Odd-chain saturated fat from dairy, proposed as a new essential fatty acid. Biomarker data is good; outcome trials are just starting.
The most interesting new fatty acid in years, with human outcome data still catching up. Watch this space rather than mortgage the house.
C15:0 (Pentadecanoic Acid (C15:0)) is a metabolic with evidence grade D, meaning it is primarily supported by animal studies. We track 2 products containing C15:0. Typical doses range from 100 to 100 mg per serving. The top-ranked product scores 4.9 out of 10 on our composite scale (dose, evidence, price, testing, transparency). Prices range up to $149.95 per month.
| Product | Brand | Dose | Price/mo | 3rd-party tested | Score |
|---|---|---|---|---|---|
| Fatty15 Daily Cellular Support (C15:0) | Fatty15 | 100 mg | $149.95 | Yes | 4.9 |
| Healthy Aging Gummies | Fatty15 | 100 mg | $79.95 | Yes | 4.0 |
Scores are editorial judgments, not a scientific standard. See how we score.
A saturated fat found in trace amounts in butter and whole milk. Higher blood levels track with lower diabetes and heart disease risk in population studies. Now sold as a purified supplement.
Dolphins taught the researchers: Navy dolphins with higher C15:0 stayed healthier, and feeding them more fixed their metabolic markers. In humans, blood C15:0 consistently predicts better metabolic health — but those are correlations, and the outcome trials in people are still underway.
The most interesting new fatty acid in years, with human outcome data still catching up. Watch this space rather than mortgage the house.
Pentadecanoic acid, odd-chain saturated fatty acid. Proposed PPAR-α/δ and AMPK modulator; candidate 'essential' fatty acid (Venn-Watson & Schork).
Venn-Watson et al. 2020 (Sci Rep): in dolphins, higher dietary C15:0 reversed elevated liver enzymes, insulin, and ferritin. Human cohort studies (Framingham, Cardiovascular Health Study) associate circulating C15:0 with lower risks of type 2 diabetes and cardiovascular disease. A 2023 analysis argued C15:0 meets criteria for an essential fatty acid. Randomized human outcome trials are registered but not yet published.
Incorporated into circulating lipids; steady state over weeks.
The healthiest cohorts get C15:0 from dairy fat — the supplement story assumes the molecule, not the milk matrix, is the active agent. That assumption is untested in human trials.
The trial dose above is our editorial pick from the published human trials for this ingredient. We choose the dose that the best-available studies used on the endpoint most relevant to longevity. The range shows the lowest and highest doses tested in published trials. The landmark studies below are the papers we read to set it. You can click through and check our work.
When new trials publish, our automated sweeps flag them. If a new study materially changes the dose, we update it through editorial review and record the old dose, new dose, and the triggering study in every affected product's recommendation history. The dose is never changed automatically.
Regulatory events, evidence grade changes, and key research milestones for C15:0, most recent first. Studies link to the paper; regulatory entries name and link the responsible authority.
Dolphin intervention + in vitro: dietary C15:0 improved metabolic and hematologic markers; mechanistic assays showed dose-dependent PPAR and anti-inflammatory activity across human cell systems.
Read study →Scientific argument paper: C15:0 fulfills published criteria for an essential fatty acid, based on dose-dependent cellular activities and population deficiency signals.
Read study →All products in our catalog that contain C15:0, ranked by our overall score. Ranking is editorial, never paid.
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Fatty15Multi-ingredient bundle
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Molecules in the same class, plus the actives most often formulated alongside C15:0 in our catalogue.
See C15:0 in context: the mechanism it acts through, the biomarker it moves, the products that dose it, and the trials that tested it.
View C15:0 on the Longevity Map →A saturated fat found in trace amounts in butter and whole milk. Higher blood levels track with lower diabetes and heart disease risk in population studies. Now sold as a purified supplement.
The trial dose in published human studies is 100 mg per day, with a range of 100 to 200 mg per day. Always consult a qualified clinician before starting any supplement.
The healthiest cohorts get C15:0 from dairy fat — the supplement story assumes the molecule, not the milk matrix, is the active agent. That assumption is untested in human trials.
We track 2 products containing C15:0. The top-ranked product scores 4.9 out of 10 on our composite scale, which evaluates dose, evidence, price, third-party testing, and transparency. See the comparison table above. Scores are editorial judgments, not a scientific standard.
C15:0 has evidence grade D, meaning it is primarily supported by animal studies. Grade A means replicated human RCTs with hard endpoints. Grade B means human RCTs with biomarker outcomes. Grade C means mixed or small human trials. See our evidence grading methodology.
Evidence grades are reviewed when new human RCTs are published. Product counts update automatically as new products are added. Dose ranges reflect published trial data, not brand recommendations. Read how we verify.