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Polyphenol / Sirtuin activator

Pterostilbene · Pterostilbene

Resveratrol's more bioavailable cousin, mostly used in blends.

D
Evidence grade
Mostly animal
Strongest study
Tier 1 · 1 linked study

Short answer

Reasonable stacking ingredient with NR; not a standalone longevity therapy.

Product and dose overview

Pterostilbene (Pterostilbene) is a polyphenol / sirtuin activator with evidence grade D, meaning it is primarily supported by animal studies. We track 9 products containing Pterostilbene. Typical doses range from 12 to 100 mg per serving. The top-ranked product scores 6.9 out of 10 on our composite scale (dose, evidence, price, testing, transparency). Prices range up to $258.00 per month.

Evidence grade: D Products in database: 9 Category: Polyphenol / Sirtuin activator

Top Pterostilbene products

ProductBrandDosePrice/mo3rd-party testedScore
Daily Ultimate EssentialsIM825 mg$129.00Yes6.9
BasisElysium Health50 mg$60.00Yes6.8
NOVOS CoreNOVOS Labs50 mg$89.00Yes6.3
Pterostilbene SupplementDouble Wood Supplements100 mg$19.95Yes5.9
SOD-NMN 3-in-1 Longevity BlendNutrield100 mg$258.00Yes5.7

Scores are editorial judgments, not a scientific standard. See how we score.

What it is

A close relative of resveratrol found in blueberries and Indian sandalwood. The chemical tweaks make it about 4× better absorbed than resveratrol.

Why people take it

Small human trials suggest cholesterol effects at high doses. Longevity data is animal-only. Often paired with NR in NAD+ formulas because of a putative synergy.

Our verdict

Reasonable stacking ingredient with NR; not a standalone longevity therapy.

Structure & class

3,5-dimethoxy-4'-hydroxy-trans-stilbene. Higher lipophilicity and bioavailability than resveratrol due to methoxy substitution.

Mechanism & clinical data

Bioavailability ~80% vs <1% for resveratrol. Riche et al. 2013 showed LDL increase at 250 mg/day, cautioning against high-dose monotherapy. Common in NR+PT stacks marketed for NAD+ support.

Pharmacokinetics

~105 min (2× longer than resveratrol).

Dose & forms

Trial dose
100 mg
/ day
Range in trials
50 to 250 mg
/ day
Common forms
Capsule, Combined with NR

What to watch out for

High-dose pterostilbene can raise LDL. Keep to <150 mg/day unless working with a clinician.

Where this dose comes from

The trial dose above is our editorial pick from the published human trials for this ingredient. We choose the dose that the best-available studies used on the endpoint most relevant to longevity. The range shows the lowest and highest doses tested in published trials. The landmark studies below are the papers we read to set it. You can click through and check our work.

When new trials publish, our automated sweeps flag them. If a new study materially changes the dose, we update it through editorial review and record the old dose, new dose, and the triggering study in every affected product's recommendation history. The dose is never changed automatically.

Regulatory status

EUFood supplement
USDietary supplement
UKFood supplement
CANHP

Timeline

Regulatory events, evidence grade changes, and key research milestones for Pterostilbene, most recent first. Studies link to the paper; regulatory entries name and link the responsible authority.

  • 2025-04 Regulatory single source
    EU Court sharpens the bar for botanical health claims
    A Court of Justice of the European Union ruling in April 2025 further tightened the requirements for how botanical ingredients (herbs, plant extracts) can be marketed with health claims in the EU, effectively removing much of the flexibility of the on-hold list.
  • 2024-06 Regulatory confirmed
    EU report identifies 117 supplement substances as potential health risks
    The HoA Working Group on Food Supplements (26 European countries) published its first report evaluating 117 substances used in food supplements. Of these, 65 were assessed as likely novel foods, 6 were already regulated, 34 had insufficient data, and 12 were prioritized for Article 8 restriction under Regulation (EC) No 1925/2006. The 12 priority substances include ashwagandha, curcumin, melatonin, piperine, St. John's wort, coumarin, p-synephrine, maca, holy basil, Melaleuca, black cohosh, and L-tryptophan. The report drew on 1,500 RASFF alerts reviewed between 2017 and mid-2022.
    Source →
  • 2013 Research milestone
    Riche et al. 2013
    12 weeks of 250 mg/day lowered blood pressure but raised LDL.
    Source →
  • 2006-12 Regulatory confirmed
    EU Health Claims Regulation adopted
    Regulation (EC) No 1924/2006 laid down harmonised rules for nutrition and health claims made on foods, including supplements. Only claims listed in the EU Register of authorised claims can be used. Rejected botanical claims are held in a separate on-hold list.
    Source →
  • 1997 Regulatory confirmed
    EU introduces the Novel Food Regulation
    Regulation (EC) No 258/97 required any food or food ingredient without a history of consumption in the EU before 15 May 1997 to be authorised before being placed on the market. This is the framework that captures NMN, spermidine as a supplement ingredient, urolithin A, and many other longevity actives.
    Source →
2026 evidence refresh

The only substantial human RCT of pterostilbene found it raised LDL cholesterol at both doses tested while lowering blood pressure, a mixed result marketers rarely mention.

Verified 2026-07-23. We update this section as new peer-reviewed trials land.

Human RCT base
2
peer-reviewed randomised trials
Largest single trial
n = 80
In adults with high cholesterol, pterostilbene monotherapy at 100 or 250 mg/day significantly increased LDL cholesterol versus placebo, while the 250 mg/day dose significantly reduced systolic and diastolic blood pressure. source

Best-supported claim

Pterostilbene's clearest human effect is on blood pressure, not cholesterol. Riche et al.'s randomized, double-blind, placebo-controlled trial in 80 adults with hypercholesterolemia found 250 mg/day of pterostilbene for 6-8 weeks significantly lowered systolic blood pressure by 7.8 mmHg and diastolic blood pressure by 7.3 mmHg versus placebo (https://pmc.ncbi.nlm.nih.gov/articles/PMC4099343/). The same trial's companion safety analysis found no adverse effects on liver, kidney, or glucose markers at doses up to 250 mg/day, establishing tolerability even though the efficacy picture was mixed (https://onlinelibrary.wiley.com/doi/10.1155/2013/463595).

Not supported by the evidence base

Pterostilbene is marketed as a more bioavailable, longevity-boosting cousin of resveratrol that improves cardiovascular and metabolic health, but the only sizable human RCT found pterostilbene monotherapy significantly increased LDL cholesterol by about 17 mg/dL, the opposite of what a heart-health supplement should do (https://pmc.ncbi.nlm.nih.gov/articles/PMC4099343/). Marketing also leans on animal data showing pterostilbene protects against diabetic cognitive impairment through gut-brain axis mechanisms and against Alzheimer's-related neurodegeneration, but this evidence comes largely from rodent models and cell studies, not human trials, and no published human cognitive RCT of pterostilbene exists as of 2026 (https://pubmed.ncbi.nlm.nih.gov/37037513/, https://pmc.ncbi.nlm.nih.gov/articles/PMC12032911/).

Typical dose

100-250 mg/day, the only doses tested in human RCTs

Safety

Pterostilbene was well tolerated up to 250 mg/day for 6-8 weeks in the only major human RCT, with no adverse drug reactions on liver, kidney, or glucose markers and no significant self-reported adverse events (https://onlinelibrary.wiley.com/doi/10.1155/2013/463595). The same trial found high-dose pterostilbene lowered HDL cholesterol by about 5 mg/dL in a subgroup not taking cholesterol medication, a potential downside for heart health. Because pterostilbene monotherapy raised LDL cholesterol in this trial, people with existing high cholesterol or cardiovascular risk should be cautious and discuss use with a physician before supplementing (https://pmc.ncbi.nlm.nih.gov/articles/PMC4099343/).

Interactions worth flagging

  • May have additive blood-pressure-lowering effects with antihypertensive medications
  • Could raise LDL cholesterol, relevant for people on statins or other lipid-lowering therapy who should monitor lipid panels

Three recent studies to know

  • Pterostilbene could alleviate diabetic cognitive impairment by suppressing TLR4/NF-κB pathway through microbiota-gut-brain axis
    Acta Pharmacologica Sinica 2023 · n = n/a

    In diabetic mice, pterostilbene improved cognitive dysfunction and reduced neuroinflammation via gut-brain axis mechanisms, but this has not been tested in human trials.

    Read study →
  • Pterostilbene: A natural neuroprotective stilbene with anti-Alzheimer's disease properties
    PMC-indexed pharmacology review 2024 · n = n/a

    Systematic review of preclinical studies finds pterostilbene shows neuroprotective and anti-Alzheimer's properties in animal and cell models, but human clinical trial data for neurological outcomes remain absent.

    Read study →
  • Unlocking the therapeutic potential of natural stilbene: Exploring pterostilbene as a powerful ally against aging and cognitive decline
    Ageing Research Reviews 2023 · n = n/a

    Review of pterostilbene's proposed anti-aging mechanisms notes the human evidence base is limited mainly to the single metabolic-parameters RCT from 2014.

    Read study →

Landmark studies

Found in these products (9)

All products in our catalog that contain Pterostilbene, ranked by our overall score. Ranking is editorial, never paid.

Longevity stack
Ingredients listed
8 ingredients listedlargest listed: Creatine 3,000 mg
Price per serving
$4.30$129.00 · 30 servings
Testing
3rd-party listed · no public lab certificate

Multi-ingredient bundle

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 6.9/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

50%
of trial dose
$17.20
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with im8health.com
Elysium Health
Basis
Longevity stack
Ingredients listed
2 ingredients listedlargest listed: NR 250 mg
Price per serving
$2.00$60.00 · 30 servings
Testing
3rd-party listed · no public lab certificate

Multi-ingredient bundle

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 6.8/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$2.40
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with www.elysiumhealth.com
NOVOS Labs
NOVOS Core
Longevity stack
Ingredients listed
12 ingredients listedlargest listed: Glycine 1,000 mg
Price per serving
$2.97$89.00 · 30 servings
Testing
3rd-party listed · no public lab certificate

Multi-ingredient bundle

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 6.3/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

50%
of trial dose
$14.83
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with novoslabs.com
Double Wood Supplements
Pterostilbene Supplement
Sirtuin activator
Active per serving
Pterostilbene 100 mgCapsule · 60 servings
Price per serving
$0.33$19.95 · 60 servings
Testing
3rd-party listed · public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 5.9/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$0.33
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with doublewoodsupplements.com
NAD+ booster
Precursor per serving
NMN 250 mg+ Pterostilbene 100 mg
Price per serving
$8.60$258.00 · 30 servings
Testing
3rd-party listed · no public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 5.7/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$17.20
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with www.nutrield.com
Sirtuin activator
Ingredients listed
3 ingredients listedlargest listed: Resveratrol 250 mg
Price per serving
$1.33$40.00 · 30 servings
Testing
3rd-party listed · public lab certificate

Multi-ingredient bundle

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 5.6/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$2.67
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with www.lifeextension.com
Longevity stack
Ingredients listed
7 ingredients listedlargest listed: Taurine 1,200 mg
Price per serving
$5.30$159.00 · 30 servings
Testing
3rd-party listed · no public lab certificate

Multi-ingredient bundle

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 5.4/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$5.30
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with drinktmrw.com
Autophagy
Ingredients listed
6 ingredients listedlargest listed: Probiotics 200 mg
Price per serving
$1.17$34.99 · 30 servings
Testing
3rd-party listed · no public lab certificate

CFU not stored

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 5.3/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

1%
of trial dose
$358.87
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with seed.com
Sirtuin activator
Active per serving
Pterostilbene 50 mgCapsule · 60 servings
Price per serving
$0.60$35.99 · 60 servings
Testing
None listed

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 4.7/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$1.20
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with jarrow.com
Editorial guides

Buying guides and comparisons

Neighbouring molecules

Related ingredients

See all in Polyphenol / Sirtuin activator →

Molecules in the same class, plus the actives most often formulated alongside Pterostilbene in our catalogue.

ResveratrolCsame categoryNMNBstacked together in 3 productsQuercetinBstacked together in 3 productsSpermidineCstacked together in 2 productsCoQ10Bstacked together in 2 productsMagnesiumAstacked together in 2 productsCa-AKGDstacked together in 2 productsCreatineAstacked together in 1 product
Product shelves
See all in Longevity stack (4)See all in Sirtuin activator (3)See all in NAD+ booster (1)See all in Autophagy (1)

See Pterostilbene in context: the mechanism it acts through, the biomarker it moves, the products that dose it, and the trials that tested it.

View Pterostilbene on the Longevity Map →

Frequently asked questions

What is Pterostilbene?

A close relative of resveratrol found in blueberries and Indian sandalwood. The chemical tweaks make it about 4× better absorbed than resveratrol.

What dose of Pterostilbene should I take?

The trial dose in published human studies is 100 mg per day, with a range of 50 to 250 mg per day. Always consult a qualified clinician before starting any supplement.

Is Pterostilbene safe?

High-dose pterostilbene can raise LDL. Keep to <150 mg/day unless working with a clinician.

What is the best Pterostilbene supplement?

We track 9 products containing Pterostilbene. The top-ranked product scores 6.9 out of 10 on our composite scale, which evaluates dose, evidence, price, third-party testing, and transparency. See the comparison table above. Scores are editorial judgments, not a scientific standard.

What is the evidence grade for Pterostilbene?

Pterostilbene has evidence grade D, meaning it is primarily supported by animal studies. Grade A means replicated human RCTs with hard endpoints. Grade B means human RCTs with biomarker outcomes. Grade C means mixed or small human trials. See our evidence grading methodology.

Independently checked

Data verification

Evidence grade
D
Mostly animal
Research dose
100 mg
Products tracked
9
Updated continuously
Safety signal
High-dose pterostilbene can raise LDL. Keep to <150 mg/da...

Evidence grades are reviewed when new human RCTs are published. Product counts update automatically as new products are added. Dose ranges reflect published trial data, not brand recommendations. Read how we verify.