The NAD+ precursor with the strongest safety file and EU approval.
The safer, more boring cousin to NMN. If you want a NAD+ booster and care about approvals, NR is the pragmatic choice.
NR (Nicotinamide Riboside) is a NAD+ precursor with evidence grade B, meaning it is supported by human RCTs. We track 27 products containing NR. Typical doses range from 300 to 1000 mg per serving. The top-ranked product scores 8.1 out of 10 on our composite scale (dose, evidence, price, testing, transparency). Prices range up to $104.40 per month.
| Product | Brand | Dose | Price/mo | 3rd-party tested | Score |
|---|---|---|---|---|---|
| Pure NR | DoNotAge | 500 mg | $55.00 | Yes | 8.1 |
| Nicotinamide Riboside Capsules | Nootropics Depot | 300 mg | $34.99 | Yes | 8.0 |
| NAD+ Cell Regenerator (NIAGEN Nicotinamide Riboside, 300mg standalone) | Life Extension | 300 mg | $24.00 | Yes | 7.8 |
| Tru Niagen PRO 1000mg | Tru Niagen (ChromaDex) | 1000 mg | $104.40 | Yes | 7.7 |
| NiaCel 400 | Thorne HealthTech | 400 mg | $65.00 | Yes | 7.7 |
Scores are editorial judgments, not a scientific standard. See how we score.
Another route to raise NAD+, the same energy/repair molecule NMN targets. NR is one step further away from NAD+ than NMN, but it's the only one of the two that's been formally approved in the EU as safe.
NR raises NAD+ reliably in humans. Multiple 8 to 12 week studies show modest improvements in some biomarkers. Whether it makes you live longer is unproven, but for staying at status quo it has more safety data than almost any longevity ingredient.
The safer, more boring cousin to NMN. If you want a NAD+ booster and care about approvals, NR is the pragmatic choice.
Nicotinamide Riboside Chloride (branded as Niagen). Salvage pathway intermediate, converts to NMN via NRK1/2 then to NAD+.
Multiple RCTs (Martens 2018, Dellinger 2017, Elhassan 2019) demonstrate 40 to 90% increase in blood NAD+ at 300 to 1000 mg/day. Effects on blood pressure, arterial stiffness, and inflammation modest but reproducible.
Rapid absorption; NAD+ elevation persists 8+ hours.
Almost all commercial NR uses licensed Niagen® from ChromaDex. If a product doesn't say Niagen, ask why.
When a product exceeds the UL or contains an ingredient with clinically significant interactions, a "Review advised" flag appears on its product page and links here.
The trial dose above is our editorial pick from the published human trials for this ingredient. We choose the dose that the best-available studies used on the endpoint most relevant to longevity. The range shows the lowest and highest doses tested in published trials. The landmark studies below are the papers we read to set it. You can click through and check our work.
When new trials publish, our automated sweeps flag them. If a new study materially changes the dose, we update it through editorial review and record the old dose, new dose, and the triggering study in every affected product's recommendation history. The dose is never changed automatically.
Regulatory events, evidence grade changes, and key research milestones for NR, most recent first. Studies link to the paper; regulatory entries name and link the responsible authority.
Consumer reports submitted to an official government adverse-event database. These reports mention this ingredient but do not prove it caused the reaction. Report volume reflects market penetration as much as inherent risk.
Retrieved from the FDA Adverse Event Reporting System (CAERS) via the openFDA API. Verified 2026-08-06. Reports are voluntary consumer submissions and mandatory serious-event filings. They establish surveillance, not causality.
Verified 2026-08-06. We update this section as new peer-reviewed trials land.
NR consistently and reliably raises blood NAD+ levels, typically 2 to 3-fold, across nearly every human trial regardless of population or dose. Chao-Yi Wu and Edmarie Guzman-Velez's 2025 trial in long-COVID patients confirmed this pharmacodynamic effect using 2000 mg/day (https://pubmed.ncbi.nlm.nih.gov/41357333/). Yasir Elhassan and colleagues showed in 2019 that NR also reaches skeletal muscle in aged men, elevating the NAD+ metabolome and lowering circulating inflammatory cytokines after 21 days at 1000 mg/day (https://pubmed.ncbi.nlm.nih.gov/31412242/). This biomarker effect is the most reproducible finding in the NR literature.
Marketers sell NR as an anti-aging, cognition-boosting, blood-pressure-lowering supplement. Human trials tell a different story on downstream effects. Miranda Orr's 2023 randomized trial in older adults with mild cognitive impairment found NR raised NAD+ 2.6-fold but produced no improvement on the Montreal Cognitive Assessment or other cognitive tests over 10 weeks (https://pubmed.ncbi.nlm.nih.gov/37994989/). The 2025 long-COVID trial found no significant benefit on cognition, fatigue, sleep, or mood despite the same NAD+ boost (https://pubmed.ncbi.nlm.nih.gov/41357333/). A 2025 pilot trial combining NR with exercise in hypertensive older adults found NR plus exercise was not superior to exercise alone for lowering systolic blood pressure (https://pubmed.ncbi.nlm.nih.gov/40770531/). Raising a biomarker is not the same as changing an outcome that matters.
300-1000 mg once daily, with some trials using up to 2000 mg/day
NR is well tolerated at doses up to 2000 mg/day for up to 24 weeks across multiple RCTs. The NR-SAFE trial in Parkinson's disease patients found high-dose NR safe but flagged it can accumulate certain metabolites that warrant monitoring in some populations. The 2025 long-COVID trial reported one serious adverse event, deemed unrelated to NR, and otherwise only mild effects like bruising or rash (https://pubmed.ncbi.nlm.nih.gov/41357333/). Long-term safety data beyond 6 months in healthy adults is limited.
6 weeks of 500 mg twice daily lowered systolic blood pressure in older adults with elevated BP.
Read study →8 weeks at 100 to 1000 mg/day dose-dependently raised NAD+ in blood.
Read study →All products in our catalog that contain NR, ranked by our overall score. Ranking is editorial, never paid.
DoNotAgeStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Nootropics DepotStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Undisclosed amounts noted
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Tru Niagen (ChromaDex)Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Thorne HealthTechStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Tru Niagen (ChromaDex)Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Tru Niagen (ChromaDex)Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Renue By ScienceStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
ProHealth LongevityStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Tru Niagen (ChromaDex)Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Renue By ScienceMulti-ingredient bundle
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
AgeMateMulti-ingredient bundle
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Thorne HealthTechMulti-ingredient bundle
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Thorne HealthTechStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
ProHealth LongevityMulti-ingredient bundle
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Innerbody LabsMulti-ingredient bundle
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Tru Niagen (ChromaDex)Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Elysium HealthMulti-ingredient bundle
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Thorne HealthTechMulti-ingredient bundle
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Tru Niagen (ChromaDex)Elemental vs compound: check label
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Elysium HealthMulti-ingredient bundle
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
MomentousMulti-ingredient bundle
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Life ExtensionMulti-ingredient bundle
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
MitoQMulti-ingredient bundle
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Vital ProteinsElemental vs compound: check label
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Tru Niagen (ChromaDex)Multi-ingredient bundle
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Molecules in the same class, plus the actives most often formulated alongside NR in our catalogue.
See NR in context: the mechanism it acts through, the biomarker it moves, the products that dose it, and the trials that tested it.
View NR on the Longevity Map →Another route to raise NAD+, the same energy/repair molecule NMN targets. NR is one step further away from NAD+ than NMN, but it's the only one of the two that's been formally approved in the EU as safe.
The trial dose in published human studies is 300 mg per day, with a range of 100 to 1000 mg per day. Always consult a qualified clinician before starting any supplement.
No formal UL established. EFSA concluded NR is safe for healthy adults up to 300 mg/day (230 mg/day for pregnant/lactating women); trials have used doses up to 2 g/day without serious adverse events.
We track 27 products containing NR. The top-ranked product scores 8.1 out of 10 on our composite scale, which evaluates dose, evidence, price, third-party testing, and transparency. See the comparison table above. Scores are editorial judgments, not a scientific standard.
NR has evidence grade B, meaning it is supported by human RCTs. Grade A means replicated human RCTs with hard endpoints. Grade B means human RCTs with biomarker outcomes. Grade C means mixed or small human trials. See our evidence grading methodology.
Evidence grades are reviewed when new human RCTs are published. Product counts update automatically as new products are added. Dose ranges reflect published trial data, not brand recommendations. Read how we verify.
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