NiaCel 400 is a NAD+ booster supplement by Thorne HealthTech. NO1GEVITY gives it a overall score of 7.7 out of 10. It ranks in the top tier of NAD+ booster products on NO1GEVITY.

How much does NiaCel 400 cost?

$65.00 for 60 servings. Cost per day at the studied dose is $0.81.

Is NiaCel 400 tested by independent lab?

Yes, tested by independent lab. Certificate of Analysis is publicly available.

What is the NO1GEVITY score for NiaCel 400?

NiaCel 400 scores 7.7/10 on the NO1GEVITY composite scale, based on evidence-graded dose (100% of trial dose), transparency, value, consumer signals, and formulation.

Does NiaCel 400 match the dose used in clinical studies?

NiaCel 400 delivers 100% of the dose used in clinical research, which is at or above the studied dose.

What is the evidence for NR?

NR is graded B on the NO1GEVITY evidence scale, meaning moderate human evidence from multiple RCTs.

Layer 1 · Decision

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Thorne HealthTech

NiaCel 400

Name: NiaCel 400
Brand: Thorne HealthTech
SKU: thorne-niacel-400
Price: 65.0 USD
Availability: InStock

NAD+ booster · Capsule (Niagen®) · 60 servings

Label snapshot

What the label says

What the product contains and what one serving costs, according to our catalog. Label amounts are not personal dose recommendations.

Precursor per serving: NR 400 mg + Betaine (TMG) 25 mg
Form: Capsule
List price (catalog, USD): $65.00
Price per serving: $1.08List price divided by servings per container. A per-day cost only if the label serving is once daily.

Full label record: servings, testing, ingredients

Servings per container: 60
Serving size (label): 0.4 g
Catalog monthly estimate: $32.50
Testing disclosure: Brand lists third-party testing and a public certificate of analysis (CoA)Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Ingredients as listed

Ingredient	Amount per serving
NR	400 mg
Betaine (TMG)	25 mg

What to check on the label

Which precursor is named. NMN and NR are different molecules and are not interchangeable milligram for milligram.
Whether the milligram figure is per capsule or per serving of several capsules. The catalog records per serving.
Whether a certificate of analysis (CoA) is published for the batch you buy. The catalog only records whether the brand lists one.
Added ingredients (resveratrol, TMG, quercetin) are listed with their own amounts below. Read them separately.

Amounts are per label serving as recorded in the catalog and are not a recommendation. Testing status reflects what the brand lists. Nothing here is medical advice.

Editorial score and research-dose calculations

These calculations describe our scoring method. They are not a recommended dose or proof of benefit from this product.

7.7/10

Overall score

#14 / 52 in NAD+ booster

Public lab certificate, tested by independent lab, top 17% value.

Read the evidence (2 studies)

Add to compare Visit brand site →

Tier 3

Ingredient RCT (matching dose)

The ingredient was tested in an RCT at the same dose this product sells.

See the 2 supporting studies

Martens et al. 2018 (NR)6 weeks of 500 mg twice daily lowered systolic blood pressure in older adults with elevated BP. Studied at 500 mg. This product: 400 mg.
Dellinger et al. 2017 (NR)8 weeks at 100 to 1000 mg/day dose-dependently raised NAD+ in blood. Studied at 1000 mg. This product: 400 mg.

How we scored this product Show the full breakdown

Dose vs. studies (50%) 7.1

Transparency (20%) 9.5

Value (10%) 9.0

Formulation (10%) 5.0 Default. No absorption data on file.

Safety (5%) 10.0

Community sentiment (5%) 6.5

Composite 7.7

7.7 composite

Dose vs. studies50%7.1

Transparency20%9.5

Value10%9.0

Formulation10%5.0

Safety5%10.0

Community5%6.5

Evidence gates dose: the evidence grade sets the ceiling, and the dose decides how much of that ceiling the product reaches. Value = inverse of price-per-trial-dose-day. Community = mean sentiment of external reviews. Safety caps applied after weighting.

This score is our editorial judgment, not a scientific standard. We combine published evidence, dose, price, transparency, and consumer signals into one composite: this is our method, not a peer-reviewed clinical rating. A higher score means a product does better on the factors we weight, not that it is medically proven to work.

Read the full method →

Best for

Full trial dose, Public lab certificate

Avoid if

No major red flags

Full-dose status

Meets trial dose

Price/month

$32

COA status

Public

Biggest caveat

Betaine (TMG) (25mg is 1% of the 3000mg trial dose) is significantly under-dosed.

Nearest alternatives

Pure NR DoNotAge · Score 8.1
Nicotinamide Riboside Capsules Nootropics Depot · Score 8.0
NAD+ Cell Regenerator (NIAGEN Nicotinamide Riboside, 300mg standalone) Life Extension · Score 7.8

Catalog snapshot. Check linked sources for current price, label and batch-specific testing.

Price verification

Current price: $65.00

Last price check: Sep 01, 2026

Add to compare Visit brand site →

Layer 2 · Context

Our summary

NiaCel 400 is Thorne's entry in the nicotinamide-riboside category, delivering 415 mg of an NR salt (nicotinamide riboside hydrogen malate) plus a small dose of betaine. The human research behind the ingredient class is real but modest: multi-week trials consistently show NR raises NAD+-related blood and, in one small study, muscle markers, with safety holding up even at doses above what's in this capsule. What those trials have not shown is a reliable, replicated functional benefit — grip strength, blood pressure, and exercise metabolism have all come back null or borderline in individual studies. No trial has been run on NiaCel 400 itself, and the salt form Thorne uses (NRHM) has essentially no standalone published human data of its own, unlike the NR chloride salt used in most of the cited studies. Buyers are, in effect, paying for a well-manufactured product built on borrowed ingredient-level science rather than product-specific proof.

In plain language

Why this scored this way

This Thorne HealthTech NiaCel 400 scores 7.7, making it a strong scorer. It delivers 400mg of NR, inside the studied range of 100–1000mg with grade B evidence (promising human data, not yet comprehensive). Transparency is a clear strength (score: 9.5), with third-party testing and a public lab certificate.

What drives the score up

Dose-evidence score of 7.1 shows decent alignment with trial doses.
Quality transparency of 9.5: tested by independent lab with a public lab certificate.
NR is dosed at the full research level with grade B evidence (promising human data, not yet comprehensive).

What drags it down

Betaine (TMG) (25mg is 1% of the 3000mg trial dose) is significantly under-dosed.

Why you'd choose it

You want a reasonably priced nad+ booster product.
You want NR from a Thorne HealthTech product.
You prioritise tested by independent lab products with public lab certificates.

Why you might skip it

You need a full trial dose of betaine (this product under-doses it).

Question 1

Does the molecule work?

The science behind each active ingredient, independent of which brand sells it.

The NAD+ precursor with the strongest safety file and EU approval.

2 landmark RCTs · US: GRAS, NDI accepted · EU: Authorised Novel Food (Commission Reg 2020/16)

Betaine (TMG)

A methyl donor added to NAD+ formulas as a supporting cofactor, not a headline active.

No landmark RCTs listed · US: Dietary supplement, GRAS · EU: Food supplement, permitted

Full ingredient breakdown

Every active in this formula, its declared dose per serving, the dose used in the primary human trial, how much of that trial dose this product delivers, and the evidence grade for the ingredient itself.

Ingredient	Dose / serving	Research dose	% of research	Evidence grade
NR	400 mg	300 mg	133%	B
Betaine (TMG)	25 mg	3000 mg	1%	C

Percentages are dose per serving ÷ primary trial dose. Below 50% means the formula is unlikely to reproduce the trial outcome for that active. Grade A = multiple large human RCTs. Grade F = no human evidence. How grades work. Full glossary →

Question 2

Is this bottle good?

The specific product: dose, price, transparency, and what buyers report.

Dose vs research

100% of trial dose

Meets or exceeds the published effective dose

Cost at trial dose

$0.81/day at trial dose

What one effective daily dose actually costs

Transparency

9.5/10 · Public lab certificate (quality: not assessed)

Independent batch testing confirmed

Consumer signals

No consumer signals collected yet

Operational signal only, never used as clinical evidence

Question 3

What's the catch?

Safety flags, transparency gaps, dosing concerns, and recurring buyer complaints.

No major red flags

Public lab certificate, tested by independent lab, dose within range

No safety, transparency, or dose concerns detected at this time.

Plain English

What’s inside

The main ingredients of this product, in plain language.

NR400 mgEvidence B

The NAD+ precursor with the strongest safety file and EU approval.

Read about NR →

Betaine (TMG)25 mgEvidence C

A methyl donor added to NAD+ formulas as a supporting cofactor, not a headline active.

Read about Betaine (TMG) →

Layer 3 · Evidence vault

Product data & verification

Hard numbers and independently checked status. Expand each block for its source.

The numbers

Price

$65

per bottle · 60 servings

Dose vs. research

of trial dose 100%

of published effective dose

$ / day at studied dose

$0.81

what one effective daily dose costs

$ / g active

$2.55

per gram of active substance

Independently checked

Data verification

COA status

Public

Evidence grade

Per-ingredient breakdown

BNR

CBetaine (TMG)

All product data is checked against original sources. Prices, doses, and testing status are updated when product pages change. Evidence grades are reviewed when new human RCTs are published. Read how we verify.

What's inside

Ingredient

Dose in this product

Trial dose

Evidence

The NAD+ precursor with the strongest safety file and EU approval.

Martens et al. 2018 Dellinger et al. 2017

400 mg 133% of trial dose

300 mg

Betaine (TMG)

A methyl donor added to NAD+ formulas as a supporting cofactor, not a headline active.

25 mg 1% of trial dose

3000 mg

3.2 /5

High confidence

441 reviews across 4 platforms (5 sources)

Source diversity: 100%

AmazonConsumerLabExamine.comTrustpilot

PraisePassed ConsumerLab identity/purity testing in NAD+ precursor category.Examine lists NR as one of the best-validated NAD+ boosters, with an established

Last checked: 2026-08-20

Consumer signals

Consumer signals gathered from 5 platforms.

Medium confidence

Consumer sentiment compiled from 3 public sources (ConsumerLab, Examine.com, Trustpilot).

ConsumerLab

positive sentiment

Praise

Passed ConsumerLab identity/purity testing in NAD+ precursor category.

Compiled from a ConsumerLab listing located during manual research; not independently re-verified against the live page at build time.

Examine.com

positive sentiment

Praise

Examine lists NR as one of the best-validated NAD+ boosters, with an established safety record.

Compiled from an Examine.com listing located during manual research; not independently re-verified against the live page at build time.

Trustpilot

77 reviews · 4.5/5 · positive sentiment

Praise

Thorne brand-level 4.5/5. Cited for practitioner-grade quality.

Compiled from a Trustpilot listing located during manual research; not independently re-verified against the live page at build time.

Amazon

329 reviews

Same brand profile on Trustpilot country sites: US 1.8.

These are consumer sentiment signals. They do not measure whether the product actually works. See our evidence section for that.

Independent external anchors

Public sources on this same product, unrelated to NO1GEVITY. NIH DSLD is the US government's registered label database (shown verbatim). SuppCo.com is a separate, unaffiliated commercial site with no partnership or data-sharing arrangement with us. NO1GEVITY scores are computed independently of both.

Unaffiliated third-party site

SuppCo.com

SuppCo is a separate, unaffiliated supplement-tracking site with no partnership, data-sharing agreement, or business relationship with NO1GEVITY. We are not endorsed by them and they do not endorse us. The two facts below are individually verified against the manufacturer or NSF; the outbound link is provided only so readers can independently cross-check on a third-party site if they want to.

Tested by independent lab, YesNSF certified, Yes

NIH DSLD registered label

DSLD ID 270802, UPC 6 93749 01208 5

Serving size1 Capsule(s)

Servings per container60

Supplement Facts panel, verbatim

Nicotinamide Riboside Hydrogen Malate415 mg

Betaine Anhydrous85 mg

What others say, with a source hierarchy

We treat external opinion very differently depending on where it comes from. Tier A is our strongest signal. Tier C is background sentiment only. Tier Rejected is what we excluded, listed openly so you can see what we discarded.

These reviews are aggregated from third-party sources, not written by NO1GEVITY. Each entry shows its source, retrieval date, and whether the source has an affiliate or paid relationship. We do not edit reviews to change their meaning. Disclosure policy.

Tier A

Independent deep reviews, lab tests, certificates of analysis

Our strongest external evidence. Long-form independent reviews, physical-product lab work, and third-party certifications.

Healthline — best vitamin brands

Has affiliate relationship Not a paid placement

Names Thorne as category-leading on purity and third-party testing despite the operational Trustpilot score.

How we use it: Facts on purity certification accepted. Editorial ranking treated with caution because Healthline runs affiliate links.

Tier C

Aggregated sentiment (Trustpilot, Reddit)

Mood indicator only. We never use aggregate stars as evidence of efficacy.

Trustpilot — Thorne (aggregated sentiment)

No affiliate relationship Not a paid placement

Aggregate score 2.4 / 5. Complaints concentrate on delivery, billing, and customer service — not on product quality or purity.

Finding: 2.4 / 5. Complaints are operational, not product.

How we use it: Sentiment only. We explicitly separate operational scores from product-quality scores in our own model.

Community threads and aggregate ratings

Additional public mentions we located, kept separate from the deep independent reviews above.

ConsumerLab

positive

Passed ConsumerLab identity/purity testing in NAD+ precursor category.

Read source → Unverified · we received no payment for this listing

Examine.com

positive

Examine lists NR as one of the best-validated NAD+ boosters, with an established safety record.

Read source → Unverified · we received no payment for this listing

Trustpilot · 4.5

positive

Thorne brand-level 4.5/5. Cited for practitioner-grade quality.

Read source → Unverified · we received no payment for this listing

Layer 3 · Evidence vault

Evidence, claims & regulation

Published evidence, claim checks, regulatory status and what could not be verified.

Evidence, what actually backs this product

Longevity brands rarely test their exact finished product. We separate what's tested from what's inferred.

Strongest evidence tier

Tier 3Ingredient RCT (matching dose)

5 studies mapped

Tier 3Ingredient RCT (matching dose)

Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults

Martens CR, Denman BA, Mazzo MR, et al. · 2018 · Nature Communications · n=24 · 500 mg NR chloride twice daily (1,000 mg/day total) · 6 weeks (2x6-week randomized, double-blind, placebo-controlled crossover)

peer-reviewed

This is the trial most often cited for NiaCel-type products. Six weeks of NR raised blood NAD+ metabolites by roughly 60% and was well tolerated, with a non-significant trend toward lower systolic blood pressure and reduced arterial stiffness that only reached significance in a post-hoc subgroup with higher starting blood pressure. It is evidence that NR reliably raises a biomarker, not proof that it slows aging or reliably improves cardiovascular measures in unselected adults.

Dose (1,000 mg/day of NR chloride) is roughly 4x the elemental NR NiaCel 400 likely delivers, and uses a different salt form than Thorne's NRHM. Not run on Thorne's product.

Conflicts: None disclosed by Thorne; independently funded university research (Colorado).

Source →

Tier 3Ingredient RCT (matching dose)

An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers

Airhart SE, Shireman LM, Risler LJ, et al. · 2017 · PLoS ONE · n=8 · Escalating single doses from 250 mg up to 1,000 mg NR · 8 days of escalating doses (single-dose pharmacokinetics)

peer-reviewed

First human pharmacokinetic study of NR. Confirmed that oral NR is absorbed and safely raises whole-blood NAD+ in a dose-dependent way, with no serious adverse events across the 250-1,000 mg range. This is a safety and absorption study, not an efficacy trial — it does not test any health outcome.

Open-label with no placebo arm and only 8 participants — useful for safety, weak for efficacy claims. Not run on Thorne's product or NRHM salt specifically.

Conflicts: Academic study (University of Washington); not Thorne-funded.

Source →

Tier 3Ingredient RCT (matching dose)

Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures

Elhassan YS, Kluckova K, Fletcher RS, et al. · 2019 · Cell Reports · n=12 · 1,000 mg/day NR · 21 days

peer-reviewed

Twenty-one days of NR raised NAD+ metabolites directly inside aged muscle tissue (not just blood) and shifted expression of some metabolic and anti-inflammatory genes. It found no improvement in hand-grip strength, muscle blood flow, glucose uptake, or measured mitochondrial function — the molecular signal did not translate into a measured functional or performance benefit in this small trial.

Dose close to what NiaCel 400 likely delivers in elemental terms is uncertain given the NRHM salt question; sample size is very small (n=12, one group).

Conflicts: Academic study (University of Birmingham); not Thorne-funded.

Source →

Tier 5Mechanistic / animal / marketing

No RCT on Thorne NiaCel 400 (or any NiaCel formulation) was identified

None · None

NO1GEVITY searched PubMed and ClinicalTrials.gov for any interventional trial naming NiaCel or run by Thorne on this specific NR + betaine capsule and found none. The clinical evidence Thorne's marketing leans on is entirely at the ingredient level (nicotinamide riboside broadly, mostly using ChromaDex's own chloride salt and clinical program), not on this finished formulation. Given that Thorne and ChromaDex were in active patent litigation over Thorne's use of NR in NiaCel and ResveraCel (2021-2024), it is unsurprising that ChromaDex's clinical program was never extended to validate Thorne's competing product.

This entry exists to make the absence explicit rather than let it go unstated. See also the ChromaDex/Dartmouth v. Thorne patent litigation entry under unverified/claim_check context.

Source →

Tier 5Mechanistic / animal / marketing

ChromaDex 2025 independent testing round of NR supplement brands

ChromaDex Corp. (testing organization) · 2025

not peer-reviewed

Reported secondhand via a supplement-review YouTube channel citing ChromaDex's 2025 test of 39 NR brands: most failed to meet label claims, but Thorne NiaCel 400 and Thorne ResveraCel were both reported as passing, with NiaCel 400 reportedly measuring about 475 mg of the labeled nicotinamide riboside compound per capsule. This is a label-accuracy check, not evidence the ingredient does anything — and NO1GEVITY has not located ChromaDex's original underlying report to confirm the exact methodology or figures, so this claim is treated as provisional.

Secondary source; original ChromaDex report not independently located.

Conflicts: ChromaDex is a commercial competitor to Thorne in the NR ingredient market, which is a notable conflict of interest for a brand-comparison test it conducted and publicized.

Source →

Evidence

Research behind this product

The studies that established the trial dose and evidence grade for each active ingredient in this product. Click through to read the original paper.

NR Martens et al. 2018

NR Dellinger et al. 2017

Claim check, vendor claims vs. our reading of the evidence

Not medical advice. We list the strongest claims made by the brand and check each against traceable evidence.

Partial support

“NiaCel 400 helps defend the body against the effects of early aging by boosting NAD+”

NR reliably raises NAD+-related blood metabolites in multiple human trials (e.g., Martens 2018), which supports the mechanistic first half of the claim. There is no human trial demonstrating that this translates into a measurable anti-aging effect, and none of those trials were run on this product.

Vendor source

Not supported

“Supports athletic performance and exercise efficiency”

The closest relevant human data (Elhassan 2019) found no improvement in hand-grip strength or muscle blood flow after NR supplementation, and other published NR-and-exercise studies have generally found no change in exercise metabolism. NO1GEVITY found no trial showing an athletic-performance benefit for NR at any dose in healthy adults.

Vendor source

Supported

“NSF Certified for Sport”

This certification is independently verifiable and real; it confirms label accuracy and absence of banned substances, which NO1GEVITY treats as a manufacturing-quality signal, not an efficacy signal.

Vendor source

Regulatory status

Rules change often. We record when we last verified each row. See the full regulatory timeline →

Legal as supplement

Marketed as a dietary supplement under DSHEA; NR chloride has an FDA-acknowledged GRAS notification, but Thorne's exact NRHM salt's individual regulatory filings were not independently verified.

Last verified 2026-08-05

Uncertain Novel Food Scope

Nicotinamide riboside chloride was authorized as an EU Novel Food in Jan 2020, but that authorization carried a 5-year data-protection period naming ChromaDex Inc. as the sole authorized applicant. Thorne's NiaCel 400 uses NR hydrogen malate, a different salt form, and NO1GEVITY could not confirm a separate EU novel food authorization covering this specific salt. Treat EU legality of this exact product as unverified rather than assumed.

Last verified 2026-08-05

Uncertain Novel Food Scope

UK Food Standards Agency lists NR chloride (≥90% purity) as an authorised novel food at up to 300 mg/day; same salt-form caveat as the EU entry applies.

Last verified 2026-08-05

Uncertain

Health Canada requires a Natural Product Number (NPN) for market sale; NO1GEVITY did not find a confirmed active NPN listing specifically for Thorne NiaCel 400.

Last verified 2026-08-05

What we could not verify

We list this openly. If a claim isn't backed by a source we can trace, we'd rather flag it than repeat it.

The precise elemental NR content of the 415 mg NRHM dose on the current label — Thorne does not publish an elemental-NR conversion figure for this product.
Whether NiaCel 400 (this specific NRHM formulation) has a confirmed EU Novel Food authorization independent of ChromaDex's NR-chloride filing.
The exact methodology and full results of the 2025 ChromaDex brand-testing round referenced only via a secondary video source.
Whether Thorne has a public, batch-specific, downloadable Certificate of Analysis for this exact SKU (the company describes internal testing but NO1GEVITY could not locate a public per-batch CoA on thorne.com for NiaCel 400).
Reddit r/Supplements community forum

positive sentiment

Community discussion exists and is predominantly positive, highlighting perceived benefits and lower cost compared with Tru Niagen. No single Reddit thread is treated as a representative product review.

no direct URLchecked 2026-08-07
Thorne on-site reviews own platform

The product page is a first-party page with customer-review presentation, but no product rating or count was extracted.

verified 2026-08-07Open source →
Amazon customers aggregator

An Amazon listing for this exact product was located. The product URL is not retained because marketplace listings can change.

no direct URLchecked 2026-08-07

Important to know

NRAlmost all commercial NR uses licensed Niagen® from ChromaDex. If a product doesn't say Niagen, ask why.

Betaine (TMG)Doses under roughly 500 mg/day (as seen in most NAD+ combination products) are well below the gram-level doses used in the supporting human trials.

Editorial notes

Best-price licensed Niagen® NR product on the market. NSF Certified for Sport.

Go deeper

Where this sits

Actives inside

NR Betaine (TMG)

Spot an error?

If you are the manufacturer or brand owner of NiaCel 400 and believe any data on this page is incorrect (wrong dose, wrong ingredient, wrong price, missing certification, outdated status), you can request a correction.

We review every request, verify it against primary sources, and publish any accepted change with a dated note. Corrections from brand owners are treated the same as corrections from anyone else: verified before they move.

Request a correction →

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NiaCel 400

What the label says

Ingredients as listed

What to check on the label

Quick verdict

Our summary

Why this scored this way

What drives the score up

What drags it down

Why you'd choose it

Why you might skip it

Does the molecule work?

Full ingredient breakdown

Is this bottle good?

What's the catch?

What’s inside

Product data & verification

The numbers

Data verification

What's inside

Consumer signals

Independent external anchors

What others say, with a source hierarchy

Independent deep reviews, lab tests, certificates of analysis

Aggregated sentiment (Trustpilot, Reddit)

Community threads and aggregate ratings

Evidence, claims & regulation

Evidence, what actually backs this product

Research behind this product

Claim check, vendor claims vs. our reading of the evidence

Regulatory status

What we could not verify

Editorial notes

Where this sits

Spot an error?

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