Study

Blueprint protocol page: sleep timing and hair regimen changes

Bryan Johnson

N=1 SELF-EXPERIMENT / PROTOCOL REVISION 2026

PROTOCOL CHANGE: the page now sets a 2-hour minimum between the last meal and bed, with 4- and 6-hour tests; hair dosing is 7% topical minoxidil, 5 mg oral minoxidil, and a 302-diode cap.

Summary What changes does this protocol make to sleep timing and hair treatment? Show / hide ↓

This protocol sets a minimum two-hour gap between your last meal and bedtime. It also suggests testing four- and six-hour gaps. The hair regimen uses 7% topical minoxidil, meaning minoxidil applied to the scalp, 5 mg oral minoxidil taken by mouth, and a cap with 302 light diodes. The information provided does not include evidence showing whether these changes work or are safe.

What this means for you: The page describes specific sleep timing and hair-treatment changes, but it does not provide enough evidence to judge their benefits or safety. Do not treat the protocol as proven.

weak evidence
DesignN=1 SELF-EXPERIMENT / PROTOCOL REVISION
TierTier 4, Ingredient RCT (different dose)
Year2026
JournalSelf-published — blueprint.bryanjohnson.com
N1
PublishedAug 19, 2026
Added to NO1GEVITYAug 19, 2026

The current Blueprint protocol page changes several practical details from the 12 August snapshot. The sleep section now says the last meal should be at least 2 hours before bed, with experiments at 4 and 6 hours. The older snapshot stated 4 hours as the target. The page still reports Johnson’s personal pattern of stopping food around noon and links a pre-bed resting heart rate of about 39 beats per minute with a good night’s sleep. The current hair section lists a 7% topical minoxidil solution at 1 mL each night, up from 5% in the prior snapshot. It lists oral minoxidil at 5 mg daily, up from 3.75 mg. The red-light device is now named the Blueprint 302 Laser Cap at 655 nm, replacing the generic red-light-cap wording. The daily routine still lists NR 450 mg or NMN 500 mg, metformin 500 mg in six-week cycles, and the other prescription items. These are protocol statements from one person, not comparative trials. The page now labels the material as historical personal protocol information and says some treatments are not FDA approved. The clearest update is the meal-timing revision; the page does not publish adherence data or a new outcome series for the change.

Try to have your last meal of the day at least two hours (experiment with 4 and 6 hours before) before bed and avoid large meals close to bedtime.
Critic notes

Niko Hems’ 13 August review says Johnson’s N=1 design cannot separate the effects of diet, exercise, sleep, and supplements, and that biomarker shifts do not prove longer healthy life. Eric Topol wrote that the 150-year Blueprint was “doomed to fail.” Neither piece supplies evidence for a meal-timing or hair-dose upgrade. URLs: https://www.years.co/en/blog/bryan-johnson-biomarkers-science-limits ; https://x.com/EricTopol/status/2088013677232521620

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