Vitamin D3's essential partner, directs calcium to bones instead of arteries.
Buy this as a D3+K2 combo unless you specifically need one alone. MK-7 form has 3× longer half-life than MK-4.
Vitamin K2 (Vitamin K2 (MK-7)) is a foundational with evidence grade B, meaning it is supported by human RCTs. We track 6 products containing Vitamin K2. Typical doses range from 0.09 to 43 mg per serving. The top-ranked product scores 8.9 out of 10 on our composite scale (dose, evidence, price, testing, transparency). Prices range up to $69.00 per month.
| Product | Brand | Dose | Price/mo | 3rd-party tested | Score |
|---|---|---|---|---|---|
| Vitamin D3+K2 | Nordic Naturals | 0.09 mg | $19.95 | Yes | 8.9 |
| Basic Nutrients 2/Day | Thorne HealthTech | 0.4 mg | $32.00 | Yes | 7.9 |
| AG Vitamin D3+K2 | AG1 (Athletic Greens) | 0.1 mg | $29.00 | Yes | 7.8 |
| Daily Longevity Blend | AgeMate | 0.2 mg | $69.00 | Yes | 7.0 |
| Seed DM-02 Daily Multivitamin | Seed Health | 43 mg | $39.99 | Yes | 6.7 |
Scores are editorial judgments, not a scientific standard. See how we score.
A form of vitamin K found in fermented foods (natto, aged cheese). It activates proteins that direct calcium into bones and teeth and keep it out of arteries and soft tissues.
The 3-year Knapen trial (2013) showed 180 μg MK-7/day slowed arterial stiffening and improved bone density in postmenopausal women. K2 status is critical when supplementing D3.
Buy this as a D3+K2 combo unless you specifically need one alone. MK-7 form has 3× longer half-life than MK-4.
Menaquinone-7 (all-trans). Activates osteocalcin (bone) and matrix Gla protein (arterial calcium inhibitor).
Knapen 2013 showed 3 years of 180 μg MK-7/day improved bone-mineral density and reduced arterial stiffening (aortic pulse-wave velocity). MK-4 requires 45 mg/day (Japan) whereas MK-7 works at 180 μg.
~72 hours (MK-7); ~1 hour (MK-4).
Interacts with blood thinners (warfarin), consult your doctor. All-trans MK-7 is the active form; cis-MK-7 is inactive filler.
When a product exceeds the UL or contains an ingredient with clinically significant interactions, a "Review advised" flag appears on its product page and links here.
Source: https://ods.od.nih.gov/factsheets/VitaminK-HealthProfessional/
The trial dose above is our editorial pick from the published human trials for this ingredient. We choose the dose that the best-available studies used on the endpoint most relevant to longevity. The range shows the lowest and highest doses tested in published trials. The landmark studies below are the papers we read to set it. You can click through and check our work.
When new trials publish, our automated sweeps flag them. If a new study materially changes the dose, we update it through editorial review and record the old dose, new dose, and the triggering study in every affected product's recommendation history. The dose is never changed automatically.
Regulatory events, evidence grade changes, and key research milestones for Vitamin K2, most recent first. Studies link to the paper; regulatory entries name and link the responsible authority.
Verified 2026-08-04. We update this section as new peer-reviewed trials land.
Vitamin K2's best-supported effect is slowing vascular and valvular calcification through activation of matrix Gla protein (MGP), a calcification inhibitor. The AVC Trial, the largest K2-specific RCT to date, found MK-7 plus vitamin D3 slowed aortic valve calcification progression over 24 months in 365 elderly men (https://pmc.ncbi.nlm.nih.gov/articles/PMC12785717/table/ijms-27-00298-t003/). Smaller trials reinforce this mechanism: a 6-month RCT in 68 people with type 2 diabetes and cardiovascular disease found MK-7 (360 mcg/day) improved arterial stiffness and reduced uncarboxylated MGP, and a 3-year trial in 244 healthy postmenopausal women found MK-7 (180 mcg/day) improved arterial elasticity. A 2023 systematic review of 14 RCTs found consistent reductions in the uncarboxylated (inactive) MGP biomarker across studies, though outcome data on hard clinical endpoints like heart attacks remains limited.
Marketers frequently claim vitamin K2 prevents heart attacks and strokes directly, but no trial has yet shown this. The evidence base consists of surrogate markers (arterial stiffness, calcification scores, MGP biomarkers) and small-to-moderate trials, not hard cardiovascular event reduction in a large outcomes trial. A 2024 meta-analysis of vitamin K supplementation and cardiovascular risk factors examined markers like blood glucose, lipids, and blood pressure and found effects, but these are risk-factor changes, not confirmed reductions in heart attacks or strokes (https://pubmed.ncbi.nlm.nih.gov/38282652/). For bone health, the evidence is genuinely mixed rather than uniformly positive: a 2019 updated meta-analysis of 36 studies found vitamin K reduced clinical fracture odds in postmenopausal or osteoporotic patients (OR 0.72), but this differs by vitamin K form and population, and general healthy-adult bone density claims are not as strongly supported as the osteoporosis-specific fracture data (https://link.springer.com/article/10.1007/s00198-019-04949-0).
90-360 mcg/day of MK-7 (menaquinone-7), the long-acting form; some cardiovascular trials use up to 720 mcg/day
Vitamin K2 has a strong safety record in trials up to 24 months, including in dialysis patients, with no significant excess adverse events reported versus placebo. The RenaKvit study in 190 hemodialysis patients found MK-7 was safe and well tolerated over 24 months (https://pmc.ncbi.nlm.nih.gov/articles/PMC12785717/table/ijms-27-00298-t003/). The main clinical caution is for people on warfarin or other vitamin K antagonist blood thinners, where vitamin K intake directly counteracts the drug's mechanism and must be kept consistent and medically supervised.
180 μg MK-7 daily for 3 years slowed arterial stiffening in postmenopausal women.
Read study →All products in our catalog that contain Vitamin K2, ranked by our overall score. Ranking is editorial, never paid.
Nordic NaturalsStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Thorne HealthTechMulti-ingredient bundle
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
AG1 (Athletic Greens)Multi-ingredient bundle
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
AgeMateMulti-ingredient bundle
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Seed HealthMulti-ingredient bundle
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Elemental vs compound: check label
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Molecules in the same class, plus the actives most often formulated alongside Vitamin K2 in our catalogue.
See Vitamin K2 in context: the mechanism it acts through, the biomarker it moves, the products that dose it, and the trials that tested it.
View Vitamin K2 on the Longevity Map →A form of vitamin K found in fermented foods (natto, aged cheese). It activates proteins that direct calcium into bones and teeth and keep it out of arteries and soft tissues.
The trial dose in published human studies is 0.18 mg per day, with a range of 0.09 to 0.36 mg per day. Always consult a qualified clinician before starting any supplement.
No formal UL (FNB states there is insufficient toxicity data to derive one). The Council for Responsible Nutrition established a Highest Observed Intake of 375 mcg/day for supplemental MK-7 in 2025.
We track 6 products containing Vitamin K2. The top-ranked product scores 8.9 out of 10 on our composite scale, which evaluates dose, evidence, price, third-party testing, and transparency. See the comparison table above. Scores are editorial judgments, not a scientific standard.
Vitamin K2 has evidence grade B, meaning it is supported by human RCTs. Grade A means replicated human RCTs with hard endpoints. Grade B means human RCTs with biomarker outcomes. Grade C means mixed or small human trials. See our evidence grading methodology.
Evidence grades are reviewed when new human RCTs are published. Product counts update automatically as new products are added. Dose ranges reflect published trial data, not brand recommendations. Read how we verify.
Vital Proteins