Study
Effects of Nicotinamide Mononucleotide on Glucose and Lipid Metabolism in Adults: A Systematic Review and Meta-analysis of Randomised Controlled Trials
A second independent 2024 meta-analysis on NMN and metabolic outcomes, published in Current Diabetes Reports, reaching broadly similar conclusions to the Zhang et al. review on the same evidence base.
Summary Does NMN improve blood sugar and cholesterol in adults? Show / hide ↓
Researchers combined results from randomized controlled trials, studies where adults were assigned by chance to take NMN or a comparison treatment. This type of review, called a meta-analysis, looked at NMN supplements and measures of blood sugar and blood fats. NMN often increased NAD, a molecule cells use for energy and repair. However, improvements in blood sugar and blood fats were inconsistent or not clearly different from the comparison treatment.
What this means for you: This is not good evidence to buy NMN for better blood sugar or cholesterol. NMN may raise NAD, but that has not yet translated into reliable health benefits in adults.
conflicting evidenceThis review, led by researchers at the University of Hong Kong and Chinese University of Hong Kong, is the companion meta-analysis to Zhang et al. 2024, published the same year in a different journal and assessing overlapping randomised trial data on NMN's effect on glucose and lipid metabolism in adults. The authors are affiliated with nursing, medicine, and food science faculties, giving this a more clinical-metabolic framing than Zhang et al.'s food-science framing. Two independent teams reaching similar conclusions from a similar pool of RCTs (that NMN raises blood NAD reliably but clinically meaningful glucose and lipid endpoints remain inconsistent or non-significant) strengthens confidence that this is the real state of the evidence rather than an artifact of one team's methodology. We were not able to fetch the full text; this entry is based on the PubMed abstract listing and article metadata. Readers should treat the summary above as provisional pending full-text confirmation, though the abstract framing tracks closely with Zhang et al.'s published findings.
n/a - full abstract text was not retrievable at time of writing
Full abstract conclusion not confirmed from primary source; entry relies on PubMed listing metadata (PMID 39531138, PMCID PMC11557618, DOI 10.1007/s11892-024-01557-z). Treat with appropriate caution until full text is reviewed.
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