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NAD+ precursor

Trigonelline · Trigonelline

Newly-identified alternative NAD+ precursor from coffee.

D
Evidence grade
Mostly animal

Short answer

Watch this space. Too early to include in a serious stack.

Product and dose overview

Trigonelline (Trigonelline) is a NAD+ precursor with evidence grade D, meaning it is primarily supported by animal studies. We track 1 products containing Trigonelline. Typical doses range from 125 to 125 mg per serving. The top-ranked product scores 7.4 out of 10 on our composite scale (dose, evidence, price, testing, transparency). Prices range up to $84.95 per month.

Evidence grade: D Products in database: 1 Category: NAD+ precursor

Top Trigonelline products

ProductBrandDosePrice/mo3rd-party testedScore
NAD+ Complete (Liposomal)Renue By Science125 mg$84.95Yes7.4

Scores are editorial judgments, not a scientific standard. See how we score.

What it is

A compound abundant in coffee and fenugreek. Recent research (Membrez 2023) shows it can raise NAD+ via a different pathway than NMN/NR.

Why people take it

Novel; single 2024 human trial shows NAD+ elevation. Long-term data absent.

Our verdict

Watch this space. Too early to include in a serious stack.

Structure & class

Methylnicotinate.

Mechanism & clinical data

Membrez et al. 2023 (Nature Metabolism) showed novel NAD+ salvage pathway.

Pharmacokinetics

Unknown.

Dose & forms

Trial dose
200 mg
/ day
Range in trials
100 to 500 mg
/ day
Common forms
Standalone capsule, Combined with NR

What to watch out for

Very new; supplements just emerging.

Where this dose comes from

The trial dose above is our editorial pick from the published human trials for this ingredient. We choose the dose that the best-available studies used on the endpoint most relevant to longevity. The range shows the lowest and highest doses tested in published trials. The landmark studies below are the papers we read to set it. You can click through and check our work.

When new trials publish, our automated sweeps flag them. If a new study materially changes the dose, we update it through editorial review and record the old dose, new dose, and the triggering study in every affected product's recommendation history. The dose is never changed automatically.

Regulatory status

EUUnclear Novel Food status
USDietary supplement
UKUnclear
CAUnclear

Timeline

Regulatory events, evidence grade changes, and key research milestones for Trigonelline, most recent first. Studies link to the paper; regulatory entries name and link the responsible authority.

  • 2025-04 Regulatory single source
    EU Court sharpens the bar for botanical health claims
    A Court of Justice of the European Union ruling in April 2025 further tightened the requirements for how botanical ingredients (herbs, plant extracts) can be marketed with health claims in the EU, effectively removing much of the flexibility of the on-hold list.
  • 2024-06 Regulatory confirmed
    EU report identifies 117 supplement substances as potential health risks
    The HoA Working Group on Food Supplements (26 European countries) published its first report evaluating 117 substances used in food supplements. Of these, 65 were assessed as likely novel foods, 6 were already regulated, 34 had insufficient data, and 12 were prioritized for Article 8 restriction under Regulation (EC) No 1925/2006. The 12 priority substances include ashwagandha, curcumin, melatonin, piperine, St. John's wort, coumarin, p-synephrine, maca, holy basil, Melaleuca, black cohosh, and L-tryptophan. The report drew on 1,500 RASFF alerts reviewed between 2017 and mid-2022.
    Source →
  • 2023 Research milestone
    Membrez et al. 2023
    Identified trigonelline as NAD+ precursor via unique pathway.
    Source →
  • 2006-12 Regulatory confirmed
    EU Health Claims Regulation adopted
    Regulation (EC) No 1924/2006 laid down harmonised rules for nutrition and health claims made on foods, including supplements. Only claims listed in the EU Register of authorised claims can be used. Rejected botanical claims are held in a separate on-hold list.
    Source →
  • 1997 Regulatory confirmed
    EU introduces the Novel Food Regulation
    Regulation (EC) No 258/97 required any food or food ingredient without a history of consumption in the EU before 15 May 1997 to be authorised before being placed on the market. This is the framework that captures NMN, spermidine as a supplement ingredient, urolithin A, and many other longevity actives.
    Source →

Landmark studies

Found in these products (1)

All products in our catalog that contain Trigonelline, ranked by our overall score. Ranking is editorial, never paid.

Renue By Science
NAD+ Complete (Liposomal)
NAD+ booster
Ingredients listed
3 ingredients listedlargest listed: NMN 250 mg
Price per serving
$1.42$84.95 · 60 servings
Testing
3rd-party listed · public lab certificate

Multi-ingredient bundle

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 7.4/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$2.83
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with renuebyscience.com
Editorial guides

Buying guides and comparisons

Neighbouring molecules

Related ingredients

See all in NAD+ precursor →

Molecules in the same class, plus the actives most often formulated alongside Trigonelline in our catalogue.

NMNBsame categoryNRBsame category
Product shelves
See all in NAD+ booster (1)

See Trigonelline in context: the mechanism it acts through, the biomarker it moves, the products that dose it, and the trials that tested it.

View Trigonelline on the Longevity Map →

Frequently asked questions

What is Trigonelline?

A compound abundant in coffee and fenugreek. Recent research (Membrez 2023) shows it can raise NAD+ via a different pathway than NMN/NR.

What dose of Trigonelline should I take?

The trial dose in published human studies is 200 mg per day, with a range of 100 to 500 mg per day. Always consult a qualified clinician before starting any supplement.

Is Trigonelline safe?

Very new; supplements just emerging.

What is the best Trigonelline supplement?

We track 1 products containing Trigonelline. The top-ranked product scores 7.4 out of 10 on our composite scale, which evaluates dose, evidence, price, third-party testing, and transparency. See the comparison table above. Scores are editorial judgments, not a scientific standard.

What is the evidence grade for Trigonelline?

Trigonelline has evidence grade D, meaning it is primarily supported by animal studies. Grade A means replicated human RCTs with hard endpoints. Grade B means human RCTs with biomarker outcomes. Grade C means mixed or small human trials. See our evidence grading methodology.

Independently checked

Data verification

Evidence grade
D
Mostly animal
Research dose
200 mg
Products tracked
1
Updated continuously
Safety signal
Very new; supplements just emerging.

Evidence grades are reviewed when new human RCTs are published. Product counts update automatically as new products are added. Dose ranges reflect published trial data, not brand recommendations. Read how we verify.