NIH DSLD registered label
Serving size1 Capsule(s)
Servings per container30
Supplement Facts panel, verbatim
Pyrroloquinoline Quinone20 mg
Layer 1 · Decision
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PQQ 20 mg
Label snapshot
What the label says
What the product contains and what one serving costs, according to our catalog. Label amounts are not personal dose recommendations.
- Active per serving
- PQQ 20 mg
- Form
- Capsule
- List price (catalog, USD)
- $35.00
- Price per serving
- $1.17List price divided by servings per container. A per-day cost only if the label serving is once daily.
Full label record: servings, testing, ingredients
- Servings per container
- 30
- Serving size (label)
- 0.02 g
- Catalog monthly estimate
- $35.00
- Testing disclosure
- Brand lists third-party testing; no public lab certificate listedStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Ingredients as listed
| Ingredient | Amount per serving |
|---|---|
| PQQ | 20 mg |
What to check on the label
- Which form of the compound the label names (for CoQ10: ubiquinol or ubiquinone) and whether the milligrams refer to that form.
- Softgel oil carriers are listed under 'other ingredients'. They are not part of the active amount.
- Branded ingredients (Mitopure, BioPQQ and similar) should be named on the label if the brand claims them.
Amounts are per label serving as recorded in the catalog and are not a recommendation. Testing status reflects what the brand lists. Nothing here is medical advice.
Editorial score and research-dose calculations
These calculations describe our scoring method. They are not a recommended dose or proof of benefit from this product.
Watch out
Tier 4
Ingredient RCT (different dose)
The ingredient was tested in an RCT but at a different dose, or only in animals.
See the 1 supporting study
- Nakano et al. 2012 (PQQ)8 weeks of 20 mg/day improved fatigue and quality-of-life scores in adults. Studied at 20 mg. This product: 20 mg.
How we scored this product Show the full breakdown
Dose vs. studies (50%)
Why 5.4 of 10. Primary ingredient is PQQ (evidence grade C). It delivers 20 mg, inside the studied range of 10–40 mg. Read the rule →
5.4
Transparency (20%)
Why 7.5 of 10. Earned points for independent third-party testing and all doses disclosed. Lost points for no public certificate of analysis. Read the rule →
7.5
Value (10%)
Why 8.5 of 10. One day at the trial dose costs about $1.17. That is cheaper than average (128 of 313 by cost per effective day). Read the rule →
8.5
Formulation (10%)
Why 5.0 of 10. No published absorption advantage or disadvantage on file. The default of 5 is not a criticism. Read the rule →
5.0
Default. No absorption data on file.
Safety (5%)
Why 7.0 of 10. Baseline 5.0. Third-party testing adds 2.0. Public lab certificate adds 1.5. NSF, USP or Informed Choice certification adds 1.5. Active safety signal subtracts 3.0. Read the rule →
7.0
Community sentiment (5%)
Why 7.0 of 10. Sentiment across 12 external review source(s) is mixed to positive. Community is a signal about daily use, not proof of effect. Read the rule →
7.0
Composite
How this 6.2 is built. 0.50 × 5.4 + 0.20 × 7.5 + 0.10 × 8.5 + 0.10 × 5.0 + 0.05 × 7.0 + 0.05 × 7.0 = 6.2 out of 10. Safety caps applied after.
6.2
6.2
composite
Dose vs. studies50%5.4
Transparency20%7.5
Value10%8.5
Formulation10%5.0
Safety5%7.0
Community5%7.0
Evidence gates dose: the evidence grade sets the ceiling, and the dose decides how much of that ceiling the product reaches. Value = inverse of price-per-trial-dose-day. Community = mean sentiment of external reviews. Safety caps applied after weighting.
This score is our editorial judgment, not a scientific standard. We combine published evidence, dose, price, transparency, and consumer signals into one composite: this is our method, not a peer-reviewed clinical rating. A higher score means a product does better on the factors we weight, not that it is medically proven to work.
Editorial verdict
Quick verdict
6.2
/ 10
Best for
Full trial dose
Avoid if
No public lab certificate
Full-dose status
Meets trial dose
Price/month
$35
COA status
Not public
Biggest caveat
Dose-evidence score of 5.4 is below average for the site.
Nearest alternatives
Catalog snapshot. Check linked sources for current price, label and batch-specific testing.
Price verification
Current price: $35.00
Last price check: Sep 01, 2026
Layer 2 · Context
Our summary
Jarrow Formulas PQQ 20 mg is a straightforward single-ingredient capsule using Mitsubishi Gas Chemical's branded BioPQQ raw material at exactly the dose (20 mg/day) most commonly used in the published PQQ human literature and at the EU's authorized novel-food maximum. The brand's mitochondrial-biogenesis marketing is grounded in a real, well-cited 2010 mouse-cell mechanism paper, but that mechanism has not been directly confirmed in humans; the actual human evidence consists of a handful of small (n=17-64), short (8-12 week), heavily Japan- and industry-affiliated trials, several with genuine double-blind placebo-controlled design showing modest cognitive-test improvements, alongside the classic Nakano 2012 study (small, open-label, no placebo). This lands PQQ 20 mg as a Tier 4 product on our scale, a real ingredient-level RCT exists at a matching or near-matching dose (Shiojima 2022, Tamakoshi 2023), which is stronger than pure mechanistic/animal evidence, but the trials are small, short, and not independently replicated outside industry-connected research groups, so buyers should not read 'clinically studied' as 'proven', especially for the heart-health and broad longevity framing Jarrow's category implies but does not specifically test. On brand quality, Jarrow's 2020 sale to New Mountain Capital and 2022 merger into Vytalogy Wellness has not visibly eroded its historically strong QA reputation on the metric that matters most, independent lab testing, where ConsumerLab continues to pass the large majority of tested Jarrow products, including this exact PQQ SKU being selected for testing.
In plain language
Why this scored this way
This Jarrow Formulas PQQ 20 mg scores 6.2, making it below the site average. It delivers 20mg of PQQ, inside the studied range of 10–40mg with grade C evidence (mostly preclinical, limited human data).
What drives the score up
- Tested by independent lab (transparency 7.5).
What drags it down
- Dose-evidence score of 5.4 is below average for the site.
- No public lab certificate available for independent verification.
Why you'd choose it
- You want a reasonably priced mitochondrial product.
- You want a tested by independent lab product.
Why you might skip it
- You want a product with a publicly available CoA.
- You want better value (this is $1.17/day with a value score of 8.5).
- You want a higher-scoring product (this scores 6.2).
Question 1
Does the molecule work?
Question 1
Does the molecule work?
The science behind each active ingredient, independent of which brand sells it.
Promising cofactor for mitochondrial biogenesis; human evidence remains thin.
Question 2
Is this bottle good?
Question 2
Is this bottle good?
The specific product: dose, price, transparency, and what buyers report.
Dose vs research
100% of trial dose
Meets or exceeds the published effective dose
Cost at trial dose
$1.17/day at trial dose
What one effective daily dose actually costs
Transparency
7.5/10 · No public lab certificate
Independent batch testing confirmed
Consumer signals
No consumer signals collected yet
Operational signal only, never used as clinical evidence
Question 3
What's the catch?
Question 3
What's the catch?
Safety flags, transparency gaps, dosing concerns, and recurring buyer complaints.
No public lab certificate
Certificate of Analysis not published
Without a public lab certificate, batch purity and potency cannot be independently verified.
Plain English
What’s inside
The main ingredients of this product, in plain language.
PQQ20 mgEvidence C
Promising cofactor for mitochondrial biogenesis; human evidence remains thin.
Read about PQQ →Layer 3 · Evidence vault
Product data & verification
Hard numbers and independently checked status. Expand each block for its source.
The numbers
Price
$35
per bottle · 30 servings
Dose vs. research
of trial dose 100%
of published effective dose
$ / day at studied dose
$1.17
what one effective daily dose costs
$ / g active
$58.33
per gram of active substance
Independently checked
Data verification
COA status
Not public
Evidence grade
C
Per-ingredient breakdown
CPQQ
All product data is checked against original sources. Prices, doses, and testing status are updated when product pages change. Evidence grades are reviewed when new human RCTs are published. Read how we verify.
What's inside
Ingredient
Dose in this product
Trial dose
Evidence
20 mg 100% of trial dose
20 mg
Medium confidence
Source diversity: 77%
AmazonExamine.comTrustpilot
Last checked: 2026-08-20
Consumer signals
Consumer signals gathered from 4 platforms.
Low confidence, small sampleConsumer sentiment compiled from 1 public source (Examine.com). Small sample size, treat as directional only.
mixed sentiment
Themes
PQQ human evidence limited; a few small trials on cognitive markers.
Compiled from an Examine.com listing located during manual research; not independently re-verified against the live page at build time.
6 reviews · 3.0/5
Same brand profile on Trustpilot country sites: Canada 4.0.
These are consumer sentiment signals. They do not measure whether the product actually works. See our evidence section for that.
Independent external anchors
Public sources on this same product, unrelated to NO1GEVITY. NIH DSLD is the US government's registered label database (shown verbatim). SuppCo.com is a separate, unaffiliated commercial site with no partnership or data-sharing arrangement with us. NO1GEVITY scores are computed independently of both.
What others say, with a source hierarchy
We treat external opinion very differently depending on where it comes from. Tier A is our strongest signal. Tier C is background sentiment only. Tier Rejected is what we excluded, listed openly so you can see what we discarded.
These reviews are aggregated from third-party sources, not written by NO1GEVITY. Each entry shows its source, retrieval date, and whether the source has an affiliate or paid relationship. We do not edit reviews to change their meaning. Disclosure policy.
Tier A
Independent deep reviews, lab tests, certificates of analysis
Our strongest external evidence. Long-form independent reviews, physical-product lab work, and third-party certifications.
ConsumerLab.com
No affiliate relationship
Not a paid placement
ConsumerLab ran real independent HPLC potency and heavy-metal testing on named PQQ products including Jarrow's, but the pass/fail result specific to Jarrow's product sits behind ConsumerLab's paid membership wall and could not be confirmed in this research pass.
Finding: 5 of 7 independently tested PQQ supplements met their label-claimed PQQ content by HPLC; 2 provided less than labeled; none of the 7 were contaminated with lead, cadmium, or arsenic. 'Jarrow Formulas PQQ 20 mg' is named as one of the 7 products ConsumerLab tested in this review round.
How we use it: Used as our strongest available third-party quality-testing evidence for this exact product, a genuine independent lab test exists, but we disclose we could not confirm the specific pass/fail outcome for Jarrow's SKU.
ConsumerLab.com, Jarrow Formulas brand page
No affiliate relationship
Not a paid placement
Across ConsumerLab's broader testing history, Jarrow Formulas passes independent quality testing at a high rate (7 of 8 products, 87.5%), a positive brand-level signal even though it doesn't confirm this specific PQQ product's individual result.
Finding: 8 Jarrow Formulas products tested by ConsumerLab overall; 7 of 8 Approved for quality, 1 of those 7 named a Top Pick.
How we use it: Used as brand-level context for Jarrow's historical QA track record with an independent lab, supporting the view that Jarrow's post-acquisition quality control has generally held up on measurable label-accuracy testing.
European Food Safety Authority (EFSA), Novel Food Scientific Opinion
No affiliate relationship
Not a paid placement
A government regulatory body (not a product reviewer) concluded BioPQQ is safe for healthy adults at up to 20 mg/day, but explicitly noted limited human ADME data and excluded pregnant/lactating women from the safety finding.
Finding: NOAEL of 100 mg/kg bw/day in a 90-day rat toxicity study; margin of exposure of 344x at the proposed 20 mg/day human dose; minimum purity of 99.0% specified for BioPQQ.
How we use it: Used as authoritative, non-commercial confirmation of PQQ's safety profile at the exact dose Jarrow sells, this is a safety finding, not an efficacy finding, and we do not use it to support any efficacy claim.
Healthline (nutrition team), PQQ Supplements: Overview, Benefits, and Side Effects
Has affiliate relationship
Not a paid placement
Finding: No specific product tested; editorial conclusion: 'there's limited evidence that the supplemental form provides any meaningful health benefits' and 'not enough strong evidence is available to warrant taking PQQ.'
How we use it: Used as an independent editorial synthesis of the ingredient-level evidence gap; Healthline's nutrition-desk content discloses methodology and is not a hidden-affiliate teardown, though the site does carry affiliate links elsewhere, so we disclose that relationship even though this specific article reads as evidence-led rather than sales-led.
Tier B
Registered dietitians and physicians, without affiliate ties
Credentialed commentary from clinicians who disclose no paid relationship. Useful as supporting critique but not a substitute for a clinical outcome trial.
Trustpilot (UK)
No affiliate relationship
Not a paid placement
Trustpilot sentiment for the brand overall is positive but the review count is too small (N=6) to be statistically meaningful, and no PQQ-specific reviews were identified.
Finding: 4.0/5 ('Great') from only 6 reviews on the UK Trustpilot page, an extremely small sample.
How we use it: Used only as a directional brand-sentiment signal with explicit low-N caveat; not used as product-specific evidence and given limited weight given the tiny sample size.
Tier C
Aggregated sentiment (Trustpilot, Reddit)
Mood indicator only. We never use aggregate stars as evidence of efficacy.
SupplementChecker, Is Jarrow Formulas Safe? Third-Party Testing & FDA Review
Has affiliate relationship
Not a paid placement
This aggregator gives Jarrow Formulas a notably lower trust score than most other sources reviewed, largely by applying a stricter 'NSF Certified for Sport'-style bar that Jarrow does not claim to meet, while appearing to disregard Jarrow's stated NSF GMP-registration and QAI certifications.
Finding: Trust score 40/100 ('Below Average'); states Jarrow is 'not tested by independent lab by NSF, USP, or Informed Sport'; cites 1 recall on record and 8 adverse event reports.
How we use it: Used cautiously and flagged as a source disagreement rather than a settled fact, its methodology for the trust score is not transparently disclosed, and its claim directly conflicts with checkable NSF/QAI certification claims on Jarrow's own site, so we do not treat this as authoritative, but include it for balance and transparency.
Community threads and aggregate ratings
Additional public mentions we located, kept separate from the deep independent reviews above.
Examine.com
mixed
PQQ human evidence limited; a few small trials on cognitive markers.
Read source →
Unverified · we received no payment for this listing
Layer 3 · Evidence vault
Evidence, claims & regulation
Published evidence, claim checks, regulatory status and what could not be verified.
Evidence, what actually backs this product
Longevity brands rarely test their exact finished product. We separate what's tested from what's inferred.
Strongest evidence tier
Tier 4Ingredient RCT (different dose)
6 studies mapped
Tier 4Ingredient RCT (different dose)
Effect of Dietary Pyrroloquinoline Quinone Disodium Salt on Cognitive Function in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study
ingredient-levelpeer-reviewed
Significant improvement vs. placebo on Cognitrax composite memory, verbal memory, reaction time, complex attention, cognitive flexibility, executive function, and motor speed, plus forgetfulness questionnaire and MMSE-J scores. No adverse events.
This is the strongest human evidence for PQQ's cognitive claims: genuinely double-blind, placebo-controlled, at a near-identical dose (21.5 mg vs Jarrow's 20 mg), but it used mnemoPQQ, not BioPQQ, so it is an ingredient-class match, not an exact-raw-material match. Population also skews toward the higher end of middle-age/elderly, not general adult use.
Conflicts: Lead authors affiliated with Ryusendo Co., Ltd. (a Japanese supplement/ingredient company) and Dr. Herbs LLC, industry-sponsored study.
Tier 4Ingredient RCT (different dose)
Pyrroloquinoline quinone disodium salt improves brain function in both younger and older adults
ingredient-levelpeer-reviewed
Double-blind, placebo-controlled study; younger adults (20-40y) showed improved cognitive flexibility, processing speed and executive speed at 8 weeks; older adults showed improvements in complex/verbal memory over 12 weeks.
Dose matches Jarrow's exactly (20 mg/day) and design is double-blind placebo-controlled, the closest match in the literature to Jarrow's exact SKU dose, though sample size (n) was not confirmed from the abstract we could access, and raw-material brand (BioPQQ vs generic) was not explicitly confirmed.
Conflicts: Not confirmed from available abstract; PQQ human RCTs are near-universally funded or co-authored by ingredient manufacturers in this literature.
Tier 5Mechanistic / animal / marketing
Pyrroloquinoline quinone stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increased PGC-1alpha expression
ingredient-levelpeer-reviewed
PQQ exposure increased mitochondrial DNA content, citrate synthase and cytochrome c oxidase activity, and oxygen respiration in mouse liver cells via CREB phosphorylation and increased PGC-1alpha expression, a proposed mechanism for mitochondrial biogenesis.
This is the foundational mechanistic paper the entire 'PQQ builds new mitochondria' marketing claim rests on. It is an in-vitro cell-culture study, not a human or even whole-animal study, and provides no evidence on oral bioavailability, dose-response in humans, or clinical outcomes.
Conflicts: Academic study (UC Davis Department of Nutrition); no dietary supplement company funding identified in the paper.
Tier 5Mechanistic / animal / marketing
Effects of Oral Supplementation with Pyrroloquinoline Quinone on Stress, Fatigue, and Sleep
ingredient-levelpeer-reviewed
Open-label (no placebo control) trial reporting improved self-reported stress, fatigue, mood-state (POMS-SF), quality-of-life, and sleep-quality questionnaire scores after 8 weeks; correlated with reduced cortisol awakening response.
This is the study named in the brief. It is small (N=17), open-label with NO placebo control or blinding, and relies entirely on subjective questionnaires, a much weaker design than the double-blind RCTs published later by different Japanese groups. Directly matches Jarrow's dose (20 mg/day) and form (PQQ disodium salt) but the design quality is low.
Conflicts: Authors include long-time PQQ/BioPQQ researchers (M. Nakano has authored most of MGC-sponsored PQQ human studies); likely industry-connected but funding source not stated in the abstract we could access.
Tier 5Mechanistic / animal / marketing
The effects of pyrroloquinoline quinone disodium salt on brain function and physiological processes
ingredient-levelpeer-reviewed
Narrative review concluding double-blind placebo-controlled trials show improvements in general/verbal/working memory and attention, with age-stratified differences (younger adults show faster cognitive-flexibility gains, older adults show memory gains at 12 weeks).
Useful for summarizing the state of the (still small) human PQQ literature, but it is a review, not new primary data, and does not itself strengthen the tier.
Conflicts: Akagawa M has long-standing publication history on PQQ, some MGC/BioPQQ-connected; not explicitly disclosed in available abstract.
Tier 5Mechanistic / animal / marketing
Dietary pyrroloquinoline quinone (PQQ) alters indicators of inflammation and mitochondrial-related metabolism in human subjects
ingredient-levelpeer-reviewed
PQQ supplementation altered urinary markers of inflammation (reduced) and metabolites linked to mitochondrial and lipid metabolism, suggesting biological activity in humans at dietary-relevant doses.
Same lead-author lineage (Chowanadisai, Rucker at UC Davis) as the 2010 mouse mechanistic paper, this is their human follow-up. It shows PQQ has measurable biological effects on inflammation/metabolic markers in people, but it does not measure any clinical endpoint (cognition, energy, disease outcome) and sample size is small.
Conflicts: Academic (UC Davis); funding not fully confirmed but this research group has received support related to PQQ studies historically.
Evidence
Research behind this product
The studies that established the trial dose and evidence grade for each active ingredient in this product. Click through to read the original paper.
Claim check, vendor claims vs. our reading of the evidence
Not medical advice. We list the strongest claims made by the brand and check each against traceable evidence.
Partial support
“PQQ... helps to protect mitochondria from oxidative stress and promotes the creation of new mitochondria, known as mitochondrial biogenesis.”
The mitochondrial biogenesis mechanism is real and well-documented, but almost entirely in mouse hepatocyte cell culture (Chowanadisai et al. 2010, https://pubmed.ncbi.nlm.nih.gov/19861415/) and other rodent/cell studies, not in confirmed human mitochondrial-biogenesis outcome data at this dose. Human studies measure downstream proxies (cognition scores, inflammation markers) rather than directly confirming new human mitochondria are created after oral 20 mg PQQ. The claim describes a real, peer-reviewed mechanism but overstates how directly that mechanism has been shown to occur in humans taking this product.
Not supported
“PQQ is helpful for efficient metabolism to produce cellular energy.”
No human RCT in the evidence registry measures cellular energy production or ATP output directly. The closest human data (Harris/Chowanadisai 2013, https://www.sciencedirect.com/science/article/pii/S0955286313001599) shows altered urinary metabolite and inflammation markers consistent with metabolic activity, but this is indirect biomarker evidence, not a demonstrated 'more cellular energy' clinical outcome.
Partial support
“PQQ also plays a role in supporting heart health and normal cognitive function.”
The cognitive-function half of this claim has the strongest human support in the whole PQQ literature: multiple double-blind, placebo-controlled RCTs at doses matching or near-matching Jarrow's 20 mg (Shiojima et al. 2022, PMID 34415830; Tamakoshi et al. 2023, PMID 36807425) show statistically significant improvements on validated cognitive batteries in healthy adults. However, all of these trials are small (n=58-64), short (8-12 weeks), conducted almost exclusively in Japanese cohorts, and heavily industry-affiliated. The 'heart health' half of the claim has essentially no direct human RCT support in the sources located, it appears to rest on general antioxidant/mitochondrial mechanistic reasoning rather than a specific cardiovascular-outcome trial.
Partial support
“Every Jarrow formula begins with peer-reviewed research... Our team reviews clinical studies to identify the ingredients, forms, and doses that actually work. If the science isn't there, the product doesn't ship.”
This is a brand-level claim, not specific to PQQ, but PQQ is a useful test case: Jarrow did select the dose (20 mg) used in several human trials, so there is real alignment between labeled dose and published research dose. But 'the science isn't there, the product doesn't ship' is too strong given that PQQ's human evidence base is genuinely thin, small samples, no independent (non-industry) replication located, and no trials on cardiovascular or 'longevity' outcomes despite marketing language implying broader benefit. The claim overstates the rigor of the underlying literature for this specific ingredient.
Regulatory status
Rules change often. We record when we last verified each row. See the full regulatory timeline →
What we could not verify
We list this openly. If a claim isn't backed by a source we can trace, we'd rather flag it than repeat it.
- No public Certificate of Analysis (COA) for this specific product or lot was located on jarrow.com; third-party purity/potency testing exists only via ConsumerLab's proprietary member-only test data, which we could not access in full to confirm pass/fail for this exact SKU.
- ConsumerLab's public summary states 2 of 7 tested PQQ products failed to meet their labeled PQQ content, but does not name which brands failed in the freely accessible summary, it is unverified (though plausible, given ConsumerLab's inclusion of it in the test set) whether Jarrow's product was one of the 2 that passed or one of the 2 that failed.
- Whether Jarrow's current-production PQQ 20 mg capsules are manufactured at Jarrow Industries' own Santa Fe Springs facility or by an outside contract manufacturer could not be confirmed for this specific SKU, Jarrow has used outside contract manufacturers for at least some products historically (e.g., the 2018 Liquid L-Carnitine recall named an 'outside contract manufacturer').
- No clinical trial exists on Jarrow Formulas PQQ 20 mg as a finished, branded product, all human evidence is on the PQQ disodium salt ingredient class, using either BioPQQ, mnemoPQQ, or unspecified PQQ disodium salt raw materials from other suppliers, none of which is confirmed as an exact match to Jarrow's specific batch/lot.
- Long-term (>12 weeks) human safety and efficacy data for daily PQQ supplementation does not exist in the literature reviewed; all human RCTs run 8-12 weeks.
- The claimed 'heart health' benefit has no specific human cardiovascular-outcome trial identified in this research pass, it could not be verified against any RCT with a heart-health primary endpoint.
Important to know
PQQPQQ is very expensive to synthesise, so cheap products may under-deliver. Look for third-party COA.
Editorial notes
Standard PQQ dose; often stacked with CoQ10.
Go deeper
Where this sits
Brand owners
Spot an error?
If you are the manufacturer or brand owner of PQQ 20 mg and believe any data on this page is incorrect (wrong dose, wrong ingredient, wrong price, missing certification, outdated status), you can request a correction.
We review every request, verify it against primary sources, and publish any accepted change with a dated note. Corrections from brand owners are treated the same as corrections from anyone else: verified before they move.
Request a correction →Same shelf
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