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Polyphenol

Luteolin · Luteolin

Flavonoid with strong anti-inflammatory and neuroprotective lab data. Human trials are essentially absent.

D
Evidence grade
Mostly animal

Short answer

Mechanistically interesting, clinically unproven. Any specific human claim goes beyond the data.

Product and dose overview

Luteolin (Luteolin) is a polyphenol with evidence grade D, meaning it is primarily supported by animal studies. We track 1 products containing Luteolin. Typical doses range from 20 to 20 mg per serving. The top-ranked product scores 4.0 out of 10 on our composite scale (dose, evidence, price, testing, transparency). Prices range up to $16.50 per month.

Evidence grade: D Products in database: 1 Category: Polyphenol

Top Luteolin products

ProductBrandDosePrice/mo3rd-party testedScore
Bio-LuteolinLife Extension20 mg$16.50Yes4.0

Scores are editorial judgments, not a scientific standard. See how we score.

What it is

A plant compound in celery, parsley, and chamomile. Popular in 'brain health' and mast-cell formulas.

Why people take it

In the lab, luteolin calms inflammatory signaling in brain immune cells (microglia) and inhibits mast-cell activation — hence its use in autism and 'histamine' protocols. But controlled human trials for these uses barely exist. What you are buying is a plausible mechanism.

Our verdict

Mechanistically interesting, clinically unproven. Any specific human claim goes beyond the data.

Structure & class

3',4',5,7-tetrahydroxyflavone. Microglial activation inhibitor and mast-cell stabilizer in vitro; low oral bioavailability (~10%).

Mechanism & clinical data

Reviews (2020) summarize neuroprotective, anti-inflammatory and anti-allergic effects across cell and animal models, with proposed benefits in neuroinflammation-driven conditions. Human evidence consists of small open-label series in autism spectrum contexts and one luteolin-containing formulation trial; no adequately powered RCT exists for any indication.

Pharmacokinetics

Short; conjugated rapidly in the gut and liver.

Dose & forms

Trial dose
100 mg
/ day
Range in trials
50 to 200 mg
/ day
Common forms
Standardized extract capsule, Liposomal formulations

What to watch out for

Bioavailability is the weak point — liposomal or complexed forms claim better uptake without published human comparisons. Enthusiastic autism-spectrum claims outrun the evidence.

Where this dose comes from

The trial dose above is our editorial pick from the published human trials for this ingredient. We choose the dose that the best-available studies used on the endpoint most relevant to longevity. The range shows the lowest and highest doses tested in published trials. The landmark studies below are the papers we read to set it. You can click through and check our work.

When new trials publish, our automated sweeps flag them. If a new study materially changes the dose, we update it through editorial review and record the old dose, new dose, and the triggering study in every affected product's recommendation history. The dose is never changed automatically.

Regulatory status

EUPermitted
USDietary supplement
UKPermitted
CANHP permitted

Timeline

Regulatory events, evidence grade changes, and key research milestones for Luteolin, most recent first. Studies link to the paper; regulatory entries name and link the responsible authority.

  • 2025-04 Regulatory single source
    EU Court sharpens the bar for botanical health claims
    A Court of Justice of the European Union ruling in April 2025 further tightened the requirements for how botanical ingredients (herbs, plant extracts) can be marketed with health claims in the EU, effectively removing much of the flexibility of the on-hold list.
  • 2024-06 Regulatory confirmed
    EU report identifies 117 supplement substances as potential health risks
    The HoA Working Group on Food Supplements (26 European countries) published its first report evaluating 117 substances used in food supplements. Of these, 65 were assessed as likely novel foods, 6 were already regulated, 34 had insufficient data, and 12 were prioritized for Article 8 restriction under Regulation (EC) No 1925/2006. The 12 priority substances include ashwagandha, curcumin, melatonin, piperine, St. John's wort, coumarin, p-synephrine, maca, holy basil, Melaleuca, black cohosh, and L-tryptophan. The report drew on 1,500 RASFF alerts reviewed between 2017 and mid-2022.
    Source →
  • 2020 Research milestone
    Luteolin neuroprotection review 2020
    Review: luteolin shows consistent neuroprotective and anti-inflammatory effects in preclinical models; authors note the near-total absence of controlled human trials.
    Source →
  • 2006-12 Regulatory confirmed
    EU Health Claims Regulation adopted
    Regulation (EC) No 1924/2006 laid down harmonised rules for nutrition and health claims made on foods, including supplements. Only claims listed in the EU Register of authorised claims can be used. Rejected botanical claims are held in a separate on-hold list.
    Source →
  • 1997 Regulatory confirmed
    EU introduces the Novel Food Regulation
    Regulation (EC) No 258/97 required any food or food ingredient without a history of consumption in the EU before 15 May 1997 to be authorised before being placed on the market. This is the framework that captures NMN, spermidine as a supplement ingredient, urolithin A, and many other longevity actives.
    Source →

Landmark studies

Found in these products (1)

All products in our catalog that contain Luteolin, ranked by our overall score. Ranking is editorial, never paid.

Life Extension
Bio-Luteolin
Antioxidant
Active per serving
Luteolin 20 mgCapsule · 30 servings
Price per serving
$0.55$16.50 · 30 servings
Testing
3rd-party listed · no public lab certificate

Undisclosed amounts noted

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 4.0/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

40%
of trial dose
$2.75
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with www.lifeextension.com
Editorial guides

Buying guides and comparisons

Neighbouring molecules

Related ingredients

See all in Polyphenol →

Molecules in the same class, plus the actives most often formulated alongside Luteolin in our catalogue.

EGCGCsame categoryMyricetinDsame category
Product shelves
See all in Antioxidant (1)

See Luteolin in context: the mechanism it acts through, the biomarker it moves, the products that dose it, and the trials that tested it.

View Luteolin on the Longevity Map →

Frequently asked questions

What is Luteolin?

A plant compound in celery, parsley, and chamomile. Popular in 'brain health' and mast-cell formulas.

What dose of Luteolin should I take?

The trial dose in published human studies is 100 mg per day, with a range of 50 to 200 mg per day. Always consult a qualified clinician before starting any supplement.

Is Luteolin safe?

Bioavailability is the weak point — liposomal or complexed forms claim better uptake without published human comparisons. Enthusiastic autism-spectrum claims outrun the evidence.

What is the best Luteolin supplement?

We track 1 products containing Luteolin. The top-ranked product scores 4.0 out of 10 on our composite scale, which evaluates dose, evidence, price, third-party testing, and transparency. See the comparison table above. Scores are editorial judgments, not a scientific standard.

What is the evidence grade for Luteolin?

Luteolin has evidence grade D, meaning it is primarily supported by animal studies. Grade A means replicated human RCTs with hard endpoints. Grade B means human RCTs with biomarker outcomes. Grade C means mixed or small human trials. See our evidence grading methodology.

Independently checked

Data verification

Evidence grade
D
Mostly animal
Research dose
100 mg
Products tracked
1
Updated continuously
Safety signal
Bioavailability is the weak point — liposomal or complexe...

Evidence grades are reviewed when new human RCTs are published. Product counts update automatically as new products are added. Dose ranges reflect published trial data, not brand recommendations. Read how we verify.