1 tablet/day slowed cognitive aging by ~0.07 SD over 3 years in older adults (COSMOS).
Cheapest evidence-backed play for adults 60+: the exact trial product costs about $2/month. Benefit is small and memory-led. A 12-year trial in 5,947 male physicians found nothing, so effects may not generalize to all adults.
Multivitamin-Mineral (Daily multivitamin-mineral supplement (adults 50+)) is a cognitive / foundational with evidence grade B, meaning it is supported by human RCTs. We track 1 products containing Multivitamin-Mineral. The top-ranked product scores 5.4 out of 10 on our composite scale (dose, evidence, price, testing, transparency). Prices range up to $10.12 per month.
| Product | Brand | Dose | Price/mo | 3rd-party tested | Score |
|---|---|---|---|---|---|
| Centrum Silver Adults 50+ | Centrum (Haleon) | See label | $10.12 | No | 5.4 |
Scores are editorial judgments, not a scientific standard. See how we score.
A standard one-a-day multivitamin for adults 50+. The COSMOS cognition trials used Centrum Silver, not a megadose premium multi.
COSMOS-Mind (N=2,262, mean age 73, 3 years) improved global cognition by 0.07 SD (p=0.007). A pooled analysis of 5,203 participants across three COSMOS substudies confirmed the effect on global cognition (+0.07 SD) and episodic memory (+0.06 SD).
Cheapest evidence-backed play for adults 60+: the exact trial product costs about $2/month. Benefit is small and memory-led. A 12-year trial in 5,947 male physicians found nothing, so effects may not generalize to all adults.
Broad-spectrum micronutrient tablet correcting multiple marginal insufficiencies affecting neuronal energy metabolism, methylation, antioxidant defense and vascular function.
Replicated small benefit in three prespecified COSMOS cognitive substudies (PMID 36102337, 37244291, 38244989). PHS II (N=5,947, ~12 years) was null (PMID 24490265). No dementia-prevention claim is supported.
Not applicable; daily nutritional repletion.
Do not stack multiple products containing vitamin A or iron. Vitamin K can alter warfarin control. Iron-free versions suit most older adults. Megadose multis are not trial-equivalent.
The trial dose above is our editorial pick from the published human trials for this ingredient. We choose the dose that the best-available studies used on the endpoint most relevant to longevity. The range shows the lowest and highest doses tested in published trials. The landmark studies below are the papers we read to set it. You can click through and check our work.
When new trials publish, our automated sweeps flag them. If a new study materially changes the dose, we update it through editorial review and record the old dose, new dose, and the triggering study in every affected product's recommendation history. The dose is never changed automatically.
Regulatory events, evidence grade changes, and key research milestones for Multivitamin-Mineral, most recent first. Studies link to the paper; regulatory entries name and link the responsible authority.
N=2,262 adults (mean 73), 3 years: daily multivitamin improved global cognition 0.07 SD (p=0.007); simultaneously randomized cocoa extract arm null.
Read study →N=3,562, 3 years: multivitamin (Centrum Silver) improved the prespecified 1-year immediate-recall endpoint (p=0.025).
Read study →5,203 non-overlapping participants across three COSMOS cognitive studies: global cognition +0.07 SD, episodic memory +0.06 SD.
Read study →N=5,947 male physicians, ~12 years of Centrum Silver: no cognitive benefit (global composite -0.01 SD).
Read study →All products in our catalog that contain Multivitamin-Mineral, ranked by our overall score. Ranking is editorial, never paid.
Centrum (Haleon)Some amounts not listed
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Molecules in the same class, plus the actives most often formulated alongside Multivitamin-Mineral in our catalogue.
Nothing else in the database sits close enough to this molecule to list.
See Multivitamin-Mineral in context: the mechanism it acts through, the biomarker it moves, the products that dose it, and the trials that tested it.
View Multivitamin-Mineral on the Longevity Map →A standard one-a-day multivitamin for adults 50+. The COSMOS cognition trials used Centrum Silver, not a megadose premium multi.
The trial dose in published human studies is None mg per day, with a range of None to None mg per day. Always consult a qualified clinician before starting any supplement.
Do not stack multiple products containing vitamin A or iron. Vitamin K can alter warfarin control. Iron-free versions suit most older adults. Megadose multis are not trial-equivalent.
We track 1 products containing Multivitamin-Mineral. The top-ranked product scores 5.4 out of 10 on our composite scale, which evaluates dose, evidence, price, third-party testing, and transparency. See the comparison table above. Scores are editorial judgments, not a scientific standard.
Multivitamin-Mineral has evidence grade B, meaning it is supported by human RCTs. Grade A means replicated human RCTs with hard endpoints. Grade B means human RCTs with biomarker outcomes. Grade C means mixed or small human trials. See our evidence grading methodology.
Evidence grades are reviewed when new human RCTs are published. Product counts update automatically as new products are added. Dose ranges reflect published trial data, not brand recommendations. Read how we verify.