence is early.

4 landmark RCTs · US: Dietary supplement · EU: Food supplement (extract-dependent)
Betaine (TMG)

A methyl donor added to NAD+ formulas as a supporting cofactor, not a headline active.

No landmark RCTs listed · US: Dietary supplement, GRAS · EU: Food supplement, permitted

Full ingredient breakdown

Every active in this formula, its declared dose per serving, the dose used in the primary human trial, how much of that trial dose this product delivers, and the evidence grade for the ingredient itself.

IngredientDose / servingResearch dose% of researchEvidence grade
NR300 mg300 mg100%B
Resveratrol150 mg500 mg30%C
Quercetin200 mg500 mg40%B
Betaine (TMG)150 mg3000 mg5%C

Percentages are dose per serving ÷ primary trial dose. Below 50% means the formula is unlikely to reproduce the trial outcome for that active. Grade A = multiple large human RCTs. Grade F = no human evidence. How grades work. Full glossary →

Question 2

Is this bottle good?

The specific product: dose, price, transparency, and what buyers report.

Dose vs research
100% of trial dose
Meets or exceeds the published effective dose
Cost at trial dose
$1.75/day at trial dose
What one effective daily dose actually costs
Transparency
9.0/10 · Public lab certificate (quality: not assessed)
Independent batch testing confirmed
Consumer signals
No consumer signals collected yet
Operational signal only, never used as clinical evidence
Question 3

What's the catch?

Safety flags, transparency gaps, dosing concerns, and recurring buyer complaints.

!
Review advised
resveratrol: CYP3A4 interactions
Safety flag
resveratrol: CYP3A4 interactions
Dose or interaction risk detected. See ingredient page for details.
Plain English

What’s inside

The main ingredients of this product, in plain language.

NR300 mgEvidence B

The NAD+ precursor with the strongest safety file and EU approval.

Read about NR →
Resveratrol150 mgEvidence C

The famous red-wine molecule; longevity claims have outrun the human evidence.

Read about Resveratrol →
Quercetin200 mgEvidence B

Best-studied 'senolytic' ingredient, though evidence is early.

Read about Quercetin →
Betaine (TMG)150 mgEvidence C

A methyl donor added to NAD+ formulas as a supporting cofactor, not a headline active.

Read about Betaine (TMG) →
Layer 3 · Evidence vault

Product data & verification

Hard numbers and independently checked status. Expand each block for its source.

The numbers

Price
$105
per bottle · 60 servings
Dose vs. research
of trial dose 100%
of published effective dose
$ / day at studied dose
$1.75
what one effective daily dose costs
$ / g active
$2.19
per gram of active substance
Independently checked

Data verification

COA status
Public
Evidence grade
BCBC
Per-ingredient breakdown
BNR
CResveratrol
BQuercetin
CBetaine (TMG)

All product data is checked against original sources. Prices, doses, and testing status are updated when product pages change. Evidence grades are reviewed when new human RCTs are published. Read how we verify.

What's inside

Ingredient
Dose in this product
Trial dose
Evidence
NR
The NAD+ precursor with the strongest safety file and EU approval.
Martens et al. 2018Dellinger et al. 2017
300 mg 100% of trial dose
300 mg
Resveratrol
The famous red-wine molecule; longevity claims have outrun the human evidence.
Timmers et al. 2011 (Cell Metabolism)RESHAW 2020Lozupone 2026 (Expert Opin Investig Drugs)
150 mg 30% of trial dose
500 mg
200 mg 40% of trial dose
500 mg
Betaine (TMG)
A methyl donor added to NAD+ formulas as a supporting cofactor, not a headline active.
150 mg 5% of trial dose
3000 mg
3.4 /5
High confidence
941 reviews across 4 platforms (4 sources)
Source diversity: 92%
AmazonConsumerLabRetailerTrustpilot
PraiseCombination product; individual actives below single-ingredient research doses b
Last checked: 2026-08-20

Consumer signals

Consumer signals gathered from 4 platforms.

Low confidence, small sample

Consumer sentiment compiled from 1 public source (ConsumerLab). Small sample size, treat as directional only.

ConsumerLab

positive sentiment

Praise

Combination product; individual actives below single-ingredient research doses but purity verified.

Compiled from a ConsumerLab listing located during manual research; not independently re-verified against the live page at build time.

Trustpilot

77 reviews · 1.9/5

Amazon

844 reviews · 4.5/5

Target

20 reviews · 4.05/5

These are consumer sentiment signals. They do not measure whether the product actually works. See our evidence section for that.

What others say, with a source hierarchy

We treat external opinion very differently depending on where it comes from. Tier A is our strongest signal. Tier C is background sentiment only. Tier Rejected is what we excluded, listed openly so you can see what we discarded.

These reviews are aggregated from third-party sources, not written by NO1GEVITY. Each entry shows its source, retrieval date, and whether the source has an affiliate or paid relationship. We do not edit reviews to change their meaning. Disclosure policy.

Tier A

Independent deep reviews, lab tests, certificates of analysis

Our strongest external evidence. Long-form independent reviews, physical-product lab work, and third-party certifications.

Healthline — best vitamin brands
Has affiliate relationship Not a paid placement

Names Thorne as category-leading on purity and third-party testing despite the operational Trustpilot score.

How we use it: Facts on purity certification accepted. Editorial ranking treated with caution because Healthline runs affiliate links.
Tier B

Registered dietitians and physicians, without affiliate ties

Credentialed commentary from clinicians who disclose no paid relationship. Useful as supporting critique but not a substitute for a clinical outcome trial.

NP review — Thorne ResveraCel
unknown Not a paid placement

Nurse practitioner explains the NAD+ / quercetin / resveratrol rationale for ResveraCel. Notes mechanistic plausibility but no product-level outcome trial.

How we use it: Supporting Tier B commentary for Thorne ResveraCel.
Tier C

Aggregated sentiment (Trustpilot, Reddit)

Mood indicator only. We never use aggregate stars as evidence of efficacy.

Trustpilot — Thorne (aggregated sentiment)
No affiliate relationship Not a paid placement

Aggregate score 2.4 / 5. Complaints concentrate on delivery, billing, and customer service — not on product quality or purity.

Finding: 2.4 / 5. Complaints are operational, not product.
How we use it: Sentiment only. We explicitly separate operational scores from product-quality scores in our own model.

Community threads and aggregate ratings

Additional public mentions we located, kept separate from the deep independent reviews above.

ConsumerLab
positive

Combination product; individual actives below single-ingredient trial doses but purity verified.

Read source → Unverified · we received no payment for this listing
Layer 3 · Evidence vault

Evidence, claims & regulation

Published evidence, claim checks, regulatory status and what could not be verified.

Evidence, what actually backs this product

Longevity brands rarely test their exact finished product. We separate what's tested from what's inferred.

Strongest evidence tier
Tier 3Ingredient RCT (matching dose)
5 studies mapped
Tier 3Ingredient RCT (matching dose)
Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults
Martens CR, Denman BA, Mazzo MR, et al. · 2018 · Nature Communications · n=24 · 1,000 mg/day NR chloride · 6 weeks
peer-reviewed
Same trial cited for NiaCel: NR raised NAD+ metabolites and showed only a non-significant trend toward better blood pressure/arterial stiffness overall. Applies to the NR component of ResveraCel only, not the finished 4-ingredient blend, and used a different NR salt at a higher elemental dose than ResveraCel likely delivers.
Ingredient-level evidence for the NR component only.
Conflicts: None disclosed; independent academic funding.
Source →
Tier 3Ingredient RCT (matching dose)
Resveratrol: cardiovascular and metabolic effects (Examine.com evidence summary)
Examine.com (secondary synthesis of primary RCTs) · 2024 · Examine.com supplement guide · Various, up to 5,000 mg/day tested for safety · Varied
peer-reviewed
Resveratrol improves endothelial function and may lower blood pressure in some populations, and improves fasting glucose, HbA1c, and insulin sensitivity specifically in adults who already have type 2 diabetes — but does not appear to benefit metabolic markers in adults without diabetes. Longevity's contribution to human lifespan remains, in Examine's words, simply 'unknown.'
Ingredient-level, not product-specific; benefit is population-dependent (diabetic vs. healthy).
Conflicts: Not applicable — secondary synthesis source.
Source →
Tier 4Ingredient RCT (different dose)
The benefits of resveratrol on cognition and physical function in older adults (systematic review)
Summarized by Examine.com from underlying RCTs · 2024 · Multiple (systematic review, per Examine.com summary) · Varied across pooled trials, typically 75-500 mg/day trans-resveratrol · Varied, typically 12-52 weeks across pooled trials
peer-reviewed
Resveratrol showed improved exercise adaptation and muscle function in generally healthy older adults, improved physical performance/mobility in adults with functional limitations, and improved cognition in adults with overweight — but results varied by population and dose across the pooled trials, and none used ResveraCel or the same 150 mg dose consistently.
Dose in ResveraCel (150 mg trans-resveratrol) falls within the range reviewed but is on the lower end; mixed results by subgroup mean this is not a clean positive signal.
Conflicts: Not disclosed in the secondary summary; underlying trials not independently vetted here.
Source →
Tier 5Mechanistic / animal / marketing
Effects of Quercetin on Metabolic Health
Phipps S (PI), Lili L (PI), Thorne HealthTech, Inc. (sponsor); Indena S.p.A. (collaborator) · 2022 · n=5 · Quercetin Phytosome (dose per registered protocol) · Registered start March 24, 2022; estimated completion September 2, 2022 — terminated early
not peer-reviewed
This is the registered trial most directly relevant to the quercetin ingredient in ResveraCel, and it is the single weakest piece of evidence in this dossier by design: ClinicalTrials.gov (NCT05297032) lists the study status as 'Terminated' with a total of only 5 enrolled participants, far short of any number needed to draw a statistically meaningful conclusion. No results have been published from this trial as of NO1GEVITY's review. It should not be cited by anyone as support for quercetin's effects, and NO1GEVITY has not seen Thorne cite it in ResveraCel marketing — but it is included here because the task requires flagging exactly this kind of registered-but-failed trial.
Terminated early with n=5; no results posted. Tier 5 reflects that this cannot support any efficacy claim.
Conflicts: Sponsored directly by Thorne HealthTech, Inc., with Thorne's own VP of Medical Affairs and VP of Research as principal investigators — a direct financial conflict of interest even though the trial never reported results.
Source →
Tier 5Mechanistic / animal / marketing
No RCT on Thorne ResveraCel as a finished product was identified
None · None
NO1GEVITY searched PubMed and ClinicalTrials.gov for any trial testing the combined NR + resveratrol + quercetin + betaine formulation as sold and found none. Each active ingredient has its own separate literature (see above entries), but there is no evidence the four-ingredient combination behaves the same way, better, or worse than the ingredients dosed individually. The vendor's own marketing PDF cites an animal study (not a human trial) suggesting quercetin plus resveratrol together improved metabolic-syndrome markers via SIRT1 upregulation in white adipose tissue — mechanistic/animal evidence, not human confirmation of the finished capsule.
Combination-specific evidence is Tier 5 (animal/mechanistic at best); individual ingredients are Tier 3-4.
Source →
Evidence

Research behind this product

The studies that established the trial dose and evidence grade for each active ingredient in this product. Click through to read the original paper.

NRMartens et al. 2018
NRDellinger et al. 2017
ResveratrolTimmers et al. 2011 (Cell Metabolism)
ResveratrolRESHAW 2020
ResveratrolLozupone 2026 (Expert Opin Investig Drugs)
QuercetinHickson et al. 2019 (senolytics in humans)
QuercetinQuercetin + blood pressure 2016 meta-analysis
QuercetinQuercetin + blood pressure 2022 meta-analysis
QuercetinD+Q pilot trial 2025 (F1000Research)

Claim check, vendor claims vs. our reading of the evidence

Not medical advice. We list the strongest claims made by the brand and check each against traceable evidence.

Partial support
“Supports healthy aging, methylation, cellular energy production and metabolism”
Each ingredient has plausible, ingredient-level human evidence for some part of this broad claim (NR for cellular NAD+/energy pathways, betaine for methylation), but no trial has tested the combined product against these outcomes directly.
Vendor source
Unsupported At Human Level
“Quercetin increases resveratrol's bioavailability and both enhance sirtuin activity, improving metabolic syndrome parameters”
The specific 'improved metabolic syndrome parameters via SIRT1' claim is referenced to an animal model of metabolic syndrome, not a human trial. The quercetin/resveratrol bioavailability interaction is plausible pharmacologically but NO1GEVITY found no human RCT confirming a downstream health benefit from this specific interaction at these doses.
Vendor source
Partial support
“Backed by rigorous clinical research and testing (implied by Thorne's general clinical-trials messaging)”
Thorne's clinical-trials program and academic partnerships (Mayo Clinic, Cleveland Clinic, Duke, Columbia, and others) are real and independently verifiable, but the one Thorne-sponsored trial most relevant to an active ingredient in this exact product — the quercetin metabolic-health study — was terminated with only 5 participants and no published results, undercutting any implication that ResveraCel specifically has been through that pipeline successfully.
Vendor source

Regulatory status

Rules change often. We record when we last verified each row. See the full regulatory timeline →

US
Legal as supplement
Marketed as a dietary supplement under DSHEA; all four actives (NR, resveratrol, quercetin, betaine) are commonly sold as supplement ingredients in the US.
Last verified 2026-08-05
EU
Uncertain Novel Food Scope
Same NR salt-form caveat as NiaCel 400 applies to the NR component. Resveratrol and quercetin are not EU Novel Foods and are broadly permitted as supplement ingredients, but the combination product's EU market status specifically was not independently verified.
Last verified 2026-08-05
UK
Uncertain Novel Food Scope
Resveratrol and quercetin are commonly sold in the UK supplement market; the NR component carries the same salt-form caveat noted for NiaCel 400.
Last verified 2026-08-05
CA
Uncertain
Health Canada's NHP framework has approved monograph-level natural health product licenses for standalone resveratrol (up to 1 g/day) and NR-containing products from other brands, but NO1GEVITY did not find a confirmed active NPN specifically for Thorne ResveraCel.
Last verified 2026-08-05

What we could not verify

We list this openly. If a claim isn't backed by a source we can trace, we'd rather flag it than repeat it.

  • The exact elemental-NR content of the 415 mg NRHM dose in this formulation.
  • Whether ResveraCel carries the NSF Certified for Sport mark on its current label — unlike NiaCel 400, this was not confirmed on Thorne's own product page.
  • The full protocol and any unpublished results from the terminated NCT05297032 quercetin trial.
  • Whether the 250 mg Quercetin Phytosome dose is bioequivalent to unencapsulated quercetin doses used in the cited resveratrol/quercetin combination research.
Important to know
NRAlmost all commercial NR uses licensed Niagen® from ChromaDex. If a product doesn't say Niagen, ask why.
Resveratrol"Resveratrol" products that don't specify trans-isomer content are unmeasurable in practice. Cis-resveratrol is biologically inactive.
QuercetinPlain quercetin dihydrate has poor absorption. Phytosome forms deliver 10 to 20× more into blood.
Betaine (TMG)Doses under roughly 500 mg/day (as seen in most NAD+ combination products) are well below the gram-level doses used in the supporting human trials.

Editorial notes

NR + resveratrol + methyl-donor in one bottle. Doses below single-ingredient research levels.

Go deeper

Where this sits

Actives inside
NRResveratrolQuercetinBetaine (TMG)
Category
See all in Longevity stack →
Ranking
See top 10 NR supplements →
Brand
Thorne HealthTech profile →
Add to compare Visit brand site →
Brand owners

Spot an error?

If you are the manufacturer or brand owner of ResveraCel and believe any data on this page is incorrect (wrong dose, wrong ingredient, wrong price, missing certification, outdated status), you can request a correction.

We review every request, verify it against primary sources, and publish any accepted change with a dated note. Corrections from brand owners are treated the same as corrections from anyone else: verified before they move.

Request a correction →
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