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Layer 1 · Decision
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Timeline Nutrition

Mitopure® Powder

Mitochondrial · Powder stick · 28 servings

Label snapshot

What the label says

What the product contains and what one serving costs, according to our catalog. Label amounts are not personal dose recommendations.

Active per serving
Urolithin A 1,000 mg
Form
Powder stick
List price (catalog, USD)
$130.00
Price per serving
$4.64List price divided by servings per container. A per-day cost only if the label serving is once daily.
Full label record: servings, testing, ingredients
Servings per container
28
Serving size (label)
8 g
Catalog monthly estimate
$139.00
Testing disclosure
Brand lists third-party testing; no public lab certificate listedStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Ingredients as listed

IngredientAmount per serving
Urolithin A1,000 mg

What to check on the label

  • Which form of the compound the label names (for CoQ10: ubiquinol or ubiquinone) and whether the milligrams refer to that form.
  • Softgel oil carriers are listed under 'other ingredients'. They are not part of the active amount.
  • Branded ingredients (Mitopure, BioPQQ and similar) should be named on the label if the brand claims them.

Amounts are per label serving as recorded in the catalog and are not a recommendation. Testing status reflects what the brand lists. Nothing here is medical advice.

Editorial score and research-dose calculations

These calculations describe our scoring method. They are not a recommended dose or proof of benefit from this product.

8.2/10
Overall score
#6 / 30 in Mitochondrial

Full trial dose, tested by independent lab.

Read the evidence (2 studies)
Add to compareVisit brand site →
Watch out
Tier 2
Product RCT (not peer-reviewed)
Product-specific RCT exists but was not peer-reviewed.
See the 2 supporting studies
How we scored this product Show the full breakdown
Dose vs. studies (50%) Why 10.0 of 10. Primary ingredient is Urolithin A (evidence grade A). It delivers 1000 mg, inside the studied range of 500–1000 mg. Read the rule → 10.0
Transparency (20%) Why 8.0 of 10. Earned points for independent third-party testing and all doses disclosed. Lost points for no public certificate of analysis. Read the rule → 8.0
Value (10%) Why 3.5 of 10. One day at the trial dose costs about $4.64. That is one of the pricier options in the catalog (275 of 313 by cost per effective day). Read the rule → 3.5
Formulation (10%) Why 5.0 of 10. No published absorption advantage or disadvantage on file. The default of 5 is not a criticism. Read the rule → 5.0 Default. No absorption data on file.
Safety (5%) Why 7.0 of 10. Baseline 5.0. Third-party testing adds 2.0. Public lab certificate adds 1.5. NSF, USP or Informed Choice certification adds 1.5. Active safety signal subtracts 3.0. Read the rule → 7.0
Community sentiment (5%) Why 7.5 of 10. Sentiment across 16 external review source(s) is mixed to positive. Community is a signal about daily use, not proof of effect. Read the rule → 7.5
Composite How this 8.2 is built. 0.50 × 10.0 + 0.20 × 8.0 + 0.10 × 3.5 + 0.10 × 5.0 + 0.05 × 7.0 + 0.05 × 7.5 = 8.2 out of 10. Safety caps applied after. 8.2
8.2 composite
Dose vs. studies50%10.0
Transparency20%8.0
Value10%3.5
Formulation10%5.0
Safety5%7.0
Community5%7.5

Evidence gates dose: the evidence grade sets the ceiling, and the dose decides how much of that ceiling the product reaches. Value = inverse of price-per-trial-dose-day. Community = mean sentiment of external reviews. Safety caps applied after weighting.

This score is our editorial judgment, not a scientific standard. We combine published evidence, dose, price, transparency, and consumer signals into one composite: this is our method, not a peer-reviewed clinical rating. A higher score means a product does better on the factors we weight, not that it is medically proven to work.

Read the full method →

Editorial verdict

Quick verdict

8.2 / 10
Best for
Full trial dose
Avoid if
No public lab certificate, Premium pricing
Full-dose status
Meets trial dose
Price/month
$139
COA status
Not public
Biggest caveat
No public lab certificate available for independent verification.
Nearest alternatives
Catalog snapshot. Check linked sources for current price, label and batch-specific testing.
Price verification
Current price: $130.00
Last price check: Sep 01, 2026
Add to compareVisit brand site →
Layer 2 · Context

Our summary

Timeline's Mitopure Powder delivers the same 500 mg dose of the company's patented, purified urolithin A used in its better-known softgel product, and, unlike many single-ingredient supplement reformulations, the powder itself was the actual dosing vehicle in the Singh 2022 'NOURISH' pharmacokinetic trial that established urolithin A's 6-fold bioavailability advantage over dietary pomegranate juice, giving this specific format its own direct human plasma data rather than relying purely on inference from the softgel. That said, the flagship muscle-strength and endurance trials most often cited in Timeline's marketing (Andreux 2019, Singh/Liu 2022) do not clearly document which oral formulation was administered, so full efficacy equivalence across all of Timeline's Mitopure formats is not yet formally confirmed pending an unreported five-formulation head-to-head PK study (NCT06362018). Buyers should also note this pure berry-flavored powder is a distinct SKU from Timeline's separate whey-protein 'Mitopure + Protein' shake, and that at $125 for a 30-day supply (as low as $85/month on a 12-month subscription), it sits at the high end of the urolithin A category, a price that an independent lab test suggests is at least backed by accurate labeling, since the product tested above its stated dose while most competing urolithin A supplements did not.
In plain language

Why this scored this way

This Timeline Nutrition Mitopure® Powder scores 8.2, making it a strong scorer. It delivers 1000mg of Urolithin A, inside the studied range of 500–1000mg with grade A evidence (strong human trial data). At $4.64/day it's among the more expensive options in Mitochondrial.

What drives the score up

  • Dose-evidence score of 10.0 reflects good alignment with trial doses.
  • Tested by independent lab (transparency 8.0).
  • Urolithin A is dosed at the full research level with grade A evidence (strong human trial data).

What drags it down

  • No public lab certificate available for independent verification.
  • At $4.64/day it's on the expensive side.

Why you'd choose it

  • You want Urolithin A from a Timeline Nutrition product.
  • You want a tested by independent lab product.
  • You want doses that align with published research.

Why you might skip it

  • You want a product with a publicly available CoA.
  • You want a cheaper option (this is $4.64/day).
Question 1

Does the molecule work?

The science behind each active ingredient, independent of which brand sells it.

Urolithin A

A mitophagy-activating metabolite with early human data; both flagship RCTs missed their primary endpoints.

2 landmark RCTs · US: FDA GRAS · EU: Authorised Novel Food (EU 2021/85)
Question 2

Is this bottle good?

The specific product: dose, price, transparency, and what buyers report.

Dose vs research
100% of trial dose
Meets or exceeds the published effective dose
Cost at trial dose
$4.64/day at trial dose
What one effective daily dose actually costs
Transparency
8.0/10 · No public lab certificate
Independent batch testing confirmed
Consumer signals
No consumer signals collected yet
Operational signal only, never used as clinical evidence
Question 3

What's the catch?

Safety flags, transparency gaps, dosing concerns, and recurring buyer complaints.

No public lab certificate
Certificate of Analysis not published
Without a public lab certificate, batch purity and potency cannot be independently verified.
Plain English

What’s inside

The main ingredients of this product, in plain language.

Urolithin A1000 mgEvidence A

A mitophagy-activating metabolite with early human data; both flagship RCTs missed their primary endpoints.

Read about Urolithin A →
Layer 3 · Evidence vault

Product data & verification

Hard numbers and independently checked status. Expand each block for its source.

The numbers

Price
$130
per bottle · 28 servings
Dose vs. research
of trial dose 100%
of published effective dose
$ / day at studied dose
$4.64
what one effective daily dose costs
$ / g active
$4.64
per gram of active substance
Independently checked

Data verification

COA status
Not public
Evidence grade
A
Per-ingredient breakdown
AUrolithin A

All product data is checked against original sources. Prices, doses, and testing status are updated when product pages change. Evidence grades are reviewed when new human RCTs are published. Read how we verify.

What's inside

Ingredient
Dose in this product
Trial dose
Evidence
Urolithin A
A mitophagy-activating metabolite with early human data; both flagship RCTs missed their primary endpoints.
Andreux et al. 2019 (Nature Metabolism)Singh et al. 2022 (Cell Reports Medicine)
1000 mg 100% of trial dose
1000 mg
3.8 /5
High confidence
2,235 reviews across 4 platforms (4 sources)
Source diversity: 92%
Cell Reports Medicine (Singh 2022)Timeline (brand site)Timeline (brand site, product page)Trustpilot
PraiseFull 1000 mg dose showed clinically meaningful strength gain in the trial arm.
Last checked: 2026-08-20

Consumer signals

Consumer signals gathered from 4 platforms.

Low confidence, small sample

Consumer sentiment compiled from 1 public source (Cell Reports Medicine (Singh 2022)). Small sample size, treat as directional only.

Cell Reports Medicine (Singh 2022)

positive sentiment

Praise

Full 1000 mg dose showed clinically meaningful strength gain in the trial arm.

Compiled from a Cell Reports Medicine (Singh 2022) listing located during manual research; not independently re-verified against the live page at build time.

Trustpilot

7 reviews · 2.5/5

Timeline (brand site)

1,114 reviews · 4.5/5

Timeline (brand site, product page)

1,114 reviews · 4.5/5

These are consumer sentiment signals. They do not measure whether the product actually works. See our evidence section for that.

What others say, with a source hierarchy

We treat external opinion very differently depending on where it comes from. Tier A is our strongest signal. Tier C is background sentiment only. Tier Rejected is what we excluded, listed openly so you can see what we discarded.

These reviews are aggregated from third-party sources, not written by NO1GEVITY. Each entry shows its source, retrieval date, and whether the source has an affiliate or paid relationship. We do not edit reviews to change their meaning. Disclosure policy.

Tier A

Independent deep reviews, lab tests, certificates of analysis

Our strongest external evidence. Long-form independent reviews, physical-product lab work, and third-party certifications.

Innerbody Research
Has affiliate relationship Not a paid placement

Innerbody's medically-reviewed team concludes Mitopure is a research-supported, NSF Certified for Sport product that can be a worthwhile investment for mitochondrial/muscle health despite a high price, but flags that capsules occasionally leaked in their testing, the powder is only available in one flavor, and long-term safety data beyond several months is still limited.

Finding: Editor's rating positive overall; pricing table shows $125/$4.17 per serving one-time, down to $85/$2.83 per serving on a 12-month subscription; notes Timeline's ~5,000 Junip platform reviews average 4.46/5 stars with 97% recommend rate
How we use it: Used as our primary independent, methodology-disclosed source for both product-testing observations (packaging, capsule leakage) and pricing verification; Innerbody discloses it may earn affiliate commissions but its review includes both positive and negative findings and its own supplement-testing protocol, meeting our Tier A bar (independent evaluation, not repackaged marketing).
SuppCo.com (independent lab-testing investigation)
No affiliate relationship Not a paid placement

Timeline's product passed independent third-party potency testing while the majority of tested competitors did not, reinforcing that Timeline's NSF Certified for Sport claim reflects real label accuracy.

Finding: Lab-tested 10 popular urolithin A products; Timeline Mitopure Urolithin A tested at 602.41 mg against a 500 mg label claim (120.48% of label, passed); 6 of 10 competing products failed to deliver their labeled dose, some containing less than 0.1% of the claimed amount
How we use it: Used as our strongest available independent quality-verification data point for actual urolithin A content, since we could not access ConsumerLab's full paywalled test data directly.
ConsumerLab.com
No affiliate relationship Not a paid placement

ConsumerLab's freely visible summary states clinical research on urolithin A for muscle health shows only 'limited benefit' in both young active adults and middle-aged/older adults, a notably more cautious framing than Timeline's own marketing.

Finding: Not accessible without membership, the public page confirms Timeline Mitopure is one of the products covered in ConsumerLab's comparative review alongside CodeAge, Pure Encapsulations, and Neurogan, but withholds the underlying test numbers and quality verdict behind a paywall
How we use it: Cited for its independent, more conservative efficacy framing and its confirmation that Timeline is included in the landscape of urolithin A products being quality-screened by a reputable independent testing body; full quantitative verdict not accessible to us and therefore not claimed.
Tier C

Aggregated sentiment (Trustpilot, Reddit)

Mood indicator only. We never use aggregate stars as evidence of efficacy.

Trustpilot (timeline.com, US)
No affiliate relationship Not a paid placement

Mixed/thin evidence, Trustpilot coverage of Timeline's official domain is fragmented across at least four country-specific subdomains (timeline.com, timeline.co.uk, timelinenutrition.com, and regional variants) each with small, inconsistent sample sizes (2-42 reviews) and ratings ranging from 2.5 to 4.5 out of 5.

Finding: Very low review count (single digits visible) on the primary US Trustpilot listing; one visible unprompted review reports no noticeable benefit after 3 months and over $300 spent
How we use it: Used with heavy caveats per our N>500 threshold for Tier B, none of the Trustpilot listings we found for Timeline's various domains meet that bar, so we treat all Trustpilot data here as Tier C (individual anecdotal signal only) rather than a reliable aggregate reputation metric.
Rejected

Sources we transparently discard

Marketing-quoted press, obviously fabricated aggregate ratings, or heavy-affiliate 'reviews'. Listed openly so you can see what we excluded.

Timeline's own storefront review aggregation (Junip platform, displayed on timeline.com)
No affiliate relationship Not a paid placement

Vendor-hosted reviews are not independent, Timeline controls collection, display, and moderation of this feedback.

Finding: Mitopure Powder shown at 4.5/5 stars based on approximately 1,097-1,113 reviews (count fluctuates slightly between page loads)
How we use it: Reported only as a data point for context (it is the largest single review pool for the powder specifically), but excluded from our tiered evidence weighting per the brief's rule against vendor-controlled testimonials.
The Quality Edit
Has affiliate relationship Paid placement

The article's own disclosure states, 'In partnership with Timeline... we only endorse products we believe in,' and it functions as a sponsored interview/advertorial rather than an arm's-length review.

Finding: None, the piece is a Q&A interview with Timeline's own Chief Medical Officer, not an independent product evaluation
How we use it: Rejected per the brief's two-question test: this source discloses a partnership/affiliate relationship AND does not independently test or evaluate the product, it repackages the vendor's own talking points via an interview format. Not used for any factual or evidentiary claim in this dossier.

Community threads and aggregate ratings

Additional public mentions we located, kept separate from the deep independent reviews above.

Cell Reports Medicine (Singh 2022)
positive

Full 1000 mg dose showed clinically meaningful strength gain in the trial arm.

Read source → Unverified · we received no payment for this listing
Layer 3 · Evidence vault

Evidence, claims & regulation

Published evidence, claim checks, regulatory status and what could not be verified.

Evidence, what actually backs this product

Longevity brands rarely test their exact finished product. We separate what's tested from what's inferred.

Strongest evidence tier
Tier 2Product RCT (not peer-reviewed)
5 studies mapped
Tier 0No source
Bioavailability of Five Mitopure Formulations
Sponsor: Mprex Healthcare Pvt. Ltd. (contract research organization); PI: Dr. Ramshyam Agarwal · 2025 · ClinicalTrials.gov registry (not yet published) · Single dose, formulation/dose arms not disclosed in registry · 72-hour plasma pharmacokinetic sampling (8 timepoints)
ingredient-levelnot peer-reviewed
Trial explicitly designed to characterize and directly compare plasma concentration-time profiles (Cmax, AUC) across five different Mitopure formulations, which should include the powder and softgel. No results have been posted as of this review.
This is the head-to-head cross-formulation PK study that would definitively settle powder-vs-softgel bioequivalence, but it has not reported results yet. A related, similarly-designed 4-formulation trial (ISRCTN60173424) is also listed as active/not recruiting for the same purpose.
Conflicts: Unknown, CRO-run trial; sponsor relationship to Amazentis/Timeline not disclosed in the public registry.
Source →
Tier 2Product RCT (not peer-reviewed)
Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults to achieve consistent levels across the population ('NOURISH')
Singh A, D'Amico D, Andreux PA, Dunngalvin G, Kern T, Blanco-Bose W, Auwerx J, Aebischer P, Rinsch C · 2022 · European Journal of Clinical Nutrition · n=100 · 500 mg Urolithin A (single dose) vs. 8 fl oz pomegranate juice · Single-dose, 24-hour plasma sampling, crossover design
on this exact productpeer-reviewed
Direct supplementation with the Mitopure powder produced plasma urolithin A/urolithin A-glucuronide levels more than 6-fold higher than drinking pomegranate juice, and delivered consistent exposure regardless of the subject's gut-microbiome 'producer' status.
This is the single most important study for the powder specifically: the paper's methods explicitly state the investigational product was 'the Mitopure powder, a fruit-flavored powder containing 500 mg of pure UA and ingredients that include blueberry, raspberry fruit powder, pomegranate natural flavoring, and fiber', i.e., this pharmacokinetic trial was run on the berry powder formulation, not the softgel. This directly answers the bioequivalence question for the powder (see claim_check).
Conflicts: Amazentis SA-funded; multiple Amazentis employee co-authors.
Source →
Tier 3Ingredient RCT (matching dose)
The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans
Andreux PA, Blanco-Bose W, Ryu D, Burdet F, Ibberson M, Aebischer P, Auwerx J, Singh A, Rinsch C · 2019 · Nature Metabolism · n=60 · 250-2000 mg single dose (ascending); 500 mg or 1,000 mg/day for 4 weeks (repeated dose) · Single dose + 4 weeks repeated dosing
ingredient-levelpeer-reviewed
Urolithin A (Mitopure) was safe, well-tolerated, and bioavailable in plasma at all tested doses; 4 weeks of 500-1,000 mg/day upregulated mitochondrial gene expression in skeletal muscle and improved plasma acylcarnitine biomarkers of mitochondrial health.
First-in-human trial; dose (500 mg) matches the powder's label dose. Formulation used in this specific trial is not explicitly disclosed as powder vs. capsule in the publicly available abstract/full text excerpts reviewed; Amazentis has historically used oral Mitopure material interchangeably across early trials. Primary endpoint was safety/biomarkers, not muscle function.
Conflicts: Multiple authors are Amazentis SA employees (Andreux, Blanco-Bose, Singh, Rinsch); company-funded and company-authored.
Source →
Tier 3Ingredient RCT (matching dose)
Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults
Singh A, D'Amico D, Andreux PA, Fouassier AM, Blanco-Bose W, Evans M, Aebischer P, Auwerx J, Rinsch C · 2022 · Cell Reports Medicine · n=88 · 500 mg or 1,000 mg Mitopure/day · 4 months
ingredient-levelpeer-reviewed
Hamstring muscle strength increased 12% (500 mg) and 9.8% (1,000 mg) vs. placebo; knee-flexion strength improved at both doses; the 1,000 mg group showed clinically meaningful (non-statistically-significant) gains in aerobic endurance and the 6-minute walk test; muscle biopsies showed increased mitophagy/mitochondrial gene and protein signatures.
This is the trial behind Timeline's '+39% mitochondrial renewal' and '12% muscle strength' marketing claims; dose (500 mg) matches the powder label. Oral Mitopure was administered but the publicly available materials reviewed do not specify powder vs. softgel form for this particular study; the primary endpoint (peak power output) was not statistically significant.
Conflicts: Amazentis SA-funded; several authors are Amazentis employees.
Source →
Tier 3Ingredient RCT (matching dose)
Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults: A Randomized Clinical Trial
Liu S, D'Amico D, Shankland E, Bhayana S, Garcia JM, Aebischer P, Rinsch C, Singh A, Marcinek DJ · 2022 · JAMA Network Open · n=66 · 1,000 mg Mitopure/day · 4 months
ingredient-levelpeer-reviewed
Muscle endurance (contractions to fatigue) significantly improved in hand and leg muscles at 2 months vs. placebo; plasma biomarkers of mitochondrial health (acylcarnitines, ceramides, CRP) improved. Primary endpoints (6-minute walk distance, maximal ATP production) were not statistically significant.
Dose (1,000 mg) is double the powder's per-stick 500 mg label dose, buyers taking one stickpack/day are at the lower, less-studied end of this trial's dose-response range. Formulation (softgel vs. powder) not specified in the reviewed materials.
Conflicts: Amazentis SA-funded; Amazentis employees are co-authors.
Source →
Evidence

Research behind this product

The studies that established the trial dose and evidence grade for each active ingredient in this product. Click through to read the original paper.

Urolithin AAndreux et al. 2019 (Nature Metabolism)
Urolithin ASingh et al. 2022 (Cell Reports Medicine)

Claim check, vendor claims vs. our reading of the evidence

Not medical advice. We list the strongest claims made by the brand and check each against traceable evidence.

Supported
“"Each stickpack contains the recommended daily dose of Urolithin A (500mg of Mitopure)"”
500 mg matches the dose used in Andreux 2019, Singh 2022 (Cell Reports Medicine), and the Singh 2022 NOURISH bioavailability trial, and an independent lab test (SuppCo) found the product delivers slightly more than its label claim (602.41 mg tested vs. 500 mg labeled), suggesting the label dose is not being shorted.
Vendor source
Partial support
“"Mitochondrial renewal increases by +39% after 16 weeks over placebo"”
This figure derives from mitophagy/mitochondrial gene-expression biomarker changes in Singh et al. 2022 (Cell Reports Medicine), a real peer-reviewed RCT at the matching 500 mg dose, but it is a molecular biomarker endpoint, not a directly felt or independently-validated 'renewal' metric, and the trial's primary functional endpoint (peak power output) did not reach statistical significance. The claim is accurately sourced but oversimplifies a secondary biomarker result as if it were the headline finding.
Vendor source
Partial support
“"Powder-vs-softgel: same 500 mg dose, so bioavailability is equivalent" (implied by Timeline's FAQ: 'Mitopure® is the active nutrient in both the Powder and Softgel products... both products provide the recommended 500mg daily dose')”
Critically, the Singh 2022 NOURISH pharmacokinetic study (PMC8821002) that Timeline itself cites for its '6X higher bioavailability than dietary sources' claim was run using the Mitopure powder as the investigational product, the paper's methods explicitly describe 'the Mitopure powder, a fruit-flavored powder containing 500 mg of pure UA.' This means the powder format DOES have its own dedicated human plasma pharmacokinetic data, which is a genuine strength most competing urolithin A powders lack. However, the muscle-function/strength trials that Timeline's marketing leans on most heavily (Andreux 2019, Singh 2022 Cell Reports Medicine, Liu 2022 JAMA Network Open) do not clearly specify in publicly available materials whether their oral dosing used the powder, the softgel, or an unbranded equivalent capsule, so we cannot confirm those specific efficacy outcomes were generated using the exact commercial powder SKU. A formal, purpose-built five-formulation head-to-head PK trial (NCT06362018) that would settle this definitively is registered but has not yet reported results. Our verdict: the core PK/bioavailability claim for the powder IS directly supported by a study using the powder itself, but cross-formulation equivalence for the muscle-strength/endurance efficacy endpoints remains formally unconfirmed.
Vendor source
Unverifiable
“"Mix it with yogurts, smoothies and other breakfast favorites" / "will not affect its bioavailability in any way"”
No published study we located specifically tests urolithin A bioavailability after mixing into food matrices like yogurt or oatmeal versus taking the powder alone/in water; the NOURISH PK study dosed the powder without specifying a food vehicle. This is a reasonable formulation claim but not independently confirmed.
Vendor source
Unverifiable
“"#1 Doctor Recommended" / "the only Urolithin A supplement to be favorably reviewed by the FDA (GRAS)"”
'#1 Doctor Recommended' is an unsourced marketing superlative with no methodology disclosed for how it was determined. The GRAS claim is independently corroborated by an FDA notice referenced by Innerbody's review (2018 GRAS status), but 'only' supplement with this status could not be independently confirmed against every competitor.
Vendor source

Regulatory status

Rules change often. We record when we last verified each row. See the full regulatory timeline →

What we could not verify

We list this openly. If a claim isn't backed by a source we can trace, we'd rather flag it than repeat it.

  • No public, batch-specific Certificate of Analysis (CoA) for the powder was located on Timeline's website, third-party testing is asserted (NSF Certified for Sport, cGMP, FSSC 22000, ISO 9001) but consumers cannot inspect a per-lot CoA themselves.
  • The exact formulation (powder vs. softgel vs. unbranded capsule) used as the oral dosing vehicle in the pivotal muscle-function trials (Andreux 2019, Singh 2022 Cell Reports Medicine, Liu 2022 JAMA Network Open) is not explicitly disclosed in the publicly available materials we reviewed, so we cannot confirm those specific strength/endurance results were generated with the exact commercial powder stickpack.
  • EU, UK, and Swiss regulatory status for urolithin A as a novel food appears to be in different stages across jurisdictions (some sources describe it as 'authorised' for Amazentis specifically, while the UK Food Standards Agency and Swiss FSVO show applications still in progress/pending as of 2025), we could not fully reconcile these into one settled EU-wide status.
  • Independent, large-sample Trustpilot data specific to Timeline's official domain (timeline.com) is thin and fragmented across country subdomains (e.g., the main US Trustpilot page shows only a handful of reviews, while a UK subdomain 'timelinenutrition.com' shows a separate small review pool), we could not verify a single authoritative, high-N Trustpilot score for the brand.
  • ConsumerLab.com has written content referencing comparative testing of Timeline Mitopure against competitor urolithin A products, but the full test results/verdict are behind a paywall we could not access; we relied on a secondary independent lab report (SuppCo) for quantitative purity data instead.
  • We could not verify whether the head-to-head, five-formulation Mitopure pharmacokinetic trial (NCT06362018) is sponsored by or affiliated with Amazentis/Timeline, nor have its results been published, so the definitive powder-vs-softgel-vs-gummy bioequivalence question remains formally open.
  • Trustpilot aggregator

    This is a brand-level customer-service profile for timeline; it does not isolate Mitopure® Powder.

    verified 2026-08-07Open source →
  • Reddit r/Supplements community forum
    mixed sentiment

    Community discussion exists, with positive mentions of clinical evidence and Urolithin A benefits alongside concerns about the high price. No single Reddit thread is treated as a representative product review.

    no direct URLchecked 2026-08-07
  • Timeline on-site reviews own platform
    4.5/51113 reviews

    Timeline displays first-party powder reviews on its public page.

    verified 2026-08-07Open source →
  • Amazon customers aggregator

    An Amazon listing for this exact product was located. The product URL is not retained because marketplace listings can change.

    no direct URLchecked 2026-08-07
Important to know
Urolithin ACheap 'urolithin A precursor' products (pomegranate extract) don't work if you lack the right gut bacteria. Only direct Urolithin A supplements are reliable.

Editorial notes

Full trial dose in one stick. Vanilla flavor.

Go deeper

Where this sits

Actives inside
Urolithin A
Category
See all in Mitochondrial →
Ranking
See top 10 Urolithin A supplements →
Brand
Timeline Nutrition profile →
Add to compare Visit brand site →
Brand owners

Spot an error?

If you are the manufacturer or brand owner of Mitopure® Powder and believe any data on this page is incorrect (wrong dose, wrong ingredient, wrong price, missing certification, outdated status), you can request a correction.

We review every request, verify it against primary sources, and publish any accepted change with a dated note. Corrections from brand owners are treated the same as corrections from anyone else: verified before they move.

Request a correction →
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Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

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Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

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Price per serving
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Testing
3rd-party listed · no public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 8.6/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

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Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$0.44
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with donotage.org
Same maker

Other products from Timeline Nutrition

Brand profile →
Timeline Nutrition
Mitopure® Softgel
Mitochondrial
Active per serving
Urolithin A 500 mgSoftgel · 30 servings
Price per serving
$2.17$65.00 · 30 servings
Testing
3rd-party listed · no public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 8.6/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$4.33
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with www.timeline.com
Mitochondrial
Active per serving
Urolithin A 500 mgGummy · 30 servings
Price per serving
$4.17$125.00 · 30 servings
Testing
3rd-party listed · no public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 8.1/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$8.33
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with www.timeline.com