Foundational

Omega-3 (EPA/DHA) · Omega-3 Fatty Acids (EPA + DHA)

Q: What dose of Omega-3 (EPA/DHA) should I take?

The trial dose in published human studies is 2000 mg per day, with a range of 1000 to 4000 mg per day. Always consult a qualified clinician before starting any supplement.

Q: Is Omega-3 (EPA/DHA) safe?

IOM has not set a formal UL; FDA advises supplement labels not to recommend more than 2 g/day EPA+DHA. Higher doses (≥1 g/day, more pronounced at 1.8-4 g/day) show a dose-dependent increase in atrial fibrillation risk in trials such as REDUCE-IT and STRENGTH.

Q: What is the best Omega-3 (EPA/DHA) supplement?

We track 42 products containing Omega-3 (EPA/DHA). The top-ranked product scores 9.3 out of 10 on our composite scale. See the comparison table above.

Q: What is the evidence grade for Omega-3 (EPA/DHA)?

Omega-3 (EPA/DHA) has evidence grade A, meaning it is well-supported by replicated human trials.

The single best-supported longevity supplement most people don't take enough of.

Evidence grade

Replicated human RCTs with hard endpoints

Short answer

If you can only pick one supplement for longevity, omega-3 is a strong candidate, especially if you don't eat fatty fish 2× a week.

Product and dose overview

Omega-3 (EPA/DHA) (Omega-3 Fatty Acids (EPA + DHA)) is a foundational with evidence grade A, meaning it is well-supported by replicated human trials. We track 42 products containing Omega-3 (EPA/DHA). Typical doses range from 950 to 2150 mg per serving. The top-ranked product scores 9.3 out of 10 on our composite scale (dose, evidence, price, testing, transparency). Prices range up to $55.99 per month.

Evidence grade: A Products in database: 42 Category: Foundational

Top Omega-3 (EPA/DHA) products

Product	Brand	Dose	Price/mo	3rd-party tested	Score
Triple Strength Omega-3 Fish Oil	Viva Naturals	2070 mg	$55.99	Yes	9.3
Omega-3 Fish Oil	Transparent Labs	1900 mg	$39.99	Yes	9.3
Lion Heart Pure Omega 3	Bare Biology	1730 mg	$40.00	Yes	9.3
Elite Omega-3 Gems	Carlson Labs	1400 mg	$42.42	Yes	9.3
Ultimate Omega	Nordic Naturals	1280 mg	$45.00	Yes	9.3

Scores are editorial judgments, not a scientific standard. See how we score.

What it is

Two specific fats found in oily fish (salmon, sardines, mackerel) and algae. Your body needs them but can't make them well from plant sources.

Why people take it

Meta-analyses of tens of thousands of participants show cardiovascular event reductions. The recent VITAL and REDUCE-IT trials clarified who benefits (people with high triglycerides, existing heart risk, or low omega-3 intake). Brain, eye, and inflammation benefits also well-documented.

Our verdict

If you can only pick one supplement for longevity, omega-3 is a strong candidate, especially if you don't eat fatty fish 2× a week.

Structure & class

EPA (eicosapentaenoic acid, 20:5 n-3) and DHA (docosahexaenoic acid, 22:6 n-3). Long-chain PUFAs.

Mechanism & clinical data

REDUCE-IT (2019) demonstrated 25% MACE reduction at 4 g EPA (icosapent ethyl) in high-risk patients. Meta-analyses confirm triglyceride and blood-pressure lowering. Omega-3 index target: 8 to 12%.

Pharmacokinetics

Days (incorporation into cell membranes).

Dose & forms

Trial dose

2000 mg

/ day

Range in trials

1000 to 4000 mg

/ day

Common forms

Triglyceride form (TG), Ethyl ester (EE), Phospholipid (krill), Algal (vegan)

What to watch out for

Ethyl ester (cheaper) absorbs worse than triglyceride form unless taken with fatty meal. Check third-party oxidation testing (TOTOX <10).

Safety limits and interactions

When a product exceeds the UL or contains an ingredient with clinically significant interactions, a "Review advised" flag appears on its product page and links here.

Known drug interactions

High doses (2-15 g/day) may increase bleeding time; caution with anticoagulants/antiplatelet drugs.

Safety note

IOM has not set a formal UL; FDA advises supplement labels not to recommend more than 2 g/day EPA+DHA. Higher doses (≥1 g/day, more pronounced at 1.8-4 g/day) show a dose-dependent increase in atrial fibrillation risk in trials such as REDUCE-IT and STRENGTH.

Source: https://ods.od.nih.gov/factsheets/Omega3FattyAcids-HealthProfessional/

Where this dose comes from

The trial dose above is our editorial pick from the published human trials for this ingredient. We choose the dose that the best-available studies used on the endpoint most relevant to longevity. The range shows the lowest and highest doses tested in published trials. The landmark studies below are the papers we read to set it. You can click through and check our work.

When new trials publish, our automated sweeps flag them. If a new study materially changes the dose, we update it through editorial review and record the old dose, new dose, and the triggering study in every affected product's recommendation history. The dose is never changed automatically.

Regulatory status

EUFood supplement, health claims authorised

USDietary supplement + Rx (Vascepa/Lovaza)

UKFood supplement

CANHP + Rx

Timeline

Regulatory events, evidence grade changes, and key research milestones for Omega-3 (EPA/DHA), most recent first. Studies link to the paper; regulatory entries name and link the responsible authority.

2026-09-03 Evidence grade

Evidence grade changed: B → B

Review queue item NCT07791797 (RDC Clinical, Aquacelle vs comparator, N=160, NOT_YET_RECRUITING, primary completion 2027-09) rejected for publication. Industry-sponsored PK absorption study of proprietary formulation, not an evidence-grade signal for omega-3.

Source →
2026 Research milestone

Abuknesha & Harris 2026 (Circ Arrhythm Electrophysiol)

Largest meta-analysis to date (35 RCTs, 114,592 participants). Omega-3 doses below 1,500 mg/day do not increase atrial fibrillation risk. Only prescription doses above 1,500 mg/day showed 0.8% absolute risk increase.

Source →
2026 Research milestone

Lok et al. 2026 PISCES Trial (NEJM)

Large international RCT in hemodialysis patients found fish oil supplementation reduced cardiovascular events by 43% compared to placebo.

Source →
2026 Research milestone

Norouzzadeh et al. 2026 (J Am Nutr Assoc)

Meta-analysis found omega-3 supplementation significantly improved vascular health biomarkers including flow-mediated dilation and arterial stiffness.

Source →
2025-04 Regulatory single source

EU Court sharpens the bar for botanical health claims

A Court of Justice of the European Union ruling in April 2025 further tightened the requirements for how botanical ingredients (herbs, plant extracts) can be marketed with health claims in the EU, effectively removing much of the flexibility of the on-hold list.
2024-06 Regulatory confirmed

EU report identifies 117 supplement substances as potential health risks

The HoA Working Group on Food Supplements (26 European countries) published its first report evaluating 117 substances used in food supplements. Of these, 65 were assessed as likely novel foods, 6 were already regulated, 34 had insufficient data, and 12 were prioritized for Article 8 restriction under Regulation (EC) No 1925/2006. The 12 priority substances include ashwagandha, curcumin, melatonin, piperine, St. John's wort, coumarin, p-synephrine, maca, holy basil, Melaleuca, black cohosh, and L-tryptophan. The report drew on 1,500 RASFF alerts reviewed between 2017 and mid-2022.

Source →
2023 Research milestone

Barbaresko et al. 2023 (cognitive review)

Review of RCTs found that 3.36 g/day EPA+DHA slowed cognitive aging by 2.5 years in cognitively healthy people with coronary artery disease, with more mixed results in general older populations.

Source →
2021 Research milestone

Khan et al. 2021 (38 RCTs meta-analysis)

A meta-analysis of 38 RCTs (149,051 participants) found omega-3 fatty acids reduced cardiovascular mortality, non-fatal MI, and major adverse cardiovascular events, with greater benefit from EPA monotherapy than EPA+DHA.

Source →
2021 Research milestone

Bernasconi et al. 2021 (Mayo Clin Proc)

Across 40 RCTs (135,267 participants), EPA/DHA supplementation reduced risk of myocardial infarction and coronary heart disease events in a dose-dependent manner.

Source →
2019-06 Regulatory confirmed

FDA adds qualified health claims for EPA/DHA and blood pressure

The FDA announced it would not object to qualified health claims stating that consuming EPA and DHA combined may reduce blood pressure and the risk of hypertension, a risk factor for coronary heart disease. The agency found some credible evidence but concluded it was inconsistent and inconclusive. Products bearing the claim must contain at least 0.8 g EPA+DHA per serving. The FDA also raised the safe upper intake limit from 3 g/day to 5 g/day for supplements using the claim.

Source →
2019 Research milestone

REDUCE-IT 2019 (NEJM)

In 8,179 statin-treated patients with elevated triglycerides, icosapent ethyl (EPA) reduced major cardiovascular events by 25% versus placebo over a median 4.9 years.

Source →
2019 Research milestone

VITAL Trial 2019 (N=25,871)

In 25,871 U.S. adults followed 5.3 years, daily marine omega-3 (1g) supplementation did not significantly reduce major cardiovascular events or total cancer incidence in the general population.

Source →
2012 Regulatory confirmed

EU authorises health claims for DHA and EPA

Regulation (EU) 432/2012 established a list of authorised health claims for DHA and EPA, including contributions to normal brain function (250 mg/day DHA), normal vision (250 mg/day DHA), normal heart function (250 mg/day EPA+DHA), maintenance of normal blood triglyceride levels (2 g/day EPA+DHA), and maintenance of normal blood pressure (3 g/day EPA+DHA). Products must contain at least 40 mg EPA+DHA per 100 g and per 100 kcal to bear the source claim.

Source →
2006-12 Regulatory confirmed

EU Health Claims Regulation adopted

Regulation (EC) No 1924/2006 laid down harmonised rules for nutrition and health claims made on foods, including supplements. Only claims listed in the EU Register of authorised claims can be used. Rejected botanical claims are held in a separate on-hold list.

Source →
2004 Regulatory confirmed

FDA allows first qualified health claim for EPA/DHA omega-3 and heart disease

The FDA permitted a qualified health claim stating that supportive but not conclusive research shows that consumption of EPA and DHA omega-3 fatty acids may reduce the risk of coronary heart disease. This was the first time the FDA allowed a heart-related claim for omega-3 supplements, though with qualifying language acknowledging the evidence was not definitive.

Source →
1997 Regulatory confirmed

EU introduces the Novel Food Regulation

Regulation (EC) No 258/97 required any food or food ingredient without a history of consumption in the EU before 15 May 1997 to be authorised before being placed on the market. This is the framework that captures NMN, spermidine as a supplement ingredient, urolithin A, and many other longevity actives.

Source →

Tolerability data

Reported adverse events

Consumer reports submitted to an official government adverse-event database. These reports mention this ingredient but do not prove it caused the reaction. Report volume reflects market penetration as much as inherent risk.

1,054

total reports

High report volume

Dyspnoea

103

Nausea

102

Diarrhoea

Choking

Vomiting

Hypersensitivity

Dizziness

Pruritus

Data source

Retrieved from the FDA Adverse Event Reporting System (CAERS) via the openFDA API. Verified 2026-08-06. Reports are voluntary consumer submissions and mandatory serious-event filings. They establish surveillance, not causality.

2026 evidence refresh

Omega-3 fish oil (EPA and DHA) lowers triglycerides and modestly cuts cardiovascular events, with effects varying sharply by formulation and dose.

Verified 2026-07-19. We update this section as new peer-reviewed trials land.

Human RCT base

80+

peer-reviewed randomised trials

Largest single trial

n = 25871

VITAL trial found no significant reduction in the primary composite cardiovascular endpoint, but did find a reduced risk of myocardial infarction as a secondary endpoint, especially among participants with low fish intake. source

Best-supported claim

The strongest human evidence is for cardiovascular risk reduction, but it depends heavily on formulation. REDUCE-IT, using 4 g/day of purified EPA (icosapent ethyl), cut the composite cardiovascular endpoint by 25% (https://www.sciencedirect.com/science/article/abs/pii/S0025619619304112). A 2021 meta-analysis of 13 RCTs and 127,477 participants found marine omega-3 significantly reduced myocardial infarction, coronary heart disease death, total CHD, CVD death, and total CVD, with effects strengthened once REDUCE-IT was included (https://www.ahajournals.org/doi/10.1161/JAHA.119.013543). A separate 2021 meta-analysis of 38 RCTs and 149,051 participants found EPA-only therapy produced a larger cardiovascular mortality reduction (RR 0.82) than EPA plus DHA combinations (RR 0.94), suggesting EPA alone may be the more potent cardioprotective form (https://pmc.ncbi.nlm.nih.gov/articles/PMC8413259/).

Not supported by the evidence base

Marketers sell omega-3 broadly as a general life-extension and all-cause mortality supplement, but the highest-quality evidence does not support this. The 2018 Cochrane review, the most rigorous synthesis available, pooled 79 RCTs and 112,059 participants and found little or no effect of long-chain omega-3 on all-cause mortality (RR 0.98) or cardiovascular mortality, rated as high-quality evidence (https://pubmed.ncbi.nlm.nih.gov/30019766/). A 2022 dose-related meta-analysis of 19 RCTs and 97,709 participants likewise found no statistically significant reduction in all-cause, cardiac, or stroke mortality at any studied dose (https://www.sciencedirect.com/science/article/abs/pii/S0261561422000735). For brain health, DHA supplementation shows benefit only in mild cognitive impairment, not in diagnosed Alzheimer's disease, per a review of RCT evidence (https://pubmed.ncbi.nlm.nih.gov/36637075/).

Typical dose

1 to 4 g/day combined EPA/DHA, with higher doses (2-4 g/day, EPA-predominant) used for triglyceride and cardiovascular-event reduction

Safety

Omega-3 supplements are generally well tolerated at typical doses. The main documented risk is bleeding and, at high doses of purified EPA, atrial fibrillation. The 2021 meta-analysis of 38 RCTs found increased AF risk with omega-3 supplementation, a known tradeoff against its cardiovascular mortality benefit (https://pmc.ncbi.nlm.nih.gov/articles/PMC8413259/). Fishy aftertaste and mild GI upset are common with lower-quality formulations. Choose products tested for oxidation and heavy metals.

Interactions worth flagging

blood thinners
antiplatelet drugs
blood pressure medications

Three recent studies to know

Marine Omega-3 Supplementation and Cardiovascular Disease: An Updated Meta-Analysis of 13 Randomized Controlled Trials Involving 127,477 Participants

Journal of the American Heart Association 2021

Read study →
Effect of omega-3 fatty acids on cardiovascular outcomes: A systematic review and meta-analysis

PMC (peer-reviewed cardiovascular journal) 2021

Read study →
Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease

Cochrane Database of Systematic Reviews 2018

Read study →

Landmark studies

REDUCE-IT 2019 (NEJM)

In 8,179 statin-treated patients with elevated triglycerides, icosapent ethyl (EPA) reduced major cardiovascular events by 25% versus placebo over a median 4.9 years.
Read study →
VITAL Trial 2019 (N=25,871)

In 25,871 U.S. adults followed 5.3 years, daily marine omega-3 (1g) supplementation did not significantly reduce major cardiovascular events or total cancer incidence in the general population.
Read study →
Khan et al. 2021 (38 RCTs meta-analysis)

A meta-analysis of 38 RCTs (149,051 participants) found omega-3 fatty acids reduced cardiovascular mortality, non-fatal MI, and major adverse cardiovascular events, with greater benefit from EPA monotherapy than EPA+DHA.
Read study →
Bernasconi et al. 2021 (Mayo Clin Proc)

Across 40 RCTs (135,267 participants), EPA/DHA supplementation reduced risk of myocardial infarction and coronary heart disease events in a dose-dependent manner.
Read study →
Barbaresko et al. 2023 (cognitive review)

Review of RCTs found that 3.36 g/day EPA+DHA slowed cognitive aging by 2.5 years in cognitively healthy people with coronary artery disease, with more mixed results in general older populations.
Read study →
Abuknesha & Harris 2026 (Circ Arrhythm Electrophysiol)

Largest meta-analysis to date (35 RCTs, 114,592 participants). Omega-3 doses below 1,500 mg/day do not increase atrial fibrillation risk. Only prescription doses above 1,500 mg/day showed 0.8% absolute risk increase.
Read study →
Lok et al. 2026 PISCES Trial (NEJM)

Large international RCT in hemodialysis patients found fish oil supplementation reduced cardiovascular events by 43% compared to placebo.
Read study →
Norouzzadeh et al. 2026 (J Am Nutr Assoc)

Meta-analysis found omega-3 supplementation significantly improved vascular health biomarkers including flow-mediated dilation and arterial stiffness.
Read study →

Found in these products (42)

All products in our catalog that contain Omega-3 (EPA/DHA), ranked by our overall score. Ranking is editorial, never paid.

Viva Naturals

Triple Strength Omega-3 Fish Oil

Omega

EPA and DHA per serving: EPA 1,500 mg · DHA 570 mgSoftgel · 45 servings
Price per serving: $1.24$55.99 · 45 servings
Testing: 3rd-party listed · public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 9.3/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%

of trial dose

$1.20

per research-dose day, not label serving

0Trial dose2×

Catalog price · Confirm current price with vivanaturals.com

Transparent Labs

Omega-3 Fish Oil

Omega

Omega-3 as listed: 1,900 mgEPA/DHA split not stored
Price per serving: $0.89$39.99 · 45 servings
Testing: 3rd-party listed · public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 9.3/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%

of trial dose

$0.94

per research-dose day, not label serving

0Trial dose2×

Catalog price · Confirm current price with www.transparentlabs.com

Bare Biology

Lion Heart Pure Omega 3

Omega

Omega-3 as listed: 1,730 mgEPA/DHA split not stored
Price per serving: $1.33$40.00 · 30 servings
Testing: 3rd-party listed · public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 9.3/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%

of trial dose

$1.54

per research-dose day, not label serving

0Trial dose2×

Catalog price · Confirm current price with www.barebiology.com

Carlson Labs

Elite Omega-3 Gems

Omega

EPA and DHA per serving: EPA 800 mg · DHA 600 mgSoftgel · 45 servings
Price per serving: $0.94$42.42 · 45 servings
Testing: 3rd-party listed · public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 9.3/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%

of trial dose

$1.35

per research-dose day, not label serving

0Trial dose2×

Catalog price · Confirm current price with www.carlsonlabs.com

Nordic Naturals

Ultimate Omega

Omega

EPA and DHA per serving: EPA 650 mg · DHA 450 mgSoftgel · 60 servings
Price per serving: $0.75$45.00 · 60 servings
Testing: 3rd-party listed · public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 9.3/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%

of trial dose

$1.17

per research-dose day, not label serving

0Trial dose2×

Catalog price · Confirm current price with www.nordicnaturals.com

WHC (UnoCardio)

UnoCardio 1000 + Vitamin D

Omega

Omega-3 as listed: 1,110 mgEPA/DHA split not stored
Price per serving: $0.83$49.95 · 60 servings
Testing: 3rd-party listed · public lab certificate

Undisclosed amounts noted

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 9.3/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%

of trial dose

$1.50

per research-dose day, not label serving

0Trial dose2×

Catalog price · Confirm current price with www.amazon.com

OmegaVia

Ultra Concentrated Omega-3

Omega

Omega-3 as listed: 1,105 mgEPA/DHA split not stored
Price per serving: $0.67$39.99 · 60 servings
Testing: 3rd-party listed · public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 9.3/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%

of trial dose

$1.21

per research-dose day, not label serving

0Trial dose2×

Catalog price · Confirm current price with omegavia.com

Sports Research

Triple Strength Omega-3 Fish Oil

Omega

EPA and DHA per serving: EPA 690 mg · DHA 260 mgSoftgel · 90 servings
Price per serving: $0.31$27.95 · 90 servings
Testing: 3rd-party listed · public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 9.3/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

95%

of trial dose

$0.65

per research-dose day, not label serving

0Trial dose2×

Catalog price · Confirm current price with www.sportsresearch.com

Puori

O3 Ultra Pure Fish Oil

Omega

EPA and DHA per serving: EPA 1,250 mg · DHA 500 mgSoftgel · 40 servings
Price per serving: $1.43$57.00 · 40 servings
Testing: 3rd-party listed · public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 9.2/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%

of trial dose

$1.63

per research-dose day, not label serving

0Trial dose2×

Catalog price · Confirm current price with puori.com

Nordic Naturals

Ultimate Omega-D3 2X

Omega

EPA and DHA per serving: EPA 1,125 mg · DHA 875 mgSoftgel · 30 servings
Price per serving: $1.86$55.95 · 30 servings
Testing: 3rd-party listed · public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 9.1/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%

of trial dose

$1.73

per research-dose day, not label serving

0Trial dose2×

Catalog price · Confirm current price with www.nordic.com

Nordic Naturals

Focus Support (formerly Omega Focus)

Cognition

Active per serving: Omega-3 (EPA/DHA) 1,280 mgSoftgel · 30 servings
Price per serving: $1.73$51.95 · 30 servings
Testing: 3rd-party listed · public lab certificate

EPA/DHA split not stored

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 9.0/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%

of trial dose

$2.71

per research-dose day, not label serving

0Trial dose2×

Catalog price · Confirm current price with www.nordic.com

Nordic Naturals

Ultimate Omega 2X

Omega

EPA and DHA per serving: EPA 1,125 mg · DHA 875 mgSoftgel · 30 servings
Price per serving: $1.77$52.95 · 30 servings
Testing: 3rd-party listed · public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 9.0/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%

of trial dose

$3.14

per research-dose day, not label serving

0Trial dose2×

Catalog price · Confirm current price with www.nordic.com

Wiley's Finest

Peak EPA

Omega

Omega-3 as listed: 1,000 mgEPA/DHA split not stored
Price per serving: $0.50$29.99 · 60 servings
Testing: 3rd-party listed · no public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 8.9/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%

of trial dose

$1.00

per research-dose day, not label serving

0Trial dose2×

Catalog price · Confirm current price with wileysfinest.com

Designs for Health

OmegAvail Hi-Po

Omega

EPA and DHA per serving: EPA 800 mg · DHA 800 mgSoftgel · 30 servings
Price per serving: $1.45$43.49 · 30 servings
Testing: 3rd-party listed · no public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 8.8/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%

of trial dose

$1.81

per research-dose day, not label serving

0Trial dose2×

Catalog price · Confirm current price with www.designsforhealth.com

Dr. Tobias

Omega 3 Fish Oil Triple Strength

Omega

Omega-3 as listed: 1,400 mgEPA/DHA split not stored
Price per serving: $0.31$27.95 · 90 servings
Testing: 3rd-party listed · no public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 8.8/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%

of trial dose

$0.44

per research-dose day, not label serving

0Trial dose2×

Catalog price · Confirm current price with drtobias.com

Carlson Labs

The Very Finest Fish Oil (Liquid)

Omega

Omega-3 as listed: 1,300 mgEPA/DHA split not stored
Price per serving: $0.47$46.75 · 100 servings
Testing: 3rd-party listed · public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 8.8/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%

of trial dose

$0.72

per research-dose day, not label serving

0Trial dose2×

Catalog price · Confirm current price with www.carlsonlabs.com

AG1 (Athletic Greens)

AG Omega3

Omega

Omega-3 as listed: 1,125 mgEPA/DHA split not stored
Price per serving: $1.30$39.00 · 30 servings
Testing: 3rd-party listed · no public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 8.8/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%

of trial dose

$2.31

per research-dose day, not label serving

0Trial dose2×

Catalog price · Confirm current price with drinkag1.com

Pure Encapsulations

O.N.E. Omega

Omega

Omega-3 as listed: 1,000 mgEPA/DHA split not stored
Price per serving: $1.52$45.50 · 30 servings
Testing: 3rd-party listed · no public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 8.7/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%

of trial dose

$3.03

per research-dose day, not label serving

0Trial dose2×

Catalog price · Confirm current price with www.pureencapsulations.com

Metagenics

OmegaGenics Fish Oil EPA-DHA 1000

Omega

EPA and DHA per serving: EPA 710 mg · DHA 290 mgSoftgel · 60 servings
Price per serving: $0.83$49.75 · 60 servings
Testing: 3rd-party listed · no public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 8.7/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%

of trial dose

$1.66

per research-dose day, not label serving

0Trial dose2×

Catalog price · Confirm current price with www.metagenics.com

Nordic Naturals

Ultimate Omega +CoQ10

Omega

EPA and DHA per serving: EPA 650 mg · DHA 450 mgSoftgel · 30 servings
Price per serving: $1.36$40.95 · 30 servings
Testing: 3rd-party listed · public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 8.5/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%

of trial dose

$2.13

per research-dose day, not label serving

0Trial dose2×

Catalog price · Confirm current price with www.nordic.com

Life Extension

Super Omega-3 EPA/DHA Fish Oil, Sesame Lignans & Olive Extract

Omega

EPA and DHA per serving: EPA 700 mg · DHA 500 mgSoftgel · 60 servings
Price per serving: $0.50$30.00 · 60 servings
Testing: 3rd-party listed · public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 8.5/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

70%

of trial dose

$1.43

per research-dose day, not label serving

0Trial dose2×

Catalog price · Confirm current price with www.lifeextension.com

Garden of Life

Oceans 3 Beyond Omega-3

Omega

Omega-3 as listed: 1,125 mgEPA/DHA split not stored
Price per serving: $1.48$29.59 · 20 servings
Testing: 3rd-party listed · no public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 8.3/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%

of trial dose

$2.63

per research-dose day, not label serving

0Trial dose2×

Catalog price · Confirm current price with www.gardenoflife.com

NOW Foods

Ultra Omega-3 Fish Oil

Omega

Omega-3 as listed: 750 mgEPA/DHA split not stored
Price per serving: $0.10$18.00 · 180 servings
Testing: 3rd-party listed · public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 8.3/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

75%

of trial dose

$0.27

per research-dose day, not label serving

0Trial dose2×

Catalog price · Confirm current price with www.nowfoods.com

Performance Lab

Omega-3

Omega

Omega-3 as listed: 810 mgEPA/DHA split not stored
Price per serving: $1.47$44.10 · 30 servings
Testing: 3rd-party listed · no public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 8.1/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

81%

of trial dose

$3.63

per research-dose day, not label serving

0Trial dose2×

Catalog price · Confirm current price with www.performancelab.com

Nordic Naturals

Algae Omega

Omega

EPA and DHA per serving: EPA 195 mg · DHA 390 mgSoftgel · 30 servings
Price per serving: $1.15$34.49 · 30 servings
Testing: 3rd-party listed · public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 8.1/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

72%

of trial dose

$3.22

per research-dose day, not label serving

0Trial dose2×

Catalog price · Confirm current price with www.nordic.com

DoNotAge

Pure Omega 3

Omega

EPA and DHA per serving: EPA 800 mg · DHA 600 mgSoftgel · 30 servings
Price per serving: $1.10$33.00 · 30 servings
Testing: 3rd-party listed · no public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 8.0/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

80%

of trial dose

$2.75

per research-dose day, not label serving

0Trial dose2×

Catalog price · Confirm current price with donotage.org

Vegetology

Opti3 Omega-3 EPA & DHA

Omega

Omega-3 as listed: 800 mgEPA/DHA split not stored
Price per serving: $0.83$24.95 · 30 servings
Testing: 3rd-party listed · public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 7.8/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

80%

of trial dose

$2.08

per research-dose day, not label serving

0Trial dose2×

Catalog price · Confirm current price with www.vegetology.com

Nordic Naturals

Memory Support (formerly Omega Memory)

Cognition

Active per serving: Omega-3 (EPA/DHA) 1,000 mg+ Curcumin 400 mg
Price per serving: $1.93$57.95 · 30 servings
Testing: 3rd-party listed · public lab certificate

EPA/DHA split not stored

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 7.7/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%

of trial dose

$3.86

per research-dose day, not label serving

0Trial dose2×

Catalog price · Confirm current price with www.nordic.com

Rosita

Extra Virgin Cod Liver Oil (Liquid)

Omega

Omega-3 as listed: 1,210 mgEPA/DHA split not stored
Price per serving: $1.60$47.99 · 30 servings
Testing: 3rd-party listed · no public lab certificate

Multi-ingredient bundle

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 7.6/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%

of trial dose

$2.64

per research-dose day, not label serving

0Trial dose2×

Catalog price · Confirm current price with www.rositausa.com

Elysium Health

Matter

Cognition

Ingredients listed: 4 ingredients listedlargest listed: Omega-3 (EPA/DHA) 550 mg
Price per serving: $1.33$40.00 · 30 servings
Testing: 3rd-party listed · no public lab certificate

EPA/DHA split not stored

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 7.6/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%

of trial dose

$1.33

per research-dose day, not label serving

0Trial dose2×

Catalog price · Confirm current price with www.elysiumhealth.com

Nordic Naturals

Ultimate Omega + Curcumin

Antioxidant

Ingredients listed: 3 ingredients listedlargest listed: Omega-3 (EPA/DHA) 1,200 mg
Price per serving: $1.73$51.95 · 30 servings
Testing: 3rd-party listed · public lab certificate

EPA/DHA split not stored

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 7.4/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%

of trial dose

$2.89

per research-dose day, not label serving

0Trial dose2×

Catalog price · Confirm current price with www.nordic.com

Nordic Naturals

Complete Omega

Omega

EPA and DHA per serving: EPA 610 mg · DHA 405 mgSoftgel · 30 servings
Price per serving: $1.73$51.95 · 30 servings
Testing: 3rd-party listed · public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 7.4/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

56%

of trial dose

$6.13

per research-dose day, not label serving

0Trial dose2×

Catalog price · Confirm current price with www.nordic.com

AG1 (Athletic Greens)

AG Omega3 + CoQ10

Omega

Omega-3 as listed: 650 mgEPA/DHA split not stored
Price per serving: $1.30$39.00 · 30 servings
Testing: 3rd-party listed · no public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 7.3/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

65%

of trial dose

$4.00

per research-dose day, not label serving

0Trial dose2×

Catalog price · Confirm current price with drinkag1.com

Nootropics Depot

Omega-3 Fish Oil Triple Strength Softgels

Omega

Omega-3 as listed: 325 mgEPA/DHA split not stored
Price per serving: $0.42$24.99 · 60 servings
Testing: 3rd-party listed · public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 7.0/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

32%

of trial dose

$2.56

per research-dose day, not label serving

0Trial dose2×

Catalog price · Confirm current price with nootropicsdepot.com

Thorne HealthTech

Super EPA

Omega

Omega-3 as listed: 425 mgEPA/DHA split not stored
Price per serving: $0.50$45.00 · 90 servings
Testing: 3rd-party listed · no public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 6.9/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

42%

of trial dose

$2.35

per research-dose day, not label serving

0Trial dose2×

Catalog price · Confirm current price with www.thorne.com

Jarrow Formulas

Jarrow Formulas Fish Oil EPA-DHA Balance

Omega

EPA and DHA per serving: EPA 800 mg · DHA 400 mgSoftgel · 60 servings
Price per serving: $1.02$61.33 · 60 servings
Testing: None listed

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 6.8/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

60%

of trial dose

$3.41

per research-dose day, not label serving

0Trial dose2×

Catalog price · Confirm current price with jarrow.com

Testa Omega-3

Omega-3 Algae Oil DHA & EPA

Omega

Omega-3 as listed: 450 mgEPA/DHA split not stored
Price per serving: $0.53$32.00 · 60 servings
Testing: 3rd-party listed · no public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 6.8/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

45%

of trial dose

$2.37

per research-dose day, not label serving

0Trial dose2×

Catalog price · Confirm current price with testa-omega3.com

Ovega-3

Ovega-3 500mg Plant-Based Omega-3

Omega

Omega-3 as listed: 370 mgEPA/DHA split not stored
Price per serving: $0.77$22.97 · 30 servings
Testing: 3rd-party listed · no public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 6.4/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

37%

of trial dose

$4.14

per research-dose day, not label serving

0Trial dose2×

Catalog price · Confirm current price with ovega.com

ID Formulas

Advanced ID

Longevity stack

Ingredients listed: 10 ingredients listedlargest listed: Collagen Peptides 5 g
Price per serving: $9.00$270.00 · 30 servings
Testing: None listed

EPA/DHA split not stored

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 6.1/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%

of trial dose

$18.00

per research-dose day, not label serving

0Trial dose2×

Catalog price · Confirm current price with www.idformulas.com

Kori Krill

Kori Krill Oil Antarctic

Omega

Omega-3 as listed: 250 mgEPA/DHA split not stored
Price per serving: $0.67$19.98 · 30 servings
Testing: 3rd-party listed · no public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 5.9/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

25%

of trial dose

$5.33

per research-dose day, not label serving

0Trial dose2×

Catalog price · Confirm current price with www.amazon.com

Freshfield

Vegan Omega 3 DHA + DPA

Omega

Omega-3 as listed: 260 mgEPA/DHA split not stored
Price per serving: $0.43$25.99 · 60 servings
Testing: 3rd-party listed · no public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 5.6/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

26%

of trial dose

$3.33

per research-dose day, not label serving

0Trial dose2×

Catalog price · Confirm current price with freshfield.life

MegaRed

MegaRed 350mg Omega-3 Krill Oil

Omega

Omega-3 as listed: 74 mgEPA/DHA split not stored
Price per serving: $0.35$44.99 · 130 servings
Testing: None listed

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 5.4/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

of trial dose

$9.35

per research-dose day, not label serving

0Trial dose2×

Catalog price · Confirm current price with www.schiffvitamins.com

Editorial guides

Buying guides and comparisons

Best Omega-3 Supplements 2026 Omega-3 EPA/DHA Ratio Guide Gum Disease and Epigenetic Age Omega-3 Evidence Review

Neighbouring molecules

Related ingredients

See all in Foundational →

Molecules in the same class, plus the actives most often formulated alongside Omega-3 (EPA/DHA) in our catalogue.

Vitamin D3 Asame categoryVitamin K2 Bsame categoryMagnesium Asame categoryVitamin B12 Asame categoryFolate (5-MTHF)Bsame categoryZinc Asame categorySelenium Asame categoryVitamin C Asame category

Product shelves

See all in Omega (37)See all in Cognition (3)See all in Antioxidant (1)See all in Longevity stack (1)

See Omega-3 (EPA/DHA) in context: the mechanism it acts through, the biomarker it moves, the products that dose it, and the trials that tested it.

View Omega-3 (EPA/DHA) on the Longevity Map →

Frequently asked questions

What is Omega-3 (EPA/DHA)?

Two specific fats found in oily fish (salmon, sardines, mackerel) and algae. Your body needs them but can't make them well from plant sources.

What dose of Omega-3 (EPA/DHA) should I take?

The trial dose in published human studies is 2000 mg per day, with a range of 1000 to 4000 mg per day. Always consult a qualified clinician before starting any supplement.

Is Omega-3 (EPA/DHA) safe?

What is the best Omega-3 (EPA/DHA) supplement?

We track 42 products containing Omega-3 (EPA/DHA). The top-ranked product scores 9.3 out of 10 on our composite scale, which evaluates dose, evidence, price, third-party testing, and transparency. See the comparison table above. Scores are editorial judgments, not a scientific standard.

What is the evidence grade for Omega-3 (EPA/DHA)?

Omega-3 (EPA/DHA) has evidence grade A, meaning it is well-supported by replicated human trials. Grade A means replicated human RCTs with hard endpoints. Grade B means human RCTs with biomarker outcomes. Grade C means mixed or small human trials. See our evidence grading methodology.

Interactions

2 documented interactions.

View interactions for Omega-3 (EPA/DHA) →

Independently checked

Data verification

Evidence grade

Replicated human RCTs with hard endpoints

Research dose

2000 mg

Products tracked

Updated continuously

Safety signal

IOM has not set a formal UL; FDA advises supplement label...

Evidence grades are reviewed when new human RCTs are published. Product counts update automatically as new products are added. Dose ranges reflect published trial data, not brand recommendations. Read how we verify.