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Adaptogen

Rhodiola Rosea · Rhodiola rosea

Adaptogen for fatigue and mild stress.

C
Evidence grade
Mixed / small human trials

Short answer

Reasonable adaptogen; standardise for rosavins and salidrosides.

Product and dose overview

Rhodiola Rosea (Rhodiola rosea) is a adaptogen with evidence grade C, meaning it is backed by mixed or small human trials. We track 2 products containing Rhodiola Rosea. Typical doses range from 200 to 250 mg per serving. The top-ranked product scores 6.3 out of 10 on our composite scale (dose, evidence, price, testing, transparency). Prices range up to $89.00 per month.

Evidence grade: C Products in database: 2 Category: Adaptogen

Top Rhodiola Rosea products

ProductBrandDosePrice/mo3rd-party testedScore
NOVOS CoreNOVOS Labs250 mg$89.00Yes6.3
Doctor's Best NMN+Doctor's Best200 mg$39.34No5.5

Scores are editorial judgments, not a scientific standard. See how we score.

What it is

An Arctic plant used to fight fatigue in stressful conditions.

Why people take it

Trials show reduced burnout and improved cognitive function in fatigued populations.

Our verdict

Reasonable adaptogen; standardise for rosavins and salidrosides.

Structure & class

Standardised to 3% rosavins / 1% salidroside.

Mechanism & clinical data

Multiple stress/fatigue trials with modest but reproducible effects.

Pharmacokinetics

Multi-hour.

Dose & forms

Trial dose
400 mg
/ day
Range in trials
200 to 600 mg
/ day
Common forms
Standardised extract

What to watch out for

Can be stimulating; take earlier in day.

Safety limits and interactions

When a product exceeds the UL or contains an ingredient with clinically significant interactions, a "Review advised" flag appears on its product page and links here.

Known drug interactions
Theoretical pharmacodynamic interactions with serotonergic drugs, MAOIs, stimulants, anticoagulants, and antihypertensives; may affect CYP-metabolized medications — clinical caution advised with polypharmacy.
Safety note
No formal UL. Rhodiola has a very low toxicity in animal studies (rat LD50 ≈23.4 g/kg equivalent to ~235 g in a 70 kg person) and is considered safe at typical clinical doses (200-680 mg/day); using more than 600 mg in one day is generally discouraged as unsafe/ineffective, and long-term use beyond 12 weeks is not well studied.

Source: https://examine.com/supplements/rhodiola-rosea/

Where this dose comes from

The trial dose above is our editorial pick from the published human trials for this ingredient. We choose the dose that the best-available studies used on the endpoint most relevant to longevity. The range shows the lowest and highest doses tested in published trials. The landmark studies below are the papers we read to set it. You can click through and check our work.

When new trials publish, our automated sweeps flag them. If a new study materially changes the dose, we update it through editorial review and record the old dose, new dose, and the triggering study in every affected product's recommendation history. The dose is never changed automatically.

Regulatory status

EUFood supplement
USDietary supplement
UKFood supplement
CANHP

Timeline

Regulatory events, evidence grade changes, and key research milestones for Rhodiola Rosea, most recent first. Studies link to the paper; regulatory entries name and link the responsible authority.

  • 2025-04 Regulatory single source
    EU Court sharpens the bar for botanical health claims
    A Court of Justice of the European Union ruling in April 2025 further tightened the requirements for how botanical ingredients (herbs, plant extracts) can be marketed with health claims in the EU, effectively removing much of the flexibility of the on-hold list.
  • 2024-06 Regulatory confirmed
    EU report identifies 117 supplement substances as potential health risks
    The HoA Working Group on Food Supplements (26 European countries) published its first report evaluating 117 substances used in food supplements. Of these, 65 were assessed as likely novel foods, 6 were already regulated, 34 had insufficient data, and 12 were prioritized for Article 8 restriction under Regulation (EC) No 1925/2006. The 12 priority substances include ashwagandha, curcumin, melatonin, piperine, St. John's wort, coumarin, p-synephrine, maca, holy basil, Melaleuca, black cohosh, and L-tryptophan. The report drew on 1,500 RASFF alerts reviewed between 2017 and mid-2022.
    Source →
  • 2006-12 Regulatory confirmed
    EU Health Claims Regulation adopted
    Regulation (EC) No 1924/2006 laid down harmonised rules for nutrition and health claims made on foods, including supplements. Only claims listed in the EU Register of authorised claims can be used. Rejected botanical claims are held in a separate on-hold list.
    Source →
  • 1997 Regulatory confirmed
    EU introduces the Novel Food Regulation
    Regulation (EC) No 258/97 required any food or food ingredient without a history of consumption in the EU before 15 May 1997 to be authorised before being placed on the market. This is the framework that captures NMN, spermidine as a supplement ingredient, urolithin A, and many other longevity actives.
    Source →

Landmark studies

Found in these products (2)

All products in our catalog that contain Rhodiola Rosea, ranked by our overall score. Ranking is editorial, never paid.

NOVOS Labs
NOVOS Core
Longevity stack
Ingredients listed
12 ingredients listedlargest listed: Glycine 1,000 mg
Price per serving
$2.97$89.00 · 30 servings
Testing
3rd-party listed · no public lab certificate

Multi-ingredient bundle

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 6.3/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

50%
of trial dose
$14.83
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with novoslabs.com
Doctor's Best
Doctor's Best NMN+
NAD+ booster
Ingredients listed
4 ingredients listedlargest listed: NMN 400 mg
Price per serving
$1.31$39.34 · 30 servings
Testing
None listed

Multi-ingredient bundle

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 5.5/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$1.64
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with www.doctorsbest.com
Editorial guides

Buying guides and comparisons

Neighbouring molecules

Related ingredients

See all in Adaptogen →

Molecules in the same class, plus the actives most often formulated alongside Rhodiola Rosea in our catalogue.

AshwagandhaBsame categoryAdaptogen blendDsame categoryVitamin CAstacked together in 1 productLithium (microdose)Dstacked together in 1 productFisetinCstacked together in 1 productPterostilbeneDstacked together in 1 productGlucosamineCstacked together in 1 productL-TheanineBstacked together in 1 product
Product shelves
See all in Longevity stack (1)See all in NAD+ booster (1)

See Rhodiola Rosea in context: the mechanism it acts through, the biomarker it moves, the products that dose it, and the trials that tested it.

View Rhodiola Rosea on the Longevity Map →

Frequently asked questions

What is Rhodiola Rosea?

An Arctic plant used to fight fatigue in stressful conditions.

What dose of Rhodiola Rosea should I take?

The trial dose in published human studies is 400 mg per day, with a range of 200 to 600 mg per day. Always consult a qualified clinician before starting any supplement.

Is Rhodiola Rosea safe?

No formal UL. Rhodiola has a very low toxicity in animal studies (rat LD50 ≈23.4 g/kg equivalent to ~235 g in a 70 kg person) and is considered safe at typical clinical doses (200-680 mg/day); using more than 600 mg in one day is generally discouraged as unsafe/ineffective, and long-term use beyond 12 weeks is not well studied.

What is the best Rhodiola Rosea supplement?

We track 2 products containing Rhodiola Rosea. The top-ranked product scores 6.3 out of 10 on our composite scale, which evaluates dose, evidence, price, third-party testing, and transparency. See the comparison table above. Scores are editorial judgments, not a scientific standard.

What is the evidence grade for Rhodiola Rosea?

Rhodiola Rosea has evidence grade C, meaning it is backed by mixed or small human trials. Grade A means replicated human RCTs with hard endpoints. Grade B means human RCTs with biomarker outcomes. Grade C means mixed or small human trials. See our evidence grading methodology.

Independently checked

Data verification

Evidence grade
C
Mixed / small human trials
Research dose
400 mg
Products tracked
2
Updated continuously
Safety signal
No formal UL. Rhodiola has a very low toxicity in animal ...

Evidence grades are reviewed when new human RCTs are published. Product counts update automatically as new products are added. Dose ranges reflect published trial data, not brand recommendations. Read how we verify.