All 127 active ingredients

The best-studied adaptogen for stress and sleep.

Adaptogen for fatigue and mild stress.

Proprietary stress-herb mixes. The ingredients often have individual trials; the blend as sold almost never does.

A climbing vine nicknamed the "immortality herb" in parts of China, studied for its gypenoside (damulin) compounds that activate AMPK, a key cellular energy and metabolic longevity pathway.

A classic adaptogenic root containing ginsenosides, studied in multiple human trials for cognitive performance in aging and mild cognitive impairment.

A parasitic desert plant used in Traditional Chinese Medicine as a tonic, with a recent human RCT showing cognitive improvements when combined with Ginkgo biloba.

Fungal adaptogen with modest performance data.

A staple Traditional Chinese Medicine root long used as an immune tonic, now studied for anti-aging effects via telomerase activity, immune modulation, and reduction of senescence-associated secretory phenotype (SASP) markers.

A medicinal mushroom long used in East Asian traditional medicine, recently shown in lab studies to extend lifespan in simple organisms via autophagy induction, though human cancer-outcome trials have not shown strong survival benefits.

A stimulant compound from bitter orange, flagged by EU regulators for cardiovascular risk.

An essential amino acid that serves as a precursor to serotonin and melatonin.

Cheap amino acid with better sleep and glutathione-precursor benefits.

The 2023 sensation; species-wide lifespan extension in mice, humans unproven.

Direct antioxidant supplement; only liposomal really raises blood levels.

A concentrated source of oligomeric proanthocyanidins (OPCs) from grape seeds that reduces postprandial oxidative stress and has shown benefits for menopausal symptoms and body composition.

A natural source of melatonin and anthocyanins with anti-inflammatory and sleep-supporting properties.

A carotenoid concentrated in the eye's macula, backed by the large AREDS2 Phase 3 trial for slowing age-related macular degeneration progression, with additional evidence for cognitive benefits.

The companion carotenoid to lutein, co-studied in the landmark AREDS2 trial for slowing age-related macular degeneration progression and supporting cognitive function.

A polyphenol-rich extract from French maritime pine bark that improves endothelial function and blood flow by boosting nitric oxide bioavailability, and scavenges free radicals.

The principal bioactive compound in olive leaves, credited in part for the cardiovascular benefits of the Mediterranean diet, with mixed human trial results on blood pressure and lipids.

A less common form of vitamin E, structurally distinct from standard tocopherols, studied for cholesterol effects (mixed results) and, in preclinical work, for senescence/SASP-suppressing properties.

A compound from magnolia bark with a long history of anxiolytic use, but for which all supporting evidence — including any longevity-relevant mechanisms — remains preclinical/animal-only.

The autophagy-inducing polyamine; the largest human trial found no cognitive benefit.

A tar-like substance exuded from Himalayan rock formations, rich in fulvic acid and minerals, studied in human RCTs for testosterone support, muscle fatigue resistance, and skin microcirculation.

The pungent alkaloid in black pepper, famous for dramatically increasing the bioavailability of curcumin and other poorly absorbed compounds when co-administered.

A botanical antidepressant flagged by EU regulators for supplement restriction.

A Peruvian root flagged by EU regulators for potential CMR properties in supplements.

An adaptogenic herb flagged by EU regulators for potential CMR properties in supplements.

A botanical flagged by EU regulators for potential CMR properties in supplements.

A menopause herb flagged by EU regulators for liver toxicity risk in supplements.

Frankincense resin extract with real, if modest, osteoarthritis trial data at standardized doses.

5+ year trials in 5,900+ older adults: does not prevent dementia.

One of the best-evidenced botanicals for nausea. Modest anti-inflammatory data beyond that.

Dried vegetable, algae and grass concentrates in one serving. Nutritious, but trial evidence for health outcomes is nearly empty.

Surprising anti-depressant efficacy at 30 mg/day.

Arginine precursor that actually works better than arginine. Meta-analyses show small blood-pressure reductions.

Concentrated dietary nitrate. Replicated blood-pressure and endurance effects — one of the few sports supplements that works.

The 'sunscreen from within' with real skin, eye, and endurance data.

The 'calm alertness' amino acid from green tea.

Cholinergic support for cognitive function.

Ayurvedic memory herb with modest but real effects at 300 mg/day.

Choline-donor form with the deepest human trial base of the cognitive choline sources.

Choline donor with European dementia trials behind it. Decent cognition data; a 2021 cohort linked long-term use to stroke risk.

Brain-cell membrane fat with qualified FDA health claim for cognitive decline. Modest but real human data.

1 tablet/day slowed cognitive aging by ~0.07 SD over 3 years in older adults (COSMOS).

30 g/day ketogenic MCT drink improved memory tests in MCI over 6 months.

A traditional Ayurvedic herb studied for mood, alertness, and cognitive support, with a meta-analysis finding modest but not statistically robust evidence for cognitive benefits.

Genuine benefits for skin and joint tissue at 10 g/day.

The gold-standard soluble fiber for cholesterol and gut function.

Oat beta-glucan for cholesterol; yeast beta-glucan for immunity.

A plant flavonoid that may slow the age-related NAD+ drain by inhibiting the CD38 enzyme.

The single best-supported longevity supplement most people don't take enough of.

Cheap, safe, and correcting a deficiency you probably have.

Vitamin D3's essential partner, directs calcium to bones instead of arteries.

One of the most common deficiencies; corrects sleep, muscle cramps, and blood pressure.

Deficiency common over 50 and in vegetarians; correcting it is essential.

The active form of folate; better for those with MTHFR variants.

Essential mineral for immunity and skin; watch out for copper depletion.

Trace mineral with a narrow safe range; often oversupplied.

Correcting deficiency is important; megadoses rarely add benefit.

Fat-soluble antioxidant; use mixed tocopherols, not alpha alone.

Essential for thyroid; deficiency now returning in non-salt-users.

Only take if deficient; excess is harmful.

Bone mineral, but excess supplementation may harm arteries.

Fat-soluble vitamin; toxicity concerns at high doses.

Cheap B-vitamin; migraine prevention at 400 mg/day.

Active form of B6; toxicity concerns at high doses of pyridoxine.

The original cholesterol vitamin. Raises HDL beautifully, improves outcomes not at all — two giant trials killed the lipid theory.

The most-studied supplement in existence; muscle, brain, and mood benefits.

Adequate protein is the single strongest longevity intervention after exercise.

Cysteine donor for glutathione synthesis; drug-strength efficacy for specific uses.

Well-studied for liver protection.

A rare mushroom-derived amino acid that accumulates in tissues under oxidative stress, blood levels drop with age.

A potent olive polyphenol with strong in vitro antioxidant activity; human outcome data still limited.

Plant-derived AMPK activator; near-drug-strength effects on blood sugar and lipids.

Mitochondrial cofactor with genuine efficacy in diabetic neuropathy.

Traditional glucose-lowering herb; small trials only.

Krebs-cycle intermediate sold as a longevity supplement. Lifespan results exist in mice; human evidence is a single retrospective, company-funded analysis.

Odd-chain saturated fat from dairy, proposed as a new essential fatty acid. Biomarker data is good; outcome trials are just starting.

A methyl donor added to NAD+ formulas as a supporting cofactor, not a headline active.

Strain-specific benefits; forget 'total CFU' marketing.

Feeds beneficial gut bacteria; go slow to avoid gas.

Gut bacterium linked to leanness and metabolic health. One human trial — pasteurized, overweight adults, positive metabolic signals.

A mitophagy-activating metabolite with early human data; both flagship RCTs missed their primary endpoints.

A well-established mitochondrial cofactor, especially useful on statins.

Promising cofactor for mitochondrial biogenesis; human evidence remains thin.

Carnitine crossing into the brain; neurological support.

The active, reduced form of CoQ10 with better absorption. Same trials, same evidence — at a higher price.

Sugar that feeds ATP production. Chronic-fatigue community favorite with one uncontrolled pilot study behind it.

Methyl donor with genuine mood and joint effects; expensive.

Leucine metabolite; muscle preservation in older adults.

A plant-derived triterpenoid studied for its potential to counter age-related muscle loss (sarcopenia) via myostatin suppression, though the sole completed human RCT found no benefit over placebo.

A cocoa-derived flavonoid that may inhibit myostatin and support muscle retention; human evidence is early-stage.

The central cellular energy molecule that declines with age. Direct supplementation aims to bypass precursor conversion.

A NAD+ building block that has become the most-hyped longevity molecule.

The NAD+ precursor with the strongest safety file and EU approval.

Newly-identified alternative NAD+ precursor from coffee.

A vitamin B3 form and direct NAD+ precursor with the strongest Phase 3 RCT evidence on this list, showing a 23% reduction in new non-melanoma skin cancers in a large clinical trial.

A willow bark compound with mild mTOR-modulating and anti-inflammatory activity; sometimes called a natural rapamycin analog.

Mushroom compound with neurotrophic factor induction; human data early.

The most potent natural Nrf2 activator; requires myrosinase or true sprout extract to work.

A naturally occurring copper peptide with tissue repair and anti-aging effects in skin; systemic longevity claims are mostly preclinical.

A plant compound flagged by EU regulators for liver toxicity risk in supplements.

A polyamine metabolite of spermidine that rises in the blood after spermidine supplementation; nearly all direct human longevity/autophagy research targets spermidine rather than spermine itself.

Green tea's active catechin; liver safety caution at high doses.

Flavonoid from berries and tea with strong lab results on inflammation and metabolism. Human trials do not exist.

Flavonoid with strong anti-inflammatory and neuroprotective lab data. Human trials are essentially absent.

Turmeric's active compound; genuinely anti-inflammatory but only in absorbable forms.

Null overall in 3 large trials; plausible only if your diet is low in flavanols.

Best-studied 'senolytic' ingredient, though evidence is early.

Highly-hyped senolytic; the strong evidence is in mice, not people.

A lecithin-bound quercetin form built to fix quercetin's biggest problem: almost none of a standard dose reaches the blood.

The famous red-wine molecule; longevity claims have outrun the human evidence.

Resveratrol's more bioavailable cousin, mostly used in blends.

A purine nucleoside studied as a way to raise protective urate levels in Parkinson's disease, with a large Phase 3 trial (SURE-PD3) finding it safely raised urate but did NOT slow disease progression.

DoNotAge's proprietary angle; genuinely interesting biology, extremely early evidence.

Skin hydration and joint comfort at 120 mg/day.

Classic joint supplement with modest osteoarthritis data and large cohort studies linking regular use to lower mortality.

Sulfur compound for joints. Small trials show modest pain relief; effects are real but limited in size.

Glucosamine's partner with mixed results: some structural benefit for knees alone, no added value in combination.

The circadian rhythm hormone; low doses (0.3 to 1 mg) work best.

The brain's main calming neurotransmitter, sold as a sleep aid. Whether oral GABA reaches the brain at all is still debated.

Direct serotonin precursor with trial support for sleep quality and older evidence for low mood. One step from serotonin.

A carbocyclic sugar that acts as a second messenger in insulin and serotonin signaling pathways.

A triterpenoid saponin derived from Astragalus membranaceus that activates the enzyme telomerase, marketed as the first natural compound shown to lengthen telomeres in humans.

Trace mineral with modest bone and hormone effects.

Trace lithium in drinking water correlates with less dementia in several ecological studies. Nobody has run the trial.