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Polyphenol

Myricetin · Myricetin

Flavonoid from berries and tea with strong lab results on inflammation and metabolism. Human trials do not exist.

D
Evidence grade
Mostly animal

Short answer

Pure preclinical promise. No human data means no way to verify the dose that would matter.

Product and dose overview

Myricetin (Myricetin) is a polyphenol with evidence grade D, meaning it is primarily supported by animal studies. We track 1 products containing Myricetin. Typical doses range from 40 to 40 mg per serving. The top-ranked product scores 5.0 out of 10 on our composite scale (dose, evidence, price, testing, transparency). Prices range up to $42.00 per month.

Evidence grade: D Products in database: 1 Category: Polyphenol

Top Myricetin products

ProductBrandDosePrice/mo3rd-party testedScore
GEROPROTECT Ageless CellLife Extension40 mg$42.00Yes5.0

Scores are editorial judgments, not a scientific standard. See how we score.

What it is

A plant compound found in berries, red wine, and tea. In longevity formulas it is included for its anti-inflammatory and senescence-related lab effects.

Why people take it

In cell and animal studies, myricetin reduces inflammatory signaling and improves metabolic markers. The problem is simple: there are no published human trials testing myricetin alone for any meaningful outcome.

Our verdict

Pure preclinical promise. No human data means no way to verify the dose that would matter.

Structure & class

3,5,7,3',4',5'-hexahydroxyflavone. Inhibits NF-κB, NLRP3 inflammasome activation, and several kinases in vitro; poor oral bioavailability.

Mechanism & clinical data

Semwal et al. and subsequent reviews (Biomed Pharmacother 2021) summarize anti-inflammatory, antidiabetic, and neuroprotective effects across in vitro and rodent models. Bioavailability is low (single-digit percent) and no human RCT with myricetin as monotherapy has been published as of 2026.

Pharmacokinetics

Short; extensive phase II metabolism.

Dose & forms

Trial dose
None mg
/ day
Range in trials
100 to 500 mg
/ day
Common forms
Standardized extract capsule

What to watch out for

Any mg number on a label is a guess — there is no validated human dose. Bioavailability is the weak point.

Where this dose comes from

The trial dose above is our editorial pick from the published human trials for this ingredient. We choose the dose that the best-available studies used on the endpoint most relevant to longevity. The range shows the lowest and highest doses tested in published trials. The landmark studies below are the papers we read to set it. You can click through and check our work.

When new trials publish, our automated sweeps flag them. If a new study materially changes the dose, we update it through editorial review and record the old dose, new dose, and the triggering study in every affected product's recommendation history. The dose is never changed automatically.

Regulatory status

EUPermitted
USDietary supplement
UKPermitted
CANHP permitted

Timeline

Regulatory events, evidence grade changes, and key research milestones for Myricetin, most recent first. Studies link to the paper; regulatory entries name and link the responsible authority.

  • 2025-04 Regulatory single source
    EU Court sharpens the bar for botanical health claims
    A Court of Justice of the European Union ruling in April 2025 further tightened the requirements for how botanical ingredients (herbs, plant extracts) can be marketed with health claims in the EU, effectively removing much of the flexibility of the on-hold list.
  • 2024-06 Regulatory confirmed
    EU report identifies 117 supplement substances as potential health risks
    The HoA Working Group on Food Supplements (26 European countries) published its first report evaluating 117 substances used in food supplements. Of these, 65 were assessed as likely novel foods, 6 were already regulated, 34 had insufficient data, and 12 were prioritized for Article 8 restriction under Regulation (EC) No 1925/2006. The 12 priority substances include ashwagandha, curcumin, melatonin, piperine, St. John's wort, coumarin, p-synephrine, maca, holy basil, Melaleuca, black cohosh, and L-tryptophan. The report drew on 1,500 RASFF alerts reviewed between 2017 and mid-2022.
    Source →
  • 2021 Research milestone
    Biomed Pharmacother 2021 review
    Review of the myricetin literature: consistent anti-inflammatory and metabolic effects in preclinical models; notes absence of controlled human trials.
    Source →
  • 2006-12 Regulatory confirmed
    EU Health Claims Regulation adopted
    Regulation (EC) No 1924/2006 laid down harmonised rules for nutrition and health claims made on foods, including supplements. Only claims listed in the EU Register of authorised claims can be used. Rejected botanical claims are held in a separate on-hold list.
    Source →
  • 1997 Regulatory confirmed
    EU introduces the Novel Food Regulation
    Regulation (EC) No 258/97 required any food or food ingredient without a history of consumption in the EU before 15 May 1997 to be authorised before being placed on the market. This is the framework that captures NMN, spermidine as a supplement ingredient, urolithin A, and many other longevity actives.
    Source →

Landmark studies

Found in these products (1)

All products in our catalog that contain Myricetin, ranked by our overall score. Ranking is editorial, never paid.

Life Extension
GEROPROTECT Ageless Cell
Senolytic
Ingredients listed
4 ingredients listedlargest listed: Quercetin 60 mg
Price per serving
$1.40$42.00 · 30 servings
Testing
3rd-party listed · public lab certificate

Multi-ingredient bundle

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 5.0/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

45%
of trial dose
$15.56
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with www.lifeextension.com
Editorial guides

Buying guides and comparisons

Neighbouring molecules

Related ingredients

See all in Polyphenol →

Molecules in the same class, plus the actives most often formulated alongside Myricetin in our catalogue.

EGCGCsame categoryLuteolinDsame categoryFisetinCstacked together in 1 productQuercetinBstacked together in 1 productCurcuminBstacked together in 1 product
Product shelves
See all in Senolytic (1)

See Myricetin in context: the mechanism it acts through, the biomarker it moves, the products that dose it, and the trials that tested it.

View Myricetin on the Longevity Map →

Frequently asked questions

What is Myricetin?

A plant compound found in berries, red wine, and tea. In longevity formulas it is included for its anti-inflammatory and senescence-related lab effects.

What dose of Myricetin should I take?

The trial dose in published human studies is None mg per day, with a range of 100 to 500 mg per day. Always consult a qualified clinician before starting any supplement.

Is Myricetin safe?

Any mg number on a label is a guess — there is no validated human dose. Bioavailability is the weak point.

What is the best Myricetin supplement?

We track 1 products containing Myricetin. The top-ranked product scores 5.0 out of 10 on our composite scale, which evaluates dose, evidence, price, third-party testing, and transparency. See the comparison table above. Scores are editorial judgments, not a scientific standard.

What is the evidence grade for Myricetin?

Myricetin has evidence grade D, meaning it is primarily supported by animal studies. Grade A means replicated human RCTs with hard endpoints. Grade B means human RCTs with biomarker outcomes. Grade C means mixed or small human trials. See our evidence grading methodology.

Independently checked

Data verification

Evidence grade
D
Mostly animal
Research dose
None mg
Products tracked
1
Updated continuously
Safety signal
Any mg number on a label is a guess — there is no validat...

Evidence grades are reviewed when new human RCTs are published. Product counts update automatically as new products are added. Dose ranges reflect published trial data, not brand recommendations. Read how we verify.