Surprising anti-depressant efficacy at 30 mg/day.
Real option for mild mood support. Look for affron® or Satiereal® standardised extract.
Saffron (Saffron extract) is a botanical / mood with evidence grade B, meaning it is supported by human RCTs. We track 2 products containing Saffron. Typical doses range from 28 to 30 mg per serving. The top-ranked product scores 7.5 out of 10 on our composite scale (dose, evidence, price, testing, transparency). Prices range up to $99.00 per month.
| Product | Brand | Dose | Price/mo | 3rd-party tested | Score |
|---|---|---|---|---|---|
| Berbelean | Enhanced Berberine (Berberine Phytosome + Black Ginger, Saffron, CurCousin, Piperine) | Nootropics Depot | 30 mg | $49.99 | Yes | 7.5 |
| AGZ: Nightly Sleep Support | AG1 (Athletic Greens) | 28 mg | $99.00 | Yes | 6.7 |
Scores are editorial judgments, not a scientific standard. See how we score.
The world's most expensive spice, from Crocus sativus. Extract at 30 mg/day matches SSRIs for mild-moderate depression in several trials.
Multiple RCTs (Hausenblas 2013, Lopresti 2014) show significant depression score reduction.
Real option for mild mood support. Look for affron® or Satiereal® standardised extract.
Crocus sativus stigma extract; crocin/safranal standardised.
Meta-analyses show effect size comparable to SSRIs in mild-moderate depression.
Multi-hour biological effect.
Not for pregnancy. Interacts with anticoagulants at high doses.
The trial dose above is our editorial pick from the published human trials for this ingredient. We choose the dose that the best-available studies used on the endpoint most relevant to longevity. The range shows the lowest and highest doses tested in published trials. The landmark studies below are the papers we read to set it. You can click through and check our work.
When new trials publish, our automated sweeps flag them. If a new study materially changes the dose, we update it through editorial review and record the old dose, new dose, and the triggering study in every affected product's recommendation history. The dose is never changed automatically.
Regulatory events, evidence grade changes, and key research milestones for Saffron, most recent first. Studies link to the paper; regulatory entries name and link the responsible authority.
Meta-analysis: saffron significantly reduces depressive symptoms.
Read study →22-week RCT in mild-moderate Alzheimer's: 30 mg/day saffron matched donepezil 10 mg on ADAS-Cog and CDR outcomes.
Read study →Systematic review of 4 RCTs: saffron improved ADAS-Cog and CDR-SB versus placebo in MCI/dementia; authors judged evidence insufficient for clinical recommendation.
Read study →All products in our catalog that contain Saffron, ranked by our overall score. Ranking is editorial, never paid.
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
AG1 (Athletic Greens)Elemental vs compound: check label
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Molecules in the same class, plus the actives most often formulated alongside Saffron in our catalogue.
See Saffron in context: the mechanism it acts through, the biomarker it moves, the products that dose it, and the trials that tested it.
View Saffron on the Longevity Map →The world's most expensive spice, from Crocus sativus. Extract at 30 mg/day matches SSRIs for mild-moderate depression in several trials.
The trial dose in published human studies is 30 mg per day, with a range of 28 to 88 mg per day. Always consult a qualified clinician before starting any supplement.
Not for pregnancy. Interacts with anticoagulants at high doses.
We track 2 products containing Saffron. The top-ranked product scores 7.5 out of 10 on our composite scale, which evaluates dose, evidence, price, third-party testing, and transparency. See the comparison table above. Scores are editorial judgments, not a scientific standard.
Saffron has evidence grade B, meaning it is supported by human RCTs. Grade A means replicated human RCTs with hard endpoints. Grade B means human RCTs with biomarker outcomes. Grade C means mixed or small human trials. See our evidence grading methodology.
Evidence grades are reviewed when new human RCTs are published. Product counts update automatically as new products are added. Dose ranges reflect published trial data, not brand recommendations. Read how we verify.
Nootropics Depot