The central cellular energy molecule that declines with age. Direct supplementation aims to bypass precursor conversion.
Liposomal delivery may improve absorption compared to plain oral NAD+. Human clinical evidence for direct NAD+ supplementation is limited compared to NMN and NR precursors.
NAD+ (Nicotinamide Adenine Dinucleotide) is a nad+ booster with evidence grade C, meaning it is backed by mixed or small human trials. We track 1 products containing NAD+. Typical doses range from 500 to 500 mg per serving. The top-ranked product scores 5.2 out of 10 on our composite scale (dose, evidence, price, testing, transparency). Prices range up to $49.99 per month.
| Product | Brand | Dose | Price/mo | 3rd-party tested | Score |
|---|---|---|---|---|---|
| Unlimit Liposomal NAD+ | Solaray | 500 mg | $49.99 | No | 5.2 |
Scores are editorial judgments, not a scientific standard. See how we score.
NAD+ is a molecule every cell needs for energy production and DNA repair. Levels drop as you age. Some supplements contain NAD+ directly rather than precursors like NMN or NR.
Direct NAD+ supplementation, especially liposomal forms, aims to deliver the active molecule without needing conversion. Whether oral NAD+ survives digestion and reaches cells is debated.
Liposomal delivery may improve absorption compared to plain oral NAD+. Human clinical evidence for direct NAD+ supplementation is limited compared to NMN and NR precursors.
Nicotinamide Adenine Dinucleotide (NAD+). Oxidized form of the redox pair NAD+/NADH. Substrate for sirtuins, PARPs, and CD38.
Liposomal formulations claim to protect NAD+ through the digestive tract. Limited human pharmacokinetic data. Precursor supplementation (NMN, NR) has stronger evidence for raising blood NAD+ levels.
Short intracellular half-life; NAD+ is continuously recycled via salvage pathway.
Oral NAD+ is largely degraded in the gut. Liposomal forms may improve bioavailability but human head-to-head data vs. precursors is lacking.
The trial dose above is our editorial pick from the published human trials for this ingredient. We choose the dose that the best-available studies used on the endpoint most relevant to longevity. The range shows the lowest and highest doses tested in published trials. The landmark studies below are the papers we read to set it. You can click through and check our work.
When new trials publish, our automated sweeps flag them. If a new study materially changes the dose, we update it through editorial review and record the old dose, new dose, and the triggering study in every affected product's recommendation history. The dose is never changed automatically.
Regulatory events, evidence grade changes, and key research milestones for NAD+, most recent first. Studies link to the paper; regulatory entries name and link the responsible authority.
All products in our catalog that contain NAD+, ranked by our overall score. Ranking is editorial, never paid.
SolarayStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Molecules in the same class, plus the actives most often formulated alongside NAD+ in our catalogue.
Nothing else in the database sits close enough to this molecule to list.
See NAD+ in context: the mechanism it acts through, the biomarker it moves, the products that dose it, and the trials that tested it.
View NAD+ on the Longevity Map →NAD+ is a molecule every cell needs for energy production and DNA repair. Levels drop as you age. Some supplements contain NAD+ directly rather than precursors like NMN or NR.
The trial dose in published human studies is 500 mg per day, with a range of 250 to 1000 mg per day. Always consult a qualified clinician before starting any supplement.
Oral NAD+ is largely degraded in the gut. Liposomal forms may improve bioavailability but human head-to-head data vs. precursors is lacking.
We track 1 products containing NAD+. The top-ranked product scores 5.2 out of 10 on our composite scale, which evaluates dose, evidence, price, third-party testing, and transparency. See the comparison table above. Scores are editorial judgments, not a scientific standard.
NAD+ has evidence grade C, meaning it is backed by mixed or small human trials. Grade A means replicated human RCTs with hard endpoints. Grade B means human RCTs with biomarker outcomes. Grade C means mixed or small human trials. See our evidence grading methodology.
Evidence grades are reviewed when new human RCTs are published. Product counts update automatically as new products are added. Dose ranges reflect published trial data, not brand recommendations. Read how we verify.