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Longevity antioxidant

Hydroxytyrosol · 3,4-Dihydroxyphenylethanol (Hydroxytyrosol)

A potent olive polyphenol with strong in vitro antioxidant activity; human outcome data still limited.

C
Evidence grade
Mixed / small human trials

Short answer

Mechanistically credible and backed by EFSA for LDL protection. Dosing is uncertain; most supplements provide 5 to 30 mg/day, which is above the EFSA claim threshold.

Product and dose overview

Hydroxytyrosol (3,4-Dihydroxyphenylethanol (Hydroxytyrosol)) is a longevity antioxidant with evidence grade C, meaning it is backed by mixed or small human trials. We track 2 products containing Hydroxytyrosol. Typical doses range from 20 to 30 mg per serving. The top-ranked product scores 7.0 out of 10 on our composite scale (dose, evidence, price, testing, transparency). Prices range up to $189.00 per month.

Evidence grade: C Products in database: 2 Category: Longevity antioxidant

Top Hydroxytyrosol products

ProductBrandDosePrice/mo3rd-party testedScore
Youngr NMNWonderfeel20 mg$88.00Yes7.0
ReleaseStemregen30 mg$189.00Yes5.8

Scores are editorial judgments, not a scientific standard. See how we score.

What it is

Hydroxytyrosol is the main antioxidant in olive oil. It is one of the most powerful free-radical scavengers known by ORAC value. European Food Safety Authority approved a health claim for olive polyphenols protecting LDL cholesterol from oxidative damage at 5 mg/day.

Why people take it

In vitro and animal studies show anti-inflammatory, cardioprotective, and neuroprotective effects. Small human trials show improved lipid profiles and reduced oxidative stress markers. No large outcome trials on longevity endpoints yet.

Our verdict

Mechanistically credible and backed by EFSA for LDL protection. Dosing is uncertain; most supplements provide 5 to 30 mg/day, which is above the EFSA claim threshold.

Structure & class

3,4-Dihydroxyphenylethanol, a phenylethanoid. Derived from oleuropein hydrolysis in olive (Olea europaea) fruit and leaves. Direct radical scavenging via two catechol hydroxyl groups.

Mechanism & clinical data

EFSA Panel on Dietetic Products (2011) approved a health claim for olive polyphenols and LDL protection at 5 mg hydroxytyrosol/day. Multiple small RCTs (n=10 to 50) show reduced oxidized LDL, improved endothelial function, and lower inflammatory markers.

Pharmacokinetics

Rapid; plasma half-life under 1 hour. Metabolites detectable for several hours.

Dose & forms

Trial dose
10 mg
/ day
Range in trials
5 to 50 mg
/ day
Common forms
Capsule (olive fruit extract), Liquid (olive leaf extract)

What to watch out for

Many olive leaf supplements contain mostly oleuropein, not hydroxytyrosol itself. Check the label for hydroxytyrosol content specifically.

Where this dose comes from

The trial dose above is our editorial pick from the published human trials for this ingredient. We choose the dose that the best-available studies used on the endpoint most relevant to longevity. The range shows the lowest and highest doses tested in published trials. The landmark studies below are the papers we read to set it. You can click through and check our work.

When new trials publish, our automated sweeps flag them. If a new study materially changes the dose, we update it through editorial review and record the old dose, new dose, and the triggering study in every affected product's recommendation history. The dose is never changed automatically.

Regulatory status

EUAuthorized (olive polyphenol health claim)
USDietary supplement
UKFood supplement
CANHP

Timeline

Regulatory events, evidence grade changes, and key research milestones for Hydroxytyrosol, most recent first. Studies link to the paper; regulatory entries name and link the responsible authority.

  • 2025-04 Regulatory single source
    EU Court sharpens the bar for botanical health claims
    A Court of Justice of the European Union ruling in April 2025 further tightened the requirements for how botanical ingredients (herbs, plant extracts) can be marketed with health claims in the EU, effectively removing much of the flexibility of the on-hold list.
  • 2024-06 Regulatory confirmed
    EU report identifies 117 supplement substances as potential health risks
    The HoA Working Group on Food Supplements (26 European countries) published its first report evaluating 117 substances used in food supplements. Of these, 65 were assessed as likely novel foods, 6 were already regulated, 34 had insufficient data, and 12 were prioritized for Article 8 restriction under Regulation (EC) No 1925/2006. The 12 priority substances include ashwagandha, curcumin, melatonin, piperine, St. John's wort, coumarin, p-synephrine, maca, holy basil, Melaleuca, black cohosh, and L-tryptophan. The report drew on 1,500 RASFF alerts reviewed between 2017 and mid-2022.
    Source →
  • 2017 Research milestone
    Lopez-Huertas 2017 (Nutrition)
    RCT (n=30): hydroxytyrosol-enriched olive oil reduced oxidized LDL by 10 to 15% in healthy adults over 3 weeks.
    Source →
  • 2011 Research milestone
    EFSA 2011
    EFSA approved health claim: olive polyphenols contribute to protection of blood lipids from oxidative stress at 5 mg hydroxytyrosol/day.
    Source →
  • 2006-12 Regulatory confirmed
    EU Health Claims Regulation adopted
    Regulation (EC) No 1924/2006 laid down harmonised rules for nutrition and health claims made on foods, including supplements. Only claims listed in the EU Register of authorised claims can be used. Rejected botanical claims are held in a separate on-hold list.
    Source →
  • 1997 Regulatory confirmed
    EU introduces the Novel Food Regulation
    Regulation (EC) No 258/97 required any food or food ingredient without a history of consumption in the EU before 15 May 1997 to be authorised before being placed on the market. This is the framework that captures NMN, spermidine as a supplement ingredient, urolithin A, and many other longevity actives.
    Source →

Landmark studies

Found in these products (2)

All products in our catalog that contain Hydroxytyrosol, ranked by our overall score. Ranking is editorial, never paid.

Wonderfeel
Youngr NMN
NAD+ booster
Ingredients listed
5 ingredients listedlargest listed: NMN 900 mg
Price per serving
$2.93$88.00 · 30 servings
Testing
3rd-party listed · no public lab certificate

Multi-ingredient bundle

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 7.0/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$1.63
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with getwonderfeel.com
Stemregen
Release
Longevity stack
Ingredients listed
1 ingredients listedlargest listed: Hydroxytyrosol 30 mg
Price per serving
$6.30$189.00 · 30 servings
Testing
3rd-party listed · no public lab certificate

Multi-ingredient bundle

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 5.8/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$2.10
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with www.stemregen.co
Editorial guides

Buying guides and comparisons

Neighbouring molecules

Related ingredients

See all in Longevity antioxidant →

Molecules in the same class, plus the actives most often formulated alongside Hydroxytyrosol in our catalogue.

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Product shelves
See all in NAD+ booster (1)See all in Longevity stack (1)

See Hydroxytyrosol in context: the mechanism it acts through, the biomarker it moves, the products that dose it, and the trials that tested it.

View Hydroxytyrosol on the Longevity Map →

Frequently asked questions

What is Hydroxytyrosol?

Hydroxytyrosol is the main antioxidant in olive oil. It is one of the most powerful free-radical scavengers known by ORAC value. European Food Safety Authority approved a health claim for olive polyphenols protecting LDL cholesterol from oxidative damage at 5 mg/day.

What dose of Hydroxytyrosol should I take?

The trial dose in published human studies is 10 mg per day, with a range of 5 to 50 mg per day. Always consult a qualified clinician before starting any supplement.

Is Hydroxytyrosol safe?

Many olive leaf supplements contain mostly oleuropein, not hydroxytyrosol itself. Check the label for hydroxytyrosol content specifically.

What is the best Hydroxytyrosol supplement?

We track 2 products containing Hydroxytyrosol. The top-ranked product scores 7.0 out of 10 on our composite scale, which evaluates dose, evidence, price, third-party testing, and transparency. See the comparison table above. Scores are editorial judgments, not a scientific standard.

What is the evidence grade for Hydroxytyrosol?

Hydroxytyrosol has evidence grade C, meaning it is backed by mixed or small human trials. Grade A means replicated human RCTs with hard endpoints. Grade B means human RCTs with biomarker outcomes. Grade C means mixed or small human trials. See our evidence grading methodology.

Independently checked

Data verification

Evidence grade
C
Mixed / small human trials
Research dose
10 mg
Products tracked
2
Updated continuously
Safety signal
Many olive leaf supplements contain mostly oleuropein, no...

Evidence grades are reviewed when new human RCTs are published. Product counts update automatically as new products are added. Dose ranges reflect published trial data, not brand recommendations. Read how we verify.