The effect of vitamin MK-7 on bone mineral density and microarchitecture in postmenopausal women with osteopenia, a 3-year randomized, placebo-controlled clinical trial

Researchers gave 148 postmenopausal women with osteopenia, meaning lower-than-normal bone strength, either vitamin K2 in the MK-7 form or a placebo for three years. The women took the study product every day while researchers measured bone mineral density, the amount of mineral in bone, and bone microarchitecture, the small internal structures that help bones resist breaking. MK-7 did not meaningfully improve bone density or these internal bone structures compared with the placebo. This was a human study, but it was relatively small.

What this means for you: This trial does not support buying MK-7 specifically to improve bone density or prevent bone weakening. Treatments with stronger evidence, along with exercise and adequate calcium and vitamin D when appropriate, should not be replaced by it.