Bone mineral, but excess supplementation may harm arteries.
Get from diet. If supplementing, pair with K2 and stay <500 mg per dose.
Calcium (Calcium (citrate/carbonate)) is a foundational with evidence grade B, meaning it is supported by human RCTs. We track 4 products containing Calcium. Typical doses range from 125 to 400 mg per serving. The top-ranked product scores 6.8 out of 10 on our composite scale (dose, evidence, price, testing, transparency). Prices range up to $72.00 per month.
| Product | Brand | Dose | Price/mo | 3rd-party tested | Score |
|---|---|---|---|---|---|
| Ca-AKG (Calcium Alpha-Ketoglutarate) | DoNotAge | 400 mg | $49.00 | Yes | 6.8 |
| Advanced Nutrients | Thorne HealthTech | 125 mg | $72.00 | Yes | 6.8 |
| Vital Proteins Bioactive Collagen Complex Bone & Joint Support | Vital Proteins | 250 mg | $59.00 | Yes | 6.6 |
| Calcium AKG 1500 | Toniiq | 200 mg | $24.97 | Yes | 5.7 |
Scores are editorial judgments, not a scientific standard. See how we score.
Bone mineral. Best from diet (dairy, greens); supplements a fallback.
Correcting deficiency prevents osteoporosis; high-dose supplements linked to cardiovascular risk.
Get from diet. If supplementing, pair with K2 and stay <500 mg per dose.
Divalent cation; citrate more soluble than carbonate.
Bolland 2010 meta-analysis raised concerns about CV risk.
Slow bone turnover.
Pair with vitamin K2 and D3.
The trial dose above is our editorial pick from the published human trials for this ingredient. We choose the dose that the best-available studies used on the endpoint most relevant to longevity. The range shows the lowest and highest doses tested in published trials. The landmark studies below are the papers we read to set it. You can click through and check our work.
When new trials publish, our automated sweeps flag them. If a new study materially changes the dose, we update it through editorial review and record the old dose, new dose, and the triggering study in every affected product's recommendation history. The dose is never changed automatically.
Regulatory events, evidence grade changes, and key research milestones for Calcium, most recent first. Studies link to the paper; regulatory entries name and link the responsible authority.
A retrospective analysis of 42 individuals taking a Ca-AKG-based formulation for an average of 7 months found an average 8-year reduction in DNA methylation age.
Read study →This registered 120-person, double-blind, placebo-controlled RCT protocol tests whether 6 months of 1g/day sustained-release Ca-AKG reduces DNA methylation age in adults with accelerated biological aging (NCT05706389).
Read study →In a cross-sectional cohort of 4,260 health enthusiasts, a delayed-release calcium-alpha-ketoglutarate plus vitamin supplement was associated with a 1.8-year lower biological age residual, an effect not seen with regular (non-delayed-release) AKG.
Read study →This ongoing randomized, double-blind, placebo-controlled trial is evaluating whether 12 weeks of Ca-AKG supplementation changes PhenoAge biological age and other aging biomarkers in adults aged 40-75.
Read study →All products in our catalog that contain Calcium, ranked by our overall score. Ranking is editorial, never paid.
DoNotAgeStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Thorne HealthTechMulti-ingredient bundle
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Elemental vs compound: check label
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
ToniiqElemental vs compound: check label
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Molecules in the same class, plus the actives most often formulated alongside Calcium in our catalogue.
See Calcium in context: the mechanism it acts through, the biomarker it moves, the products that dose it, and the trials that tested it.
View Calcium on the Longevity Map →Bone mineral. Best from diet (dairy, greens); supplements a fallback.
The trial dose in published human studies is 500 mg per day, with a range of 500 to 1200 mg per day. Always consult a qualified clinician before starting any supplement.
Pair with vitamin K2 and D3.
We track 4 products containing Calcium. The top-ranked product scores 6.8 out of 10 on our composite scale, which evaluates dose, evidence, price, third-party testing, and transparency. See the comparison table above. Scores are editorial judgments, not a scientific standard.
Calcium has evidence grade B, meaning it is supported by human RCTs. Grade A means replicated human RCTs with hard endpoints. Grade B means human RCTs with biomarker outcomes. Grade C means mixed or small human trials. See our evidence grading methodology.
Evidence grades are reviewed when new human RCTs are published. Product counts update automatically as new products are added. Dose ranges reflect published trial data, not brand recommendations. Read how we verify.
Vital Proteins