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Layer 1 · Decision
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TMG Supplement (Trimethylglycine)

Methyl donor · Capsule · 90 servings

Label snapshot

What the label says

What the product contains and what one serving costs, according to our catalog. Label amounts are not personal dose recommendations.

Active per serving
Betaine (TMG) 1,000 mg
Form
Capsule
List price (catalog, USD)
$19.95
Price per serving
$0.22List price divided by servings per container. A per-day cost only if the label serving is once daily.
Full label record: servings, testing, ingredients
Servings per container
90
Catalog monthly estimate
$6.65
Testing disclosure
Brand lists third-party testing and a public certificate of analysis (CoA)Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Ingredients as listed

IngredientAmount per serving
Betaine (TMG)1,000 mg

What to check on the label

  • Whether the label says betaine anhydrous (TMG) or betaine HCl. They are different products.
  • For folate, the form named (5-MTHF, methylfolate, folic acid) and the microgram amount.

Amounts are per label serving as recorded in the catalog and are not a recommendation. Testing status reflects what the brand lists. Nothing here is medical advice.

Editorial score and research-dose calculations

These calculations describe our scoring method. They are not a recommended dose or proof of benefit from this product.

6.1/10
Overall score
#4 / 5 in Methyl donor

Public lab certificate, tested by independent lab, top 12% value.

Read the full evidence vault
Tier 4
Ingredient RCT (different dose)
The ingredient was tested in an RCT but at a different dose, or only in animals.
How we scored this product Show the full breakdown
Composite How this 6.1 is built. 0.50 × 4.2 + 0.20 × 9.0 + 0.10 × 9.2 + 0.10 × 5.0 + 0.05 × 8.5 + 0.05 × 7.0 = 6.1 out of 10. Safety caps applied after. 6.1
6.1 composite
Dose vs. studies50%4.2
Transparency20%9.0
Value10%9.2
Formulation10%5.0
Safety5%8.5
Community5%7.0

Evidence gates dose: the evidence grade sets the ceiling, and the dose decides how much of that ceiling the product reaches. Value = inverse of price-per-trial-dose-day. Community = mean sentiment of external reviews. Safety caps applied after weighting.

This score is our editorial judgment, not a scientific standard. We combine published evidence, dose, price, transparency, and consumer signals into one composite: this is our method, not a peer-reviewed clinical rating. A higher score means a product does better on the factors we weight, not that it is medically proven to work.

Read the full method →

Editorial verdict

Quick verdict

6.1 / 10
Best for
Public lab certificate, Budget-friendly
Avoid if
Only 67% of trial dose
Full-dose status
67% of trial dose
Price/month
$7
COA status
Public
Biggest caveat
Dose-evidence score of 4.2 is below average for the site.
Nearest alternatives
Catalog snapshot. Check linked sources for current price, label and batch-specific testing.
Price verification
Current price: $19.95
Last price check: Sep 01, 2026
Layer 2 · Context
In plain language

Why this scored this way

This Double Wood Supplements TMG Supplement (Trimethylglycine) scores 6.1, making it below the site average. It delivers 1000mg of Betaine (TMG), 66% of the studied range low edge (1500mg) with grade C evidence (mostly preclinical, limited human data). Transparency is a clear strength (score: 9.0), with third-party testing and a public lab certificate.

What drives the score up

  • Quality transparency of 9.0: tested by independent lab with a public lab certificate.

What drags it down

  • Dose-evidence score of 4.2 is below average for the site.
  • Betaine (TMG) (1000.0mg is 33% of the 3000mg trial dose) is significantly under-dosed.

Why you'd choose it

  • You want good value at $0.66/day.
  • You prioritise tested by independent lab products with public lab certificates.

Why you might skip it

  • You need a full trial dose of betaine (this product under-doses it).
  • You want a higher-scoring product (this scores 6.1).
Question 1

Does the molecule work?

The science behind each active ingredient, independent of which brand sells it.

Betaine (TMG)

A methyl donor added to NAD+ formulas as a supporting cofactor, not a headline active.

No landmark RCTs listed · US: Dietary supplement, GRAS · EU: Food supplement, permitted
Question 2

Is this bottle good?

The specific product: dose, price, transparency, and what buyers report.

Dose vs research
67% of trial dose
Below the full trial dose
Cost at trial dose
$0.66/day at trial dose
What one effective daily dose actually costs
Transparency
9.0/10 · Public lab certificate (quality: not assessed)
Independent batch testing confirmed
Consumer signals
169 reviews across platforms · 3.5/5 · medium confidence
Operational signal only, never used as clinical evidence
Question 3

What's the catch?

Safety flags, transparency gaps, dosing concerns, and recurring buyer complaints.

Buyer complaints
Trustpilot: Customer service and fulfillment complaints; Amazon: Some report no noticeable effect
Recurring themes from consumer review platforms.
Plain English

What’s inside

The main ingredients of this product, in plain language.

Betaine (TMG)1000 mgEvidence C

A methyl donor added to NAD+ formulas as a supporting cofactor, not a headline active.

Read about Betaine (TMG) →
Layer 3 · Evidence vault

Product data & verification

Hard numbers and independently checked status. Expand each block for its source.

The numbers

Price
$20
per bottle · 90 servings
Dose vs. research
Below trial dose 67%
of published effective dose
$ / day at studied dose
$0.66
what one effective daily dose costs
$ / g active
$0.22
per gram of active substance
Independently checked

Data verification

COA status
Public
Evidence grade
C
Per-ingredient breakdown
CBetaine (TMG)

All product data is checked against original sources. Prices, doses, and testing status are updated when product pages change. Evidence grades are reviewed when new human RCTs are published. Read how we verify.

What's inside

Ingredient
Dose in this product
Trial dose
Evidence
Betaine (TMG)
A methyl donor added to NAD+ formulas as a supporting cofactor, not a headline active.
1000 mg 33% of trial dose
3000 mg
3.5 /5
High confidence
169 reviews across 4 platforms (4 sources)
Source diversity: 92%
AmazonRedditTrustpilotiHerb
PraiseEffective methylation support reported by someGood value for money
ComplaintsCustomer service and fulfillment complaintsSome report no noticeable effect
Last checked: 2026-08-20

Consumer signals

3.5 out of 5 across 169 verified reviews on 4 platforms.

Medium confidence

Consumer sentiment compiled from 4 public sources.

169 reviews · 3.5/5 · mixed sentiment

PraiseEffective methylation support reported by some
ComplaintsCustomer service and fulfillment complaints
Themes

Double Wood's brand-wide Trustpilot rating remains average due to recurring service issues.

Compiled from Trustpilot listing located during research; verified at build time.

positive sentiment

PraiseGood value for moneyEffective for homocysteine/methylation support
ComplaintsSome report no noticeable effect
Themes

Amazon customers appreciate the value, quality, and effectiveness of this TMG supplement.

Compiled from Amazon listing located during research; verified at build time.

positive sentiment

PraiseWorks well alongside methylated multivitaminsReasonably dosed
ComplaintsNot confirmed as sold on iHerb
Themes

Not verified as available on iHerb; brand's related methylated multivitamin product gets positive customer feedback.

Compiled from iHerb listing located during research; verified at build time.

negative sentiment

PraiseSome find the products effective and well-priced
ComplaintsOrder/refund disputesTrust concerns about the brand generally
Themes

Reddit sentiment toward Double Wood as a brand is notably negative due to service complaints, even though individual product reviews are often positive.

Compiled from Reddit listing located during research; verified at build time.

These are consumer sentiment signals. They do not measure whether the product actually works. See our evidence section for that.

What others say (unverified)

No external reviews aggregated yet for this product.

Layer 3 · Evidence vault

Evidence, claims & regulation

Published evidence, claim checks, regulatory status and what could not be verified.

Evidence

Research behind this product

No landmark studies linked yet. See the ingredient pages for the full evidence breakdown.

Important to know
Betaine (TMG)Doses under roughly 500 mg/day (as seen in most NAD+ combination products) are well below the gram-level doses used in the supporting human trials.

Editorial notes

Frequently backordered/unavailable (was listed as backordered at time of check). Label serving (1000mg) is well below the 3000mg dose the vendor's own marketing cites for homocysteine reduction, would require 3x the recommended serving to hit the cited trial dose.

Brand owners

Spot an error?

If you are the manufacturer or brand owner of TMG Supplement (Trimethylglycine) and believe any data on this page is incorrect (wrong dose, wrong ingredient, wrong price, missing certification, outdated status), you can request a correction.

We review every request, verify it against primary sources, and publish any accepted change with a dated note. Corrections from brand owners are treated the same as corrections from anyone else: verified before they move.

Request a correction →
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