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Pure Fisetin - 250 mg, 60 capsules

Autophagy · Capsule · 60 servings

Label snapshot

What the label says

What the product contains and what one serving costs, according to our catalog. Label amounts are not personal dose recommendations.

Active per serving
Fisetin 250 mg
Form
Capsule
List price (catalog, USD)
$39.17
Price per serving
$0.65List price divided by servings per container. A per-day cost only if the label serving is once daily.
Full label record: servings, testing, ingredients
Servings per container
60
Catalog monthly estimate
$19.59
Testing disclosure
Brand lists third-party testing and a public certificate of analysis (CoA)Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Ingredients as listed

IngredientAmount per serving
Fisetin250 mg

What to check on the label

  • Read the spermidine line, not the extract line. '800 mg wheat-germ extract' may contain only a few milligrams of spermidine.
  • Check the serving size. Capsule counts per serving vary from one to three.
  • If wheat-germ based, the label states gluten content. The catalog does not store allergen data.

Amounts are per label serving as recorded in the catalog and are not a recommendation. Testing status reflects what the brand lists. Nothing here is medical advice.

Editorial score and research-dose calculations

These calculations describe our scoring method. They are not a recommended dose or proof of benefit from this product.

5.8/10
Overall score
#11 / 25 in Autophagy

Public lab certificate, tested by independent lab.

Read the evidence (3 studies)
Tier 4
Ingredient RCT (different dose)
The ingredient was tested in an RCT but at a different dose, or only in animals.
See the 3 supporting studies
  • Fisetin pilot 2024 (biological aging) (Fisetin)In a 10-person pilot study, intermittent fisetin dosing (500 mg/day, one week per month for six months) produced mixed effects on biological age with no significant change in telomere length. Studied at 500 mg. This product: 250 mg.
  • AFFIRM-LITE (NCT03675724) (Fisetin)This randomized, placebo-controlled pilot trial tests whether two consecutive days of fisetin (20 mg/kg/day) reduces blood inflammation markers in older adults, as a senolytic intervention for frailty. Studied at 20 mg. This product: 250 mg.
  • Yousefzadeh et al. 2018 (preclinical, EBioMedicine) (Fisetin)This preclinical study (mouse models plus human ex vivo adipose tissue) showed fisetin selectively clears senescent cells and extends median and maximum lifespan in mice, providing the basis for human senolytic trials of fisetin.
How we scored this product Show the full breakdown
Composite How this 5.8 is built. 0.50 × 5.4 + 0.20 × 9.0 + 0.10 × 8.3 + 0.10 × 5.0 + 0.05 × 8.5 + 0.05 × 7.5 = 5.8 out of 10. Safety caps applied after. 5.8
5.8 composite
Dose vs. studies50%5.4
Transparency20%9.0
Value10%8.3
Formulation10%5.0
Safety5%8.5
Community5%7.5

Evidence gates dose: the evidence grade sets the ceiling, and the dose decides how much of that ceiling the product reaches. Value = inverse of price-per-trial-dose-day. Community = mean sentiment of external reviews. Safety caps applied after weighting.

This score is our editorial judgment, not a scientific standard. We combine published evidence, dose, price, transparency, and consumer signals into one composite: this is our method, not a peer-reviewed clinical rating. A higher score means a product does better on the factors we weight, not that it is medically proven to work.

Read the full method →

Editorial verdict

Quick verdict

5.8 / 10
Best for
Full trial dose, Public lab certificate, Budget-friendly
Avoid if
No major red flags
Full-dose status
Meets trial dose
Price/month
$20
COA status
Public
Biggest caveat
Dose-evidence score of 5.4 is below average for the site.
Nearest alternatives
Catalog snapshot. Check linked sources for current price, label and batch-specific testing.
Price verification
Current price: $39.17
Last price check: Sep 01, 2026
Layer 2 · Context
In plain language

Why this scored this way

This ProHealth Longevity Pure Fisetin - 250 mg, 60 capsules scores 6.6, making it a mid-tier product with both strengths and weaknesses. It delivers 250mg of Fisetin, inside the studied range of 100–1400mg with grade C evidence (mostly preclinical, limited human data). Transparency is a clear strength (score: 9.0), with third-party testing and a public lab certificate.

What drives the score up

  • Quality transparency of 9.0: tested by independent lab with a public lab certificate.

What drags it down

  • Dose-evidence score of 5.4 is below average for the site.

Why you'd choose it

  • You want a reasonably priced autophagy product.
  • You prioritise tested by independent lab products with public lab certificates.

Why you might skip it

  • You want better value (this is $1.31/day with a value score of 8.3).
Question 1

Does the molecule work?

The science behind each active ingredient, independent of which brand sells it.

Fisetin

Highly-hyped senolytic; the strong evidence is in mice, not people.

3 landmark RCTs · US: Dietary supplement · EU: Food supplement
Question 2

Is this bottle good?

The specific product: dose, price, transparency, and what buyers report.

Dose vs research
100% of trial dose
Meets or exceeds the published effective dose
Cost at trial dose
$1.31/day at trial dose
What one effective daily dose actually costs
Transparency
9.0/10 · Public lab certificate (quality: not assessed)
Independent batch testing confirmed
Consumer signals
No consumer signals collected yet
Operational signal only, never used as clinical evidence
Question 3

What's the catch?

Safety flags, transparency gaps, dosing concerns, and recurring buyer complaints.

Safety signals
Drug interaction risk — fisetin
May potentiate warfarin via competition for glucuronidation; theoretical mild antiplatelet activity warrants caution with anticoagulants and chemotherapy agents.
Read more
Safety flag
fisetin: warfarin/anticoagulant interaction
Dose or interaction risk detected. See ingredient page for details.
Buyer complaints
iHerb: Cost performance described as good but 'not great'; iHerb: Some concern about reduced dosage in smaller bottle size
Recurring themes from consumer review platforms.
Plain English

What’s inside

The main ingredients of this product, in plain language.

Fisetin250 mgEvidence C

Highly-hyped senolytic; the strong evidence is in mice, not people.

Read about Fisetin →
Layer 3 · Evidence vault

Product data & verification

Hard numbers and independently checked status. Expand each block for its source.

The numbers

Price
$39
per bottle · 60 servings
Dose vs. research
of trial dose 100%
of published effective dose
$ / day at studied dose
$1.31
what one effective daily dose costs
$ / g active
$2.61
per gram of active substance
Independently checked

Data verification

COA status
Public
Evidence grade
C
Per-ingredient breakdown
CFisetin

All product data is checked against original sources. Prices, doses, and testing status are updated when product pages change. Evidence grades are reviewed when new human RCTs are published. Read how we verify.

What's inside

Ingredient
Dose in this product
Trial dose
Evidence
250 mg 50% of trial dose
500 mg
3.8 /5
High confidence
80 reviews across 3 platforms (3 sources)
Source diversity: 69%
AmazonTrustpilotiHerb
PraiseHigh 250mg per-capsule dosageConvenient one-capsule daily serving
ComplaintsCost performance described as good but 'not great'Some concern about reduced dosage in smaller bottle size
Last checked: 2026-08-07

Consumer signals

Consumer signals gathered from 3 platforms.

Medium confidence

mixed sentiment

PraiseHigh 250mg per-capsule dosageConvenient one-capsule daily servingMinimal taste when mixed into shakes
ComplaintsCost performance described as good but 'not great'Some concern about reduced dosage in smaller bottle size
Themes

iHerb reviewers appreciate ProHealth Pure Fisetin's high per-capsule dose and convenience, though some flag pricing and dosage-consistency concerns.

Compiled from a iHerb listing located during research; verified at build time.

mixed sentiment

PraiseSolid, pure, high-quality fisetinOdorless, flavorless, easy-to-swallow capsulesNo side effects or stomach upset reported
ComplaintsHigh cost

Limited/lackluster recent supporting research noted by one reviewer

Themes

Amazon reviewers of ProHealth Pure Fisetin 250mg find the product well-tolerated and high quality, with price and evolving research evidence as the main reservations.

Compiled from a Amazon listing located during research; verified at build time.

80 reviews · 3.8/5

These are consumer sentiment signals. They do not measure whether the product actually works. See our evidence section for that.

What others say (unverified)

No external reviews aggregated yet for this product.

Layer 3 · Evidence vault

Evidence, claims & regulation

Published evidence, claim checks, regulatory status and what could not be verified.

Evidence

Research behind this product

The studies that established the trial dose and evidence grade for each active ingredient in this product. Click through to read the original paper.

Important to know
FisetinStandard capsules have <5% absorption. Look for liposomal or with piperine.

Editorial notes

A well-dosed (250mg/capsule, 1500mg/day protocol) senolytic fisetin product following the intermittent high-dose research paradigm; price shown ($39.17) is a discounted subscribe-and-save price on ProHealth's own site (one-time price $55.95).

Brand owners

Spot an error?

If you are the manufacturer or brand owner of Pure Fisetin - 250 mg, 60 capsules and believe any data on this page is incorrect (wrong dose, wrong ingredient, wrong price, missing certification, outdated status), you can request a correction.

We review every request, verify it against primary sources, and publish any accepted change with a dated note. Corrections from brand owners are treated the same as corrections from anyone else: verified before they move.

Request a correction →
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