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Sirtuin / Longevity

SIRT6 Activator · Fucoidan (SIRT6-activating)

DoNotAge's proprietary angle; genuinely interesting biology, extremely early evidence.

E
Evidence grade
Mechanistic only

Short answer

Interesting mechanism, no meaningful human evidence yet. Priced like a proven longevity drug. Wait for actual data unless you're happy to fund early-stage research.

Product and dose overview

SIRT6 Activator (Fucoidan (SIRT6-activating)) is a sirtuin / longevity with evidence grade E, meaning it is only mechanistic evidence so far. We track 2 products containing SIRT6 Activator. Typical doses range from 400 to 1600 mg per serving. The top-ranked product scores 6.7 out of 10 on our composite scale (dose, evidence, price, testing, transparency). Prices range up to $203.00 per month.

Evidence grade: E Products in database: 2 Category: Sirtuin / Longevity

Top SIRT6 Activator products

ProductBrandDosePrice/mo3rd-party testedScore
DoNotAge® routine (15-in-1 Daily Sachet)DoNotAge1600 mg$203.00Yes6.7
SIRT6Activator®DoNotAge400 mg$97.00Yes3.8

Scores are editorial judgments, not a scientific standard. See how we score.

What it is

SIRT6 is a longevity gene. Mice overexpressing it live ~30% longer. A specific type of seaweed extract (fucoidan) activates SIRT6 in the lab. DoNotAge markets it as 'SIRT6 Activator'.

Why people take it

Mechanism looks real: fucoidan increases SIRT6 activity in cell studies. Human trials on longevity endpoints don't exist yet. Rodent lifespan data is preliminary.

Our verdict

Interesting mechanism, no meaningful human evidence yet. Priced like a proven longevity drug. Wait for actual data unless you're happy to fund early-stage research.

Structure & class

Sulfated polysaccharide from Fucus vesiculosus/Ecklonia cava. Reported allosteric SIRT6 activator.

Mechanism & clinical data

Rezaei-Sadabady et al. and DoNotAge's in-house data show SIRT6 activation and mouse healthspan signals. No human RCTs. Estimated human-equivalent dose from mouse studies is ~4 g/day, far above marketed doses.

Pharmacokinetics

Uncertain in humans.

Dose & forms

Trial dose
4000 mg
/ day
Range in trials
1000 to 4000 mg
/ day
Common forms
Fucoidan capsule, SIRT6 Activator (DoNotAge)

What to watch out for

Fucoidan is inexpensive as a seaweed extract. High-priced 'SIRT6 activator' branding doesn't mean higher potency, check fucoidan mg/capsule.

Where this dose comes from

The trial dose above is our editorial pick from the published human trials for this ingredient. We choose the dose that the best-available studies used on the endpoint most relevant to longevity. The range shows the lowest and highest doses tested in published trials. The landmark studies below are the papers we read to set it. You can click through and check our work.

When new trials publish, our automated sweeps flag them. If a new study materially changes the dose, we update it through editorial review and record the old dose, new dose, and the triggering study in every affected product's recommendation history. The dose is never changed automatically.

Regulatory status

EUFood supplement (seaweed-derived)
USDietary supplement
UKFood supplement
CANHP

Timeline

Regulatory events, evidence grade changes, and key research milestones for SIRT6 Activator, most recent first. Studies link to the paper; regulatory entries name and link the responsible authority.

  • 2025-04 Regulatory single source
    EU Court sharpens the bar for botanical health claims
    A Court of Justice of the European Union ruling in April 2025 further tightened the requirements for how botanical ingredients (herbs, plant extracts) can be marketed with health claims in the EU, effectively removing much of the flexibility of the on-hold list.
  • 2024-06 Regulatory confirmed
    EU report identifies 117 supplement substances as potential health risks
    The HoA Working Group on Food Supplements (26 European countries) published its first report evaluating 117 substances used in food supplements. Of these, 65 were assessed as likely novel foods, 6 were already regulated, 34 had insufficient data, and 12 were prioritized for Article 8 restriction under Regulation (EC) No 1925/2006. The 12 priority substances include ashwagandha, curcumin, melatonin, piperine, St. John's wort, coumarin, p-synephrine, maca, holy basil, Melaleuca, black cohosh, and L-tryptophan. The report drew on 1,500 RASFF alerts reviewed between 2017 and mid-2022.
    Source →
  • 2014 Research milestone
    Rahman et al. 2014
    Preclinical evidence for SIRT6-dependent metabolic effects of fucoidan.
    Source →
  • 2006-12 Regulatory confirmed
    EU Health Claims Regulation adopted
    Regulation (EC) No 1924/2006 laid down harmonised rules for nutrition and health claims made on foods, including supplements. Only claims listed in the EU Register of authorised claims can be used. Rejected botanical claims are held in a separate on-hold list.
    Source →
  • 1997 Regulatory confirmed
    EU introduces the Novel Food Regulation
    Regulation (EC) No 258/97 required any food or food ingredient without a history of consumption in the EU before 15 May 1997 to be authorised before being placed on the market. This is the framework that captures NMN, spermidine as a supplement ingredient, urolithin A, and many other longevity actives.
    Source →

Landmark studies

Found in these products (2)

All products in our catalog that contain SIRT6 Activator, ranked by our overall score. Ranking is editorial, never paid.

Multi/greens
Ingredients listed
5 ingredients listedlargest listed: SIRT6 Activator 1,600 mg
Price per serving
$7.25$203.00 · 28 servings
Testing
3rd-party listed · no public lab certificate

Multi-ingredient bundle

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 6.7/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

400%
of trial dose
$3.62
per research-dose day, not label serving
400% · over 2× trial dose0Trial dose2×
Catalog price · Confirm current price with routine.donotage.org
DoNotAge
SIRT6Activator®
Sirtuin activator
Active per serving
SIRT6 Activator 400 mgCapsule · 366 servings
Price per serving
$0.27$97.00 · 366 servings
Testing
3rd-party listed · no public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 3.8/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

40%
of trial dose
$2.65
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with donotage.org
Editorial guides

Buying guides and comparisons

Neighbouring molecules

Related ingredients

See all in Sirtuin / Longevity →

Molecules in the same class, plus the actives most often formulated alongside SIRT6 Activator in our catalogue.

NMNBstacked together in 1 productBetaine (TMG)Cstacked together in 1 productCoQ10Bstacked together in 1 productSpermidineCstacked together in 1 product
Product shelves
See all in Multi/greens (1)See all in Sirtuin activator (1)

See SIRT6 Activator in context: the mechanism it acts through, the biomarker it moves, the products that dose it, and the trials that tested it.

View SIRT6 Activator on the Longevity Map →

Frequently asked questions

What is SIRT6 Activator?

SIRT6 is a longevity gene. Mice overexpressing it live ~30% longer. A specific type of seaweed extract (fucoidan) activates SIRT6 in the lab. DoNotAge markets it as 'SIRT6 Activator'.

What dose of SIRT6 Activator should I take?

The trial dose in published human studies is 4000 mg per day, with a range of 1000 to 4000 mg per day. Always consult a qualified clinician before starting any supplement.

Is SIRT6 Activator safe?

Fucoidan is inexpensive as a seaweed extract. High-priced 'SIRT6 activator' branding doesn't mean higher potency, check fucoidan mg/capsule.

What is the best SIRT6 Activator supplement?

We track 2 products containing SIRT6 Activator. The top-ranked product scores 6.7 out of 10 on our composite scale, which evaluates dose, evidence, price, third-party testing, and transparency. See the comparison table above. Scores are editorial judgments, not a scientific standard.

What is the evidence grade for SIRT6 Activator?

SIRT6 Activator has evidence grade E, meaning it is only mechanistic evidence so far. Grade A means replicated human RCTs with hard endpoints. Grade B means human RCTs with biomarker outcomes. Grade C means mixed or small human trials. See our evidence grading methodology.

Independently checked

Data verification

Evidence grade
E
Mechanistic only
Research dose
4000 mg
Products tracked
2
Updated continuously
Safety signal
Fucoidan is inexpensive as a seaweed extract. High-priced...

Evidence grades are reviewed when new human RCTs are published. Product counts update automatically as new products are added. Dose ranges reflect published trial data, not brand recommendations. Read how we verify.