Alpha-ketoglutarate supplementation and BiologicaL agE in middle-aged adults (ABLE) — intervention study protocol

Researchers planned a controlled trial of alpha-ketoglutarate, a substance made naturally by the body and sold as a supplement. Middle-aged adults would take the supplement or a look-alike inactive pill for a set period. The team would compare changes in biological age, estimates based on body measurements and chemical markers, along with health and physical-function measures. This paper describes the study plan, so it does not report whether the supplement worked.

What this means for you: This study gives no reason to buy alpha-ketoglutarate yet because it has not provided results. Wait for the completed trial, especially because biological-age estimates do not necessarily mean living longer or healthier.