Pure NR is a NAD+ booster supplement by DoNotAge. NO1GEVITY gives it a overall score of 8.1 out of 10. It ranks in the top tier of NAD+ booster products on NO1GEVITY.

How much does Pure NR cost?

$55.00 for 30 servings. Cost per day at the studied dose is $1.10.

Is Pure NR tested by independent lab?

Yes, tested by independent lab. Certificate of Analysis is publicly available.

What is the NO1GEVITY score for Pure NR?

Pure NR scores 8.1/10 on the NO1GEVITY composite scale, based on evidence-graded dose (100% of trial dose), transparency, value, consumer signals, and formulation.

Does Pure NR match the dose used in clinical studies?

Pure NR delivers 100% of the dose used in clinical research, which is at or above the studied dose.

What is the evidence for NR?

NR is graded B on the NO1GEVITY evidence scale, meaning moderate human evidence from multiple RCTs.

Layer 1 · Decision

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DoNotAge

Pure NR

Name: Pure NR
Brand: DoNotAge
SKU: donotage-pure-nr
Price: 55.0 USD
Availability: InStock

NAD+ booster · Powder · 30 servings

Label snapshot

What the label says

What the product contains and what one serving costs, according to our catalog. Label amounts are not personal dose recommendations.

Precursor per serving: NR 500 mg
Form: Powder
List price (catalog, USD): $55.00
Price per serving: $1.83List price divided by servings per container. A per-day cost only if the label serving is once daily.

Full label record: servings, testing, ingredients

Servings per container: 30
Serving size (label): 0.5 g
Catalog monthly estimate: $55.00
Testing disclosure: Brand lists third-party testing and a public certificate of analysis (CoA)Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Ingredients as listed

Ingredient	Amount per serving
NR	500 mg

What to check on the label

Which precursor is named. NMN and NR are different molecules and are not interchangeable milligram for milligram.
Whether the milligram figure is per capsule or per serving of several capsules. The catalog records per serving.
Whether a certificate of analysis (CoA) is published for the batch you buy. The catalog only records whether the brand lists one.
Added ingredients (resveratrol, TMG, quercetin) are listed with their own amounts below. Read them separately.

Amounts are per label serving as recorded in the catalog and are not a recommendation. Testing status reflects what the brand lists. Nothing here is medical advice.

Editorial score and research-dose calculations

These calculations describe our scoring method. They are not a recommended dose or proof of benefit from this product.

8.1/10

Overall score

#2 / 52 in NAD+ booster

Full trial dose, public lab certificate, tested by independent lab.

Read the evidence (2 studies)

Add to compare Visit brand site →

Tier 3

Ingredient RCT (matching dose)

The ingredient was tested in an RCT at the same dose this product sells.

See the 2 supporting studies

Martens et al. 2018 (NR)6 weeks of 500 mg twice daily lowered systolic blood pressure in older adults with elevated BP. Studied at 500 mg. This product: 500 mg.
Dellinger et al. 2017 (NR)8 weeks at 100 to 1000 mg/day dose-dependently raised NAD+ in blood. Studied at 1000 mg. This product: 500 mg.

How we scored this product Show the full breakdown

Dose vs. studies (50%) 8.0

Transparency (20%) 9.5

Value (10%) 8.6

Formulation (10%) 5.0 Default. No absorption data on file.

Safety (5%) 8.5

Community sentiment (5%) 8.7

Composite 8.1

8.1 composite

Dose vs. studies50%8.0

Transparency20%9.5

Value10%8.6

Formulation10%5.0

Safety5%8.5

Community5%8.7

Evidence gates dose: the evidence grade sets the ceiling, and the dose decides how much of that ceiling the product reaches. Value = inverse of price-per-trial-dose-day. Community = mean sentiment of external reviews. Safety caps applied after weighting.

This score is our editorial judgment, not a scientific standard. We combine published evidence, dose, price, transparency, and consumer signals into one composite: this is our method, not a peer-reviewed clinical rating. A higher score means a product does better on the factors we weight, not that it is medically proven to work.

Read the full method →

Best for

Full trial dose, Public lab certificate

Avoid if

No major red flags

Full-dose status

Meets trial dose

Price/month

$55

COA status

Public

Biggest caveat

NR (500mg is 167% of the 300mg trial dose) is well above the trial dose. More is not always better.

Nearest alternatives

Nicotinamide Riboside Capsules Nootropics Depot · Score 8.0
NAD+ Cell Regenerator (NIAGEN Nicotinamide Riboside, 300mg standalone) Life Extension · Score 7.8
NiaCel 400 Thorne HealthTech · Score 7.7

Catalog snapshot. Check linked sources for current price, label and batch-specific testing.

Price verification

Current price: $55.00

Last price check: Sep 01, 2026

Add to compare Visit brand site →

Layer 2 · Context

Our summary

Pure NR is a straightforward nicotinamide riboside chloride powder/capsule product offering 350 mg per unit, positioned as a cheaper alternative to patented Niagen-brand NR products like Tru Niagen. The ingredient itself has solid repeat-dose human evidence for raising NAD+ (Trammell 2016, Martens 2018) at doses matching DoNotAge's higher subscription tier, and one disease-specific trial (Brakedal 2022, Parkinson's) showing a modest clinical benefit — but healthy-population functional outcomes (energy, cognition) remain thin. NR also currently sits on firmer regulatory ground than NMN in both the US and EU. Buyers should note that the clinical evidence base is built on a different branded raw material than DoNotAge's own supply.

In plain language

Why this scored this way

This DoNotAge Pure NR scores 8.1, making it a strong scorer. It delivers 500mg of NR, inside the studied range of 100–1000mg with grade B evidence (promising human data, not yet comprehensive). Transparency is a clear strength (score: 9.5), with third-party testing and a public lab certificate.

What drives the score up

Dose-evidence score of 8.0 reflects good alignment with trial doses.
Quality transparency of 9.5: tested by independent lab with a public lab certificate.
Community score of 8.7 with positive consumer feedback.
NR is dosed at the full research level with grade B evidence (promising human data, not yet comprehensive).

What drags it down

NR (500mg is 167% of the 300mg trial dose) is well above the trial dose. More is not always better.

Why you'd choose it

You want a reasonably priced nad+ booster product.
You want NR from a DoNotAge product.
You prioritise tested by independent lab products with public lab certificates.

Why you might skip it

You want a standard dose of nr (this product is well above it).
You want better value (this is $1.10/day with a value score of 8.6).

Question 1

Does the molecule work?

The science behind each active ingredient, independent of which brand sells it.

The NAD+ precursor with the strongest safety file and EU approval.

2 landmark RCTs · US: GRAS, NDI accepted · EU: Authorised Novel Food (Commission Reg 2020/16)

Question 2

Is this bottle good?

The specific product: dose, price, transparency, and what buyers report.

Dose vs research

100% of trial dose

Meets or exceeds the published effective dose

Cost at trial dose

$1.10/day at trial dose

What one effective daily dose actually costs

Transparency

9.5/10 · Public lab certificate (quality: not assessed)

Independent batch testing confirmed

Consumer signals

No consumer signals collected yet

Operational signal only, never used as clinical evidence

Question 3

What's the catch?

Safety flags, transparency gaps, dosing concerns, and recurring buyer complaints.

No major red flags

Public lab certificate, tested by independent lab, dose within range

No safety, transparency, or dose concerns detected at this time.

Plain English

What’s inside

The main ingredients of this product, in plain language.

NR500 mgEvidence B

The NAD+ precursor with the strongest safety file and EU approval.

Read about NR →

Layer 3 · Evidence vault

Product data & verification

Hard numbers and independently checked status. Expand each block for its source.

The numbers

Price

$55

per bottle · 30 servings

Dose vs. research

of trial dose 100%

of published effective dose

$ / day at studied dose

$1.10

what one effective daily dose costs

$ / g active

$3.67

per gram of active substance

Independently checked

Data verification

COA status

Public

Evidence grade

Per-ingredient breakdown

BNR

All product data is checked against original sources. Prices, doses, and testing status are updated when product pages change. Evidence grades are reviewed when new human RCTs are published. Read how we verify.

What's inside

Ingredient

Dose in this product

Trial dose

Evidence

The NAD+ precursor with the strongest safety file and EU approval.

Martens et al. 2018 Dellinger et al. 2017

500 mg 167% of trial dose

300 mg

4.3 /5

Medium confidence Strong value signal

3,152 reviews across 2 platforms (7 sources)

Source diversity: 70%

RedditTrustpilot

PraisePopular as a cheaper alternative to Tru Niagen, though it isn't licensed Niagen®

Last checked: 2026-08-20

Consumer signals

Consumer signals gathered from 7 platforms.

Low confidence, small sample

Consumer sentiment compiled from 1 public source (Reddit). Small sample size, treat as directional only.

1 thread discussed · positive sentiment

Praise

Popular as a cheaper alternative to Tru Niagen, though it isn't licensed Niagen®.

Compiled from a Reddit r/longevity listing located during manual research; not independently re-verified against the live page at build time.

Trustpilot

556 reviews · 4.1/5

Same brand profile on Trustpilot country sites: UK 4.4 · Germany 4.4 · Switzerland 4.4 · Italy 4.3 · Spain 4.5.

These are consumer sentiment signals. They do not measure whether the product actually works. See our evidence section for that.

Independent external anchors

Public sources on this same product, unrelated to NO1GEVITY. NIH DSLD is the US government's registered label database (shown verbatim). SuppCo.com is a separate, unaffiliated commercial site with no partnership or data-sharing arrangement with us. NO1GEVITY scores are computed independently of both.

Unaffiliated third-party site

SuppCo.com

SuppCo is a separate, unaffiliated supplement-tracking site with no partnership, data-sharing agreement, or business relationship with NO1GEVITY. We are not endorsed by them and they do not endorse us. The two facts below are individually verified against the manufacturer or NSF; the outbound link is provided only so readers can independently cross-check on a third-party site if they want to.

Tested by independent lab, YesNSF certified, Yes

NIH DSLD registered label

DSLD ID 315492, UPC n/a

Serving size2 Capsule(s)

Servings per container30

Supplement Facts panel, verbatim

Nicotinamide Riboside700 mg

What others say, with a source hierarchy

We treat external opinion very differently depending on where it comes from. Tier A is our strongest signal. Tier C is background sentiment only. Tier Rejected is what we excluded, listed openly so you can see what we discarded.

These reviews are aggregated from third-party sources, not written by NO1GEVITY. Each entry shows its source, retrieval date, and whether the source has an affiliate or paid relationship. We do not edit reviews to change their meaning. Disclosure policy.

Tier B

Registered dietitians and physicians, without affiliate ties

Credentialed commentary from clinicians who disclose no paid relationship. Useful as supporting critique but not a substitute for a clinical outcome trial.

Physician YouTube analysis — DoNotAge Longevity Sachet

Has affiliate relationship Not a paid placement

Detailed ingredient walk-through. Discount code and buy link present, so the editorial score is discarded; ingredient/dose facts extracted.

How we use it: Ingredient/dose facts only. Editorial rating rejected.

Tier C

Aggregated sentiment (Trustpilot, Reddit)

Mood indicator only. We never use aggregate stars as evidence of efficacy.

Trustpilot — DoNotAge (aggregated sentiment)

No affiliate relationship Not a paid placement

Aggregate score ≈ 4.3-4.5 / 5. Mood indicator only.

Finding: 4.3-4.5 / 5.

How we use it: Sentiment only. Never used as evidence of efficacy.

Community threads and aggregate ratings

Additional public mentions we located, kept separate from the deep independent reviews above.

Reddit r/longevity

positive

Popular as a cheaper alternative to Tru Niagen, though it isn't licensed Niagen®.

Read source → Unverified · we received no payment for this listing

Layer 3 · Evidence vault

Evidence, claims & regulation

Published evidence, claim checks, regulatory status and what could not be verified.

Evidence, what actually backs this product

Longevity brands rarely test their exact finished product. We separate what's tested from what's inferred.

Strongest evidence tier

Tier 3Ingredient RCT (matching dose)

3 studies mapped

Tier 3Ingredient RCT (matching dose)

Nicotinamide riboside is uniquely and orally bioavailable in mice and humans

Trammell SA, Schmidt MS, Weidemann BJ, et al. · 2016 · Nature Communications · n=12 · 100, 300, and 1000 mg single doses · Single-dose pharmacokinetic study

ingredient-levelpeer-reviewed

This first human pharmacokinetic study of NR established that oral NR is well absorbed and raises whole-blood NAD+ metabolites in a dose-dependent way, providing the foundational human safety and absorption data for NR supplementation generally.

Single-dose pharmacokinetics only — it measured absorption and blood metabolite changes after one dose, not repeated daily use or clinical outcomes. The 1000 mg dose tested is close to DoNotAge's higher subscription tier but well above its base 350-700 mg/day option.

Conflicts: Some co-authors were affiliated with ChromaDex (patent holder of Niagen-brand NR); this is a widely cited disclosure in NR literature.

Source →

Tier 4Ingredient RCT (different dose)

Nicotinamide riboside supplementation for chronic dosing in healthy middle-aged and older adults

Martens CR, Denman BA, Mazzo MR, et al. · 2018 · Nature Communications · n=24 · 1000 mg/day · 6 weeks

ingredient-levelpeer-reviewed

Six weeks of 1000 mg/day NR raised whole-blood NAD+ substantially and was well tolerated, but produced no significant improvements in blood pressure, arterial stiffness, or other cardiovascular/metabolic markers measured in the study.

This is a genuinely useful negative-outcome trial: it confirms NR reliably raises NAD+ at 1000 mg/day, but shows that boosting NAD+ alone did not translate into measurable cardiovascular benefit in this healthy older cohort over six weeks — a useful caution against assuming NAD+ elevation automatically improves health markers.

Conflicts: Academic (University of Colorado Boulder); funded by NIH grants.

Source →

Tier 4Ingredient RCT (different dose)

Nicotinamide riboside efficacy in Parkinson's disease

Brakedal B, Dölle C, Riemer F, et al. · 2022 · Cell Metabolism · n=30 · 1000 mg/day · 30 days

ingredient-levelpeer-reviewed

In this Parkinson's disease trial, NR raised brain and blood NAD+ levels and produced modest improvements on a clinical motor-symptom scale, offering one of the few examples where an NR-related clinical endpoint (rather than just a biomarker) moved in a positive direction.

Encouraging but disease-specific: it applies to Parkinson's patients, not the healthy-aging population DoNotAge markets to, and cannot be generalized to claims about general cognitive benefit in healthy consumers.

Conflicts: Academic (University of Bergen); no disclosed link to DoNotAge.

Source →

Evidence

Research behind this product

The studies that established the trial dose and evidence grade for each active ingredient in this product. Click through to read the original paper.

NR Martens et al. 2018

NR Dellinger et al. 2017

Claim check, vendor claims vs. our reading of the evidence

Not medical advice. We list the strongest claims made by the brand and check each against traceable evidence.

No evidence

“Pure NR is 'backed by research showing support for brain function and focus'”

No specific citation is given for cognitive/focus benefits in healthy users; the closest relevant human data (Brakedal 2022) is in Parkinson's patients, not a healthy-population cognitive-focus outcome.

Vendor source

Supported

“Pure NR restores NAD+ levels and supports mitochondrial health”

Multiple independent human trials (Trammell 2016, Martens 2018, Brakedal 2022) consistently show oral NR raises blood and tissue NAD+ in a dose-dependent way, including at doses close to DoNotAge's higher subscription tier.

Vendor source

Not supported

“Our Pure NR is used by leading researchers in clinical trials, not just sold as a supplement”

We could not identify a specific registered clinical trial using DoNotAge-branded NR as the study material; the major NR trials cited in the scientific literature (Trammell, Martens, Brakedal) used Niagen-brand NR from ChromaDex, not DoNotAge's product.

Vendor source

Regulatory status

Rules change often. We record when we last verified each row. See the full regulatory timeline →

Legal as supplement

Nicotinamide riboside chloride has an accepted New Dietary Ingredient history in the US (originally via ChromaDex's Niagen) and has not faced the same FDA drug-preclusion dispute that affected NMN.

Last verified 2026-08-05

Legal as supplement

NR (as nicotinamide riboside chloride) is an approved EU Novel Food ingredient, making it currently the more legally secure NAD+ precursor for EU sale compared with NMN.

Last verified 2026-08-05

Legal

Sold as a standard food supplement in the UK, consistent with its EU Novel Food approval carried over post-Brexit.

Last verified 2026-08-05

Restricted

NR-containing products require a Health Canada Natural Health Product licence and NPN; DoNotAge's product does not appear to hold Canadian NPN registration.

Last verified 2026-08-05

What we could not verify

We list this openly. If a claim isn't backed by a source we can trace, we'd rather flag it than repeat it.

Whether DoNotAge's Pure NR has ever been the specific material used in an independent academic clinical trial (as opposed to Niagen/ChromaDex-brand NR) could not be confirmed.
The exact identity of the third-party lab used for batch purity testing was not disclosed.

Important to know

NRAlmost all commercial NR uses licensed Niagen® from ChromaDex. If a product doesn't say Niagen, ask why.

Editorial notes

Non-Niagen® NR at a fraction of Tru Niagen's price.

Go deeper

Where this sits

Actives inside

Spot an error?

If you are the manufacturer or brand owner of Pure NR and believe any data on this page is incorrect (wrong dose, wrong ingredient, wrong price, missing certification, outdated status), you can request a correction.

We review every request, verify it against primary sources, and publish any accepted change with a dated note. Corrections from brand owners are treated the same as corrections from anyone else: verified before they move.

Request a correction →

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Pure NR

What the label says

Ingredients as listed

What to check on the label

Quick verdict

Our summary

Why this scored this way

What drives the score up

What drags it down

Why you'd choose it

Why you might skip it

Does the molecule work?

Is this bottle good?

What's the catch?

What’s inside

Product data & verification

The numbers

Data verification

What's inside

Consumer signals

Independent external anchors

What others say, with a source hierarchy

Registered dietitians and physicians, without affiliate ties

Aggregated sentiment (Trustpilot, Reddit)

Community threads and aggregate ratings

Evidence, claims & regulation

Evidence, what actually backs this product

Research behind this product

Claim check, vendor claims vs. our reading of the evidence

Regulatory status

What we could not verify

Editorial notes

Where this sits

Spot an error?

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