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Category · 5 products

Methyl donor

Methylation support: folate, B12, TMG and their neighbours. One-carbon metabolism in a bottle.

Category statistics and scoring
5
6.3
B
3
$0.20
Compare the top 3 → Filter the full index →
Ranked

Every Methyl donor product we score

Same formula as the rest of the site. Position here has never been bought.

Reading guide

How to read this shelf

TMG (betaine anhydrous) and methylfolate. TMG is labelled in hundreds of milligrams to grams, methylfolate in micrograms. Both are stored per label serving.

Check on every label

  • Whether the label says betaine anhydrous (TMG) or betaine HCl. They are different products.
  • For folate, the form named (5-MTHF, methylfolate, folic acid) and the microgram amount.
Catalog figures for this shelf (5)
Products
5
Most common lead ingredients
Betaine (TMG) (4), Folate (5-MTHF) (1)
Forms
Capsule (2), Powder (2), Tablet (1)
Range of Betaine (TMG) per serving
1,000 mg to 2,000 mg across 4 products
Price per serving
$0.10 to $1.00
Testing listed
3 of 5 list third-party testing · 3 publish a CoA

Counts and ranges are catalog facts about the labels, not a ranking. The score, evidence and safety sections below are separate.

Top 3 for this shelf

The three best-evidenced options here, with the plain verdict and the catch first. The full ranking continues below.

Methyl donor
Active per serving
Folate (5-MTHF) 400 µgCapsule · 60 servings
Price per serving
$0.20$11.99 · 60 servings
Testing
None listed

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 6.7/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$0.20
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with jarrow.com

Verdict: This Jarrow Formulas Jarrow Formulas Methyl Folate, 400 mcg scores 6.7, making it a mid-tier product with both strengths and weaknesses. It delivers 0mg of Folate (5-MTHF), inside the studied range of 0–1mg with grade B evidence (promising human data, not yet comprehensive). The quality transparency (5.0) is limited by the lack of third-party testing. At $0.20/day it's priced well for what you get.

The catch: No third-party testing, which caps the quality transparency.

02
DoNotAge
Pure TMG
Methyl donor
Active per serving
Betaine (TMG) 2,000 mgPowder · 30 servings
Price per serving
$1.00$30.00 · 30 servings
Testing
3rd-party listed · public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 6.7/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$1.50
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with donotage.org

Verdict: This DoNotAge Pure TMG scores 6.7, making it a mid-tier product with both strengths and weaknesses. It delivers 2000mg of Betaine (TMG), inside the studied range of 1500–6000mg with grade C evidence (mostly preclinical, limited human data). Transparency is a clear strength (score: 9.5), with third-party testing and a public lab certificate. At $1.50/day it's among the more expensive options in Methyl donor.

The catch: Dose-evidence score of 5.4 is below average for the site.

Methyl donor
Active per serving
Betaine (TMG) 1,000 mgTablet · 120 servings
Price per serving
$0.10$11.60 · 120 servings
Testing
3rd-party listed · public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 6.2/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

67%
of trial dose
$0.29
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with www.prohealth.com

Verdict: This ProHealth Longevity TMG Pro Tablets - 1000 mg, 120 tablets scores 6.2, making it below the site average. It delivers 1000mg of Betaine (TMG), 66% of the studied range low edge (1500mg) with grade C evidence (mostly preclinical, limited human data). Transparency is a clear strength (score: 9.0), with third-party testing and a public lab certificate. At $0.29/day it's priced well for what you get.

The catch: Dose-evidence score of 4.2 is below average for the site.

Quick compare

Top 5 in Methyl donor

Sorted by overall score. Same numbers you'll see on each product page.

#ProductScorePrimary activeDose vs RCTPrice/moValue rankDose+Evidence
#1Jarrow Formulas Methyl Folate, 400 mcg
Jarrow Formulas
6.70/10Folate (5-MTHF) 0mg✅ 100%$12/moTop 1%7.2/10
#2Pure TMG
DoNotAge
6.70/10Betaine (TMG) 2000mg✅ 100%$30/moBottom 1%5.4/10
#3TMG Pro Tablets - 1000 mg, 120 tablets
ProHealth Longevity
6.20/10Betaine (TMG) 1000mg⚠️ 66%$3/moTop 25%4.2/10
#4TMG Supplement (Trimethylglycine)
Double Wood Supplements
6.10/10Betaine (TMG) 1000mg⚠️ 66%$7/moBottom 25%4.2/10
#5Betaine Anhydrous (TMG) Powder
BulkSupplements
5.80/10Betaine (TMG) 1500mg✅ 100%$9/moMid-range5.4/10

Tied scores are shown to two decimals. Ties break in this order: dose vs study dose, then transparency, then value, then price per day at studied dose.

04
Double Wood Supplements
TMG Supplement (Trimethylglycine)
Methyl donor
Active per serving
Betaine (TMG) 1,000 mgCapsule · 90 servings
Price per serving
$0.22$19.95 · 90 servings
Testing
3rd-party listed · public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 6.1/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

67%
of trial dose
$0.66
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with doublewoodsupplements.com
05
BulkSupplements
Betaine Anhydrous (TMG) Powder
Methyl donor
Active per serving
Betaine (TMG) 1,500 mgPowder · 66 servings
Price per serving
$0.30$19.97 · 66 servings
Testing
None listed

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 5.8/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$0.61
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with www.bulksupplements.com
Connected

What defines this shelf

Actives used here
Betaine (TMG) (4)Folate (5-MTHF) (1)
Brands competing
Jarrow Formulas (1)DoNotAge (1)ProHealth Longevity (1)Double Wood Supplements (1)BulkSupplements (1)
Consumer signals
5 products with consumer ratings 3 high-confidence signals 10,617 total consumer reviews
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