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Editorial ranking
Best Urolithin A Supplements 2026: independent ranking by dose, price, testing and evidence
We track 9 Urolithin A products from 7 brands. Every product is scored on the same six-pillar composite: dose vs. studies, transparency, value, formulation, safety, and community. No brand pays for placement. The ranking updates automatically when product data changes.
Independent rankingNo paid placementAuto-updated
Summary Which urolithin A supplement has the best value and documentation? Show / hide ↓
This ranking compares nine products from seven brands using dose, price, testing, transparency, formulation, safety, and community feedback. The top product scores 8.6 out of 10, provides 500 mg, costs $65 per month, and has been tested. The runner-up has the same score and costs $55.97 per month, while the third-ranked product costs $59 and provides 1,000 mg. The suggested amount is 250 to 500 mg daily, and studies used 500 mg daily for four weeks. Urolithin A is a compound made by gut bacteria from certain foods, but only about 40% of people make it, so supplements bypass this step. Two randomized controlled trials, meaning studies where people are assigned to groups by chance, found improvements in muscle endurance, but the article says human evidence is still early.
What this means for you: Choose a product with 250 to 500 mg of pure urolithin A, independent lab testing, and a reasonable monthly price. The leading products look credible, but long-term benefits and safety are not fully established.
moderate evidenceTop 10 Urolithin A supplements
2
Runner-up
Full Spectrum Urolithin A - 60 capsules
ProHealth Longevity
100%
of trial dose
$3.73
per day
Score: 8.6/10
TestedCoA
View review
3
Ranked #3
Urolithin-A Liposomal 1,000mg
Perpetua Life
100%
of trial dose
$1.97
per day
Score: 8.4/10
Tested
View review
4
5
Timeline Mitopure Gummies (Urolithin A, Strawberry)
Timeline Nutrition
Score: 8.1/10
100%
of trial dose
$8.33
per day
Tested
View review
6
Nutri Urolithin A NAD+ Boost 500mg
Nature's Fusions
Score: 7.5/10
100%
of trial dose
$3.73
per day
7
8
Urolithin A+
AOR (Advanced Orthomolecular Research)
Score: 6.6/10
100%
of trial dose
$3.21
per day
Tested
View review
9
Detailed comparison
| Rank | Product | Brand | Dose | Price/mo | Tested | Score |
|---|---|---|---|---|---|---|
| 1 | Mitopure® Softgel | Timeline Nutrition | 500 mg | $65.00 | Yes | 8.6 |
| 2 | Full Spectrum Urolithin A - 60 capsules | ProHealth Longevity | 500.0 mg | $55.97 | Yes | 8.6 |
| 3 | Urolithin-A Liposomal 1,000mg | Perpetua Life | 1000 mg | $59.00 | Yes | 8.4 |
| 4 | Mitopure® Powder | Timeline Nutrition | 1000 mg | $130.00 | Yes | 8.2 |
| 5 | Timeline Mitopure Gummies (Urolithin A, Strawberry) | Timeline Nutrition | 500.0 mg | $125.00 | Yes | 8.1 |
| 6 | Nutri Urolithin A NAD+ Boost 500mg | Nature's Fusions | 500 mg | $28.00 | No | 7.5 |
| 7 | Liposomal Urolithin A | Codeage | 500 mg | $99.99 | Yes | 6.7 |
| 8 | Urolithin A+ | AOR (Advanced Orthomolecular Research) | 1000 mg | $96.44 | Yes | 6.6 |
| 9 | Creatine+ | Elysium Health | 300 mg | $70.00 | No | 6.5 |
Scores are editorial judgments, not a scientific standard. See our scoring methodology for how the composite is calculated. Prices are USD and may vary.
What is Urolithin A?
Urolithin A is a postbiotic compound produced when gut bacteria metabolize ellagitannins from pomegranates, walnuts, and berries. Not everyone produces it endogenously; about 40% of adults lack the right gut bacteria. Urolithin A activates mitophagy (selective removal of damaged mitochondria) and has been shown in two published randomized controlled trials to improve muscle endurance and reduce mitochondrial dysfunction in middle-aged adults. It is one of the few longevity-oriented supplements with replicated human trial data showing functional outcomes.
Evidence grade: A. The only longevity ingredient with a replicated RCT showing muscle-strength gains. Read the full evidence review: Urolithin A ingredient page.
How we rank Urolithin A supplements
Every Urolithin A product in our database gets the same overall score, built on six weighted components:
- Dose vs studies (50%): How close the label dose is to the dose used in human trials for Urolithin A. Products far above or below the studied dose lose points.
- Transparency (20%): Is the full formula public, with every ingredient amount disclosed, and a published Certificate of Analysis?
- Value (10%): Monthly cost at the studied dose, not the sticker price of the bottle.
- Formulation (10%): Form and co-ingredients compared with the forms used in trials. Unproven delivery claims add nothing.
- Safety (5%): Doses above upper intake levels or with documented adverse-event signals lose points.
- Community (5%): Verified review signals from independent platforms, weighted low and never able to override the evidence components.
See the full methodology for the scoring formula.
What to look for in a Urolithin A supplement
- Dose: 250 to 500 mg per day. Clinical trials used 500 mg urolithin A daily for 4 weeks.
- Form: Pure urolithin A is the only form with human trial data. Pomegranate extract is not equivalent; it requires specific gut bacteria to convert.
- Purity: Look for products with published CoA showing 98%+ purity urolithin A.
- Price: Urolithin A is expensive to manufacture. Prices range from $40 to $80+ per month.
- Testing: Third-party testing is essential given the high price point and limited manufacturers.
See the full Urolithin A evidence page for dosing, safety, and landmark studies.
Frequently asked questions
How often is this ranking updated?
Our database checks product prices, availability, and testing status continuously. The ranking recalculates whenever product data changes. The "last updated" date on each product page reflects the most recent verified change.
Do brands pay for placement on this list?
No. We do not accept payment for ranking position. Brands can purchase clearly labeled ad slots, but these never appear in or influence editorial rankings. See our advertising policy.
What dose of Urolithin A should I take?
Human trials for Urolithin A typically use 500 to 1000 mg per day. See the Urolithin A ingredient page for the full range and safety data, and talk to a clinician before starting.
Is Urolithin A safe?
Urolithin A has evidence grade A. Read the safety section on the ingredient page for known interactions and contraindications.