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Skin / Joint

Hyaluronic Acid · Sodium Hyaluronate (low MW)

Skin hydration and joint comfort at 120 mg/day.

B
Evidence grade
Human RCTs, biomarker outcomes
Strongest study
Tier 1 · 1 linked study

Short answer

Nice-to-have; skip standalone if already using collagen.

Product and dose overview

Hyaluronic Acid (Sodium Hyaluronate (low MW)) is a skin / joint with evidence grade B, meaning it is supported by human RCTs. We track 11 products containing Hyaluronic Acid. Typical doses range from 40 to 200 mg per serving. The top-ranked product scores 7.3 out of 10 on our composite scale (dose, evidence, price, testing, transparency). Prices range up to $69.00 per month.

Evidence grade: B Products in database: 11 Category: Skin / Joint

Top Hyaluronic Acid products

ProductBrandDosePrice/mo3rd-party testedScore
Pure Hyaluronic AcidDoNotAge200 mg$45.00Yes7.3
Vital Proteins Collagen Peptides Advanced (with Hyaluronic Acid & Vitamin C)Vital Proteins120 mg$46.99Yes7.0
Daily Longevity BlendAgeMate100 mg$69.00Yes7.0
Vital Proteins Beauty Collagen (with Hyaluronic Acid & Biotin)Vital Proteins60 mg$37.00Yes7.0
Longevity Mix - Blood OrangeBlueprint100 mg$49.00Yes6.7

Scores are editorial judgments, not a scientific standard. See how we score.

What it is

A large sugar molecule your body makes to keep tissue hydrated. Levels drop with age. Supplementing raises skin hydration.

Why people take it

Small trials show improved skin hydration and joint comfort. Effect modest but real. Low-molecular-weight forms absorb better.

Our verdict

Nice-to-have; skip standalone if already using collagen.

Structure & class

GAG polymer; MW 5 to 200 kDa in supplements.

Mechanism & clinical data

Kawada 2015 confirmed skin benefits.

Pharmacokinetics

~1 day (skin turnover).

Dose & forms

Trial dose
120 mg
/ day
Range in trials
80 to 240 mg
/ day
Common forms
Capsule (ExceptionHA®), Combined with collagen

What to watch out for

MW matters for absorption; look for <10 kDa marketing.

Where this dose comes from

The trial dose above is our editorial pick from the published human trials for this ingredient. We choose the dose that the best-available studies used on the endpoint most relevant to longevity. The range shows the lowest and highest doses tested in published trials. The landmark studies below are the papers we read to set it. You can click through and check our work.

When new trials publish, our automated sweeps flag them. If a new study materially changes the dose, we update it through editorial review and record the old dose, new dose, and the triggering study in every affected product's recommendation history. The dose is never changed automatically.

Regulatory status

EUFood supplement
USDietary supplement
UKFood supplement
CANHP

Timeline

Regulatory events, evidence grade changes, and key research milestones for Hyaluronic Acid, most recent first. Studies link to the paper; regulatory entries name and link the responsible authority.

  • 2025-04 Regulatory single source
    EU Court sharpens the bar for botanical health claims
    A Court of Justice of the European Union ruling in April 2025 further tightened the requirements for how botanical ingredients (herbs, plant extracts) can be marketed with health claims in the EU, effectively removing much of the flexibility of the on-hold list.
  • 2024-06 Regulatory confirmed
    EU report identifies 117 supplement substances as potential health risks
    The HoA Working Group on Food Supplements (26 European countries) published its first report evaluating 117 substances used in food supplements. Of these, 65 were assessed as likely novel foods, 6 were already regulated, 34 had insufficient data, and 12 were prioritized for Article 8 restriction under Regulation (EC) No 1925/2006. The 12 priority substances include ashwagandha, curcumin, melatonin, piperine, St. John's wort, coumarin, p-synephrine, maca, holy basil, Melaleuca, black cohosh, and L-tryptophan. The report drew on 1,500 RASFF alerts reviewed between 2017 and mid-2022.
    Source →
  • 2015 Research milestone
    Kawada 2015
    120 mg/day HA improved skin hydration.
    Source →
  • 2006-12 Regulatory confirmed
    EU Health Claims Regulation adopted
    Regulation (EC) No 1924/2006 laid down harmonised rules for nutrition and health claims made on foods, including supplements. Only claims listed in the EU Register of authorised claims can be used. Rejected botanical claims are held in a separate on-hold list.
    Source →
  • 1997 Regulatory confirmed
    EU introduces the Novel Food Regulation
    Regulation (EC) No 258/97 required any food or food ingredient without a history of consumption in the EU before 15 May 1997 to be authorised before being placed on the market. This is the framework that captures NMN, spermidine as a supplement ingredient, urolithin A, and many other longevity actives.
    Source →

Landmark studies

Found in these products (11)

All products in our catalog that contain Hyaluronic Acid, ranked by our overall score. Ranking is editorial, never paid.

Connective tissue
Active per serving
Hyaluronic Acid 200 mgCapsule · 366 servings
Price per serving
$0.12$45.00 · 366 servings
Testing
3rd-party listed · no public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 7.3/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$0.07
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with donotage.org
Connective tissue
Active per serving
Collagen Peptides 20 g+ Hyaluronic Acid 120 mg
Price per serving
$1.68$46.99 · 28 servings
Testing
3rd-party listed · no public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 7.0/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

800%
of trial dose
$0.84
per research-dose day, not label serving
800% · over 2× trial dose0Trial dose2×
Catalog price · Confirm current price with www.vitalproteins.com
Longevity stack
Ingredients listed
8 ingredients listedlargest listed: Glycine 700 mg
Price per serving
$2.30$69.00 · 30 servings
Testing
3rd-party listed · no public lab certificate

Multi-ingredient bundle

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 7.0/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$1.38
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with agemate.com
Connective tissue
Ingredients listed
3 ingredients listedlargest listed: Collagen Peptides 15 g
Price per serving
$2.47$37.00 · 15 servings
Testing
3rd-party listed · no public lab certificate

Multi-ingredient bundle

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 7.0/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$1.64
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with www.vitalproteins.com
Longevity stack
Ingredients listed
6 ingredients listedlargest listed: Creatine 2,500 mg
Price per serving
$1.63$49.00 · 30 servings
Testing
3rd-party listed · no public lab certificate

Multi-ingredient bundle

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 6.7/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

83%
of trial dose
$3.27
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with blueprint.bryanjohnson.com
Connective tissue
Ingredients listed
6 ingredients listedlargest listed: Collagen Peptides 10 g
Price per serving
$1.97$59.00 · 30 servings
Testing
3rd-party listed · no public lab certificate

Elemental vs compound: check label

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 6.6/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$1.97
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with www.vitalproteins.com
Elysium Health
Cofactor
Connective tissue
Ingredients listed
4 ingredients listedlargest listed: Collagen Peptides 20 g
Price per serving
$2.68$75.00 · 28 servings
Testing
None listed

Multi-ingredient bundle

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 6.5/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

800%
of trial dose
$1.34
per research-dose day, not label serving
800% · over 2× trial dose0Trial dose2×
Catalog price · Confirm current price with www.elysiumhealth.com
NOVOS Labs
NOVOS Core
Longevity stack
Ingredients listed
12 ingredients listedlargest listed: Glycine 1,000 mg
Price per serving
$2.97$89.00 · 30 servings
Testing
3rd-party listed · no public lab certificate

Multi-ingredient bundle

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 6.3/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

50%
of trial dose
$14.83
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with novoslabs.com
Tru Niagen (ChromaDex)
Tru Niagen Beauty
Connective tissue
Ingredients listed
4 ingredients listedlargest listed: Hyaluronic Acid 120 mg
Price per serving
$2.07$62.00 · 30 servings
Testing
None listed

Multi-ingredient bundle

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 5.9/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$6.20
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with www.truniagen.com
Connective tissue
Active per serving
Collagen Peptides 7 g+ Hyaluronic Acid 60 mg
Price per serving
$3.00$36.00 · 12 servings
Testing
None listed

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 5.8/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$4.29
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with www.vitalproteins.com
Elysium Health
Mosaic
Connective tissue
Ingredients listed
3 ingredients listedlargest listed: Hyaluronic Acid 120 mg
Price per serving
$3.00$90.00 · 30 servings
Testing
None listed

Elemental vs compound: check label

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 5.6/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

10%
of trial dose
$38.14
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with www.elysiumhealth.com
Editorial guides

Buying guides and comparisons

Neighbouring molecules

Related ingredients

See all in Skin / Joint →

Molecules in the same class, plus the actives most often formulated alongside Hyaluronic Acid in our catalogue.

GlucosamineCsame categoryMSMCsame categoryChondroitinCsame categoryCollagen PeptidesBstacked together in 5 productsVitamin CAstacked together in 4 productsNRBstacked together in 3 productsGlycineBstacked together in 3 productsL-TheanineBstacked together in 3 products
Product shelves
See all in Connective tissue (8)See all in Longevity stack (3)

See Hyaluronic Acid in context: the mechanism it acts through, the biomarker it moves, the products that dose it, and the trials that tested it.

View Hyaluronic Acid on the Longevity Map →

Frequently asked questions

What is Hyaluronic Acid?

A large sugar molecule your body makes to keep tissue hydrated. Levels drop with age. Supplementing raises skin hydration.

What dose of Hyaluronic Acid should I take?

The trial dose in published human studies is 120 mg per day, with a range of 80 to 240 mg per day. Always consult a qualified clinician before starting any supplement.

Is Hyaluronic Acid safe?

MW matters for absorption; look for <10 kDa marketing.

What is the best Hyaluronic Acid supplement?

We track 11 products containing Hyaluronic Acid. The top-ranked product scores 7.3 out of 10 on our composite scale, which evaluates dose, evidence, price, third-party testing, and transparency. See the comparison table above. Scores are editorial judgments, not a scientific standard.

What is the evidence grade for Hyaluronic Acid?

Hyaluronic Acid has evidence grade B, meaning it is supported by human RCTs. Grade A means replicated human RCTs with hard endpoints. Grade B means human RCTs with biomarker outcomes. Grade C means mixed or small human trials. See our evidence grading methodology.

Independently checked

Data verification

Evidence grade
B
Human RCTs, biomarker outcomes
Research dose
120 mg
Products tracked
11
Updated continuously
Safety signal
MW matters for absorption; look for <10 kDa marketing.

Evidence grades are reviewed when new human RCTs are published. Product counts update automatically as new products are added. Dose ranges reflect published trial data, not brand recommendations. Read how we verify.